And Special Thanks to Our Educational Grant Sponsors:
Sunday
Sunday 1100
1300
Lunch on Own @ Your Choice
Some nearby (within one block) recommendations include:
1. The Heart of Joy (Vegetarian and Vegan)
2. my Indigo Kongresshaus (Asian Fusion, with fast take-away options)
3. Cafe Fingerlos (Cafe with the best breakfast in town)
4. IMLAUER Sky (Rooftop patio with a view)
5. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily with Sunday Brunch buffet until 2pm)
6. Braurestaurant IMLAUER (Austrian, traditional interior plus a beer garden, good for groups)
A little further afield:
1. Steiglkeller (Historic building with a great view over the Old Town, near the Fortress)
2. Cafe Sacher (for a patio on the river)
3. Barenwirt (Cozy and Traditional Austrian, fills up so arrive early)
4. Antichi Sapori (Tasty Italian food and pizza in casual family run style, Open 11:30-2:00pm and 5:30-9:00pm, Closed Wed and Thurs)
Or see the complete list of suggested Places to Eat.
910
Sunday 1100
1830
Badge Pickup @ Entrance Foyer
911
1130
1230
Pre-Con Workshop(s)
No workshops currently booked for this time period.
A quick touch of wine and cheese before exploring the city for dinner.
923
Sunday 1800
Dinner on Own @ Your Choice
Dinner Suggestions:
1. Steiglkeller (Historic building with a great view over the Old Town, near the Fortress)
2. Gablerbrau (Historic ambiance with traditional food)
3. Augustiner Braustubl (Historic Abby turned beer garden with food stalls)
4. Antichi Sapori (Tasty Italian food and pizza in casual family run style, open 11:30-2:00pm and 5:30-9:00pm, closed Wed and Thurs)
5. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily)
6. Braurestaurant IMLAUER (Austrian, traditional interior plus a beer garden, good for groups)
Early-career scientists (ECS) are invited to meet at one of Salzburg’s biggest brew houses (Augustiner Brau)
for an informal networking evening. This is a great opportunity for ECS to get together and
meet one another in a relaxed environment. Perfect if it’s your first time at MASCL EU in
Salzburg or if you want to meet your peers while exploring the city and enjoying some
typical Austrian food and drink.
1598
Monday
Monday 800
830
Welcome Coffee @ Entrance Foyer
Enjoy coffee, a pastry and a chat with colleagues before the day starts.
A quick touch of wine and cheese before exploring the city for dinner.
946
Monday 1800
Dinner on Own @ Your Choice
Dinner suggestions:
1. Braurestaurant IMLAUER (Austrian, traditional interior plus a beer garden, good for groups)
2. Zum fidelen Affen (best patio dinner on a nice evening, closed Sunday)
3. Die Wiesse (Brewery Pub with beer garden open till 2am Mon-Sat)
4. Gablerbrau (Historic ambiance with traditional food)
5. Augustiner Braustubl (Historic Abby turned beer garden with food stalls)
6. Antichi Sapori (Tasty Italian food and pizza in casual family run style, open 5:30-9:00pm, closed Wed and Thurs)
7. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily)
Or see the complete list of suggested Places to Eat.
947
Monday 1830
2030
Private Faculty Dinner @ TBA
925
Tuesday
Tuesday 615
715
Early-Career Scientists Committee (ECSC) – Morning City Run @ Entrance Foyer
Chair:Nicola Gray
Everyone is welcome to join the ECSC for a morning 5 km run in Salzburg. An ideal way to
see some of the city while working off the Austrian cuisine! All abilities welcome.
1599
Tuesday 800
1600
Place Posters @ 1st Floor Exhibit Hall
ALL posters should be placed by 16:00.
950
Tuesday 800
830
Welcome Coffee @ Entrance Foyer
Enjoy coffee, a pastry and a chat with colleagues before the day starts.
Chairs:Roland Geyer & Anne Schmedes This series of Primers on emerging fields within Clinical Mass Spec is free to attend for ALL registrants of the MSACL Congress or Short Courses, including Partial Pass holders.
Take aways for each session include:
1. Be able to define what the field is, why it matters, and why you personally should care. What is the clinical relevance?
