MSACL 2019 US Abstract

Practical Method for Molecular Imaging with Single-Cell Resolution and Very High Speed

Marvin Vestal1, Evgenia Dobrinskikh2, Xiaoxin Wang3Christina Vestal1, Sicheng Li1, Kenneth Parker1
(1)Virgin Instruments Corp, Marlborough, MA (2) Colorado University, Denver, CO(3) Georgetown Univeristy, Washington,DC

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Marvin Vestal (Presenter) SimulTOF Systems of Virgin Instruments Corp

Presenter Bio: The past 30 years have focused on developing improved MALDI-TOF instruments and technology for biomedical applications.

Relevant Financial Disclosures (within past 24 months) Discussing Products? YES, presenter will present educational content related to products/services of one or more ineligible company(ies) listed above. Conflict mitigation IN PROCESS.

A new high performance linear MALDI-TOF mass spectrometer provides high spatial resolution and acquisition speeds up to 1000 pixels/s. Application of this instrument to imaging large tissue sections with 10 micrometer spatial resolution generates huge files that challenge our ability to process and store the results. Ten days of operation produced 100 million spectra from 100 cm2 of tissue comprising 5 terabytes of data. In this work full images are acquired at a rate of 3 min/cm2 with 10,000 spectra/cm2, and these can be used to identify regions of interest that are imaged at 5 micrometer resolution at a rate of 6 min/mm2.