MSACL 2019 US Abstract

Self-Classified Topic Area(s): Metabolomics

Spatially Resolved Analysis of Thermally Injured Skin using Desorption Electrospray Ionisation Mass Spectrometry Imaging

Josh Cuddihy (1,2), Andreas Dannhorn (1), James McKenzie (1), Hiromi Kudo (1), Declan Collins (2), Istvan Nagy (1), Marcela Vizcaychipi (1,2), Zoltan Takats (1)
(1) Imperial College London, London, UK (2) Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.

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Josh Cuddihy (Presenter)
Imperial College London, UK

Presenter Bio: Dr Josh Cuddihy is a clinical academic fellow at Chelsea and Westminster Hospital, London, working in critical care and burns critical care. Special interests include burns critical care and burns research. Prior to training as a medical doctor, Josh Cuddihy worked as a physiotherapist as part of the burns unit team at Chelsea and Westminster Hospital. Josh Cuddihy is a PhD candidate in the Department of Cancer and Surgery, investigating the mass spectrometry changes in burned skin in human patients.

Relevant Financial Disclosures (within past 24 months)

Grant/Research Support Westminster Medical School Research Trust and CW+ charity, awarded by the Joint Research Committee.

Discussing Products? NO, presenter will NOT present educational content related to products/services of the ineligible company(ies) listed above.

Conflict mitigation NOT REQUIRED.

Abstract

Burn injury to skin results in complex inflammatory processes with significant associated adverse outcomes for patients, proportionate to the degree of skin damage. Desorption electrospray ionisation mass spectrometry imaging (DESI MSI) enables spatially resolved, multiplexed detection of endogenous and xenobiotic metabolites within the burned tissue granting deep insight into the complex underlying pathology. Preliminary results from DESI-MSI analysis of burned and non-burned skin from human patients show alteration of the tissue metabolome in the directly affected as well as adjacent tissue areas. These insights show promise for development of novel therapies to improve care for affected patients.