2. Understand what role mass spectrometry plays in this field. Where does mass spec fit in to the big picture of the field?
3. Define any terminology that is specific to this field.
4. Describe how it works, what are the methods and workflows used when studying this field and/or how is it implemented in clinical labs.
5. Identify any challenges to implementation/adoption, where do the opportunities lie?
09:00 - 09:40 Glycomics with Manfred Wuhrer
09:50 - 10:30 Mass Spec Imaging with Tiffany Porta
10:40 - 11:20 Lipidomics with Anne Bendt
11:30 - 12:10 Data Science with Shannon Haymond
12:20 - 13:00 Breath Analysis with Ilaria Belluomo
961
Tuesday 1130
1400
Lunch on Own @ Your Choice
Some nearby (within one block) recommendations include:
1. The Heart of Joy (Vegetarian and Vegan)
2. my Indigo Kongresshaus (Asian Fusion, great choice if short on time, pre-packaged take-away options available, pleasant interior)
3. Cafe Fingerlos (Cafe with the best breakfast in town)
4. IMLAUER Sky (Rooftop patio with a view)
5. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily with Sunday Brunch buffet until 2pm)
6. Braurestaurant IMLAUER (Austrian, traditional interior plus a beer garden, good for groups)
A little further afield:
1. Balkan Grill Walter (Take-away street food at its best in the Old Town. Grab a FroYo at Fabi's after.)
2. Stieglkeller (Lovely historical building in Old Town, it's Beer Garden has a fantastic view over the town. Large beer selection.)
3. Krimpelstatter (Traditional Austrian food since 1584, Beer Garden, Good for groups up to 50pax)
Or see the complete list of suggested Places to Eat.
964
Tuesday 13:10
13:50
Discussion Group: Study Design and Logistics for Metabolomics Studies @ Papageno Hall
Chair:Jerzy Adamski
Study design is a very critical step in metabolomic experiment. It has to ensure that phenotype resolution, metabolite coverage, quality-driving resources and logistic processes are considered. During the session we will interactively discuss steps like type of the study, consideration of confounders, power calculation, pre-analytical requirements, sample storage, randomization, metabolite analytics to be chosen and replication considerations.
1586
Tuesday 1400
CONGRESS OPEN @ Mozart 1-5
965
Tuesday 1400
1415
Welcome, Introduction & Orientation @ Mozart 1-5
966
1415
Opening Plenary Lecture
@ Mozart 1-5 Chair: Anne Bendt
1415
1500
Inflammatory Stories in Time and Space: Using Mass Spectrometry Imaging, Ion Mobility and High Throughput Lipidomics to Understand Human Disease Jules Griffin Computational and Systems Medicine, Surgery and Cancer, Imperial College London, London and Department of Biochemistry, University of Cambridge, Cambridge, UK
Prof. Jules Griffin is the Professor of Biological Chemistry at Imperial College London. He received his D.Phil in Biochemistry from the University of Oxford in 1997. He then took up a Fellowship in Radiology and Cardiology at Harvard Medical School and Massachusetts General Hospital, Boston, USA. He returned to the UK in 1999 to take up a research associate with Prof. Jeremy Nicholson and then held a Royal Society University Research Fellowship. He moved to the University of Cambridge in 2003 and became the Professor of Metabolism and Nutrition in 2016. During this time, he held a group leader position at the Medical Research Council Human Nutrition Research unit. In 2019 he joined Imperial College London to head the section of Computational and Systems Medicine. He is the current President of the Metabolomics Society, an Agilent Thought Leader, a Fellow of King?s College Cambridge and a Fellow of the Royal Society of Chemistry.
