= Emerging. More than 5 years before clinical availability. (9.82%)
= Expected to be clinically available in 1 to 4 years. (12.95%)
= Clinically available now. (22.77%)
MSACL 2018 EU : Kuzyk

MSACL 2018 EU Abstract

Topic: Glycomics

Podium Presentation in the Ether on Wednesday at 14:30 (Chair: TBA)

In-Depth Characterisation of Heavily Glycosylated Proteins and Their Potential as Colorectal Cancer Biomarkers

Valeriia Kuzyk (Presenter)
Vrije Universiteit Amsterdam

Presenter Bio(s): Completed Bachelors degree in Biology and Master degrees in Biochemistry and Bioinformatics. Research interests: glycomics, proteomics, mass-spectrometry, capillary electrophoresis, biomarker research, method development.

Authors: Valeriia Kuzyk (1,2), Guinevere S.M. Kammeijer (2), Rob Haselberg (1), Manfred Wuhrer (2), Govert W. Somsen (1)
(1) Vrije Universiteit Amsterdam, Division of Bioanalytical Chemistry, Amsterdam, The Netherlands, (2) Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, The Netherlands

Abstract

Protein glycosylation is known to rapidly change in disease, as well as in cancer progression. Therefore, heavily glycosylated tumor-derived circulating proteins hold a great potential to perform as “disease ambassadors” in the bloodstream, enabling more sensitive and specific diagnostics. However, proper characterization is challenging due to low quantity in serum and the high heterogeneity of the glycan distribution. Here, we present a comparison between different analytical platforms for the in-depth characterization of two glycoproteins (carcinoembryonic antigen and laminin B1). Further studies will examine if altered glycosylation profiles of these glycoproteins can be used as prognostic tools for colorectal cancer.


Financial Disclosure

DescriptionY/NSource
GrantsyesEuropean Commission, Horizon 2020 programme under grant agreement number 676421
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Board Memberno
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IP Royaltyno

Planning to mention or discuss specific products or technology of the company(ies) listed above:

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