MSACL 2019 US Abstract

Comparison of a Coated Blade Spray - Mass Spectrometry (CBS-MS) Method vs a Point of Care (POC- CUP) Test for the Drug Screening in Chronic Pain Patients

Shirin Hooshfar (1), Simone Tchu (1), German A. Gómez-Ríos (2, 3), Daniel A. Rickert (2), Janusz Pawliszyn (2) and Kara Lynch (1)
(1) Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA (2) Department of Chemistry, University of Waterloo, Waterloo, Canada (3) Restek Corporation, Bellefonte, PA, USA

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Shirin Hooshfar (Presenter) University of California San Francisco

Presenter Bio: I am currently working as a postdoctoral fellow in the field of clinical mass spectrometry with Dr. Kara Lynch at the University of California San Francisco (UCSF). My research is mainly focused on the development and validation of new clinical diagnostic assays using technologies such as liquid chromatography tandem mass spectrometry, liquid chromatography high resolution mass spectrometry, and surface plasmon resonance. I also work on the development of a rapid diagnostic methods based on the direct coupling of biocompatible Solid Phase Micro Extraction (SPME) devices to mass spectrometry instruments using Coated Blade Spray (CBS) as an ionization technique.
I have received my Pharm.D. from Shahid Beheshti University of Medical Sciences in Iran and I was a Ph.D. student in this university during the 2011-2015.

Relevant Financial Disclosures (within past 24 months) No relevant financial relationship(s) to disclose. Discussing Products? NO, presenter will NOT present educational content related to products/services of the ineligible company(ies) listed above. Conflict mitigation NOT REQUIRED.

This study compared the capabilities of coated blade spray (CBS) mass spectrometry (MS) with a point of care (POC- CUP) test, as an alternative method for drug screening in urine. 81 pain patient urine samples were tested with both methods and an LC-MS/MS method was used to confirm the results. The CBS method identified 32% more drugs than POC-CUP test and had a lower rate of false-negatives. This technology has shown great potential for fast drug screening and provides better analytical performance than immunoassay.