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MSACL 2016 EU: Congress Program

Salzburg Congress Center, AUSTRIA • September 12-15, 2016

With Thanks to Our Corporate Sponsors:
Thermo SCIEX Shimadzu Agilent Chromsystems

And Special Thanks to Our Travel Grant Sponsor:
Thermo

MONDAY

8:00
9:00
WELCOME COFFEE
@ Mozart 1-3

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
9:00
18:00

SHORT COURSES
10-15 minute Coffee Breaks at every :45, except before lunch Lunch 12:00 - 13:00 at Mozart 1-3.

Data Science 101
Breaking up with Excel: A Newbie's Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Stephen Master, MD PhD
Level: 1-2 (Beginner - Intermediate)
Location: Mozart 5
Lab Medicine 101
Basics of Laboratory Medicine
Prof. Dr. med. Michael Vogeser
Level: 1 (Beginner)
Location: Doppler
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD & Grace van der Gugten
Level: 1-2 (Beginner - Intermediate)
Location: Mozart 4
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
Erik J. Soderblom, PhD, J. Will Thompson, PhD
Level: 2 (Intermediate)
Location: Trakl
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Brian Rappold
Level: 3 (Advanced)
Location: Papageno Hall
Proteomics 201
Clinical Proteomics
Cory Bystrom, PhD & Chris Shuford, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Paracelsus
Every 0:45
for 15 min
COFFEE BREAK
@ Mozart 1-3

Take a break and get a coffee, water and/or snack. Commune with colleagues or perhaps go for a short walk outside to refresh for the next session.
12:00
13:00
LUNCH
@ Mozart 1-3

Lunch to be provided in Mozart 1-3 with the possibility to eat outside in front of the Congress Center on bistro tables, weather permitting.
14:45
15:15
COFFEE BREAK (Energize)
@ Mozart 1-3

Take a break with some creamy yoghurt with fresh berries, crunchy cereal, nuts, seeds and mint. Or select from a variety of cup cakes including lemon-meringue or chocolate-cream cheese or peanut butter-chocolate. Pair it with a fruit or vegetable juice (orange, mango, strawberry, banana, tomato).
18:00
20:00
PRIVATE: GRANTEE DINNER RECEPTION
@ Mozart 1-3

A special evening reception in honor of the Travel Grantees & Scientific Committee
20:00
Your Decision
ENJOY THE CITY
@ Salzburg Old City

Explore the Old Town of Salzburg.
MONDAY CLOSED

TUESDAY

8:00
9:00
WELCOME COFFEE
@ Mozart 1-3

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
9:00
18:00

SHORT COURSES
10-15 minute Coffee Breaks at every :45, except before lunch Lunch 12:00 - 13:00 at Mozart 1-3.

Data Science 101
Breaking up with Excel: A Newbie's Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Stephen Master, MD PhD
Level: 1-2 (Beginner - Intermediate)
Location: Mozart 5
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD & Grace van der Gugten
Level: 1-2 (Beginner - Intermediate)
Location: Mozart 4
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
Erik J. Soderblom, PhD, J. Will Thompson, PhD
Level: 2 (Intermediate)
Location: Trakl
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Brian Rappold
Level: 3 (Advanced)
Location: Papageno Hall
Metabolomics 201
Metabolomics: Approaches, Applications and Challenges
Julijana Ivanisevic, PhD & Elizabeth Want, PhD
Level: 1-2 (Beginner to Intermediate)
Location: Doppler
Proteomic Microbiology 201
Bottom-Up and Top-Down Proteomic Approaches for Bacterial Identification and Characterization, a Focus on MALDI-TOF and Advanced Technologies
Jean-Armengaud, PhD, Dr. med. Irene Burckhardt, Stefan Zimmermann, MD
Level: 1-2 (Beginner - Intermediate)
Location: Trapp
Proteomics 201
Clinical Proteomics
Cory Bystrom, PhD & Chris Shuford, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Paracelsus
Every 0:45
for 15 min
COFFEE BREAK
@ Mozart 1-3

Take a break and get a coffee, water and/or snack.
12:00
13:00
LUNCH
@ Mozart 1-3

