= Emerging. More than 5 years before clinical availability. (9.82%)
= Expected to be clinically available in 1 to 4 years. (12.95%)
= Clinically available now. (22.77%)
MSACL 2018 EU : Moore

MSACL 2018 EU Abstract

Keynote Presentation

Topic: Microbiology

Podium Presentation in the Ether on Thursday at 9:00 (Chair: Jean Armengaud)

Tandem MS-Proteotyping: Proteomics- and Genomics-based Characterization and Typing of Infectious Bacteria

Edward Moore (Presenter)
University of Gothenburg

Presenter Bio(s): Edward Moore earned a PhD in Biology & Biochemistry (Microbiology) from the University of Houston, USA. He worked as Post-doctoral Researcher and Senior Researcher at the National Research Centre (GBF) in Braunschweig, Germany, and, later, as Senior Research Officer at the Macaulay Research Centre and Aberdeen University in Scotland, studying microbial ecology. In 2004, he changed research directions, moving to establish a research group to work on developments in diagnostics of infectious diseases at the Sahlgrenska University Hospital and the Department of Infectious Diseases, University of Gothenburg in Sweden. He is Director and Curator of the Culture Collection University of Gothenburg (CCUG), one of the largest public collections for clinically-relevant microorganisms in the world. In 2005, he was appointed Professor of Bacteriology at the Sahlgrenska Academy, University of Gothenburg.

Authors: Edward R.B. Moore (1,2,3), Lucia Gonzales-Siles (1,2) Francisco Salvà-Serra (1,2,4), Hedvig Engström Jakobsson (1,2), Daniel Jaén-Luchoro (1,3), Beatriz Piñeiro (3), Marga Gomila (4), Roger Karlsson (1,3,5)
(1) Department of Clinical Microbiology, Sahlgrenska University Hospital, Gothenburg, Sweden; (2) Department of Infectious Diseases, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; (3) Culture Collection University of Gothenburg (CCUG), Gothenburg, Sweden; (4) Microbiology, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain; (5) Nanoxis Consulting AB, Gothenburg, Sweden.

Abstract

LC-MS/MS proteomics- and genomics-based characterization and typing of microorganisms, i.e., ‘proteotyping’, using peptides digested from expressed proteins and matched to genomic sequence data, can be applied for sensitive and accurate detection and typing of pathogenic bacteria. Proteotyping is capable of resolving and identifying closely-related bacterial taxa with simultaneous detection of virulence and antibiotic resistance features, providing for comprehensive characterizations of infectious bacteria. The methodology may be applied directly to analyses of clinical samples without prior cultivation and isolation, thus providing for rapid, reliable, infectious disease diagnostics.


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