MSACL 2019 US Abstract

A Multi-omic Investigation of Molecular Signatures Indicative of Preeclampsia and Gestational Diabetes

Melanie Odenkirk (1), Kristin E. Burnum-Johnson (2), Brandie D. Taylor (3), Kelly G. Stratton (2), Marina A. Gritsenko (2), Therese Clauss (2), Xueyun Zhenq (2), Jennifer E. Kyle (2), Kent Bloodsworth (2), Karl Weitz (2), Heather M. Brewer (2), Erin S. Baker (1)
(1) Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695 (2) Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352 (3) College of Public Health, Temple University, Philadelphia, PA 19122

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Melanie Odenkirk (Presenter) North Carolina State University

Relevant Financial Disclosures (within past 24 months) Grant/Research Support NIGMS and NIEHS Discussing Products? NO, presenter will NOT present educational content related to products/services of the ineligible company(ies) listed above. Conflict mitigation NOT REQUIRED.

Pregnancy disorders such as preeclampsia (PE) and gestational diabetes mellitus (GDM) have been correlated with infant distress and the development of cardiovascular and metabolic diseases in the mother post pregnancy. In this study, lipidomic and proteomic analyses using LC-MS/MS and LC-IMS-MS were conducted to elucidate specific molecular changes between mothers with and without these pregnancy disorders. Proteomic data revealed statistically significant proteins with known functions that varied among diagnoses. Lipidomic data also revealed overall up and down-regulation of lipid classes specific for GDM and PE patients, as well as variations based on specific fatty acid backbones.