Saturday |
|
Saturday 1730 |
Registration and Help Desk open for Badge Pickup. Linger in the registration lobby with a drink to meet friends as they arrive and/or find a buddy for dinner out.
2697
|
|
Saturday 2030 |
Timeout Market (open till 10pm) is a good balance of proximity, ease and quality -- and a great option if flying solo. MSACL recommendations. Note that MSACL Reg Desk will be closed during this time, MSACL Staff need to eat, too. ;)
2778
|
|
Saturday 2130 |
Registration and Help Desk open for Badge Pickup. Linger in the registration lobby with a drink to meet friends as they arrive.
2779
|
Sunday |
|
Sunday 1930 |
Open for Badge Pickup
2535
|
|
Sunday 900 |
Pick-up your badge on the conference level then find breakfast, prior to your Short Course, in the room adjacent to the reg desk (Montreal 1-3) where you can touch base with other attendees.
2536
|
|
Sunday 1200 |
Course Schedule
Segment 1 : Sunday 08:40 - 12:00 (3.00 contact hrs) --------------- 2753
|
||||||||
|
Sunday 1200 |
Course Schedule
Segment 1 : Sunday 08:40 - 12:00 (3.00 contact hrs) --------------- 2763
|
|||||||||||
|
Sunday 1200 |
Course Schedule
Segment 1 : Sunday 08:40 - 12:00 (3.00 contact hrs) --------------- 2537
|
|||||||||||
|
Sunday 1220 |
2780
|
|
Sunday 1220 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2728
|
|||||||||||
|
Sunday 1220 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2701
|
||||||||
|
Sunday 1220 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2700
|
||||||||
|
Sunday 1220 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2734
|
|||||
|
Sunday 1420 |
Your choice! This non-MSACL sponsored meal break is your chance to explore the culinary delights within the city of Montreal. MSACL recommendations. Timeout Market is a good balance of proximity, ease and quality -- and a great option if flying solo.
2784
|
|
Sunday 1740 |
2781
|
|
Sunday 1740 |
Course Schedule
Segment 1 : Sunday 14:20 - 17:40 (3.00 contact hrs) --------------- 2550
|
|||||||||||
|
Sunday 1740 |
Course Schedule
Segment 1 : Sunday 08:40 - 12:00 (3.00 contact hrs) --------------- 2754
|
|
Sunday 1740 |
Course Schedule
Segment 1 : Sunday 08:40 - 12:00 (3.00 contact hrs) --------------- 2580
|
|
Sunday 1740 |
Course Schedule
Segment 1 : Sunday 08:40 - 12:00 (3.00 contact hrs) --------------- 2698
|
|
Sunday 1740 |
Course Schedule
Segment 1 : Sunday 14:20 - 17:40 (3.00 contact hrs) --------------- 2552
|
||||||||
|
Sunday 1800 |
Course Schedule
Segment 1 : Sunday 14:40 - 18:00 (3.00 contact hrs) --------------- 2725
|
||||||||
|
Sunday 1800 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2729
|
|
Sunday 1800 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2540
|
|
Sunday 1800 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2538
|
|
Sunday 1800 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2736
|
|
Sunday 1930 |
An informal dinner for Short Course attendees and sponsors. If you are arriving later because your course begins Monday morning, note that dinner will be served through 7:30pm, at the latest.
2542
|
|
Sunday 2200 |
All conference attendees are welcome to close out the evening. MSACL will host snacks and drinks (requires token - pick up tokens at the door or from MSACL Staff). Must be wearing your badge to attend (badge pick up closes at 7:30pm). Drinks will be available through 10:00pm. The Lounge includes a pleasant outdoor patio along a stream and among some small trees and shrubbery, which may be enjoyable should we have nice weather. Open to all conference registrants.
2703
|
Monday |
|
Monday 1830 |
Open for Badge Pickup
2544
|
|
Monday 900 |
Pick-up your badge on the conference level then find breakfast, prior to your Short Course, in the room adjacent to the reg desk (Montreal 1-3) where you can touch base with other attendees.
