MSACL 2022 : Strathmann

MSACL 2022 Industry Workshop Presentation

*This Podium Presentation is occuring in the context of an Industry Workshop that starts at the time below. Its actual start time may be up to 40 minutes later, depending on order of presentation if there are multiple presentations planned by the workshop host.

Workshop Host:Agilent Technologies
Day:Wednesday April 6
Location:De Anza 3 (Track 3)

Keeping an “Eye on” Mobility Technologies for Clinical Research Laboratory Workflows
Frederick Strathmann, PhD, MBA
MOBILion Systems

Presenter Bio: Fred has been in laboratory medicine for over 10 years and has held various positions including Assistant Professor of Pathology & Laboratory Medicine, Medical Director of Toxicology, Scientific Director of Mass Spectrometry, and Senior Vice President of Operations and R&D. He has worked in hospital and national reference laboratory environments, is board certified by the American Board of Clinical Chemistry in both Clinical Chemistry and Toxicological Chemistry and qualifies as a CLIA Certified Laboratory Director for High Complexity Testing. He completed his MS and PhD in Pathology & Laboratory Medicine and a postdoctoral fellowship in Biomedical Genetics from the University of Rochester School of Medicine and Dentistry in Rochester, New York, a Clinical Fellowship at the University of Washington in Seattle, Washington, and an MBA from the University of Utah in Salt Lake City, Utah. Fred is driven by the impact that laboratory testing has on healthcare outcomes and is thrilled to be a part of MOBILion’s mission and to help extend its capabilities into clinical diagnostics.


Mass spectrometers are at their best when they are collecting data and do this on millisecond and microsecond time scales providing the capability for rich data collection. The reliance on chromatographic separations results in mass spectrometers sitting idle far too often. Technologies to enable fast chromatographic run times boost laboratory capacity, reduce capital costs, and are one tool in the toolbox for meeting turnaround times. Use cases of these solutions will highlight the inherent value and challenges of chromatographic separations while the quiet upswing in ion mobility commercialization is opening our eyes to what we have been missing. Ion mobility is another dimension of separation in every sense of the word and ion mobility based on Structures for Lossless Ion Manipulations (SLIM) is providing a wave of new possibilities and the potential to radically challenge our past notions of test design and workflow. Ion mobility has become integral to proteomics, metabolomics, and lipidomics workflows and a use case of SLIM based High Resolution Ion Mobility Mass Spectrometry (HRIM-MS) in Parkinson’s Disease research provides a translatable example of the value this technology brings. Incorporating arrival times and collisional cross sections as physical properties of the analytes of interest could enhance lab-to-lab reproducibility in test results and doing so with MOBILion’s ion mobility technology could add potential benefits of reducing run times and solvent use without compromising specificity. Improved separations, enhanced sensitivity, and revealing what others have left unseen in our data is right around the corner.

For Research Use Only. Not for use in diagnostic procedures

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