MSACL 2019 US Abstract

Association of Free and Total 25 Hydroxy Vitamin D with Biomarkers of Polycystic Ovary Syndrome

Mark M Kushnir (1), Vitaly A Kushnir (2), Joely A Straseski (3)
(1) ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA, (2) The Center for Human Reproduction, New York, NY, USA, (3) University of Utah School of Medicine, Salt Lake City, UT, USA.

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Mark Kushnir (Presenter) ARUP Institute for Clinical & Experimental Patholo

Presenter Bio: Dr Kushnir is Scientific Director, Mass Spectrometry R&D at ARUP Institute for Clinical and Experimental Pathology and Adjunct Assistant Professor at the Department of Pathology, University of Utah School of Medicine. Dr Mark Kushnir received PhD in Analytical Chemistry from Uppsala University (Uppsala, Sweden); his main areas of research include mass spectrometry and separation sciences and their application in clinical diagnostics. Dr Kushnir is author/coauthor of over 100 scientific peer reviewed publications.

Relevant Financial Disclosures (within past 24 months) Salary ARUP Laboratories Discussing Products? NO, presenter will NOT present educational content related to products/services of the ineligible company(ies) listed above. Conflict mitigation NOT REQUIRED.

Prior studies disagree whether association exists between 25 hydroxy vitamin D (25OHD), anti-Mullerian hormone (AMH, marker of ovarian reserve), androgens, and polycystic ovary syndrome (PCOS). Using samples from women with and without biochemical signs of PCOS (n=122), we observed lower total 25OHD (T25OHD) and higher percent Free 25OHD (F25OHD) associated with PCOS; elevated AMH was associated with VITD insufficiency; and lower androgen precursors were associated with VITD deficiency. Associations of F25OHD with AMH, androgens and PCOS have not been described previously. The higher percent F25OHD in women with PCOS is likely explained by lower binding protein concentrations observed in PCOS.