2545
|
|
Monday 1200 |
Course Schedule
Segment 1 : Sunday 14:20 - 17:40 (3.00 contact hrs) --------------- 2582
|
|
Monday 1200 |
Course Schedule
Segment 1 : Sunday 08:40 - 12:00 (3.00 contact hrs) --------------- 2755
|
|
Monday 1200 |
Course Schedule
Segment 1 : Monday 08:40 - 12:00 (3.00 contact hrs) --------------- 2762
|
|||||
|
Monday 1200 |
Course Schedule
Segment 1 : Sunday 08:40 - 12:00 (3.00 contact hrs) --------------- 2555
|
|
Monday 1200 |
Course Schedule
Segment 1 : Sunday 14:20 - 17:40 (3.00 contact hrs) --------------- 2721
|
|
Monday 1200 |
Course Schedule
Segment 1 : Monday 08:40 - 12:00 (3.00 contact hrs) --------------- 2702
|
|||||
|
Monday 1200 |
Course Schedule
Segment 1 : Monday 08:40 - 12:00 (3.00 contact hrs) --------------- 2549
|
|||||||||||
|
Monday 1220 |
2782
|
|
Monday 1220 |
Course Schedule
Segment 1 : Sunday 14:40 - 18:00 (3.00 contact hrs) --------------- 2723
|
|
Monday 1220 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2730
|
|
Monday 1220 |
Course Schedule
Segment 1 : Monday 09:00 - 12:20 (3.00 contact hrs) --------------- 2750
|
||||||||
|
Monday 1220 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2551
|
|
Monday 1220 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2547
|
|
Monday 1220 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2733
|
|
Monday 1200 |
Course Schedule
Segment 1 : Monday 09:50 - 12:00 (2.00 contact hrs) --------------- 2558
|
|||||||||||
|
Monday 1420 |
Your choice! This non-MSACL sponsored meal break is your chance to explore the culinary delights within the city of Montreal. MSACL recommendations. Timeout Market is a good balance of proximity, ease and quality -- and a great option if flying solo.
2785
|
|
Monday 1740 |
2783
|
|
Monday 1740 |
Course Schedule
Segment 1 : Sunday 14:20 - 17:40 (3.00 contact hrs) --------------- 2745
|
|
Monday 1740 |
Course Schedule
Segment 1 : Sunday 08:40 - 12:00 (3.00 contact hrs) --------------- 2757
|
|
Monday 1740 |
Course Schedule
Segment 1 : Monday 08:40 - 12:00 (3.00 contact hrs) --------------- 2760
|
|
Monday 1740 |
Course Schedule
Segment 1 : Sunday 08:40 - 12:00 (3.00 contact hrs) --------------- 2567
|
|
Monday 1740 |
Course Schedule
Segment 1 : Monday 14:20 - 17:40 (3.00 contact hrs) --------------- 2743
|
|||||
|
Monday 1740 |
Course Schedule
Segment 1 : Monday 09:50 - 12:00 (2.00 contact hrs) --------------- 2752
|
|
Monday 1740 |
Course Schedule
Segment 1 : Sunday 14:20 - 17:40 (3.00 contact hrs) --------------- 2566
|
|
Monday 1740 |
Course Schedule
Segment 1 : Monday 08:40 - 12:00 (3.00 contact hrs) --------------- 2748
|
|
Monday 1740 |
Course Schedule
Segment 1 : Monday 08:40 - 12:00 (3.00 contact hrs) --------------- 2565
|
|
Monday 1800 |
Course Schedule
Segment 1 : Sunday 14:40 - 18:00 (3.00 contact hrs) --------------- 2724
|
|
Monday 1800 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2731
|
|
Monday 1800 |
Course Schedule
Segment 1 : Monday 09:00 - 12:20 (3.00 contact hrs) --------------- 2564
|
|
Monday 1800 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2561
|
|
Monday 1800 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2563
|
|
Monday 1800 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2735
|
|
Monday 1830 |
Open to all conference registrants. Use this time to finalize dinner plans with fellow attendees.
2569
|
|
Monday 2100 |
Your choice! This non-MSACL sponsored meal break is your chance to explore the culinary delights within the city of Montreal. MSACL recommendations.
2570
|
|
Monday 2330 |
All attendees are welcome to close out the evening in the Bisco (Hotel breakfast area). MSACL will host snacks and drinks (requires token - pick up tokens at the door or from MSACL Staff). Must be wearing your badge to attend. Drinks will be available through 11:30pm. The Lounge includes a pleasant outdoor patio along a stream and among some small trees and shrubbery, which may be enjoyable should we have nice weather. Open to all conference registrants.
