MALDI Imaging MS: Transforming Drug Discovery and Development Through Molecular Images of Biological Systems

Steve Castellino
GlaxoSmithKline

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Steve Castellino (Presenter) GlaxoSmithKline

Relevant Financial Disclosures (within past 24 months) Salary GlaxoSmithKline Discussing Products? YES, presenter will present educational content related to products/services of one or more ineligible company(ies) listed above. Conflict mitigation IN PROCESS.

The application of MALDI IMS in drug discovery and development has evolved from providing “snap shots” of drug and drug metabolite tissue distributions to addressing the more fundamental questions pertaining to quantitative disposition, validation of delivery strategies, and understanding the complex mechanistic relationships between molecular initiation events of pharmacologically active compounds and the cascade of biological consequences. Cumulative IMS experimental data of disease states and pharmacology models have been transformational in building and expanding our knowledge on drug delivery, disposition, pharmacology and underlying mechanisms of disease. This knowledge is critical in translating results from in vitro and in vivo models into safe and efficacious medicines to meet the medical needs of a diverse population. This presentation will include examples from early and late stage medicinal development where MALDI IMS has had a significant impact on our understanding of pharmacology and mechanisms of disease states.