= Emerging. More than 5 years before clinical availability. (9.82%)
= Expected to be clinically available in 1 to 4 years. (12.95%)
= Clinically available now. (22.77%)
MSACL 2018 EU : Yanshole

MSACL 2018 EU Abstract

Topic: Metabolomics

Podium Presentation in the Ether on Thursday at 9:40 (Chair: Oleg Mayboroda)

Estimation of the Post Mortem Interval via Metabolomic Approach

Lyudmila Yanshole (Presenter)
International Tomography Center SB RAS

Presenter Bio(s): Lyudmila Yanshole obtained M.Sc. at the Novosibirsk State University (Novosibirsk, Russia, 2003-2008), Faculty of natural sciences. In 2011 she received Ph.D. in physical chemistry.
Since 2006 she is working at the International Tomography Center in the fields of proteomics, metabolomics and mass-spectrometry, photochemistry earlier. Now she is one of the leading specialists in the institute in these fields. Lyudmila numerously attended mass-spectrometry courses and is experienced in MALDI-TOF and high-resolution LC-MS techniques, high frequency NMR also. Current research interest is mainly devoted to the quantitative metabolomic profiling of different human tissues and liquids. One of the main interests is the search of metabolomic biomarkers of different diseases. Recent investigations include the metabolomic profiling of normal and keratoconic cornea and aqueous humor.

Authors: Lyudmila V. Yanshole (1,2), Ekaterina A. Zelentsova (1,2), Vadim V. Yanshole (1,2), Olga A. Snytnikova (1,2), Yuri P. Tsentalovich (1,2)
(1) International Tomography Center SB RAS, Novosibirsk, Russia (2) Novosibirsk State University, Novosibirsk, Russia

Abstract

The analysis of post-mortem metabolomic changes in biological fluids opens the way to develop new methods for the estimation of post-mortem interval (PMI) which appears to be an actual problem in forensic medicine. The combination of modern research methods - high frequency NMR and high-performance liquid chromatography with high-resolution mass spectrometry (HPLC-MS) was used in this work. Metabolomic profiling of rabbit and human biological fluids obtained at different times after death is performed in this work: the quantitative levels of 61 metabolites have been measured. The obtained results suggest that the ocular fluids AH and VH may have some advantages over blood serum for the search of potential biochemical markers for the PMI estimation. Among the compounds studied in the present work, hypoxanthine, choline and glycerol give the biggest promise as the potential PMI biomarkers.


Financial Disclosure

DescriptionY/NSource
GrantsyesRussian Scientific Foundation
SalaryyesInternational Tomography Center
Board Memberno
Stockno
Expensesno
IP Royaltyno

Planning to mention or discuss specific products or technology of the company(ies) listed above:

no