2571
|
Tuesday |
|
Tuesday 2100 |
2575
|
|
Tuesday 845 |
Industry Breakfast Workshop(s) |
| Open to All Conference Registrants.
Guidance for Hosts: Presentations should end at 8:35 so that short course attendees can head to their courses during Q&A. | |||||
Workshop summary coming soon ... |
|||||
|
Tuesday 900 |
Pick-up your badge on the conference level then find breakfast in the room adjacent to the reg desk (Montreal 1-3) where you can touch base with other attendees. Alternatively, pair your breakfast with a workshop, upstairs, in Salon Bonaventure.
2576
|
|
Tuesday 1200 |
Course Schedule
Segment 1 : Sunday 14:20 - 17:40 (3.00 contact hrs) --------------- 2746
|
|
Tuesday 1200 |
Course Schedule
Segment 1 : Sunday 08:40 - 12:00 (3.00 contact hrs) --------------- 2756
|
|
Tuesday 1200 |
Course Schedule
Segment 1 : Monday 08:40 - 12:00 (3.00 contact hrs) --------------- 2560
|
|
Tuesday 1200 |
Course Schedule
Segment 1 : Sunday 08:40 - 12:00 (3.00 contact hrs) --------------- 2584
|
|
Tuesday 1200 |
Course Schedule
Segment 1 : Monday 14:20 - 17:40 (3.00 contact hrs) --------------- 2744
|
|
Tuesday 1200 |
Course Schedule
Segment 1 : Monday 09:50 - 12:00 (2.00 contact hrs) --------------- 2585
|
|
Tuesday 1200 |
Course Schedule
Segment 1 : Sunday 14:20 - 17:40 (3.00 contact hrs) --------------- 2749
|
|
Tuesday 1200 |
Course Schedule
Segment 1 : Monday 08:40 - 12:00 (3.00 contact hrs) --------------- 2747
|
|
Tuesday 1200 |
Course Schedule
Segment 1 : Monday 08:40 - 12:00 (3.00 contact hrs) --------------- 2587
|
|
Tuesday 1230 |
2786
|
|
Tuesday 1220 |
Course Schedule
Segment 1 : Sunday 14:40 - 18:00 (3.00 contact hrs) --------------- 2727
|
|
Tuesday 1220 |
Course Schedule
Segment 1 : Monday 09:00 - 12:20 (3.00 contact hrs) --------------- 2586
|
|
Tuesday 1220 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2581
|
|
Tuesday 1220 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2583
|
|
Tuesday 1220 |
Course Schedule
Segment 1 : Sunday 09:00 - 12:20 (3.00 contact hrs) --------------- 2732
|
|
Tuesday 1030 |
Industry Workshop(s) |
| No workshops currently booked for this time period. |
|
Tuesday 1100 |
2787
|
|
Tuesday 1200 |
Industry Workshop(s) |
| No workshops currently booked for this time period. |
|
Tuesday 1230 |
2788
|
|
Tuesday 1345 |
Industry Workshop(s) |
| Pre-register for your session of choice to help us order lunches accordingly. | ||||||
Workshop summary coming soon ... |
Workshop summary coming soon ... |
Workshop summary coming soon ... |
||||
|
Tuesday 1415 |
WEDNESDAY posters to be placed.