A central aspect of the development of many of the pathologies associated with the metabolic syndrome is a chronic progression of inflammation in the affected tissues. This is in part driven by lipid remodelling in the cell membrane and the production of pro-inflammatory lipid mediators produced from polyunsaturated fatty acids such as arachidonic, docosahexaenoic and eicosapentaenoic acids. To explore lipid remodelling during the development of non-alcoholic fatty liver disease we have applied MALDI-based mass spectrometry imaging (MSI) to examine both human tissue and animal models of the disease progression. Using a combination of high fat feeding and genetic modification (the ob/ob mouse which lacks leptin) to cause hepatic steatosis with and without inflammation, MSI shows that one of the events associated with disease progression is a lipid remodelling of phosphatidylcholines (PCs), and in particular, a reduction in arachidonic acid containing PCs. We have also developed a ultra-high performance liquid chromatography ion mobility mass spectrometry-based method to profile known and novel lipid mediators, using a KNIME workflow to process the data and annotate the detected lipids, in part relying on collision cross-section values for these species to aid assignments. This will be illustrated in following the time course of lipid changes in thrombin activated human platelets.
Tuesday 1500
1515
Intermission @ Entrance Foyer
970
1515
1615
State of the Science Address @ Mozart 1-5
Chairs: Elizabeth Want and Roland Geyer Speakers: Ilaria Belluomo, Graeme Eisenhofer, Manfred Wuhrer, Anne Bendt, Oleg Mayboroda, Edward Moore, Lars Melholt Rasmussen, Jody van den Ouweland, Tiffany Porta, Grace van der Gugten
Presented by MSACL EU Scientific Committee, this address will provide an overview of the applications and technologies currently being used in Clinical Labs, and a clear view of the development pipeline. It will highlight applications expected to be available in the near-future, as well as emerging applications, and key contributors. Exemplary talks, posters, and people present at the congress will be identified, enabling you to optimize your learning path and more effectively target potential network connections. Whether you are new to Clinical Mass Spectrometry, or a seasoned veteran, the State of the Science address should be on your agenda.
Tuesday 1615
1630
Intermission @ Entrance Foyer
973
Tuesday 1630
1700
Poster Lightning Talks @ Mozart 1-5
Chairs:Ilaria Belluomo and Julien Boccard Judges: Simon Cameron, Eva Hunyadi-Gulyas, Guinevere Lageveen-Kammeijer, Renee Ruhaak, Will Slade, Karl Storbeck, Elizabeth Want
Poster Contest Semi-Finalists will be selected to present their pitch from the plenary podium within 90 seconds and with 1 slide (PDF format).
Chair: Nicola Gray Presenting Companies: Bioinformatics Solutions, Cambridge Isotope Labs, Chromsystems, Merck, Pharmafluidics, Shimadzu, Tecan, Thermo Fisher Scientific, UTAK Laboratories, Waters
10 -12 exhibitors selected to present their pitch from the plenary podium within 90 seconds and with 1 slide (PDF format).
975
Tuesday 1715
EXHIBITS OPEN @ 1st Floor Exhibit Hall
977
Tuesday 1715
1930
Exhibitor Reception @ 1st Floor Exhibit Hall
Dinner served.
976
Tuesday 1800
1900
Meet-a-Mentor : Booth Tours @ 1st Floor Exhibit Hall
Chair:Renee Ruhaak Mentors: David Herold, Laura Owen, Grace van der Gugten, Michael Wright
Join an expert mentor as they tour the booths and learn more about technologies available, what experts are looking for during the exchange, and how they interact with the booth vendors. Increase your network and your knowledge of products and services available.
978
Tuesday 1930
2030
Early-Career Scientists (ECS) - Career Options in Clinical Mass Spectrometry Discussion @ Mozart 4-5
Chair:Nicola Gray
Organized by the ECSC, this discussion group is aimed at early-career scientists and those involved with training and
recruitment of the next generation. It is meant to create awareness on career development
and planning, considering your career path, where you would like to be and how to get
there. The discussion panel will comprise speakers from a variety of sectors including
academia, industry and entrepreneurship and will explore transitioning between different
sectors. The invited speakers include Christiane Auray-Blais (University of Sherbrooke,
Canada), Brian Keevil (University of Manchester, UK), Flaminia Flanelli (University of
Bologna, Italy), Christian Scherling (Tecan, Germany), and Will Slade (LabCorp, USA) who will discuss their own professional career pathways and how they got there.
1601
Tuesday 1930
2030
FeMS: Networking Reception @ Mozart 1-3
Chairs: Anne Bendt, Grace van der Gugten, Margrét Þorsteinsdóttir
Please join us for this inaugural FeMS event! Over wine and cheese, a few thought-provoking questions will be posed. Afterwards we’ll have a discussion group.
