= Discovery stage. (17.55%, 2019 US)
= Translation stage. (42.72%, 2019 US)
= Clinically available. (39.74%, 2019 US)
MSACL 2019 US : Li

MSACL 2019 US Abstract

Self-Classified Topic Area(s): Tox / TDM / Endocrine

Toxicology Screening by Mass Spectrometry for Emergency Intoxication

Shuijun Li (1), Youli Lu (1), Wei Wang (2), Fengli Jiang (1), Chaoyang Tong (3), Jie Shen (4)
(1) Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, China, (2) Emergency Department, Shanghai Xuhui Central Hospital, Shanghai, China, (3) Emergency Department, Zhongshan Hospital, Fudan University, Shanghai, China, (4) Center of Emergency & Intensive Care Unit, Jinshan Hospital, Fudan University, Shanghai, China


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 Shuijun Li (Presenter)
Shanghai Xuhui Central Hospital, China

Presenter Bio: Shuijun Li is the Director of Central Laboratory, Shanghai Xuhui Central Hospital. He is also the principal investigator of Shanghai Clinical Research Center, Chinese Academy of Sciences. His expertise includes laboratory management, clinical application of mass spectrometry, molecular diagnosis for patient care. His research interests focus on biomarker discovery, therapeutic drug monitoring, and clinical pharmacology and toxicology with triple quadrupole, time of flight and obitrap mass spectrometry. He served as members of serval professional associations such as AACC, Chinese Medical Doctor Association. He has published 76 peer-reviewed papers, 8 book chapters, and 25 abstracts. He edited the first book on clinical mass spectrometry in China.

Relevant Financial Disclosures (within past 24 months)
No relevant financial relationship(s) to disclose.

Abstract

Clinical toxicology screening is critical for diagnosis and management of acute drug overdose and emergency intoxication. In our hospital, we developed and validated and an LC-QTOF/MS for screening and the other LC-QQQ/MS for confirming toxic drugs and poisons, which include sedative-hypnotics, antipsychotics, analgesics, pesticides and rodenticides, and drugs of abuse. The results for these determinations were reported 2-4 hours of sample receipt. Among the 105 tested clinical cases, drugs/poisons were identified in 55% (58/105) cases, of which drug overdose, pesticide poisoning, and other poisons accounted for 79% (46/58), 17% (10/58), and 3% (2/58), respectively. LC-QTOF/MS and LC-QQQ/MS are proved to be prompt and reliable diagnostic tools for emergency toxicology screening and confirmation.