MSACL 2019 US Abstract

A High Resolution Mass Spectrometry Method for Detecting a Comprehensive Pain-Management Drug Panel in Oral Fluid

Adina Badea, Alan H.B. Wu, Kara L. Lynch
Department of Laboratory Medicine, University of California, San Francisco

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Adina Badea (Presenter) University of California, San Francisco

Presenter Bio: Adina Badea received her PhD in organic/materials chemistry from the University of Illinois at Urbana-Champaign, after having earned her BA in Chemistry from Wellesley College. She is currently a clinical chemistry fellow at the University of California, San Francisco, where she works under the supervision of Dr. Kara Lynch and Dr. Alan Wu.

Relevant Financial Disclosures (within past 24 months) No relevant financial relationship(s) to disclose. Discussing Products? NO, presenter will NOT present educational content related to products/services of the ineligible company(ies) listed above. Conflict mitigation NOT REQUIRED.

With the increased use of pain-management drugs comes the added risk of misuse and addiction. Close monitoring of patients to identify abuse and ensure compliance is essential in preventing disastrous outcomes such as overdose deaths. Oral fluid is emerging as a promising biological matrix for drug testing due to its noninvasive collection and minimal potential for adulteration. We have developed a high resolution mass spectrometry method for detecting a panel of 82 pain-management drugs and metabolites in oral fluid, compatible with the widely used Quantisal® oral fluid collection device. The sample preparation is performed by in-tip solid-phase extraction (SPE, DPX®) and automated via a ViaFlo® electronic 96-channel pipette. The extraction procedure takes under 10 minutes, making this method suitable for use in clinical labs as a complement or replacement of urine drug testing methods.