2717
|
|
Tuesday 1415 |
2594
|
|
Tuesday 1545 |
Summary: Syllabus:
Objectives:
2596
|
|||||
|
Tuesday 1545 |
SummaryLiquid-chromatography mass spectrometry (LC-MS) is utilized in many larger clinical laboratories, reference laboratories or research laboratories for developing assays for new biomarkers, for analytes for which alternative technologies lack specificity, or for high volume assays requiring greater throughput. In the life cycle of a new assay, CLSI guidance documents are used by laboratory developed test (LDT) developers to meet regulatory and accreditation requirements during the design, development, validation and implementation of LDTs into the clinical lab setting. These same documents may also be useful for researchers to use for good practice study design, clinical trials and/or publishing study results. Since these consensus-driven documents are developed to be broadly applicable, they can be challenging to navigate, may not fully address technology-specific study design considerations, use terminology and examples not common to the general laboratory and may not be specific or applicable to LC-MS. In response, CLSI has undertaken a strategic re-envisioning of the Method Evaluation (formerly referred to as Evaluation Protocol) category of documents. This workshop will showcase improvements that CLSI is implementing to improve the experience for those who utilize their documents. The presenters will provide before-and-after examples, in an interactive format with the audience, to demonstrate how CLSI can better support those who work with LC-MS technology. Finally, the workshop will also consist of interactive brainstorming between the presenters and audience on topics such as gaps seen with current CLSI documents and how researchers and LDT developers who utilize LC-MS may take advantage of the new CLSI model to propose new targeted or niche-scoped guidance, examples, and tools. Syllabus
Objectives
2601
|
||||||||
|
Tuesday 1545 |
SummaryDesign of experiments (DoE) is an efficient strategy for developing and optimizing LC-MS/MS methods used to quantify biomarkers in complex biological matrices. Because LC‑MS/MS workflows involve multiple interdependent processes and numerous experimental variables, DoE provides a structured and efficient framework for identifying influential factors, modelling system behavior, and achieving maximum analytical performance with minimal experimental effort. This workshop will introduce the fundamental principles of DoE with a strong focus on practical implementation. Participants will be guided through the three main stages of a DoE‑driven method development strategy: factor screening, response optimization, and robustness assessment. To demonstrate the value of DoE compared with traditional one‑factor‑at‑a‑time approaches, two applied case studies will be presented. The first case study focuses on optimizing sample preparation in a bottom-up targeted protein LC-MS workflow. The second demonstrates DoE based optimization of a UPLC-MS/MS assay for clinical diagnostic and therapeutic drug monitoring in patients with adenine phosphoribosyltransferase (APRT) deficiency. In both studies, polynomial models were constructed, central composite designs were used to evaluate significant factors, and partial least squares (PLS) regression was applied to relate variables to analytical responses. These studies demonstrate how DoE can reduce sample preparation time and enable efficient optimization of biomarker quantification, including urinary 2,8‑dihydroxyadenine (DHA) and adenine. Finally, a demonstration of DoE‑based robustness testing, showing how intentional variation of key parameters can reveal critical factors and interactions that influence method performance. Attendees will gain practical insight into applying DoE to assessing method reliability and supporting long‑term method robustness.
Syllabus
Objectives
2595
|
|||||||||||
|
Tuesday 1545 |
SummaryDiabetes represents a collection of endocrine disorders with severe systemic complications, including type 1 diabetes, an autoimmune condition characterized by insulin deficiency. The disease pathogenesis, trajectory, and end-organ damage are variable from patient to patient. As a result, the precise and accurate quantification of proteins and peptides involved in diabetes will help facilitate research into disease pathogenesis and ultimately improve the diagnosis, prognosis, and therapeutic management of patients with diabetes. Unfortunately, most of the studies to date have relied on immunoassays, with little effort put into demonstrating the specificity of the reagents or the robustness of the assays. Furthermore, recent publications have highlighted the limitations of many commercial assays, including a failure to detect the intended target. Rigor and reproducibility could be substantially improved by applying mass spectrometry to the quantification of these biomarkers. Major improvements in sample preparation and instrumentation have made mass spectrometry–based targeted proteomics a highly reproducible methodology for detecting and quantifying proteins and peptides. In addition, the ability to quantify specific proteoforms provides insight into prohormone processing and post-translational modifications and creates an opportunity to identify and validate new biomarkers that can be used for disease stratification. The NIDDK continues to fund several projects that aim to use targeted mass spectrometry to quantify human plasma/serum proteins and peptides of interest to the diabetes clinical research community. During this workshop, the presenters will provide an update on their recent progress toward this goal that have been made by the Targeted Mass spectrometry Assays for Diabetes and Obesity Research (TaMADOR) consortium, with a special focus on biomarkers important in type 1 diabetes. Syllabus
Objectives
2600
|
|||||||||||||||||
|
Tuesday 1615 |
If you have not already connected, meet your Buddy during this coffee break in this dedicated area where you you can take in a view of the outdoor water, tree and duck features. Spend a short time connecting and getting oriented before continuing onto the plenary session.
2607
|
|
Tuesday 1615 |
2602
|
|
Tuesday 1640 |
What you need to know for this week from the Conference Chair. Plus a JMSACL Update from the Co-Editors-in-Chief.
