= Emerging. More than 5 years before clinical availability. (16.60%, 2024)
= Expected to be clinically available in 1 to 4 years. (37.02%, 2024)
= Clinically available now. (46.38%, 2024)
MSACL 2024 : Angel

MSACL 2024 Abstract

Self-Classified Topic Area(s): Imaging > Imaging > none

Podium Presentation in De Anza 1 on Thursday at 14:45 (Chair: Surendra Dasari / Angela Kruse)

The Extracellular Microenvironment as a Pathological Differentiator

Peggi Angel
Medical University of South Carolina

Peggi Angel, PhD (Presenter)
MUSC Proteomics Center

Presenter Bio: Peggi Angel is Associate Professor at Medical University of South Carolina, where she works on technology advancements in MALDI imaging mass spectrometry (IMS) and biomarker imaging analyses in cancer disparities. Dr. Angel attended graduate school at the University of Georgia’s Complex Carbohydrate Research Center, graduating with a PhD in 2007. Her graduate research was on development of technologies for mapping N-linked glycan sites in mammalian development. After a postdoctoral fellowship at Emory University focused on membrane proteomics of fetal alcohol syndrome, she won a competitive Postdoctoral Fellowship with the Systems-based Consortium for Organ Design and Engineering. With the Fellowship, she worked at Vanderbilt University in the laboratory of Richard Caprioli on methods using MALDI IMS for developmental biology. Dr. Angel has developed IMS methods for increasing sensitivity of protein detection from tissues, analysis and identification of signaling lipids in negative mode, targeted metabolomics on tissue and cell culture, extracellular matrix protein detection in FFPE tissues, and N-glycomic strategies for proteins, cells, and tissue. Dr. Angel is a co-founder of Glycopath, a company that focuses on glycosylation patterns as a prognostic or diagnostic tool. She serves on the board of N-Zyme Scientifics, a company that produces enzymes for mass spectrometry. Dr. Angel is committed to serving the imaging mass spectrometry community and serves as President-Elect for the US Imaging Mass Spectrometry Society.


The extracellular microenvironment shapes cell signaling, localizes and recruits cells, and facilitates communication between cells. The chemical biology presented by the extracellular microenvironment is underutilized for biomarker mining and understanding pathological biosignatures. This presentation will focus on spatial proteomics targeting the extracellular microenvironment from clinically archived formalin-fixed, paraffin-embedded tissue sections. Analytical performance, use of internal standards, and considerations for multiplexing will be discussed. A recently published method adapting the tissue imaging approaches to survey extracellular proteins in serum will be discussed.

Financial Disclosure

Board MemberyesGlycoPath, N-zyme Scientifics Board Member
Stockyes GlycoPath
IP Royaltyyes

Planning to mention or discuss specific products or technology of the company(ies) listed above: