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MSACL 2026 Abstract
Self-Classified Topic Area(s): Practical Training > Troubleshooting > Various OTHER
Dude, Where’s my Peak? Best Practices for Optimizing and Troubleshooting Chromatography
Alison Lightfoot, Chris Thompson, Peter Wegwerth Mayo Clinic, Rochester, MN
Peter Wegwerth (Presenter) Mayo Clinic
Relevant Financial Disclosures
(within past 24 months, reported on Apr 01, 2026)
No relevant financial relationship(s) to disclose.
Alison Lightfoot, Masters in Chemistry with Mathematics, PhD in Materials Chemistry (Presenter) Mayo Clinic
Relevant Financial Disclosures
(within past 24 months)
Not yet reported.
Chris Thompson, B.S. Biochemistry (Presenter) Mayo Clinic
Relevant Financial Disclosures
(within past 24 months)
Not yet reported.
Abstract
Description:
This training session will provide attendees with actionable best practices for optimizing chromatography and addressing common troubleshooting challenges. Using real-world examples, participants will explore advantages as well as common pitfalls when optimizing autosampler settings, LC pump configurations, column chemistries, mobile phase compositions, and gradients. The session will also demonstrate how these techniques can be effectively applied to identify and resolve common issues with sample injection and chromatographic separations.
Pearls:
After attending this training, participants will be able to:
1. Implement best practices for optimizing chromatographic conditions to improve performance and data quality
2. Design efficient experiments to determine best autosampler settings, columns, mobile phases, and gradients for specific applications
3. Utilize troubleshooting techniques demonstrated in the session to identify and resolve common sample injection and chromatography issues in their laboratories.
= Discovery stage. (57.21%, 2026)
= Translation stage. (23.38%, 2026)
= Clinically available. (19.40%, 2026)
