MSACL 2019 US Abstract

Self-Classified Topic Area(s): Natural Products / Environmental

Hormone Modulations of 4-Hydroxyestradiol, 5α-Androstane-3α,17β-diol, and Glucocorticoids in Urine of Menopausal Women Taking a Hop Botanical Dietary Supplemen

Alan Wong, Richard B van Breemen
Linus Pauling Institute and College of Pharmacy, Oregon State University, Corvallis, OR

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Alan Wong (Presenter)
Linus Pauling Institute, Oregon State University

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Abstract

A highly-sensitive and transferable LC-MS/MS method was developed to monitor modulations of estrogen and estrogen metabolites in the urine of post- and peri-menopausal women. The method utilizes derivatization agents with differential-isotope for dual purpose of enhancing MS sensitivity and generating stable-isotope internal standards. From a Phase 1 clinical trial of 16 women receiving a hop (Humulus lupulus) supplement, urine analysis identified a reduction in the levels of 4-hydroxyestradiol, a toxic estrogen metabolite, and a significant increase of 5α-androstane-3α,17β-diol, a weak androgen that is estrogen receptor β-selective. Modulations to glucocorticoids levels suggest possible effects on cortisol production by a hop dietary supplement.