MSACL 2019 US Abstract

Monitoring of Acetone and Short Chain Fatty Acids Levels in Mouth and Nose Breath following Fasting and Re-Feeding with Selected Ion Flow Tube Mass Spectrometry

Belluomo I, Vadhwana B, Boshier PR, Hanna GB
Department of Surgery and Cancer Imperial College London

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Ilaria Belluomo (Presenter) Imperial College London

Presenter Bio: Ilaria Belluomo is a postdoc scientist at the Surgery and Cancer department of Imperial College London. Her main interest is analysis of volatile organic compounds (VOCs) in human breath as non-invasive diagnostic technique for early detection of different types of cancer. Currently, she is the head scientist in the laboratory of Professor George Hanna, at St Mary’s hospital in London.
Ilaria is a biotechnologist graduated at the Alma Mater Studiorum, University of Bologna. In 2013 she finished her PhD in experimental pathology with a thesis in analytical chemistry applied to endocrinology, in which she investigated the relationship between plasma steroid hormones and endocannabinoids levels with obesity. This PhD project was carried out between Italy (CRBA, centre of applied biomedical research, Bologna) and France (Neurocentre Magendie INSERM, Bordeaux) as part of a European PhD program.

Relevant Financial Disclosures (within past 24 months) No relevant financial relationship(s) to disclose. Discussing Products? NO, presenter will NOT present educational content related to products/services of the ineligible company(ies) listed above. Conflict mitigation NOT REQUIRED.

Non-invasive diagnostic techniques, such as the quantification of volatile organic compounds in breath, represent the future of diagnostic medicine. Acetone and short-chain fatty acids are end products of normal metabolic processes, and they can be identified and quantified in breath with direct injection on-line techniques, such as selected ion flow tube mass spectrometry (SIFT-MS). We defined a different kinetic of these VOCs following fasting and re-feeding at different hours of the day, to investigate different metabolic response in healthy subjects.