MSACL 2019 US Abstract

Early Prediction of Cardiac Events via Remote Monitoring Coupled with an Apolipoprotein Targeted MRM Panel

Kelly N. Mouapi (1), Irene van den Broek (1), Mitra Mastali (1), Qin Fu (1), Sandy Joung (2), Shivani Dhawan (2), Garth Fuller (3) Mayra Lopez (3), Chrisandra Shufelt (2), Brennan Spiegel (3), Noel Bairey Merz (2), and Jennifer E Van Eyk (1,2)
1. Advanced Clinical Biosystems Research Institute, Smidt Heart Institute, Cedars-Sinai Medical Center 2. Barbra Streisand Women’s Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center 3. Cedars-Sinai Center for Outcomes Research and Education (CS-CORE), Cedars-Sinai Medical Center

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Kelly Mouapi (Presenter) Cedar-Sinai Medical Center

Relevant Financial Disclosures (within past 24 months) No relevant financial relationship(s) to disclose. Discussing Products? NO, presenter will NOT present educational content related to products/services of the ineligible company(ies) listed above. Conflict mitigation NOT REQUIRED.

In this study, we assessed the feasibility of remote longitudinal blood collection using Mitra™ microsampling device, coupled with a targeted multiple reaction monitoring (MRM) mass spectrometry approach. Fingerprick samples from patients with stable ischemic heart disease (n=200) were collected at baseline (t0), one-month (t30), two-months (t60) and three-months (t90). At t30 and t60, patients collected samples from home and mailed to the laboratory. We obtained over 80% compliance from home and 90% in hospital setting. We evaluated Mitra™ tip quality and process quality control during batch analysis. We measured apolipoprotein B (apoB)/ apolipoprotein A-I (apoA-I) ratios from Mitra™ tips using an MRM apolipoprotein panel.