= Emerging. More than 5 years before clinical availability. (33.70%)
= Expected to be clinically available in 1 to 4 years. (35.56%)
= Clinically available now. (30.74%)
Percent of confirmed presenters indicating Clinical Use Status: 100.00%



MSACL 2019 EU: Congress Program

Salzburg, Austria • September 22 - 26, 2019

With Thanks to Our Corporate Congress Sponsors:
Waters Thermo   Shimadzu
Agilent
Chromsystems
And Special Thanks to Our Educational Grant Sponsors:
Thermo

Sunday

1100
1830
Badge Pickup
@ Entrance Foyer
1100
1300
Lunch on Own
@ Your Choice

Some nearby (within one block) recommendations include:
1. The Heart of Joy (Vegetarian and Vegan)
2. my Indigo Kongresshaus (Asian Fusion, with fast take-away options)
3. Cafe Fingerlos (Cafe with the best breakfast in town)
4. IMLAUER Sky (Rooftop patio with a view)
5. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily with Sunday Brunch buffet until 2pm)
6. Braurestaurant IMLAUER (Austrian, traditional interior plus a beer garden, good for groups)

A little further afield:
1. Steiglkeller (Historic building with a great view over the Old Town, near the Fortress)
2. Cafe Sacher (for a patio on the river)
3. Barenwirt (Cozy and Traditional Austrian, fills up so arrive early)
4. Antichi Sapori (Tasty Italian food and pizza in casual family run style, Open 11:30-2:00pm and 5:30-9:00pm, Closed Wed and Thurs)

Or see the complete list of suggested Places to Eat.

1130
1230

Pre-Con Workshop(s)

No workshops currently booked for this time period.

1300
1800

Short Course

COURSE START
Data Science 101
Breaking up with Excel: An Introduction to the R Statistical Programming Language
Daniel Holmes, MD, William Slade, PhD & Stephen Master, MD, PhD
Level: Beginner - Intermediate
@ Trakl Hall
COURSE START
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Shannon Haymond, PhD
Level: Intermediate
@ Mozart 3
COURSE START
Glyco-Proteomics 101
Unravelling The Sweetness Of Life: Clinical Glyco(Proteo)Mics By Mass Spectrometry
Noortje de Haan, PhD & Guinevere Lageveen-Kammeijer, PhD
Level: Beginner to Intermediate
@ Mozart 2
COURSE START
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Laura Owen, PhD, Michael Wright, Coral Munday & Grace van der Gugten
Level: Beginner
@ Paracelsus Hall
COURSE START
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Brian Rappold & Chris Shuford, PhD
Level: Advanced
@ Mozart 4-5
COURSE START
Metabolomics 202
Metabolomics: Approaches, Applications and Challenges
Julijana Ivanisevic, PhD & Elizabeth Want, PhD
Level: Beginner to Intermediate
@ Doppler Hall
Every 0:50
for 10 min
Coffee Break
@ Entrance Foyer

1800
1830
Petite Reception
@ Entrance Foyer

A quick touch of wine and cheese before exploring the city for dinner.
1800
Dinner on Own
@ Your Choice

Dinner Suggestions:
1. Steiglkeller (Historic building with a great view over the Old Town, near the Fortress)
2. Gablerbrau (Historic ambiance with traditional food)
3. Augustiner Braustubl (Historic Abby turned beer garden with food stalls)
4. Antichi Sapori (Tasty Italian food and pizza in casual family run style, open 11:30-2:00pm and 5:30-9:00pm, closed Wed and Thurs)
5. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily)
6. Braurestaurant IMLAUER (Austrian, traditional interior plus a beer garden, good for groups)

After dinner:
1. Murphys Law Irish Pub

Or see the complete list of suggested Places to Eat.

1845
Private Instructor Dinner
@ TBA
1900
2300
Early-Career Scientists Committee (ECSC) – MSACL EU Welcome Event
@ TBA

Early-career scientists (ECS) are invited to meet at one of Salzburg’s biggest brew houses (Augustiner Brau) for an informal networking evening. This is a great opportunity for ECS to get together and meet one another in a relaxed environment. Perfect if it’s your first time at MASCL EU in Salzburg or if you want to meet your peers while exploring the city and enjoying some typical Austrian food and drink.

Monday

800
830
Welcome Coffee
@ Entrance Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
830
1230

Short Course

Continued from Sunday
Data Science 101
Breaking up with Excel: An Introduction to the R Statistical Programming Language
Daniel Holmes, MD, William Slade, PhD & Stephen Master, MD, PhD
Level: Beginner - Intermediate
@ Trakl Hall
Continued from Sunday
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Shannon Haymond, PhD
Level: Intermediate
@ Mozart 3
Continued from Sunday
Glyco-Proteomics 101
Unravelling The Sweetness Of Life: Clinical Glyco(Proteo)Mics By Mass Spectrometry
Noortje de Haan, PhD & Guinevere Lageveen-Kammeijer, PhD
Level: Beginner to Intermediate
@ Mozart 2
Continued from Sunday
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Laura Owen, PhD, Michael Wright, Coral Munday & Grace van der Gugten
Level: Beginner
@ Paracelsus Hall
Continued from Sunday
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Brian Rappold & Chris Shuford, PhD
Level: Advanced
@ Mozart 4-5
COURSE START
Lipidomics 101
Mass Spectrometry-based Lipidomics and Clinical Applications
Anne K Bendt, PhD, Amaury Cazenave-Gassiot, PhD, Michael Chen, MD
Level: Beginner - Intermediate
@ Papageno Hall
Continued from Sunday
Metabolomics 202
Metabolomics: Approaches, Applications and Challenges
Julijana Ivanisevic, PhD & Elizabeth Want, PhD
Level: Beginner to Intermediate
@ Doppler Hall
1230
1330
Lunch
@ Entrance Foyer

Lunch provided for short course attendees.
1330
1730

Short Course

COURSE START
Proteomic Microbiology 201
Bottom-Up and Top-Down Proteomic Approaches for Bacterial Identification and Characterization, a Focus on MALDI-TOF and Advanced Technologies
Jean Armengaud, PhD, Stefan Zimmermann, MD
Level: Beginner - Intermediate
@ Trapp Zimmer
Continued from Monday AM
Data Science 101
Breaking up with Excel: An Introduction to the R Statistical Programming Language
Daniel Holmes, MD, William Slade, PhD & Stephen Master, MD, PhD
Level: Beginner - Intermediate
@ Trakl Hall
Continued from Monday AM
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Shannon Haymond, PhD
Level: Intermediate
@ Mozart 3
Continued from Monday AM
Glyco-Proteomics 101
Unravelling The Sweetness Of Life: Clinical Glyco(Proteo)Mics By Mass Spectrometry
Noortje de Haan, PhD & Guinevere Lageveen-Kammeijer, PhD
Level: Beginner to Intermediate
@ Mozart 2
Continued from Monday AM
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Laura Owen, PhD, Michael Wright, Coral Munday & Grace van der Gugten
Level: Beginner
@ Paracelsus Hall
Continued from Monday AM
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Brian Rappold & Chris Shuford, PhD
Level: Advanced
@ Mozart 4-5
Continued from Monday AM
Lipidomics 101
Mass Spectrometry-based Lipidomics and Clinical Applications
Anne K Bendt, PhD, Amaury Cazenave-Gassiot, PhD, Michael Chen, MD
Level: Beginner - Intermediate
@ Papageno Hall
Continued from Monday AM
Metabolomics 202
Metabolomics: Approaches, Applications and Challenges
Julijana Ivanisevic, PhD & Elizabeth Want, PhD
Level: Beginner to Intermediate
@ Doppler Hall
1730
1800
Petite Reception
@ Entrance Foyer

A quick touch of wine and cheese before exploring the city for dinner.
1800
Dinner on Own
@ Your Choice

Dinner suggestions:
1. Braurestaurant IMLAUER (Austrian, traditional interior plus a beer garden, good for groups)
2. Zum fidelen Affen (best patio dinner on a nice evening, closed Sunday)
3. Die Wiesse (Brewery Pub with beer garden open till 2am Mon-Sat)
4. Gablerbrau (Historic ambiance with traditional food)
5. Augustiner Braustubl (Historic Abby turned beer garden with food stalls)
6. Antichi Sapori (Tasty Italian food and pizza in casual family run style, open 5:30-9:00pm, closed Wed and Thurs)
7. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily)

After dinner:
1. Murphys Law Irish Pub

Or see the complete list of suggested Places to Eat.

1830
2030
Private Faculty Dinner
@ TBA

Tuesday

615
715
Early-Career Scientists Committee (ECSC) – Morning City Run
@ Entrance Foyer

Chair: Nicola Gray
Everyone is welcome to join the ECSC for a morning 5 km run in Salzburg. An ideal way to see some of the city while working off the Austrian cuisine! All abilities welcome.
800
1600
Place Posters
@ 1st Floor Exhibit Hall

ALL posters should be placed by 16:00.
800
830
Welcome Coffee
@ Entrance Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
830
1130

Short Course

Continued from Monday PM
Proteomic Microbiology 201
Bottom-Up and Top-Down Proteomic Approaches for Bacterial Identification and Characterization, a Focus on MALDI-TOF and Advanced Technologies
Jean Armengaud, PhD, Stefan Zimmermann, MD
Level: Beginner - Intermediate
@ Trapp Zimmer
Continued from Monday PM
Data Science 101
Breaking up with Excel: An Introduction to the R Statistical Programming Language
Daniel Holmes, MD, William Slade, PhD & Stephen Master, MD, PhD
Level: Beginner - Intermediate
@ Trakl Hall
Continued from Monday PM
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Shannon Haymond, PhD
Level: Intermediate
@ Mozart 3
Continued from Monday PM
Glyco-Proteomics 101
Unravelling The Sweetness Of Life: Clinical Glyco(Proteo)Mics By Mass Spectrometry
Noortje de Haan, PhD & Guinevere Lageveen-Kammeijer, PhD
Level: Beginner to Intermediate
@ Mozart 2
Continued from Monday PM
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Laura Owen, PhD, Michael Wright, Coral Munday & Grace van der Gugten
Level: Beginner
@ Paracelsus Hall
Continued from Monday PM
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Brian Rappold & Chris Shuford, PhD
Level: Advanced
@ Mozart 4-5
Continued from Monday PM
Metabolomics 202
Metabolomics: Approaches, Applications and Challenges
Julijana Ivanisevic, PhD & Elizabeth Want, PhD
Level: Beginner to Intermediate
@ Doppler Hall
900
1300
Get the Basics
@ Papageno Hall

Chairs: Roland Geyer & Anne Schmedes
This series of Primers on emerging fields within Clinical Mass Spec is free to attend for ALL registrants of the MSACL Congress or Short Courses, including Partial Pass holders.

Take aways for each session include:
1. Be able to define what the field is, why it matters, and why you personally should care. What is the clinical relevance?
2. Understand what role mass spectrometry plays in this field. Where does mass spec fit in to the big picture of the field?
3. Define any terminology that is specific to this field.
4. Describe how it works, what are the methods and workflows used when studying this field and/or how is it implemented in clinical labs.
5. Identify any challenges to implementation/adoption, where do the opportunities lie?

09:00 - 09:40 Glycomics with Manfred Wuhrer
09:50 - 10:30 Mass Spec Imaging with Tiffany Porta
10:40 - 11:20 Lipidomics with Anne Bendt
11:30 - 12:10 Data Science with Shannon Haymond
12:20 - 13:00 Breath Analysis with Ilaria Belluomo
1130
1400
Lunch on Own
@ Your Choice

Some nearby (within one block) recommendations include:
1. The Heart of Joy (Vegetarian and Vegan)
2. my Indigo Kongresshaus (Asian Fusion, great choice if short on time, pre-packaged take-away options available, pleasant interior)
3. Cafe Fingerlos (Cafe with the best breakfast in town)
4. IMLAUER Sky (Rooftop patio with a view)
5. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily with Sunday Brunch buffet until 2pm)
6. Braurestaurant IMLAUER (Austrian, traditional interior plus a beer garden, good for groups)

A little further afield:
1. Balkan Grill Walter (Take-away street food at its best in the Old Town. Grab a FroYo at Fabi's after.)
2. Stieglkeller (Lovely historical building in Old Town, it's Beer Garden has a fantastic view over the town. Large beer selection.)
3. Krimpelstatter (Traditional Austrian food since 1584, Beer Garden, Good for groups up to 50pax)

Or see the complete list of suggested Places to Eat.

13:10
13:50
Discussion Group: Study Design and Logistics for Metabolomics Studies
@ Papageno Hall

Chair: Jerzy Adamski
Study design is a very critical step in metabolomic experiment. It has to ensure that phenotype resolution, metabolite coverage, quality-driving resources and logistic processes are considered. During the session we will interactively discuss steps like type of the study, consideration of confounders, power calculation, pre-analytical requirements, sample storage, randomization, metabolite analytics to be chosen and replication considerations.
1400
CONGRESS OPEN
@ Mozart 1-5
1400
1415
Welcome, Introduction & Orientation
@ Mozart 1-5
1415

Opening Plenary Lecture


@ Mozart 1-5
Chair: Anne Bendt

1415
1500
Inflammatory Stories in Time and Space: Using Mass Spectrometry Imaging, Ion Mobility and High Throughput Lipidomics to Understand Human Disease
Jules Griffin
Computational and Systems Medicine, Surgery and Cancer, Imperial College London, London and Department of Biochemistry, University of Cambridge, Cambridge, UK

A central aspect of the development of many of the pathologies associated with the metabolic syndrome is a chronic progression of inflammation in the affected tissues. This is in part driven by lipid remodelling in the cell membrane and the production of pro-inflammatory lipid mediators produced from polyunsaturated fatty acids such as arachidonic, docosahexaenoic and eicosapentaenoic acids. To explore lipid remodelling during the development of non-alcoholic fatty liver disease we have applied MALDI-based mass spectrometry imaging (MSI) to examine both human tissue and animal models of the disease progression. Using a combination of high fat feeding and genetic modification (the ob/ob mouse which lacks leptin) to cause hepatic steatosis with and without inflammation, MSI shows that one of the events associated with disease progression is a lipid remodelling of phosphatidylcholines (PCs), and in particular, a reduction in arachidonic acid containing PCs. We have also developed a ultra-high performance liquid chromatography ion mobility mass spectrometry-based method to profile known and novel lipid mediators, using a KNIME workflow to process the data and annotate the detected lipids, in part relying on collision cross-section values for these species to aid assignments. This will be illustrated in following the time course of lipid changes in thrombin activated human platelets.

1500
1515
Intermission
@ Entrance Foyer
1515
1615

State of the Science Address
@ Mozart 1-5

Chairs: Elizabeth Want and Roland Geyer
Speakers: Ilaria Belluomo, Graeme Eisenhofer, Manfred Wuhrer, Anne Bendt, Oleg Mayboroda, Edward Moore, Lars Melholt Rasmussen, Jody van den Ouweland, Tiffany Porta, Grace van der Gugten
Presented by MSACL EU Scientific Committee, this address will provide an overview of the applications and technologies currently being used in Clinical Labs, and a clear view of the development pipeline. It will highlight applications expected to be available in the near-future, as well as emerging applications, and key contributors. Exemplary talks, posters, and people present at the congress will be identified, enabling you to optimize your learning path and more effectively target potential network connections. Whether you are new to Clinical Mass Spectrometry, or a seasoned veteran, the State of the Science address should be on your agenda.
1615
1630
Intermission
@ Entrance Foyer
1630
1700
Poster Lightning Talks
@ Mozart 1-5

Chairs: Ilaria Belluomo and Julien Boccard
Judges: Simon Cameron, Eva Hunyadi-Gulyas, Guinevere Lageveen-Kammeijer, Renee Ruhaak, Will Slade, Karl Storbeck, Elizabeth Want
Poster Contest Semi-Finalists will be selected to present their pitch from the plenary podium within 90 seconds and with 1 slide (PDF format).
1700
1715
Exhibitor Lightning Talks (View)
@ Mozart 1-5

Chair: Nicola Gray
Presenting Companies: Bioinformatics Solutions, Cambridge Isotope Labs, Chromsystems, Merck, Pharmafluidics, Shimadzu, Tecan, Thermo Fisher Scientific, UTAK Laboratories, Waters
10 -12 exhibitors selected to present their pitch from the plenary podium within 90 seconds and with 1 slide (PDF format).
1715
EXHIBITS OPEN
@ 1st Floor Exhibit Hall
1715
1930
Exhibitor Reception
@ 1st Floor Exhibit Hall

Dinner served.
1800
1900
Meet-a-Mentor : Booth Tours
@ 1st Floor Exhibit Hall

Chair: Renee Ruhaak
Mentors: David Herold, Laura Owen, Grace van der Gugten, Michael Wright
Join an expert mentor as they tour the booths and learn more about technologies available, what experts are looking for during the exchange, and how they interact with the booth vendors. Increase your network and your knowledge of products and services available.
1930
2030
Early-Career Scientists (ECS) - Career Options in Clinical Mass Spectrometry Discussion
@ Mozart 4-5

Chair: Nicola Gray
Organized by the ECSC, this discussion group is aimed at early-career scientists and those involved with training and recruitment of the next generation. It is meant to create awareness on career development and planning, considering your career path, where you would like to be and how to get there. The discussion panel will comprise speakers from a variety of sectors including academia, industry and entrepreneurship and will explore transitioning between different sectors. The invited speakers include Christiane Auray-Blais (University of Sherbrooke, Canada), Brian Keevil (University of Manchester, UK), Flaminia Flanelli (University of Bologna, Italy), Christian Scherling (Tecan, Germany), and Will Slade (LabCorp, USA) who will discuss their own professional career pathways and how they got there.
1930
2030
FeMS: Networking Reception
@ Mozart 1-3

Chairs: Anne Bendt, Grace van der Gugten, Margrét Þorsteinsdóttir
Please join us for this inaugural FeMS event! Over wine and cheese, a few thought-provoking questions will be posed. Afterwards we’ll have a discussion group.
Organized by Females in Mass Spectrometry (FeMS), an initiative to bring together women in the mass spectrometry field.
2030
2130
FeMS : Discussion Group : How to Gain Visibility in the Field of Mass Spectrometry
@ Mozart 1-3

Chair: Rita Horvath
Panelists: Gwen McMillin, Margrét Þorsteinsdóttir, Julijana Ivanisevic, I-Lin Tsai, Elizabeth Want, Isa Cabruja
Thought-provoking questions, followed by a discussion with women at various stages in their careers, including an open period for audience questions. Exploring themes such as: (i) Best practices to achieve more visibility; (ii) How can the mass spec community participate in supporting its male and female members? (iii) How can we encourage each other to succeed? What questions do you have? Open to all! Additionally, the Rowena Shaw Avanti Award for Women in Mass Spectrometry, a $2000 USD discretionary award funded by Avanti Polar Lipids, will be introduced.
2030
Enjoy the City
@ Your Choice

or get a good night's sleep

Wednesday

745
900
Welcome Coffee
@ Entrance Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
800
845

Corporate Workshop(s)

Merck
@ Mozart 4-5 (Track 2)

Pre-Register

Enhancing Accuracy: Matrix Selection, Internal Standard Selection, and Sample Clean-Up Solutions for Clinical Mass Spectrometry

Speaker:
Geoffrey Rule, PhD – Merck, Principal Scientist, R&D

Why isn’t my calibration curve perfectly linear? How does my choice of matrix calibrator impact my assays? There are several reasons a calibration curve may be nonlinear, and the use of a co-eluting, isotopically labelled internal standards is the first step in obtaining a linear regression across a broad concentration range. We discuss how to select isotopically labelled internal standards for accurate quantification, how to remedy nonlinear calibration curves, and touch on use of isotopically labelled therapeutic antibodies. We will also review matrix calibrators for endogenous analytes, and how our Cerilliant Certified Reference Materials in matrix can help reduce variability. Lastly, we’ll touch on sample preparation options for clinical testing methods, including the use of our HybridSPE phospholipid and protein removal plates for automated high-throughput determination of 25-hydroxy vitamin D in serum.

Thermo Fisher Scientific
@ Papageno (Track 3)

Achieve Superior Confidence in Your LC-MS Analysis
Speaker: Claudio DeNardi, Thermo Fisher Scientific, EU
The superior selectivity, specificity, robustness, and sensitivity offered by liquid-chromatography (LC) - mass spectrometry (MS) has made this technique one of the most advantageous in the field, here we highlight our comprehensive portfolio of LC-MS platforms and novel applications.

Trying to stay one-step ahead – how High-Resolution Accurate Mass LCMS has enabled early detection of fentanyl analogues (including carfentanil) and synthetic cannabinoids in the UK
Speaker: Simon Hudson, Technical Director, LGC; Fordham, England, UK
One of the biggest challenges facing forensic toxicology is to ensure that detection methodologies keep up with new drugs, such as New Psychoactive Substances (NPS) that are continuously entering the (black) marketplace. High Resolution Accurate Mass based LCMS allows the analyst to rapidly respond to new drug threats and to even monitor for predicted new designer compounds whilst still covering all the existing drug threats.
Two screening workflows are described:
1. The detection of fentanyl analogues as part of a broad drug screen including the first detection of carfentanil in post mortem samples in the UK in February 2017
2. The continuing evolution and detection of synthetic cannabinoid receptor agonists (SCRAs) in the UK.

SCIEX
@ Paracelsus (Track 4)

Pre-Register

Advanced mass spectrometry techniques provide deeper access into the vitamin D metabolome

Vitamin D has an important role in bone metabolism. Its functional involvement in other diseases such cancer or cardiovascular diseases is less clear, however, and is currently the subject of intense research. Typically, 25-hydroxyvitamin D is used for assessing vitamin D status of individuals, because it is readily accessible by analytical measurements and represents vitamin D substrate availability. This simplified assessment ignores dynamic effects of downstream metabolites though. More elaborate functional correlations of vitamin D metabolite distributions (‘chemotypes’) and disease phenotypes require derivatization for simultaneous quantification of all vitamin D metabolites as well as reducing isobaric background. In this seminar I describe vitamin D chemotyping based on Amplifex derivatization, UHPLC-MS/MS measurements and its application to patients with chronic liver diseases during vitamin D replacement therapy.