Lunch to be provided in Mozart 1-3 with the possibility to eat outside in front of the Congress Center on bistro tables, weather permitting.
12:15
17:00
PLACE POSTERS
@ Exhibit Hall on 1st Floor

ALL Poster presenters to place posters before start of Opening Reception.
14:45
15:15
COFFEE BREAK (Mozart)
@ Mozart 1-3

Take a break and sample a variation of cakes ‘Salzburg style’ with fresh fruits.
18:00
EXHIBITS OPEN
@ Exhibit Hall on 1st Floor
18:00
20:00
OPENING RECEPTION
@ Exhibit Hall on 1st Floor

Enjoy mingling with colleagues and Exhibitors. Take time to explore the Posters. Buffet dinner and drinks to be provided.

Sponsored by:
Thermo SCIEX Shimadzu Agilent
18:30
19:30
POSTERS
@ Exhibit Hall on 1st Floor

Select posters to be attended for 1 hour. Refer to program for posters attended during this period.
20:00
21:00

DISCUSSION GROUPS
... with a touch of wine and cheese, and other beverages.
@ Papageno

21:00
Your Decision
ENJOY THE CITY
@ Salzburg Old City

Explore the Old Town of Salzburg.
TUESDAY CLOSED

WEDNESDAY

7:45
9:00
WELCOME COFFEE
@ Registration Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
8:00
8:45

CORPORATE WORKSHOPS (AM)

Thermo Scientific
@ Papageno

Microsampling Techniques and LC-MS/MS: Therapeutic Drug Monitoring Research to Help Personalize Medicine for Our Children
Giuliana Cangemi, PhD, MSC - Istituto Giannina Gaslini Children
Pre-Register

The first part of this session will focus on some basic principles of TDM in pediatrics. Analytical challenges and opportunities will be explored. The second part of this session will focus on alternative sampling strategies such as dried blood spot, volumetric microsampling devices and dried plasma spot coupled to tandem mass spectrometry. Application to routine clinical analysis in pediatrics will be discussed.

PLENARY LECTURE SERIES
@ Mozart Hall
Chair: Julijana Ivanisevich
9:00
9:45
Metabolomics Enabling Personalized Medicine
Thomas Hankemeier
Leiden University/Netherlands Metabolomics Centre
Metabolism is at the core of physiology and therefore metabolomics is ideally suited to assess someone’s health state. In this presentation strategies are discussed how personalized medicine can be realized by using metabolomics and by integrating it with other omics data. Examples are shown how disease pathology can be studied using metabolomics in clinical studies, and how mechanistic insights can be obtained using advanced in-vitro models and translational metabolomics. Pharmacometabolomics can help to study how pharmacology modulates disease pathology, and to predict efficacy and adverse effects of pharmacological interventions . An outlook will be given how metabolomics will impact clinical research and ultimately clinical decision support.
9:45
10:15

WELCOME, INTRODUCTION & ORIENTATION
@ Mozart Hall

Welcome to the 3rd Annual European MSACL Congress!

Introducing the new Clinical Mass Spectrometry journal!



Congress Mobile Apps
Apps to facilitate contact collection and Scientific Program browsing.

(1) The Mobile Program App

(2) BadgerScan™ for Contact Lead Collection. Available on Google Play and the Apple App Store (iTunes).
10:15
11:00
COFFEE BREAK & POSTERS
@ Exhibit Hall on 1st Floor

Visit the Exhibit Hall to procure coffee, juice, water and/or snacks. Explore what's on offer from the Exhibiting vendors, reconnect with colleagues, or go for a short walk outside to refresh for the next session.