Organized by Females in Mass Spectrometry (FeMS), an initiative to bring together women in the mass spectrometry field.
1609
Tuesday 2030
2130
FeMS : Discussion Group : How to Gain Visibility in the Field of Mass Spectrometry @ Mozart 1-3
Chair: Rita Horvath Panelists:Gwen McMillin, Margrét Þorsteinsdóttir, Julijana Ivanisevic, I-Lin Tsai, Elizabeth Want, Isa Cabruja
Thought-provoking questions, followed by a discussion with women at various stages in their careers, including an open period for audience questions. Exploring themes such as: (i) Best practices to achieve more visibility; (ii) How can the mass spec community participate in supporting its male and female members? (iii) How can we encourage each other to succeed? What questions do you have? Open to all! Additionally, the Rowena Shaw Avanti Award for Women in Mass Spectrometry, a $2000 USD discretionary award funded by Avanti Polar Lipids, will be introduced.
980
Tuesday 2030
Enjoy the City @ Your Choice
or get a good night's sleep
981
Wednesday
Wednesday 745
900
Welcome Coffee @ Entrance Foyer
Enjoy coffee, a pastry and a chat with colleagues before the day starts.
Enhancing Accuracy: Matrix Selection, Internal Standard Selection, and Sample Clean-Up Solutions for Clinical Mass Spectrometry
Speaker:
Geoffrey Rule, PhD – Merck, Principal Scientist, R&D
Why isn’t my calibration curve perfectly linear? How does my choice of matrix calibrator impact my assays? There are several reasons a calibration curve may be nonlinear, and the use of a co-eluting, isotopically labelled internal standards is the first step in obtaining a linear regression across a broad concentration range. We discuss how to select isotopically labelled internal standards for accurate quantification, how to remedy nonlinear calibration curves, and touch on use of isotopically labelled therapeutic antibodies. We will also review matrix calibrators for endogenous analytes, and how our Cerilliant Certified Reference Materials in matrix can help reduce variability. Lastly, we’ll touch on sample preparation options for clinical testing methods, including the use of our HybridSPE phospholipid and protein removal plates for automated high-throughput determination of 25-hydroxy vitamin D in serum.
Thermo Fisher Scientific @ Papageno (Track 3)
Achieve Superior Confidence in Your LC-MS Analysis
Speaker: Claudio DeNardi, Thermo Fisher Scientific, EU
The superior selectivity, specificity, robustness, and sensitivity offered by liquid-chromatography (LC) - mass spectrometry (MS) has made this technique one of the most advantageous in the field, here we highlight our comprehensive portfolio of LC-MS platforms and novel applications.
Trying to stay one-step ahead – how High-Resolution Accurate Mass LCMS has enabled early detection of fentanyl analogues (including carfentanil) and synthetic cannabinoids in the UK
Speaker: Simon Hudson, Technical Director, LGC; Fordham, England, UK
One of the biggest challenges facing forensic toxicology is to ensure that detection methodologies keep up with new drugs, such as New Psychoactive Substances (NPS) that are continuously entering the (black) marketplace. High Resolution Accurate Mass based LCMS allows the analyst to rapidly respond to new drug threats and to even monitor for predicted new designer compounds whilst still covering all the existing drug threats.
Two screening workflows are described:
1. The detection of fentanyl analogues as part of a broad drug screen including the first detection of carfentanil in post mortem samples in the UK in February 2017
2. The continuing evolution and detection of synthetic cannabinoid receptor agonists (SCRAs) in the UK.
Advanced mass spectrometry techniques provide deeper access into the vitamin D metabolome
Vitamin D has an important role in bone metabolism. Its functional involvement in other diseases such cancer or cardiovascular diseases is less clear, however, and is currently the subject of intense research. Typically, 25-hydroxyvitamin D is used for assessing vitamin D status of individuals, because it is readily accessible by analytical measurements and represents vitamin D substrate availability. This simplified assessment ignores dynamic effects of downstream metabolites though. More elaborate functional correlations of vitamin D metabolite distributions (‘chemotypes’) and disease phenotypes require derivatization for simultaneous quantification of all vitamin D metabolites as well as reducing isobaric background. In this seminar I describe vitamin D chemotyping based on Amplifex derivatization, UHPLC-MS/MS measurements and its application to patients with chronic liver diseases during vitamin D replacement therapy.
