MSACL 2019 US Abstract

Imaging Mass Spectrometry Reveals Crosstalk Between the Fallopian Tube and the Ovary that Drives Primary Metastasis of Ovarian Cancer

Laura M Sanchez, Katherine E Zink, Matt Dean, Joanna E Burdette
University of Illinois at Chicago, Department of Medicinal Chemistry and Pharmacognosy

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Laura Sanchez (Presenter) University of Illinois at Chicago

Presenter Bio: Dr. Sanchez was born and raised in Northern California. She attended Whitman College in Walla Walla, WA. Laura decided to pursue a Ph.D. in Chemistry at the University of California, Santa Cruz to work with Prof. Roger Linington as an NSF graduate research fellow on natural products. In the Fall of 2012, she continued to move south to join Prof. Pieter Dorrestein's lab at UC San Diego as an NIH IRACDA Fellow. Her postdoctoral research focused on establishing methods for probing and characterizing metabolic exchanges in polymicrobial communities, specifically those associated with cheese rinds. Since 2015, she has been in her independent position at UIC and her NIH and NSF funded research program utilizes a variety of mass spectrometry techniques to probe how cells and microbes use chemistry to coordinate activities in a variety of biological systems.

Relevant Financial Disclosures (within past 24 months) Grant/Research Support NSF, NIH Discussing Products? YES, presenter will present educational content related to products/services of one or more ineligible company(ies) listed above. Conflict mitigation IN PROCESS.

High grade serous ovarian cancer originates in fallopian tubes (FTE). We describe an imaging mass spectrometry method to visualize the small molecules produced in the ovarian microenvironment that may contribute to the migration of tumorigenic FTE cells.