Sponsored by:
Thermo SCIEX Shimadzu Agilent
General Scientific Presentations : Session 1
Track 1
Mozart 1-3
Microbiology
Chair: Kevin Downard
Track 2
Mozart 4-5
References and Standards
Chair: Niek Dirks
Track 3
Papageno Hall
Biomarkers
Chair: Michel Salzet
Track 4
Paracelsus Hall
Basics of Mass Spectrometry
Chair: Daniel Holmes
11:00
11:20
Membrane Proteins for Diagnosis of Bacterial Infection: A Story About Lyme Disease
Illarion Turko
National Institute of Standards and Technology
Various Calibration Procedures Result in Optimal Standardization of Routinely Used 25(OH)D ID-LC-MS/MS Methods
Niek Dirks
VU University Medical Center
Alternative Proteins : The Hidden World of Potential Biomarkers
Julien Franck
PRISM INSERM U1192 Lab
Tuning Your Mass Spectrometer: How to Make It Sing
Jörg Hanreider
University of Gothenburg
11:20
11:40
New Advances in Mass Spectrometry to Improve the Clinical Surveillance of the Influenza Virus
Kevin Downard
University of New South Wales
Development of a Reference Method for the Quantification of the Cardiac Marker 1-32 B-Type Natriuretic Peptide
Attila Frank Torma
LGC LTD
Multiplex Plasma Protein Analysis: Quantitation of Dozens of Biomarkers from a Droplet of Blood Using Immunoaffinity Mass Spectrometry
Thomas O Joos
NMI Natural and Medical Sciences Institute

This talk by Thomas Joos replaces that originally scheduled for Christophe Hirtz, who had to cancel his attendance. The talks are not related.
Varying Those Vexing Voltages: Compound Specific Tuning
Daniel Holmes
St. Paul's Hospital, Vancouver
11:40
12:00
Quick Survey of Complex Microbiota by Tandem Mass Spectrometry
Jean Armengaud
CEA-Li2D
Mass Spectrometry as a Key Element of External Quality Assessment in Germany
Anja Kessler
Reference Institute for Bioanalytics
Novel Therapeutic Targets of Spinal Cord Injury Based on Spatio-Temporal Proteomics Analysis
Michel Salzet
PRISM INSERM U1192 - University of Lille
Building Your Assay, Breaking Your Compound: Developing MRM Transitions
Stephen Master
Weill Cornell Medical College
12:00
14:00
LUNCH
@ Exhibit Hall on 1st Floor

Lunch to be provided in the Exhibit Hall.

Sponsored by:
Thermo SCIEX Shimadzu Agilent
12:30
13:30
POSTERS
@ Exhibit Hall on 1st Floor

Select posters to be attended for 1 hour. Refer to program for posters attended during this period.
14:00
14:45

CORPORATE WORKSHOPS (PM)

Shimadzu
@ Mozart 4-5

Smart Solutions for Clinical Applications
Dr. Antonio D'AVOLIO, Neil LOFTUS
Pre-Register

-----------------------------------------------
The Internal Standard Normalized Matrix Effects (IS-nME): a new tool for the mass spectrometry method validation and its use in clinical applications
Dr. Antonio D'AVOLIO - Università degli Studi di Torino / ASL TO2 - Turin (Italy)

-----------------------------------------------
Quantitative Multi Target Screening (MTS) using liquid chromatography-tandem mass spectrometry with MS/MS library based identification for clinical toxicology.
Neil LOFTUS - SHIMADZU MS Business Unit Overseas - Manchester (UK)

-----------------------------------------------

For Research Use Only. Not for use in diagnostic procedures.

Thermo Scientific
@ Papageno

Speeding up the cancer biomarker discovery: Advanced Clinical Proteomics workflow with High Resolution MS
Sebastien Gallien- Former researcher at CRP-Santé LIH Luxembourg Insitute of health
Pre-Register

Adoption of cancer biomarkers in clinical labs has been plagued by the speed with which these biomarkers are discovered and validated for clinical use. Clinical proteomics approaches where the use of predefined set of surrogate peptides for proteins has been helpful in systematically identifying these markers. Targeted analyses using parallel reaction monitoring (PRM), performed on high resolution and accurate-mass (HRAM) quadrupole-orbitrap mass spectrometers, present the selectivity and sensitivity to confidently quantify peptides in complex samples. The internal standards (IS) used for isotope dilution quantification were recently leveraged to actually drive the acquisition (“internal standard triggered-parallel reaction monitoring”, IS-PRM), thus improving the acquisition efficiency.

Agilent
@ Paracelsus

Metabolomics in Clinical Research
Dr. Andrew Davison, Dr. Christopher Gerner
Pre-Register

Metabolomics of Fingersweat: Individual Assessment of Metabolic Parameters based on Fingerprint Analyses
Christopher Gerner, Institute of Analytical Chemistry, University of Vienna

Non-Targeted Metabolomic Evaluation of patients with Alkaptonuria (AKU)
Andrew Davison, Department of Clinical Biochemistry and Metabolic Medicine, Liverpool Clinical Laboratories, Royal Liverpool & Broadgreen University Hospital Trust, UK

For Research Use Only. Not for use in diagnostic procedures.