Guest Speaker: Pascal Schorr, Humboldt-University, Berlin

Places are limited, we would recommend to pre-register and get the clinical compendium no 2.

We will also be at booth 6 in the exhibition area and happy to see you there.

845
900
Intermission
@ Entrance Foyer

Scientific Session 1

Track 1
Mozart 1-3

Metabolomics Keynote: Oscar Yanes
Chair: Oleg Mayboroda
2nd Chair: Hanifa Koguna

Track 2
Mozart 4-5

Proteomics: Reinventing Old Biomarkers
Chair: Kevin Mills

Track 3
Papageno Hall

Quality Control
Chair: Rita Horvath

Track 4
Paracelsus Hall

Small Molecules: Metabolomics in Toxicology
Chair: Jody van den Ouweland
2nd Chair: Juliane Fagotti

Track 5
Trakl Hall

Lipidomics: Applications for Doping, Nutrition and Lab Med
Chair: Erika Dorado
2nd Chair: Panagiotis Vorkas

Track 6
Doppler Hall

Breath Analysis and VOC in Cancer
Chair: Kseniya Dryahina

900
920
From Spectrometric Data to Metabolic Networks: An Integrated Quantitative View of Cell Metabolism
Oscar Yanes
CIBER & URV & IISPV
HILIC-LC-MRM-MS Enables the Quantitation of PSA and its Major Glycoforms to Improve Prostate Cancer Diagnostics
L.Renee Ruhaak
Leiden University Medical Center
A Proposal to Standardize the Description of LC-MS -based Measurement Methods in Laboratory Medicine
Michael Vogeser
Hospital of the University of Munich (LMU)
UPLC-MS/MS-based Assays for Diagnosis and Therapeutic Monitoring in Patients with APRT Deficiency
Unnur Arna Thorsteinsdottir
University of Iceland
Development and Validation of a Gas-Chromatography Mass Spectrometry Method for the Analysis of Testosterone Esters in Biological Matrices
Michele Iannone
Laboratorio Antidoping FMSI, Rome, Italy
Investigating the Relationship between TRIM44 and P53 Metabolic Pathways in Human Colon Cancer Cells in a 3D Model, Using PTR-ToF-MS
Katerina-Vanessa Savva
PhD, Imperial College London
920
940
...
Keynote
...
Proteomic Analysis of Prostate Cancer Biopsies
Gábor Tóth
MS Proteomics Research Group, RCNS-HAS
Metrological Traceability of Lp(a) Requires Defining the Measurand and Introducing Molar Units
Christa Cobbaert
Leiden University Medical Center
Investigation of Bacterial β-Glucuronidase Inhibition on the Metabolic Profile of Mice Using a Combined Platform of NMR and LCMS-based Untargeted Metabolomics
Marine Letertre
Imperial College London
Determination of Serum Triglyceride by Isotope Dilution LC-MS/MS
Weiyan Zhou
NCCL,Beijing Hospital
VOC-based Real-Time Breast Cancer Diagnostic Using LTP-MS
Flore Herve
PhD student, PRISM U1192
940
1000
...
Keynote
...
The Analysis of Alpha-1-Antitrypsin Glycosylation in HCC Patient Serum
Haidi Yin
The Hong Kong Polytechnic University
Rigorous Quality Management Enables Long-Term Robustness of MS-based Protein Quantitation
Nico Smit
Leiden University Medical Center
Development of a Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (LC-QTof MS) Method for the Screening of Antihypertensive Drugs in Urine
Alexander Lawson
University Hospitals Birmingham NHS FT
Whole Blood Omega-3 Index by Gas Chromatography Dependence on Age and Gender in Caucasian Population
Vasiliy Yurasov
Scientific laboratory "Chromolab"
Volatile Organic Compound (VOC) Profiling in Liver Disease via Selected-Ion Flow-Tube Mass Spectrometry (SIFT-MS)
Michael Hewitt
Imperial College London
1000
1100
Poster Session 1
@ 1st Floor Exhibit Hall

Selected posters to be attended for 1 hour. Refer to program for posters attended during this period.

Scientific Session 2

Track 1
Mozart 1-3

Metabolomics: Clinical Apps I
Chair: Oleg Mayboroda
2nd Chair: Chung-Ho Lau

Track 2
Mozart 4-5

Proteomics: Metrological Traceability and Absolute Quantification
Chair: Christa Cobbaert

Track 3
Papageno Hall

Practical Training: Traceable Clinical Measurement
Chair: Roland Geyer

Track 4
Paracelsus Hall

Endocrinology: Serum Steroids
Chair: Karl Storbeck
2nd Chair: Elizabeth Baranowski

Track 5
Trakl Hall

Clinical Glycomics I
Chair: Guinevere Lageveen-Kammeijer
2nd Chair: Gábor Tóth

Track 6
Doppler Hall

Microbiology Keynote: Johan Malmström
Chair: Roger Karlsson
2nd Chair: Petra Paizs

1100
1120
Metabolomics Analysis of Blood Plasma for Early Diagnosis of Uterus Leiomyoma Recurrences
Vladimir Frankevich
Research Center for Obstetrics and Gynecology
Development of an Immunoprecipitation Method for the Analysis of Intact Parathyroid Hormone (PTH) and Related Forms by LC-MS/MS
Jordi Farré-Segura
University of Liège
Traceable Clinical Measurement
Chris Hopley
NML
The Harmoster Initiative: Preliminary Results on the Comparability of Circulating Steroid Measurement Among Ten European Laboratories Using LC-MS/MS
Flaminia Fanelli
University of Bologna
Comprehensive Glycopeptide Profiling in Blood Plasma for Clinical Applications
Melissa Baerenfaenger
Radboudumc
Large-Scale Inference of Protein Tissue Origin in Sepsis Plasma Using Quantitative Targeted Proteomics
Johan Malmström
Department of Clinical Sciences
1120
1140
Metabolomics Applied to Coronary Clinical Burden: Use of Mass Spectrometry to Re-Stratify Asymptomatic Subjects of Intermediate Cardiovascular Risk
Aline Martins
Universidad CEU San Pablo Madrid
Multiplexing Kidney Injury and Kidney Specific Biomarkers in Urine Using MS-based Bottom-Up Proteomics: A Robust and Feasible Approach
Tirsa van Duijl
Leiden University Medical Center (LUMC)
...
Extended Session
...
Multidimensional Diagnostics with Machine Learning for Primary Aldosteronism
Graeme Eisenhofer
Technische Universität Dresden
Ultrahigh Resolution MS Profiling of Plasma N-Glycans in Large Type 2 Diabetes Cohorts
Elham Memarian
Leiden University Medical Center
...
Keynote
...
1140
1200
Metabotyping Burn Injury Using UPLC-MS Coupled with Microdialysis
Elizabeth Want
Imperial College London
The Combined Use of Lys-C and Trypsin Provides Better Digestion Efficiency for MS-based Protein Quantitation
Fred Romijn
Leiden University Medical Center
...
Extended Session
...
An Ultrasensitive High-Throughput LCMS/MS-Method for Estradiol and Estrone in the Sub-Picomolar Range
Bjørn-Erik Bertelsen
Hormone Laboratory, Haukeland University Hospital
IgG and IgA Glycopeptide Characterization by LC-MS Reveals Associations with Inflammatory Bowel Disease Subtypes and Behavior
Noortje de Haan
Leiden University Medical Center
...
Keynote
...
1200
1330
Lunch
@ 1st Floor Exhibit Hall

