MSACL 2019 US Abstract

The Impact of Remote Monitoring in Pediatric Renal Transplant Patients: Multiplexed Quantification of Immunosuppressants and Creatinine by LC-MS/MS

C. Gordon (1), K. Sadilkova (1), R.M. Jack (1,2), J.A. Dickerson (1,2)
(1) Department of Laboratories, Seattle Children’s Hospital, Seattle, Washington, 98105 (2)Department of Laboratory Medicine, University of Washington, Seattle, Washington, 98195

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Jane Dickerson (Presenter) Seattle Children's Hospital

Presenter Bio: Jane Dickerson, PhD, DABCC is Co-director of Chemistry and Director of Reference Lab Services at Seattle Children’s Hospital. She completed her post-doctoral training at the University of Washington where she was a clinical chemistry fellow in the department of Lab Medicine. As a faculty member at Seattle Children’s and the University of Washington Department of Lab Medicine, Dr. Dickerson focuses her research on the science of the delivery of care—improving processes to get the right test ordered (utilization management), performed (analysis of alternative matrices), and resulted (failure to retrieve) for the best patient care.

Relevant Financial Disclosures (within past 24 months) No relevant financial relationship(s) to disclose. Discussing Products? NO, presenter will NOT present educational content related to products/services of the ineligible company(ies) listed above. Conflict mitigation NOT REQUIRED.

We have previously described implementing a clinical dried blood spot program for monitoring immunosuppressants. Improving compliance in the adolescent population is a major effort of the clinical team. To assist their efforts, we developed and validated a liquid chromatography-mass spectrometry (LC-MS/MS) assay for quantitation of creatinine in dried blood spots (DBS). The method correlated well with plasma creatinine measured on an Ortho Vitros. We believe this research will improve the clinical utility of remote collection of dried blood spots for renal transplant patients by monitoring both immunosuppressant and creatinine levels.