Neoteryx
@ Trakl

The Microsampling Workshop
Stephen Stephenson, Chief Biomedical Scientist of Transplant, Cellular, and Clinical Immunology, Leeds Teaching Hospital; Dr. Bikalpa Neupane, Research Fellow University of Leicester; John Dutton, Senior Research Fellow and Holly Nicholls, Research Technician, University of East Anglia Bioanalytical Facility
Pre-Register

This workshop examines three clinical research labs investigating volumetric absorptive microsampling (VAMS™) as an alternative to “wet” sampling. The first talk reviews a potential at-home LC-MS/MS assay for tacrolimus monitoring including extractions and initial validation results. Talk two describes a clinical PK children’s study which aims to compare PK of midazolam in critically-ill with that in otherwise healthy children undergoing elective surgery and measure blood midazolam concentrations in “wet” sample against those in VAMS. The final talk discusses a LC-MS/MS assay for the quantitation of 25(OH)D3 in whole blood collected using DBS and VAMS. The two microsampling techniques are compared against plasma and the impact of different haematocrit levels on the 25(OH)D3 concentration is investigated.

General Scientific Presentations : Session 2
Track 1
Mozart 1-3
Metabolomic Biomarkers
Chair: Christiane Auray-Blais
Track 2
Mozart 4-5
Endocrine
Chair: Caroline Le Goff
Track 3
Papageno Hall
Tissue Imaging
Chair: Jörg Hanrieder
Track 4
Paracelsus Hall
Understanding Matrix Effects
Chair: Grace van der Gugten
15:00
15:20
A Multi-Platform Mass Spectrometric Approach for Investigating Schizophrenia
Elizabeth Want
Imperial College, London
Evaluation of Routine Immunoassay Methods for Cortisol Against LC-MS/MS: Ramifications for Patient Care.
Brian Keevil
UHSM
Real-time Mass Spectrometry Analysis for Guided-surgery: Application to Ovarian Cancer
Benoit Fatou
PRISM Laboratory, University of Lille
Surviving Matrix Effects Experiments: PART 1
Grace van der Gugten
St Paul's Hospital
15:20
15:40
Lipid Phenotyping of Normal and Cancerous Human Breast Tissue with Rapid Evaporative Ionization Mass Spectrometry
Edward St John
Imperial College
Quantification of Serum Androstanediol Glucuronide by LC-MS/MS
Caroline Le Goff
University Hospital of Liege
Metabolic Phenotyping of Colorectal Tissue Samples by Desorption Electrospray Ionization Mass Spectrometry Imaging
Anna Mroz
Imperial College London
Surviving Matrix Effects Experiments: PART 2
Grace van der Gugten
St Paul's Hospital
15:40
16:00
Mass Spectrometry Applications: from Biomarker Discovery to Detection of Patients with Fabry Disease Having a Late-Onset Cardiac Mutation
Christiane Auray-Blais
Université de Sherbrooke
Development of a New Methodology for the Simultaneous Determination of Cholecalciferol and 24,25(OH)2D3 by LC-MS/MS
Neus Fabregat-Cabello
University of Liège, CHU de Liège.
Improved MALDI Imaging Mass Spectrometry of Cortical Lipids in Human Alzheimer’s Brain
Jörg Hanrieder
University of Gothenburg
Surviving Matrix Effects Experiments: PART 3
Grace van der Gugten
St Paul's Hospital
16:00
16:45
COFFEE BREAK (Kickstart) & POSTERS
@ Exhibit Hall on 1st Floor

Visit the Exhibit Hall to procure coffee, juice, water and/or snacks. Try the fruit skewers with mango-pomegranate-chili dip, Kiwi-grenadine essence, pineapple-grape syrup, strawberry-chocolate sauce. Or maybe smoothies banana-strawberry or blueberry and essence of mint, blueberry, raspberry or lemon. Or perhaps baked apple slices with Ricotta served with vanilla and raspberry sauce.