Lunch to be provided in the Exhibit Hall. Get ready to join a Corporate Workshop after lunch.
1230
1315
Troubleshooting Poster Rounds
@ 1st Floor Exhibit Hall

Chair: Grace van der Gugten
12:30 at poster #24a
The Hurdles of Developing an LC-MS/MS Assay for Desmosine, a Biomarker for Elastin Degradation
Jody van den Ouweland
Canisius-Wilhelmina Hospital
12:45 at poster #24b
Fast and Efficient Method for Detection and Quantification of Catecholamines in Human Plasma by LC-MS/MS - Troubleshooting
Chiara Calaprice
University hospital of Liege
13:00 at poster #24c
Matrix Dilemmas in LC-MS/MS: The Use of Appropriate Calibrators and Internal Standards to Facilitate Acceptable Criteria for Quantification
Tania Grobler
North-West University
1330
1415

Corporate Workshop(s)

Shimadzu
@ Mozart 4-5 (Track 2)

Pre-Register

Discover our innovative platforms and proven solutions for advanced healthcare.
-----------------------------------------------------------------------------------------------------------------
“MALDI-MS technology combined with automated interpretation software, a solution adapted to high throughput screening: Sickle cell disease screening in newborns as a first application”
Patrick DUCOROY - BIOMANEO - France

"Robustness and reliability of the novel pre-analytical filtration system CLAM-2030 and LCMS-8050"
Dr Frank STREIT - University Hospital Gottingen - Germany

"Rethinking the capability and workflows in clinical metabolomics and biomarker research using the LCMS-9030 Q-TOF technologies"
Emily ARMITAGE - Shimadzu Corp - UK

Thermo Fisher Scientific
@ Papageno (Track 3)

Laboratory-Developed Mass Spectrometry testing vs Regulatory-Approved tests: Pros and Cons
Moderator: Torsten Binscheck-Domass, Lead Scientist, Clinical Mass Spectrometry, Thermo Fisher Scientific

Part 1: Balancing the pros and cons of Mass Spec-based Lab-Developed-Tests as compared to Regulatory-Approved Tests under the new IVD Regulation 2017/746 in Europe
Speaker: Prof. Dr. Christa Cobbaert, Head of Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, NE; also EC observer in EC IVD working group 8 under the Medical Device Coordination Group.

Part 2: Cascadion™ SM 25-Hydroxy Vitamin D* and Immunosuppressants Panel**—Assays on the Cascadion™ SM Clinical Analyzer*
Speaker: Ville Rajala, Sr Product Manager, Clinical Mass Spectrometry, Thermo Fisher Scientific

* Cascadion SM Clinical Analyzer is IVD/CE marked but not 510(k)-cleared and not yet available for sale in the U.S. Availability of product in each country depends on local regulatory marketing authorization status.
** Immunosuppresants Panel for Cascadion SM Clinical Analyzer is in development. Only preliminary feasibility data will be introduced. Product is not IVD/CE marked or 510(k) cleared, and is not available for sale.

Waters
@ Paracelsus (Track 4)

Pre-Register

Mass Spectrometry advantages for Therapeutic Drug Monitoring: a closer look at teicoplanin

Guest Speaker: Brian Keevil, Professor at University Hospital Southern Manchester, UK

When performing Therapeutic Drug Monitoring LC-MS/MS is an important technique in the clinical laboratory. In this workshop we will discuss the use of LC-MS/MS for the measurement of antibiotics, inhaled Steroids, azole antifungal drugs, and anti-cancer drugs. The specificity and sensitivity of LC-MS/MS over traditional techniques improves the accuracy of measurement and the ability to perform therapeutic drug monitoring for a number of different analytes.

Agilent Technologies
@ Trakl (Track 5)

Pre-Register

Fast Track your Cannabinoid Urine Analysis using MassHunter StreamSelect LC-MS System
Moritz Wagner, Product Specialist, Agilent Technologies

Liquid chromatography triple quadrupole mass spectrometry (LC/MS/MS) is the ideal solution for the simultaneous analysis of multiple cannabinoids and metabolites due to the high specificity and analytical sensitivity of the instrumentation. A six minute chromatographic method was developed on an Agilent Poroshell 120 EC-C18 column to separate 6 cannabinoids analytes using an Agilent 1290 Infinity II Liquid Chromatograph coupled with an Agilent 6470 triple quadrupole mass spectrometer. Sample throughput was nearly quadrupled (3.7x) by running four simultaneous, staggered chromatographic analyses on a single mass spectrometer using Agilent's MassHunter StreamSelect LC-MS software. This equates to 97 seconds per analysis, compared to a 6-minute runtime the same analysis using traditional LC-MS.

For Research Use Only. Not for use in diagnostic procedures.

1415
1430
Intermission
@ Entrance Foyer

Scientific Session 3

Track 1
Mozart 1-3

Metabolomics: Clinical Apps II
Chair: Nicola Gray

Track 2
Mozart 4-5

Proteomics Keynote: Kevin Mills
Chair: Christa Cobbaert

Track 3
Papageno Hall

Breath Analysis Keynote: Patrik Španěl
Chair: Ilaria Belluomo

Track 4
Paracelsus Hall

Small Molecules: From Vitamins, Drugs to Chemical Warfare
Chair: Michael Vogeser

Track 5
Trakl Hall

Lipidomics in Cancer
Chair: Vladimir Frankevich
2nd Chair: Kenji Nakayama

Track 6
Doppler Hall

MALDI for the Clinical Laboratory
Chair: David Herold

1430
1450
Assessing the Metabolome of Preterm Newborns: Findings from a Danish Population-based Study
Madeleine Ernst
Statens Serum Institut
The Development of Targeted Proteomic Assays, Attempting to Take Biomarkers from the Research Lab to the Clinic
Kevin Mills
University College London
Selected Ion Flow Tube Mass Spectrometry SIFT-MS for Real-Time Measurement of Trace Concentrations of Volatile Compounds in Breath and Culture Headspace
Patrik Španěl
J. Heyrovský Institute of Physical Chemistry
Development of an LC-MS/MS Assay for Biotin Quantitation to Support Research on Biotin Interference of Immunoassays
Antoinette IJpelaar
CWZ Hospital
MALDI-TOF/MS Analyses of Urinary Phospholipids and Lysophospholipids as Potential Diagnostic Biomarkers for Prostate Cancer
Xin Li
Kyoto University
Optimization of MALDI-based Techniques for the Rapid Diagnostics of Sepsis
Miriam Cordovana
A.O.U. Policlinico Sant'Orsola-Malpighi
1450
1510
Podocyturia Evaluation in Women with Preeclampsia and Fabry Disease Patients Using a Tandem Mass Spectrometry Approach
Christiane Auray-Blais
Université de Sherbrooke
...
Keynote
...
...
Keynote
...
LC-MS/MS for Peptide-Adduct Analysis to Verify Poisoning with Chemical Warfare Agents and Pesticides
Harald John
Bundeswehr Institute of Pharmacology & Toxicology
Can Rapid Evaporative Ionization Mass Spectrometry (REIMS), the Intelligent Surgical Knife (iKnife) Provide a Point-of-Care Diagnosis for Endometrial Cancer
Diana Marcus
Imperial College London
MALDI Chip Technology for in situ Detection of Human Procalcitonin
Petr Pompach
Institute of Microbiology
1510
1530
Exploratory Metabolomics of Urine and Plasma to Identify Novel Pharmacodynamic Biomarkers in a Phase I Clinical Trial of AZD3965
Alexandros Siskos
Imperial College London
...
Keynote
...
...
Keynote
...
Analysis of Fentanyl and Metabolite in Clinical and Post-Mortem Samples
Karen Scott
Arcadia University
Lipidomic Study of Cell Lines Reveals Differences between Breast Cancer Subtypes
Finnur Freyr Eiriksson
University of Iceland
Potential of TiO2 Nanoparticles for Mass Spectrometric Detection and Quantification of Biologically-Relevant Small Molecules
Marijana Petkovic
University of Madeira, CQM-Centre for Chemistry
1530
1630
Meet-a-Mentor : Poster Tours
@ 1st Floor Exhibit Hall

