MSACL 2019 US Abstract

Vexed by Vitamins-Conform, Confirm or Create?

Hemamalini Ketha (1), Matthew L. Crawford (1), André Valcour (1), Adam B. Girtman (3), Elizabeth L. Frank (2), Ravinder J. Singh (3) and Russell P. Grant (1)
(1) Laboratory Corporation of America Holdings, Center for Esoteric Testing, Burlington, North Carolina, (2) Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah, (3) Mayo Clinic, Department of Laboratory Medicine and Pathology, Rochester, Minnesota.

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Hemamalini Ketha (Presenter) Laboratory Corporation of America Holdings

Presenter Bio: Hema Ketha currently serves as the Technical Director of Toxicology and Mass Spectrometry at LabCorp's Center for Esoteric Testing in Burlington, North Carolina.

Relevant Financial Disclosures (within past 24 months) Grant/Research Support Laboratory Corporation of America Holdings Discussing Products? YES, presenter will present educational content related to products/services of one or more ineligible company(ies) listed above. Conflict mitigation IN PROCESS.

Clinical assays for quantitation of retinol, α-tocopherol and γ-tocopherol have recently transitioned from HPLC to LC-MS/MS in some reference laboratories including ours (LabCorp). In this investigation we demonstrate (a) the power of validation parameters including intra-assay replication study and Standard Reference Material (SRM) analysis for cross-sectional and longitudinal traceability assessment (b) non-commutability of the HPLC-based NHANES RI for retinol and (c) results from a multi-center method comparison and clinical concordance study to assess the current state standardization for retinol, α-tocopherol and γ-tocopherol assays.