Sponsored by:
Thermo SCIEX Shimadzu Agilent
PLENARY LECTURE SERIES
@ Mozart Hall
Chair: Russell Grant
16:45
17:30
What We Can Learn from a Drop of Urine – Metabolomics at its Earliest: Discoveries of Bile Acid Synthesis Disorders, a New Category of Fatal Metabolic Liver Disease and Development of a Treatment
Kenneth Setchell
Cincinnati Children's Hospital Medical Center
This presentation will highlight how mass spectrometry was successfully applied to define new genetic defects in the cholesterol-bile acid biosynthetic pathway as a specific class of metabolic liver disease. Bile acid synthesis disorders due to single enzyme defects generally present in infancy or early childhood with a progressive cholestatic hepatitis that, unchecked, lead to cirrhosis, liver failure, and death. Prior to the seminal work of Setchell and colleagues in identifying 6 genetic diseases as discrete entities, and conceiving of an effective therapy, children with these autosomal recessive diseases either underwent liver transplantation, or more commonly, were given supportive care until they died of liver failure of unknown origin. To be described are the combined use an untargeted and targeted approach with FAB-MS, GC-MS and ESI-LC-MS/MS that led to the elucidation of the biochemical basis of these diseases, the development of an international screening program, and the evaluation of the therapeutic responses that served to ultimately gain regulatory approval from the FDA for a life-saving therapy based on oral administration of cholic acid. This application of mass spectrometry to clinical chemistry has been a game-changer that has led to a radical change in the evaluation and treatment of patients with idiopathic progressive familial intrahepatic cholestasis syndromes.1
17:30
19:00
RECEPTION & POSTERS
@ Exhibit Hall on 1st Floor

Enjoy mingling with colleagues and Exhibitors. Take time to browse the posters. Buffet dinner, appetizers and drinks to be provided.
Sponsored by:
Thermo
18:00
19:00
TROUBLESHOOTING GRAND ROUNDS
@ Exhibit Hall on 1st Floor

Review the Troubleshooting Posters with Judy Stone and colleagues as they explore and investigate troubleshooting issues in clinical mass spectrometry.
19:00
20:00

DISCUSSION GROUPS
... with a touch of wine and cheese, and other beverages.
@ Mozart 1-3, 4-5, Papageno, Paracelsus, Trakl

Eating A Whale, One Bite at a Time
@ Mozart 1-3
Lead(s): Russell Grant & Brian Rappold

Yo ho ho mateys’ – do you know your ragged ends from your missed cleavages? Full proteins or peptides for internal standardization? If not… it’s time to charge the guns and hoist the mainsail. The evenings’ entertainment will focus on bottom up protein assays through finding the flaws in proposed methods. Let the grog flow (yes there will be grog) and battle(ships) commence as we learn how to eat a whale of a “clinical protein” assay, one bite at a time.

Practical Mass Spectrometry - not just the Fundamentals
@ Mozart 4-5
Lead(s): Judy Stone, Grace van der Gugten, Michael Wright

Feedback on the Practical Mass Spectrometry track and Troubleshooting Forum. What works? What needs to be improved? How you can contribute to its development.

Design of Experiments - Get it right from the beginning
@ Papageno
Lead(s): Margrét Thorsteinsdóttir & Unnur Thorsteinsdottir

We will demonstrate how method development can become much more efficient by utilizing design of experiments (DoE) approach. DoE offers many advantages including performing experiments in accordance to predefined plan, modelling by empirical functions and graphical visualization. Example from optimization of a LC-MS/MS clinical diagnostic method will show that DoE is very cost-effective, allowing the effect of variables to be assessed with only a fraction of the experiments that would be required by changing one-separate-factor-at-time (COST) approach and spots critical setting early on.

Exhibitor Feedback Meeting
@ Paracelsus
Lead(s): Amber Herold

Exhibitors, let MSACL know your thoughts on the way the conference is working for you and what we can do to make the experience better in the long run.

Scientific Committee Meeting
@ Trakl
Lead(s): Chris Herold

Meeting of Scientific Committee members to review the process of soliciting and assigning abstracts, as well as developing content for the congress program.

