MSACL 2022 : Gill

MSACL 2022 Industry Workshop Presentation

*This Podium Presentation is occuring in the context of an Industry Workshop that starts at the time below. Its actual start time may be up to 40 minutes later, depending on order of presentation if there are multiple presentations planned by the workshop host.

Workshop Host:Thermo Fisher Scientific
Day:Thursday April 7
Location:De Anza 1 (Track 1)

Part 2 : High Throughput Paper-Spray Mass Spectrometry (PS-MS) for Validated Clozapine Therapeutic Drug Monitoring in Human Serum
Chris Gill, Ph.D.
Vancouver Island University

Presenter Bio: Chris is a Chemistry Professor at Vancouver Island University (Nanaimo, BC) as well as co-director of the Applied Environmental Research Laboratories (AERL). He maintains an active international collaboration network, including the tenure of visiting professorships during sabbaticals in Germany and Italy. He has been awarded the Distinguished Researcher Award at VIU, a Distinguished Chemistry Alumni Award at the University of British Columbia, and has recently moved his laboratories into expanded space in the recently completed VIU Health and Sciences Centre. The AERL conducts pure & applied research, with a central theme the development of direct, online mass spectrometry methods for measurements in complex samples. This has lead to numerous advances for direct environmental, industrial and clinical/bioanalytical measurements. The AERL’s development of mobilized direct mass spectrometry platforms for geospatially resolved quantitative environmental measurements as well as numerous hyphenated methodologies has transformed capacity for in field chemical determinations. Chris’ current research interests continue to involve the development of direct mass spectrometry instrumentation and their applications for direct, real-time chemical measurements. This includes high precision systems and approaches for improved environmental monitoring, clinical diagnostics, forensic testing, and the development and implementation of rapid, on-site drug testing strategies for use in the opioid overdose crisis.


Therapeutic drug monitoring (TDM) represents significant workflow demands and revenue generation for clinical laboratories. A high throughput, validated paper spray mass spectrometry assay using the Thermo Scientific™ VeriSpray™ source is presented as a facile and rapid TDM strategy for the direct, quantitative analysis of clozapine and its metabolite in human serum samples. Quantitative results obtained compare favourably with a validated clinical LC-MS assay.

For Research Use Only. Not for use in diagnostic procedures.
Thermo Scientific™ Orbitrap™ mass spectrometers are intended for General Laboratory Use Only, and not for Diagnostic or Clinical Use.