Cannabinoid Concentrations in Whole Blood, Oral Fluid, and Breath After Recent Use
Jacqueline A. Hubbard, Ph.D. (1) (1) University of California, San Diego, CA
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Jacqueline Hubbard (Presenter) University of California, San Diego
Presenter Bio: Jacqueline Hubbard graduated from the University of Vermont in 2010 with a B.S. in Biochemistry and a minor in Pharmacology. She then enrolled in the Biochemistry and Molecular Biology program at the University of California, Riverside (UCR) where she earned my M.S. and Ph.D. After completing a one year postdoc at UCR, she took a position as a Clinical Chemistry Postdoctoral Fellow at the University of California, San Diego. She is now in her second year working in the Toxicology lab under the supervision of Robert Fitzgerald, Ph.D., D.A.B.C.C. Her main research focus is detecting levels of cannabinoids in various biological matrices.
Relevant Financial Disclosures
(within past 24 months)
No relevant financial relationship(s) to disclose.
Abstract
The growing popularity of cannabis use has raised concerns regarding its impact on driving performance and safety. In this study, participants are given a placebo, low dose, or high dose of ∆9-tetrahydrocannabinol (THC), the main psychoactive component of marijuana, in a cannabis cigarette. After smoking, they drive in a driving simulator, complete iPad-based cognition tests, undergo a field sobriety test, and submit whole blood, oral fluid, and breath samples several times throughout the day. The liquid chromatography tandem mass spectrometry (LC-MS/MS) method used to quantify cannabinoids in these matrices and the general pharmacokinetics of each metabolite will be discussed.
= Discovery stage. (17.55%, 2019 US)
= Translation stage. (42.72%, 2019 US)
= Clinically available. (39.74%, 2019 US)