Chair: Renee Ruhaak
Mentors: Isabelle Fournier, David Herold, Anna Nicolaou, Brian Rappold
1530
1630
Poster Session 2
@ 1st Floor Exhibit Hall
1630

Distinguished Contribution Award Lecture


@ Mozart 1-5
Chair: Elizabeth Want

1630
1730

On the Award

15 years of Ambient Mass Spectrometry: From Amino Acid Clusters to Surgical Robotics
Zoltan Takats
Imperial College London

1730
1900
Exhibitor Reception
@ 1st Floor Exhibit Hall

Wine and Light Appetizers served in Exhibit Hall.
1800
1900
Meet-a-Mentor : Office Hours Forum
@ 1st Floor Cafe

Chair: Renee Ruhaak
Mentors: Christiane Auray-Blais, Anne Bendt, Shannon Haymond, David Herold, Daniel Holmes, Patrick Mathias, Anna Nicolaou, Brian Rappold, Chris Shuford, Will Slade, Grace van der Gugten, Elizabeth Want
Have a question from the congress that you have been itching to ask? Or a problem from work that you want to get feedback on? Need career advice? Sign up at the registration desk for 15-min blocks to share time and ideas with domain experts in a relaxed setting.
1900
Enjoy the City
@ Your Choice

Plan to join a few colleagues for dinner in Salzburg tonight. Some places to try:
1. Braurestaurant IMLAUER (Austrian, traditional interior plus a beer garden, good for groups, close to congress)
2. Pitterkeller (Austrian, one of the oldest beer cellars in Salzburg, good for groups, close to congress)
3. Krimpelstatter (Traditional Austrian food since 1584, Beer Garden, Good for groups up to 50pax, serving hot food to 9pm, open to 11pm)
4. Steiglkeller (Historic building with a great view over the Old Town, near the Fortress)
5. Gablerbrau (Historic ambiance with traditional food)
6. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily, close to congress)
7. Die Weisse
8. Indian Restaurant Taj Mahal

For a special meal (reservation advised):
1. Restaurant Goldener Hirsch
2. Stiftskeller St. Peter
3. Zum fidelen Affen
4. M32

After dinner:
1. Murphys Law Irish Pub (Common place to meet MSACL folks for drinks and music.)

Or see the complete list of suggested Places to Eat.

Thursday

800
830
Welcome Coffee
@ Entrance Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.

Scientific Session 4

Track 1
Mozart 1-3

Metabolomics: Clinical Applications III
Chair: Christiane Auray-Blais
2nd Chair: Vitaliy Chagovets

Track 2
Mozart 4-5

Proteomics: High Throughput Methodology
Chair: Éva Hunyadi-Gulyás

Track 3
Papageno Hall

Practical Training
Chair: Michael Wright

Track 4
Paracelsus Hall

Endocrinology Keynote: Karl Storbeck
Chair: Brian Keevil

Track 5
Trakl Hall

Clinical Glycomics II
Chair: Valeriia Kuzyk

Track 6
Doppler Hall

Data Science
Chair: Stephen Master

830
850
The Use of Rapid Evaporative Ionisation Mass Spectrometry (REIMS) as a Real-Time Bedside Test in Cervical Cancer Screening
Maria Paraskevaidi
Imperial College London
Maximize the Output of Routine Proteome Analyses by Using Micro Pillar Array Column Technology
Christof Mitterer
PharmaFluidics NV
Multi-Analyte Methods: A Free Lunch or a Frightening Bill?
Coral Munday
LGC Ltd
Rethinking Sex Steroids: Understanding the Clinical Relevance of 11-Oxygenated Androgens
Karl Storbeck
Stellenbosch University
Successful Faecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection Associates with Decreased Complexity of the Serum N-Glycome
Maja Pučić Baković
Genos Glycoscience Research Laboratory
A Chromatogram Says a Thousand Numbers: Data, Decisions, and Directions
William Slade
Laboratory Corporation of America Holdings
850
910
Clinically Relevant Metabolites of the Human Gut Microbiota
Zdenek Spacil
Masaryk University
DirectMS1: A High-Throughput Analysis for Identification and Quantification of 1000 Proteins in 5 Minutes
Mark Ivanov
INEPCP FRCCP RAS
...
Extended Session
...
...
Keynote
...
Novel Glycopeptide Analysis Strategy for Prostate-Specific Antigen in Seminal Plasma of Infertile Men
Wei Wang
Leiden University Medical Center
Chemometric Strategies for Sensitive Regions of Interest Annotation in Complex Imaging Mass Spectrometry Data
Patrick Wehrli
University of Gothenburg
910
930
Exploring the Interactions between Dietary Polyphenols, the Gut Microbiome and Human Health
Nicola Gray
University of Reading, UK
Comparison of MRM- and DIA-based Protein Quantification Using a 500 Protein Blood Panel in Plasma Samples Demonstrates Linearity between Methods
Claudia Escher
Biognosys AG
...
Extended Session
...
...
Keynote
...
Colorectal Cancer Cell Lines Reveal Striking Isomeric Diversity of Human Cancer O-Glycome
Katarina Madunic
LUMC
TBA
930
1030
Poster Contest Finalist Interviews
@ 1st Floor Exhibit Hall

Chairs: Ilaria Belluomo and Julien Boccard
Judges: Simon Cameron, Eva Hunyadi-Gulyas, Guinevere Lageveen-Kammeijer, Renee Ruhaak, Will Slade, Karl Storbeck, Grace van der Gugten, Elizabeth Want
Poster Contest Finalists to attend posters and meet with poster Judges. Judges may arrive in groups or individually.
930
1030
Poster Session 3
@ 1st Floor Exhibit Hall

Selected posters to be attended for 1 hour. Refer to program for posters attended during this period.
1030
1130
Exhibitor Feedback Discussion
@ 1st Floor Cafe

Chair: Chris Herold
An opportunity for exhibiting vendors to provide feedback on what worked and what could use improvement. All Exhibitors are welcome to attend this discussion with the organizers.

