MSACL 2019 US Abstract

Analysis of Urinary Biomarkers of Exposure to Volatile Organic Compounds from the Population Assessment of Tobacco and Health (PATH) Study (Wave 1)

Víctor R. De Jesús (1), Deepak Bhandari (1), John Ruhl (1), Nathan Geldner (1), B. Rey deCastro (1), Christopher Reese (1), Kimberly Capella (1), Alai Fernandez (1), Declan McCarthy (1), Daniel Milan (1), Cameron Movassaghi (1), Anish Patel (1), Katharine Roland (1), Denise Tevis (1), Dana van Bemmel (2), Arseima Y. Del Valle-Pinero (2), Guy Lagaud (2), Joanne Chang (2), Heather Kimmel (3), Eva Sharma (4), Maciej Goniewicz (5), Andrew Hyland (5), and Benjamin C. Blount (1)
(1) Division of Laboratory Sciences, National Center for Environmental Health, U.S. Centers for Disease Control & Prevention, Atlanta, GA 30341, USA (2) Office of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, MD 20993 USA (3) National Institutes of Health, Bethesda, MD, USA (4) Westat, 1600 Research Boulevard, Rockville, MD, 20850, USA (5) Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA

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Victor De Jesus (Presenter) Centers for Disease Control and Prevention

Relevant Financial Disclosures (within past 24 months) No relevant financial relationship(s) to disclose. Discussing Products? NO, presenter will NOT present educational content related to products/services of the ineligible company(ies) listed above. Conflict mitigation NOT REQUIRED.

Tobacco smoke is the major non-occupational source of exposure to a number of harmful volatile organic compounds (VOCs) such as acrolein, acrylonitrile, benzene, and 1,3-butadiene. The Population Assessment of Tobacco and Health (PATH) Study is a national longitudinal study in the US that examines tobacco use patterns, attitudes, and related health outcomes. We analyzed and reported data for 20 VOC metabolites from 11,043 PATH Study Wave 1 samples to better characterize and compare VOC exposures among users of different tobacco products and non-users. We provide reliable estimates of population exposure to 16 harmful and/or carcinogenic parent VOCs resulting in well-characterized VOCM ranges for four tobacco user groups. These data can be used to establish a baseline of exposures to VOCs to identify exposure trends as a result of changes in tobacco use behavior over time.