Guest Speaker: Pascal Schorr, Humboldt-University, Berlin
Places are limited, we would recommend to pre-register and get the clinical compendium no 2.
We will also be at booth 6 in the exhibition area and happy to see you there.
Discover our innovative platforms and proven solutions for advanced healthcare.
----------------------------------------------------------------------------------------------------------------- “MALDI-MS technology combined with automated interpretation software, a solution adapted to high throughput screening: Sickle cell disease screening in newborns as a first application”
Patrick DUCOROY - BIOMANEO - France
"Robustness and reliability of the novel pre-analytical filtration system CLAM-2030 and LCMS-8050"
Dr Frank STREIT - University Hospital Gottingen - Germany
"Rethinking the capability and workflows in clinical metabolomics and biomarker research using the LCMS-9030 Q-TOF technologies"
Emily ARMITAGE - Shimadzu Corp - UK
Thermo Fisher Scientific @ Papageno (Track 3)
Laboratory-Developed Mass Spectrometry testing vs Regulatory-Approved tests: Pros and Cons
Moderator: Torsten Binscheck-Domass, Lead Scientist, Clinical Mass Spectrometry, Thermo Fisher Scientific
Part 1: Balancing the pros and cons of Mass Spec-based Lab-Developed-Tests as compared to Regulatory-Approved Tests under the new IVD Regulation 2017/746 in Europe Speaker: Prof. Dr. Christa Cobbaert, Head of Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, NE; also EC observer in EC IVD working group 8 under the Medical Device Coordination Group.
Part 2: Cascadion™ SM 25-Hydroxy Vitamin D* and Immunosuppressants Panel**—Assays on the Cascadion™ SM Clinical Analyzer* Speaker: Ville Rajala, Sr Product Manager, Clinical Mass Spectrometry, Thermo Fisher Scientific
* Cascadion SM Clinical Analyzer is IVD/CE marked but not 510(k)-cleared and not yet available for sale in the U.S. Availability of product in each country depends on local regulatory marketing authorization status.
** Immunosuppresants Panel for Cascadion SM Clinical Analyzer is in development. Only preliminary feasibility data will be introduced. Product is not IVD/CE marked or 510(k) cleared, and is not available for sale.
Mass Spectrometry advantages for Therapeutic Drug Monitoring: a closer look at teicoplanin
Guest Speaker: Brian Keevil, Professor at University Hospital Southern Manchester, UK
When performing Therapeutic Drug Monitoring LC-MS/MS is an important technique in the clinical laboratory. In this workshop we will discuss the use of LC-MS/MS for the measurement of antibiotics, inhaled Steroids, azole antifungal drugs, and anti-cancer drugs. The specificity and sensitivity of LC-MS/MS over traditional techniques improves the accuracy of measurement and the ability to perform therapeutic drug monitoring for a number of different analytes.
Fast Track your Cannabinoid Urine Analysis using MassHunter StreamSelect LC-MS System Moritz Wagner, Product Specialist, Agilent Technologies
Liquid chromatography triple quadrupole mass spectrometry (LC/MS/MS) is the ideal solution for the simultaneous analysis of multiple cannabinoids and metabolites due to the high specificity and analytical sensitivity of the instrumentation. A six minute chromatographic method was developed on an Agilent Poroshell 120 EC-C18 column to separate 6 cannabinoids analytes using an Agilent 1290 Infinity II Liquid Chromatograph coupled with an Agilent 6470 triple quadrupole mass spectrometer. Sample throughput was nearly quadrupled (3.7x) by running four simultaneous, staggered chromatographic analyses on a single mass spectrometer using Agilent's MassHunter StreamSelect LC-MS software. This equates to 97 seconds per analysis, compared to a 6-minute runtime the same analysis using traditional LC-MS.
For Research Use Only. Not for use in diagnostic procedures.