20:00
Your Decision
ENJOY THE CITY
@ Salzburg Old City

Explore the Old Town of Salzburg.
WEDNESDAY CLOSED

THURSDAY

7:45
9:00
WELCOME COFFEE
@ Registration Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
8:00
8:45

CORPORATE WORKSHOPS (AM)

Biognosys
@ Papageno

Latest Advancements in High Content Protein Quantification
Karel Novy, Fadi Abdi
Biognosys is the leading proteomics company offering services and tools for highly multiplexed protein quantification. Its cutting-edge technology has been applied in biomarker research, drug and target discovery, pathway modeling, mode of action studies, and many other areas. Two Biognosys’ platforms for protein analysis will be presented in the workshop: discovery and targeted proteomics. Discovery proteomics platform allows an unmatched proteome coverage with accurate quantification of up to 8’000 proteins per sample, and is ideal for identifying over-expressed proteins on a proteome level without the need for any previous knowledge. On the other hand, the targeted proteomics platform allows an absolute quantification of up to a 150 pre-defined proteins that can be analyzed in a high-through put mode in thousands of samples.

PLENARY LECTURE SERIES
@ Mozart Hall
Chair: Elizabeth Want
9:00
9:45
Molecular Tissue-Typing in Clinical Translational Research: Towards Precision Medicine
Ron Heeren
Maastricht University
A multimodal approach for molecular imaging for clinical studies is trending the field of imaging mass spectrometry. More and more researchers realize that a single technology provides only a subset of the molecular information needed to obtain an in depth understanding of a clinical problem. Multimodal approaches enable the study of clinical samples at a variety of molecular and spatial scales. The molecular complexity on the genome, proteome and metabolome level all needs to be taken into account. The distribution of several hundreds of molecules on the surface of complex (biological) surfaces can be determined directly in complementary imaging MS experiment with different desorption and ionization strategies.
PLENARY LECTURE SERIES
@ Mozart Hall
Chair: Elizabeth Want
9:45
10:30
Frontiers of Orbitrap Mass Spectrometry
Alexander Makarov
Thermo Fisher Scientific
The talk provides an overview of a short but eventful history of Orbitrap mass spectrometry, from laying down the first principles of the technology to its current status in mainstream mass spectrometry as the leading technique for high-resolution, high mass accuracy quantitative analysis. While describing new possibilities arising from the recent extensions of two latest families of instruments, Fusion and (Q) Exactive, a special emphasis is placed on technical solutions that enhance quantitative analysis in these instruments. Future trends and perspectives of Orbitrap mass spectrometry are discussed, particularly in relation to high-throughput clinical analysis.
10:30
11:15
COFFEE BREAK & POSTERS
@ Exhibit Hall on 1st Floor

Visit the Exhibit Hall to procure coffee, juice, water. Explore what's on offer from the Exhibiting vendors, reconnect with colleagues, or go for a short walk outside to refresh for the next session.

Sponsored by:
Thermo SCIEX Shimadzu Agilent
General Scientific Presentations : Session 3
Track 1
Mozart 1-3
Metabolomics
Chair: Rawi Ramautar
Track 2
Mozart 4-5
Small Molecule Methods
Chair: Brian Rappold
Track 3
Papageno Hall
Protein Quantitation
Chair: Nicholas Dupuis
Track 4
Paracelsus Hall
LC-MSMS Troubleshooting 101
Chair: Judy Stone
11:15
11:35
Quantitative Metabolomic Profiling of the Human Eye Lens
Vadim Yanshole
International Tomography Center
Clinical Application of Paper Spray Ionization-tandem Mass Spectrometry for Real-time Pharmacokinetics of the Chemotherapeutic Drug Melphalan in Whole Blood
Kenneth Setchell
Cincinnati Children’s Hospital Medical Center
Immuno-MALDI for Quantifying PI3K/AKT/mTOR Signaling Pathway Activity in Tumors
Robert Popp
UVic - Genome BC Proteomics Centre
LC-MSMS Troubleshooting 101: Tips and Tricks for Getting Started : PART 1
J. Will Thompson
Duke University School of Medicine
11:35
11:55
Enhancing Coverage of Polar Metabolites and Isomer Separation in Volume-Limited Clinical Metabolomics by Capillary Electrophoresis-Mass Spectrometry
Rawi Ramautar
Leiden University
The Necessity for Chromatography in the Analysis of Opioids in LC-MS/MS Workflows
Brian Rappold
Essential Testing
Authentic or Analogue Calibration: Is there a Difference in Protein Quantification?
Christopher Shuford
Laboratory Corporation of America
LC-MSMS Troubleshooting 101: Tips and Tricks for Getting Started: PART 2
J. Will Thompson
Duke University School of Medicine
11:55
12:15
Comprehensive Profiling of Bile Acids in Human and Mouse Using LC-MS/MS-based Metabolomics
Christoph Borchers
University of Victoria - Genome BC Proteomics Cent
Evaluation and Integration of Accurate Mass LC-MS into the Routine Clinical Laboratory
Joanne Adaway
University Hospital South Manchester
Active Control of MALDI-TOF Mass Spectra Acquisition with Internal Standards for Improved Quantitative Serum Protein Profiles
Nicholas Dupuis
Biodesix Inc
LC-MSMS Troubleshooting 101: Tips and Tricks for Getting Started: PART 3
J. Will Thompson
Duke University School of Medicine
12:15
14:00
LUNCH
@ Exhibit Hall on 1st Floor

