A Comprehensive Map and Functional Annotation of the Normal Human Cerebrospinal Fluid Proteome
Yajie Wang(1), Ce Wang(2), Chengbin Wang(2) (1)Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University,No.8 East Jing Shun Rd, Beijing 100015, China; (2)Department of Clinical Laboratory, Chinese People's Liberation Army General Hospital, Beijing 100853, China
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Yajie Wang (Presenter) Dept of Clinical Laboratory, Beijing Ditan Hosp
Presenter Bio: Dr. Wang is the director of Clinical Laboratory Department of Beijing Ditan hospital, Capital Medical University. She is also a Chief physician and doctoral supervisor. She serves as a member of the youth committee of laboratory science branch of Beijing Medical Association.
Relevant Financial Disclosures
(within past 24 months)
No relevant financial relationship(s) to disclose.
Abstract
In this study, high-pH reverse-phase liquid chromatography (hp-RPLC) was first integrated with mass spectrometer to profile the normal CSF proteome. A total of 49,836 unique peptides and 3256 non-redundant proteins were identified. Then, 2513 proteins with at least 2 unique peptides were further selected as bona fide CSF proteins. Nearly 30% of the identified CSF proteins have not been previously reported in the normal CSF proteome. More than 30% of the CSF proteins (788 proteins) were related to neurological diseases. This study identified the largest high-precision dataset of the CSF proteome, which offers a baseline reference for CSF biomarker discovery.
= Discovery stage. (17.55%, 2019 US)
= Translation stage. (42.72%, 2019 US)
= Clinically available. (39.74%, 2019 US)
