MSACL 2019 US Abstract

Self-Classified Topic Area(s): Practical Training

Non-Specific Binding in LC-MS/MS Bioanalysis: What is it and How to Deal with It?

Jack Henion

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Jack Henion (Presenter)
Advion, Inc

Presenter Bio: Professor Jack Henion is Emeritus Professor of Toxicology at Cornell University where he was a member of the College of Veterinary Medicine commencing in 1976. Dr. Henion was co-founder of Advion BioSciences in 1993 and is now CSO of Advion, Inc. Professor Henion has received three Doctor Honoris Causa (Honorary Doctorate) degrees in recognition of his international reputation in modern analytical techniques from the University of Ghent. Uppsala University and Albany University. During his tenure at Cornell Professor Henion conducted research and explored applications in many areas of liquid chromatography/mass spectrometry (LC/MS) employing atmospheric pressure ionization (API) sources. Professor Henion has published over 235 peer reviewed papers in the scientific literature, trained nearly 100 students, post-doctoral scientists, and trainees while receiving 12 patents for invention

Relevant Financial Disclosures (within past 24 months)

Honorarium/Expenses MSACL

Committee/Board/Advisory Board Sport Medicine and Testing Laboratory (SMRTL)

Salary Advion, Inc

Discussing Products? YES, presenter will present educational content related to products/services of one or more ineligible company(ies) listed above.

Conflict mitigation IN PROCESS.

Abstract

This tutorial will describe problems that can occur during method development and validation of bioanalytical methods when particularly ‘sticky’ compounds are involved. These compounds can adsorb (stick to) the inside surfaces of pipettes, multi-well plates, syringes and autosampler injectors causing a variety of problems. This pratical presentation will tell you how to remedy these issues.