Lunch to be provided in the Exhibit Hall. • Get ready to join a Corporate Workshop.

Sponsored by:
Thermo SCIEX Shimadzu Agilent
12:30
13:30
POSTERS
@ Exhibit Hall on 1st Floor

Select posters to be attended for 1 hour. Refer to program for posters attended during this period.
14:00
EXHIBITS CLOSED
@ Exhibit Hall on 1st Floor
14:00
14:45

CORPORATE WORKSHOPS (PM)

SCIEX
@ Papageno

New MS Aspects for Biology Driven Metabolomics and Proteomics in Translational Research
Prof. Dr. Thomas Hankemeier Leiden University, Netherlands & Dr. Jörg Dojahn, SCIEX, Germany
Pre-Register

During this seminar two talks will be presented by Prof. Dr. Thomas Hankemeier Leiden University, Netherlands & Dr. Jörg Dojahn, SCIEX, Germany The first talk will cover MS-based Platforms for Targeted and Biology-driven Metabolomics, whereas the second one will focus on high throughput SWATH® acquisition for proteomics in translational research.

BioVendor
@ Paracelsus

New Technologies in Affinity Mass Spectrometry and Colony Picking
Petr Pompach, Jaroslav Hrabak, Helena Husakova
Pre-Register

BioVendor is a consistent leader in the development of top quality immunodiagnostics and biomedical research tools. The workshop is divided into two sessions: In the first session, the antibody-functionalized MALDI surfaces prepared by ambient ion landing will be described. The effectivity of antibody-functionalized MALDI surfaces to enrich protein antigen form serum will be demonstrated on determination of haptoglobin phenotype - an important biomarker in patient survival. The second session will be focused on presentation of the intelligent robot for colony picking and complete MALDI target preparation – MALDI COLONYST®. The robot improves MALDI identification scores up to 15% by utilizing principle of patented adaptive geometry and wet deposition. All steps of process are recorded, which makes system fully transparent and documented.

14:45
15:00
COFFEE BREAK
@ Registration Foyer & Front Patio

Visit the Registration Foyer for a quick break before the start of the next session.

