= Emerging. More than 5 years before clinical availability. (9.82%)
= Expected to be clinically available in 1 to 4 years. (12.95%)
= Clinically available now. (22.77%)
MSACL 2018 EU : Shuford

MSACL 2018 EU Abstract

Topic: Practical Training

Podium Presentation in the Ether on Wednesday at 11:00 (Chair: Chris Shuford)

Calibrators and Internal Standards in Protein Mass Spectrometry Assays: Differences, Commonalities, and Best-Practice

Christopher Shuford (Presenter)
Laboratory Corporation of America

Authors: Christopher M. Shuford (1)
(1) Laboratory Corporation of America, Burlington, NC, USA


Internal standards are not calibrators. This fact is often overlooked in the field of proteomics, which has propagated misconceptions as new protein mass spectrometry assays are translating into the clinical chemistry lab. In the first part of this 3 part series, the distinction between calibrators and internal standard will be highlighted in the context of protein measurements by mass spectrometry. In the second part of the series, best practices for calibration and standardization/harmonization of protein mass spectrometry assays will be discussed. Finally, options for internal standardization of protein mass spectrometry assays will be reviewed and contrasted in the third part of the series.

Financial Disclosure

SalaryyesLaboratory Corporation of America
Board Memberno
Stockyes Laboratory Corporation of America
IP Royaltyno

Planning to mention or discuss specific products or technology of the company(ies) listed above: