MSACL 2016 US Plenary Abstract

Mass Spectrometry in Clinical Science

R Graham Cooks (Presenter)
Purdue University

Authorship: R. Graham Cooks, Karen E Cesafsky, Alan K. Jarmusch, Valentina Pirro, Christina Ferreira, Fernanda Bertuccez Cordeiro, Zheng Ouyang
Department of Chemistry, School of Biomedical Engineering, and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, IN 47907

Short Abstract

This presentation attempts to elucidate the forces converging to create a major increase in the applications (and applicability) of mass spectrometry in the clinic. The forces include: i) ambient ionization methods for direct examination of biological samples, including tissue and whole biofluids, ii) miniature mass spectrometers capable of unit resolution and MS/MS, iii) ion transfer over long distances to the Mini MS iv) quantitation out of complex mixtures by multiple reaction monitoring (MRM), and v) multivariate data analysis for confident assignment of complex spectral patterns to particular biological and disease states. Example applications include surgical margins, drug and microorganism (e.g. strep) detection.

Long Abstract

This presentation attempts to elucidate the forces converging to create a major increase in the applications (and applicability) of mass spectrometry in the clinic. The forces include: i) ambient ionization methods for direct examination of biological samples, including tissue and whole biofluids, ii) miniature mass spectrometers capable of unit resolution and MS/MS, iii) ion transfer over long distances to the Mini MS iv) quantitation out of complex mixtures by multiple reaction monitoring (MRM), and v) multivariate data analysis for confident assignment of complex spectral patterns to particular biological and disease states. Example applications include surgical margins, drug and microorganism (e.g. strep) detection.


References & Acknowledgements:


Financial Disclosure

DescriptionY/NSource
GrantsyesSiemens, Merck, Amgen
SalaryyesMerck
Board Memberno
Stockno
ExpensesyesMerck, Amgen

IP Royalty: yes

IP Desc:Miniature mass spectrometers

Planning to mention or discuss specific products or technology of the company(ies) listed above:

no