Sponsored by:
Thermo SCIEX Shimadzu Agilent
General Scientific Presentations : Session 4
Track 1
Mozart 1-3
Microbiology 2
Chair: Simon Cameron
Track 2
Mozart 4-5
Endocrine 2
Chair: Mirko Peitzsch
Track 3
Papageno Hall
Imaging in Brain Cancer
Chair: Isabelle Fournier
Track 4
Paracelsus Hall
Challenges in Chromotography
Chair: Grace van der Gugten
15:00
15:20
Rapid Evaporative Ionisation Mass Spectrometry (REIMS): A Platform for Microbial Identification, Functional Classification, and Direct-from-Sample Analysis
Simon Cameron
Imperial College London
Pediatric Reference Intervals of Plasma Free Normetanephrine, Metanephrine and 3-methoxytyramine: Application for Diagnosis of Neuroblastoma
Mirko Peitzsch
University Hospital Dresden
Unsupervised Molecular Classification of Glioma by MALDI MS Imaging Combined to MicroProteomics
Isabelle Fournier
PRISM INSERM U1192 - University of Lille
Challenges in Chromatography: PART 1
Grace van der Gugten
St Paul's Hospital
15:20
15:40
Bacterial Antibiotic Resistance Determination by Metal Oxide Laser Ionization MS Fatty Acid Profiling
Christopher Cox
Colorado School of Mines
Quantification of Human Urine and Serum Iodine by Inductively Coupled Plasma Mass Spectrometry
Songlin Yu
Peking Union Medical College Hospital
Molecular and Elemental Mass Spectrometry Imaging of Brain Tumors Resected by Fluorescence-guided Surgery
Sabrina Kröger
University of Münster
Challenges in Chromatography: PART 2
Grace van der Gugten
St Paul's Hospital
15:40
16:00
COFFEE & STRUDEL BREAK
@ Registration Foyer & Front Patio

Visit the Registration Foyer for a tasty Austrian Strudel before the start of the next session.

Sponsored by:
Thermo SCIEX Shimadzu Agilent
General Scientific Presentations : Session 5
Track 1
Mozart 1-3
Evaluation of Renal Function
Chair: Oleg Mayboroda
Track 2
Mozart 4-5
Testosterone Reference Ranges
Chair: Grace van der Gugten
Track 3
Papageno Hall
Translational and Quantitative Proteomics
Chair: Jerome Vialaret
Track 4
Paracelsus Hall
Intro to System Suitability Testing
Chair: Michael Wright
16:00
16:20
Predicting the Time Required for Resolution of Delayed Graft Function Using Urinary Metabolic Profiles
Oleg Mayboroda
LUMC
LC-MS/MS-based Reference Intervals for Testosterone, Dihydrotestosterone and their Ratio Established in 240 Healthy Adults
Anna van der Veen
University Medical Center Groningen
Translation of a Predictive Protein Response Signature to Lumretuzumab from a Fresh Frozen Xenograft Model to Formalin-fixed, Paraffin-embedded Human Tumors
Axel Ducret
Pharmaceutical Sciences
Introduction to System Suitability Tests
Michael Wright
LGC
View Video
16:20
16:40
Sample Collection-free Metabolic Profiling of Kidney During Organ Preservation: A Step Towards New Tool in Transplantology
Barbara Bojko
Nicolaus Copernicus University
Ladies Testosterone Cooperative: Excellent Comparison of 4 Testosterone LC-MS/MS Assays
Grace van der Gugten
St. Paul's Hospital
New Method of Bevacizumab Dosage, a Monoclonal Antibody, Thanks to a Protein A Immunoenrichment Following by a LC-QqQ Analysis
Jerome Vialaret
CHU Montpellier
Case Studies: Troubleshooting Failed System Suitability Tests
Michael Wright
LGC
16:40
17:00
COFFEE BREAK
@ Registration Foyer & Front Patio

Visit the Registration Foyer for a quick break before the start of the next session.

Sponsored by:
Thermo SCIEX Shimadzu Agilent
Keynote Presentations : Session 6
Track 1
Mozart 1-3
Evaluation of Primary Aldosteronism
Chair: Jody van den Ouweland
Track 2
Mozart 4-5
Investigation of Insulin-Mediated Hypoglycemia
Chair: Stephen Master
17:00
17:40
LC-MS/MS-based Steroid Profiling for Diagnosis and Subtype Evaluation of Patients with Primary Aldosteronism
Graeme Eisenhofer
Technische Universität Dresden
Investigation of Insulin-Mediated Hypoglycemia in the Living and the Dead: The Role of LC-MS/MS
Daniel Holmes
St. Paul's Hospital
Track ClosedTrack Closed
17:40
19:00
CLOSING RECEPTION
@ Registration Foyer & Front Patio

Enjoy some last bits of time mingling with colleagues. Located in Registration Foyer and Front Patio, weather permitting. Drinks and light appetizers to be provided.
Sponsored by:
Thermo
19:00
CONGRESS CLOSED
@ Congress Center
THURSDAY CLOSED

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Exhibit Hall Map