Scientific Session 5

Track 1
Mozart 1-3

Metabolomics: Data Analysis Workflows
Chair: Julien Boccard
2nd Chair: Víctor González Ruiz

Track 2
Mozart 4-5

Proteomics: Pre-analytical Considerations for Patient and Specimen Preparation
Chair: Lars Rasmussen

Track 3
Papageno Hall

Practical Training: Assessing the Quality and Robustness of LC-MS/MS assays
Chair: Laura Owen

Track 4
Paracelsus Hall

Small Molecules: From Basic to Novel Approaches in TDM
Chair: Marine Letertre
2nd Chair: Alexandros Siskos

Track 5
Trakl Hall

Glycomics Keynote: Gordan Lauc
Chair: Manfred Wuhrer

Track 6
Doppler Hall

Microbiology: Tandem MS-MS Proteomics and Clinical Diagnostics
Chair: Jean Armengaud
2nd Chair: Miriam Cordovana

1030
1050
Plasma Metabolomics Profiles Associated with Endothelial Health and Dysfunction and their Influence on Endothelial Metabolism
Óttar Rolfsson
University of Iceland
Precise Quantitative Serum LC-MS/MS Profiling: The Impact of Sample Preparation and Sample Source on Biomarker Discovery Studies
Oleksandr Boychenko
Thermo Fisher Scientific
Assessing the Quality and Robustness of LC-MS/MS Assays
James Hawley
Manchester University NHS Foundation Trust
Application of a Molecular Networking Approach for Therapeutic Drug Monitoring (TDM) and Toxicology
Emmanuel Bourgogne
Université de Paris, Faculté de Pharmacie, UMR8038
The Human Glycome Project - Exploring the New Frontier in Personalised Medicine
Gordan Lauc
University of Zagreb
Discovery of Species-Unique Peptides as Candidate Peptide Biomarkers for Respiratory Tract Pathogens Using Tandem Mass Spectrometry-based Proteotyping
Roger Karlsson
Sahlgrenska University Hospital
1050
1110
KIMBLE: A Versatile Visual NMR Metabolomics Workbench in KNIME
Aswin Verhoeven
Leiden University Medical Center
Proteomic Discovery and Validation of the Confounding Effect of Heparin Administration on the Analysis of Candidate Cardiovascular Biomarkers
Hans Christian Beck
Odense universitetshospital
...
Extended Session
...
Potential of MALDI MS for Detection of [Ru(η5-C5H5)(PPh3)2Cl] Metabolites in Patient Body Fluids – a Preliminary Study
Nádia Nunes
CQM, University of Madeira
...
Keynote
...
Quick Pathogen Identification and Antibiogram for the Clinics by MS/MS Proteotyping
Jean Armengaud
CEA
1110
1130
Computational Analysis of Mass Spectrometry Data for Standardised Diagnosis of Inborn Disorders of Steroidogenesis
Elizabeth Baranowski
IMSR, University of Birmingham
The Predictive Potential of Salivary Proteomics for Characterization of the Phases of Allogeneic Hematopoietic Stem Cell Transplants
Milena Souza
International Research Center, A.C.Camargo Cancer
...
Extended Session
...
Therapeutic Drug Monitoring of Clofazimine in Indian MDR-TB Patients
Prerna Chawla
P.D. HINDUJA HOSPITAL & MRC
...
Keynote
...
Robust Accurate Identification and Biomass Estimates of Microorganisms via Tandem Mass Spectrometry
Yu Yi-Kuo
National Center for Biotechnology Information
1130
1315
Lunch
@ 1st Floor Exhibit Hall
1200
1300
Poster Session 4
@ 1st Floor Exhibit Hall

Selected posters to be attended for 1 hour. Refer to program for posters attended during this period.
1200
1300
Meet-a-Mentor : Poster Tours
@ 1st Floor Exhibit Hall

Chair: Renee Ruhaak
Mentors: Isabelle Fournier, David Herold, Brian Rappold
1300
1315
Remove Posters
@ 1st Floor Exhibit Hall
1315
EXHIBITS CLOSED
@ 1st Floor Exhibit Hall

Scientific Session 6

Track 1
Mozart 1-3

Metabolomics of Model Systems
Chair: Petra Paizs

Track 2
Mozart 4-5

Proteomics Keynote: Theo Luider
Chair: Christa Cobbaert

Track 3
Papageno Hall

Practical Training: Calibration and Metrology for Protein MS tests
Chair: Grace van der Gugten

Track 4
Paracelsus Hall

Endocrinology: Miscellaneous
Chair: Flaminia Fanelli

Track 5
Trakl Hall

MS Imaging: Method Development
Chair: Isabelle Fournier

Track 6
Doppler Hall

Breath Analysis and VOC: New Technology
Chair: Patrik Spanel

1315
1335
LC- and CE-MS-based Workflow for Metabolic Read-Across of New Toxicants in Neuroinflammation
Víctor González-Ruiz
University of Geneva
Antibody Sequencing and Quantitation
Theo Marten Luider
Erasmus MC
Calibration and Metrology for Protein MS Tests
L.Renee Ruhaak
Leiden University Medical Center
Validation of a Rapid LC-MS/MS Method with Simple Solid Phase Extraction for Analysis of Catecholamines and their Metabolites in Plasma
Songlin Yu
Peking Union Medical College Hospital
Imaging Spatial Abeta Plaque Aggregation Dynamics in Evolving AD Pathology Using iSILK
Wojciech Michno
Sahlgrenka Academy at the University of Gothenburg
Real-Time Therapeutic Monitoring of Valproic Acid in Exhaled Breath
Kapil Dev Singh
University of Basel
1335
1355
Metabolomic Analysis of Human Atherosclerotic Plaques Reveals a Pathway of Foam Cell Apoptosis in Advanced Atherosclerosis
Panagiotis Vorkas
Imperial College London
...
Keynote
...
...
Extended Session
...
A Novel LC-MS/MS Method for the Quantification of Five Androgens in Saliva
Malcolm McTaggart
Manchester University NHS Foundation Trust
High-Throughput Automated Tissue Imaging by DESI-MS, Three-Dimensional Tissue Imaging or Large Sample Cohort Mapping
Emrys Jones
Waters Corporation
Determination of Aldehydes, Ketones, Short Chain Fatty Acids and Alkanes in Breath and Biofluids with GcxGC-TOF-MS-FID
Antonis Myridakis
Imperial College London
1355
1415
Nontargeted Metabolite Profiling of Human Lung Epithelial Cells (A549) with HILIC Mode UPLC HRMS: Silica Nanoparticle Mediated Cytotoxicity Effects
Kalyan Paila
Pemiscot Memorial Hospital
...
Keynote
...
...
Extended Session
...
C-20 Hydrogenation is Involved in Intrauterine Cortisol Homeostasis Offering an Additional Sex-Driven Protection to Prenatal Stress. Implications in Birthweight
Alex Gomez
Fundació Institut Mar d'Investigacions Mèdiques
Strategy for the Prediction of Neoadjuvant Therapy Response in Breast Cancer by MALDI-MSI
Tiffany Porta
M4I institute, Maastricht University
Deep Urinary Volatile Organic Compound Profiling with Headspace Sorptive Extraction and GCxGC-MS for Oesophago-Gastric Cancer Detection
Qing Wen
Imperial College London
1415
1430
Intermission
@ Entrance Foyer

Scientific Session 7

Track 1
Mozart 1-3

Exploratory Metabolomics
Chair: Zdenek Spacil

Track 2
Mozart 4-5

Proteomics: Emerging Clinical Applications
Chair: Renee Ruhaak
2nd Chair: Tirsa van Duijl

Track 3
Papageno Hall

Practical Training: Biomarker Discovery and Translational Research
Chair: Grace van der Gugten

Track 4
Paracelsus Hall

Small Molecule Keynote: Folker Spitzenberger
Chair: Ido Kema (pending)

Track 5
Trakl Hall

MS Imaging: Clinical Diagnostics
Chair: Jörg Hanrieder
2nd Chair: Eftychios Manoli