Wednesday 1415
1430
Intermission @ Entrance Foyer
1009
Scientific Session 3
Track 1 Mozart 1-3
Metabolomics: Clinical Apps II Chair: Nicola Gray
Track 2 Mozart 4-5
Proteomics Keynote: Kevin Mills Chair: Christa Cobbaert
15 years of Ambient Mass Spectrometry: From Amino Acid Clusters to Surgical Robotics Zoltan Takats Imperial College London
Professor Takats obtained his PhD from E?tv?s Lor?nd University, Budapest, Hungary. He worked as a post-doctoral research associate at Purdue University, Indiana, USA. After returning to Hungary, he served as Director of the Cell Screen Research Centre and also as Head of Newborn Screening and Metabolic Diagnostic Laboratory at Semmelweis University, Budapest.
Professor Takats was awarded a Starting Grant by the European Research Council in 2008 and he subsequently became a Junior Research Group Leader at Justus Liebig University, Gie?en, Germany. He moved to the United Kingdom in 2012 and is currently a Professor of Analytical Chemistry and Director of Mass Spectrometry Research within Division of Computational Systems and Medicine at Imperial College London.
Professor Takats has pursued pioneering research in mass spectrometry and he is one of the founders of the field of ?Ambient Mass Spectrometry?. He is the primary inventor of six mass spectrometric ionisation techniques, including Desorption Electrospray Ionization and Rapid Evaporative Ionization Mass Spectrometry.
He was the recipient of the prestigious Mattauch-Herzog Award of the German Mass Spectrometry Society and the Hungarian Star Award for Outstanding Innovators. He is the founder of Prosolia Inc, Medimass Ltd and Massprom Ltd, all companies pursuing analytical and medical device development. Professor Takats has published over 100 peer-reviewed articles in the fields of analytical chemistry and translational medicine.
Wednesday 1730
1900
Exhibitor Reception @ 1st Floor Exhibit Hall
Wine and Light Appetizers served in Exhibit Hall.
1019
Wednesday 1800
1900
Meet-a-Mentor : Office Hours Forum @ 1st Floor Cafe
Chair: Renee Ruhaak
Mentors: Christiane Auray-Blais, Anne Bendt, Shannon Haymond, David Herold, Daniel Holmes, Patrick Mathias, Anna Nicolaou, Brian Rappold, Chris Shuford, Will Slade, Grace van der Gugten, Elizabeth Want
Have a question from the congress that you have been itching to ask? Or a problem from work that you want to get feedback on? Need career advice? Sign up at the registration desk for 15-min blocks to share time and ideas with domain experts in a relaxed setting.
1020
Wednesday 1900
Enjoy the City @ Your Choice
Plan to join a few colleagues for dinner in Salzburg tonight. Some places to try:
1. Braurestaurant IMLAUER (Austrian, traditional interior plus a beer garden, good for groups, close to congress)
2. Pitterkeller (Austrian, one of the oldest beer cellars in Salzburg, good for groups, close to congress)
3. Krimpelstatter (Traditional Austrian food since 1584, Beer Garden, Good for groups up to 50pax, serving hot food to 9pm, open to 11pm)
4. Steiglkeller (Historic building with a great view over the Old Town, near the Fortress)
5. Gablerbrau (Historic ambiance with traditional food)
6. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily, close to congress)
7. Die Weisse
8. Indian Restaurant Taj Mahal
Poster Contest Finalist Interviews @ 1st Floor Exhibit Hall
Chairs:Ilaria Belluomo and Julien Boccard Judges: Simon Cameron, Eva Hunyadi-Gulyas, Guinevere Lageveen-Kammeijer, Renee Ruhaak, Will Slade, Karl Storbeck, Grace van der Gugten, Elizabeth Want
Poster Contest Finalists to attend posters and meet with poster Judges. Judges may arrive in groups or individually.
1040
Thursday 930
1030
Poster Session 3 @ 1st Floor Exhibit Hall
Selected posters to be attended for 1 hour. Refer to program for posters attended during this period.
1039
Thursday 1030
1130
Exhibitor Feedback Discussion @ 1st Floor Cafe
Chair: Chris Herold
An opportunity for exhibiting vendors to provide feedback on what worked and what could use improvement. All Exhibitors are welcome to attend this discussion with the organizers.
