MSACL 2019 US Abstract

MS & MS: Micro Sampling & Mass Spectrometry

Matthew L. Crawford, Jennifer Pollock, Bradley Collier, Meghan Bradley, Russell P. Grant
Laboratory Corporation of America, Burlington NC

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Matthew Crawford (Presenter) LabCorp

Presenter Bio: I am a Researcher at LabCorp for the Mass Spectrometry Research and Development department. I entered the clinical lab space as a technician at LabCorp’s Esoterix Endocrinology in Calabasas CA and then moved to be a part of the corporate R&D team in North Carolina. My efforts are focused high-throughput small molecule method development, laboratory automation, and method validation (CAP, CLIA, and FDA Bioanalytical).

Relevant Financial Disclosures (within past 24 months) Salary LabCorp Discussing Products? NO, presenter will NOT present educational content related to products/services of the ineligible company(ies) listed above. Conflict mitigation NOT REQUIRED.

Standard phlebotomy contains requirements that make obtaining samples laborious. The ability to collect a small volume sample from a finger stick would obviate needs that come with phlebotomy. The trade off for ease of collection comes with challenges and considerations that must be faced in order to maintain accuracy and precision of the analytical measurement. As such, a LC-MS/MS method for the measurement of testosterone from a dried plasma sample obtained from a finger stick was developed. An endogenous internal standardization approach along with calibration to venous samples has yielded an isotope dilution assay anchored to the CDC HoSt program.