Track 6
Doppler Hall

Microbiology: Novel MS Clinical Applications
Chair: Simon Cameron
2nd Chair: Belen Rodriguez-Sanchez

1430
1450
Untargeted Steroidomics for the Identification of Novel Steroid Profiles in Dysregulated Steroidogenesis
Paal William Wallace
Technische Universität Dresden
The End of Kozak Dogma: The Ghost Proteome
Michel Salzet
Université Lille
Biomarker Discovery and Translational Research Leading to Clinical Utility: Experimental Approaches and Pitfalls
Christiane/Michel Auray-Blais/Boutin
Université de Sherbrooke
Impact of the New European IVD Regulation on Medical Laboratories - Opportunities and Challenges
Folker Spitzenberger
University of Applied Sciences Luebeck
High-Throughput Analysis on FFPE Breast Cancer TMAs with DESI-MSI
Olof Gerdur Isberg
University of Iceland
MBT FAST – Rapid Antimicrobial Susceptibility Testing by MALDI-TOF MS
Markus Kostrzewa
Bruker Daltonik GmbH
1450
1510
Untargeted Metabolomic Profiles of Newborns that Will or Will Not Develop Autism: A Pilot Study on Dried Blood Spots
Julie Courraud
Statens Serum Institut
Shortgun Proteomics for Differential Diagnosis of HPV-associated Cervix Transformation
Natalia Starodubtseva
National Medical Research Center of Obstetrics
...
Extended Session
...
...
Keynote
...
Laser Desorption Imaging – Rapid Evaporative Ionisation Mass Spectrometry Platform for Tissue Imaging
Daniel Simon
Imperial College London
Detection of Vancomycin-Resistant Enterococcus faecium Using MALDI-TOF Mass Spectrometry
Belén Rodríguez-Sanchez
Hospital General Universitario Gregorio Marañón
1510
1530
Exploring the Volatomic Fingerprinting of Breast Cancer Tissue as an Untargeted Approach to Identify Potential Biomarkers
Rosa Perestrelo
Centro de Química da Madeira, UMa
Multiplex Assay for Absolute Quantification of Inflammatory Proteins in 134 Meconium and First Stool Swabs from CELSPAC-TNG Birth Cohort Study
Eliška Stuchlíková
Masaryk University
...
Extended Session
...
...
Keynote
...
Towards In vivo Molecular Diagnostics of Esogastric Cancer with Spidermass Real-Time, Mini Invasive Analysis
Nina Ogrinc
University of Lille, PRISM laboratory
Development of Laser Assisted Rapid Evaporative Ionization Mass Spectrometry (LA-REIMS) as a Platform for Clinical Microbiology: The Past and the Future
Simon Cameron
Queen's University Belfast
1530
1545
Intermission
@ Entrance Foyer

Scientific Session 8

Track 1
Mozart 1-3

Metabolomics: Tackling Challenging Samples
Chair: Elizabeth Want

Track 2
Mozart 4-5

MS Imaging Keynote: Frits Koning
Chair: Tiffany Porta

Track 3
Papageno Hall

Practical Training
Chair: Grace van der Gugten

Track 4
Paracelsus Hall

Late-Breaking Science
Chair: Jody van den Ouweland

Track 5
Trakl Hall

Lipidomics Keynote: Anna Nicolaou
Chair: Anne Bendt

Track 6
Doppler Hall

TBA
Chair: TBA

1545
1605
Determination of D- and L-Lactic Acid in Urine by UPLC-MS with Electrospray Ionization Quantification
Juliane Fagotti
Imperial College London
Imaging the Unimaginable with Imaging Mass Cytometry
Frits Koning
LUMC
Design of Experiments (DoE) – Get it Right from the Beginning
Margrét Thorsteinsdottir
University of Iceland
TBA Skin Lipidomics in the Diagnosis and Treatment of Cutaneous Inflammation
Anna Nicolaou
The University of Manchester
TBA
1605
1625
Optimising Laser Assisted - Rapid Evaporative Ionization - Mass Spectrometry Imaging (LA-REI-MSI) for the Spatially Resolved Analysis of Faecal Metabolites
Petra Paizs
Imperial College London
...
Keynote
...
...
Extended Session
...
TBA...
Keynote
...
TBA
1625
1645
Steroidomics Profile Analysis by LCHR-MS in Human Seminal Fluid
Eulalia Olesti
University of Geneve
...
Keynote
...
...
Extended Session
...
TBA...
Keynote
...
TBA
1645
1700
Plenary Reception
@ Entrance Foyer

Ground Floor Bar to serve wine and other beverages for intermission while preparing for the poster awards.
1700
1715
Poster Award Presentation
@ Mozart 4-5

Chairs: Ilaria Belluomo and Julien Boccard
1715

Closing Plenary Lecture


@ Mozart 4-5
Chair: Stephen Master

1715
1800
Donor-derived cell-free DNA as a biomarker in organ transplantation
Michael Oellerich
Institute for Clinical Pharmacology, University Medicine Göttingen, Germany

Molecular biomarkers have attracted special attention in solid organ transplantation because of unresolved problems that limit long-term outcome. There is a lack of reliable noninvasive markers. Immunosuppressive drug monitoring mainly indicates potential toxicity, but is a poor biomarker of graft damage. In kidney transplant patients, for example, an increase of plasma creatinine may be also be due to exsiccation, the use of ACE inhibitors, or immunosuppressive drug toxicity. By the time a rejection-related increase in plasma creatinine is evident, a significant degree of tissue damage has already occurred within the kidney. A further limitation of the current standard of care is that rejection episodes can only be confirmed by biopsies. Biomarkers are needed to achieve personalized immunosuppression to reduce premature graft loss. Against this background, a particularly promising new approach for the early detection of acute or chronic rejection or asymptomatic graft injury leading to irreversible damage is based on the determination of donor-derived circulating cell-free DNA (dd-cfDNA). Data on clinical validity have been documented in more than 48 independent studies which have shown that dd-cfDNA detects rejection episodes early, at an actionable stage, and is a more reliable marker of graft injury, compared to conventional tests. dd-cfDNA may also be useful to guide changes in immunosuppression, to monitor immunosuppression minimization (e.g. during tapering), and to prevent immune activation. The high negative predictive value of dd-cfDNA is the reason why this test can be helpful to avoid unnecessary biopsies. It could be shown that dd-cfDNA can be useful to detect subclinical (e.g. clinically unsuspected) graft damage as a result of immune activation triggered by under-immunosuppression. Early diagnosis of subclinical antibody-mediated rejection may improve outcomes after kidney transplantation. In summary, dd-cfDNA monitoring will allow more personalized treatment that shifts emphasis from reaction to prevention.

1800
1815
Final Remarks
@ Mozart 4-5

Final remarks from Dr. Elizabeth Want, Scientific Committee Chair, 2019-2021.
1815
1900
Closing Petite Reception
@ Entrance Foyer

Wine & Cheese, Beer & Nuts. Winning posters to be on display.
1900
CONGRESS CLOSED
@ Entrance Foyer
1900
2200
After Congress Meet-Up
@ Your Choice

Meet up at the Augustiner Braustubl (Historic Abby turned beer garden with food stalls) for an unofficial and unsponsored post-con gathering. If you need a hearty meal first, stop by the nearby Krimpelstatter.

Friday

800
1000
SciCom Group Meeting
@ TBA

Private Meeting for Scientific Committee Topic Leads and Incoming Leads; Planning for next event.