Ground Floor Bar to serve wine and other beverages for intermission while preparing for the poster awards.
1063
Thursday 1700
1715
Poster Award Presentation @ Mozart 4-5
Chairs: Ilaria Belluomo and Julien Boccard
1064
1715
Closing Plenary Lecture
@ Mozart 4-5 Chair: Stephen Master
1715
1800
Donor-derived cell-free DNA as a biomarker in organ transplantation Michael Oellerich Institute for Clinical Pharmacology, University Medicine G?ttingen, Germany
Michael Oellerich, MD, HonMD, FAACC, FAMM, FFPath (RCPI), FRCPath, is currently a Distinguished Research Professor at the Department of Clinical Pharmacology, University Medical Center (UMG), Goettingen, Germany. He was Chairman of the Department of Clinical Chemistry at UMG from 1991 to 2012, Dean of the Faculty of Medicine, and President of professional organizations (IATDMCT, DGLM, DGKL, WASPaLM). He currently is Associate Editor of the journal Therapeutic Drug Monitoring (TDM). He was Editor-in-Chief of the TDM journal (2003-2018), Associate Editor of Clinical Biochemistry (1996-2007) and Clinical Chemistry (2007-2013). His current research interests are in the field of cfDNA in cancer and transplantation. He authored more than 460 publications and received various awards (e.g. Ludolf-Krehl Award, IATDMCT Charles Pippenger Award, WASPaLM Medal of Honor, WASPaLM Gold-Headed Cane).
Molecular biomarkers have attracted special attention in solid organ transplantation because of unresolved problems that limit long-term outcome. There is a lack of reliable noninvasive markers. Immunosuppressive drug monitoring mainly indicates potential toxicity, but is a poor biomarker of graft damage. In kidney transplant patients, for example, an increase of plasma creatinine may be also be due to exsiccation, the use of ACE inhibitors, or immunosuppressive drug toxicity. By the time a rejection-related increase in plasma creatinine is evident, a significant degree of tissue damage has already occurred within the kidney. A further limitation of the current standard of care is that rejection episodes can only be confirmed by biopsies. Biomarkers are needed to achieve personalized immunosuppression to reduce premature graft loss. Against this background, a particularly promising new approach for the early detection of acute or chronic rejection or asymptomatic graft injury leading to irreversible damage is based on the determination of donor-derived circulating cell-free DNA (dd-cfDNA). Data on clinical validity have been documented in more than 48 independent studies which have shown that dd-cfDNA detects rejection episodes early, at an actionable stage, and is a more reliable marker of graft injury, compared to conventional tests. dd-cfDNA may also be useful to guide changes in immunosuppression, to monitor immunosuppression minimization (e.g. during tapering), and to prevent immune activation. The high negative predictive value of dd-cfDNA is the reason why this test can be helpful to avoid unnecessary biopsies. It could be shown that dd-cfDNA can be useful to detect subclinical (e.g. clinically unsuspected) graft damage as a result of immune activation triggered by under-immunosuppression. Early diagnosis of subclinical antibody-mediated rejection may improve outcomes after kidney transplantation. In summary, dd-cfDNA monitoring will allow more personalized treatment that shifts emphasis from reaction to prevention.
Thursday 1800
1815
Final Remarks @ Mozart 4-5
Final remarks from Dr. Elizabeth Want, Scientific Committee Chair, 2019-2021.
1142
Thursday 1815
1900
Closing Petite Reception @ Entrance Foyer
Wine & Cheese, Beer & Nuts.
Winning posters to be on display.
1066
Thursday 1900
CONGRESS CLOSED @ Entrance Foyer
1143
Thursday 1900
2200
After Congress Meet-Up
@ Your Choice
Meet up at the Augustiner Braustubl (Historic Abby turned beer garden with food stalls) for an unofficial and unsponsored post-con gathering. If you need a hearty meal first, stop by the nearby Krimpelstatter.
1067
Friday
Friday 800
1000
SciCom Group Meeting @ TBA
Private Meeting for Scientific Committee Topic Leads and Incoming Leads; Planning for next event.
COURSE START 
