= Emerging. More than 5 years before clinical availability. (9.82%)
= Expected to be clinically available in 1 to 4 years. (12.95%)
= Clinically available now. (22.77%)
MSACL 2018 EU : Vogeser

MSACL 2018 EU Abstract

Topic: Small Molecules

Podium Presentation in the Ether on Thursday at 9:20 (Chair: Anne Bendt)

Stable Isotope-Dilution-LC-MS/MS-based Reference Methods – Suggestion for Description of Methods and Structure of Analytical Series

Michael Vogeser (Presenter)
University Hospital, LMU Munich

Presenter Bio(s): Professor of Laboratory Medicine at the LMU Munich and Senior Physician at the University Hospital. Co-Editor-in-Chief of CMS. Secretary of the German Association of Clinical Chemistry and Laboratory Medicine.

Authors: Michael Vogeser (1), Carina Schuster (1), Christina Ritter-Sket (2). Anja Kessler (2)
(1) University Hospital, LMU Munich, Institute of Laboratory Medicine, Munich, Germany (2) Referenzinstitut für Bioanalytik), Bonn, Germany


ID-LC-MS/MS methods are increasingly used as reference for routine methods, but actually the characteristics of such reference methods (RM) are so far not conclusively specified. A RM concept specifically for ID-LC/MS was developed, including three key elements: 1. Standardized method description – differentiating between essential characteristics (such as recorded mass transitions) and variable features that realistically can not be standardized over time (such as lot of columns). 2. Standardized structure of analytical series, including several features for performance verification (e.g., addressing matrix effects). 3. Based on this, a series-related validation concept according to pre-defined criteria as essential characteristic of the RM. This novel approach was successfully applied to a RM for the quantification of linezolid in serum.

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