2603
|
|
Tuesday 1730 |
2604
|
|||||
|
Tuesday 2000 |
2606
|
|
Tuesday 1950 |
Early Career and first time attendees are encouraged to meet at the MSACL registration desk at 5 minutes prior to start time to join a tour of the vendor booths with a guiding mentor. Booth Tour Overview
2608
|
|
Tuesday 2100 |
2605
|
|||||
|
Tuesday 2330 |
All attendees are welcome to close out the evening in Salon Bonaventure. MSACL will host snacks and drinks (requires token - pick up tokens at the door or from MSACL Staff). Must be wearing your badge to attend. Drinks will be available through 11:30pm. The Lounge includes a pleasant outdoor patio along a stream and among some small trees and shrubbery, which may be enjoyable should we have nice weather. Open to all conference registrants.
2609
|
Wednesday |
|
Wednesday 1815 |
2610
|
|
Wednesday 900 |
Industry Workshop(s) |
| Pre-register for your session of choice to help us order breakfasts accordingly. | ||||||||
Workshop summary coming soon ... |
Workshop summary coming soon ... |
Workshop summary coming soon ... |
Workshop summary coming soon ... |
|||||
|
Wednesday 1700 |
2617
|
|
Wednesday 1030 |
2623
|
|
Wednesday 1020 |
Early Career and first time attendees are encouraged to meet at the MSACL registration desk at 9:25am to join a POSTER TOUR with a guiding mentor. Poster Tour Overview
2624
|
|
Wednesday 1130 |
2625
|
|
Wednesday 1245 |
Buffet Lunch hosted by MSACL. Alternatively, attend an exhibitor lunch workshop.
2626
|
|
Wednesday 1245 |
Industry Workshop(s) |
| Host Guidance: Host presentations should not run past 12:40 so attendees have time to get to the next activity starting at 12:45. | |||||
Workshop summary coming soon ... |
|||||
|
Wednesday 1245 |
Pick up lunch in the exhibit hall before grabbing a petite suite seat. Host Guidance: Plan for a 45-minute speaker from 11:45-12:30.
2707
|
Scientific Session 1 |
| Montreal 4 Keynote : Spatialomics
|
Montreal 5 Longitudinal Metabolomics
|
Montreal 6 Proteomics - Multiple Myeloma
|
Montreal 7-8 Endocrinology
|
Salon Bonaventure, Hotel Level Practical Training
|
|||||||||
1305 |
|
|
| ||||||||||
1325 | ... Keynote, continued ... |
| ... Extended Talk ... | ||||||||||
1345 |
|
|
|
| ... Extended Talk ... |
|
Wednesday 1500 |
2627
|
Scientific Session 2 |
| Montreal 4 Keynote : Microbiology
|
Montreal 5 Automation in Clinical MS
|
Montreal 6 Metabolomic Profiling
|
Montreal 7-8 Proteomics - CVD
|
Salon Bonaventure, Hotel Level Practical Training
|
|||||||
1520 |
|
|
|
Peter Wegwerth, Alison Lightfoot, Chris Thompson | |||||||
1540 |
|
|
| ... Extended Talk ... | |||||||
1600 | ... Keynote, continued ... |
Gabriel Stefan Horkovics-Kováts University of Regensburg |
| ... Extended Talk ... |
|
Wednesday 1700 |
2639
|
|
Wednesday 1630 |
WEDNESDAY posters to be removed.
2715
|
|
Wednesday 1700 |
THURSDAY posters to be placed.
2716
|
|
Wednesday 1830 |
Discover clinical mass spectrometry career paths. This networking event is geared to early career attendees, but open to all. Get insights through informative, brief presentations on various job profiles within clinical mass spectrometry. Experts and seasoned professionals will guide you through diverse roles, making it easier to envision your own journey in this exciting industry. In addition to short panelist presentations, the event promises a delightful networking experience. Unwind and engage with fellow attendees, experts, and potential employers to expand your professional connections. Enjoy selections of refreshments; creating a relaxed environment for further discussion and relationship-building. This networking event is the perfect opportunity to continue conversations, ask questions, and make lasting connections. Employers This is your chance to connect with talent. We invite you to advertise your job postings at the event and interact with potential candidates who are passionate about clinical mass spectrometry. Share your opportunities and meet prospective candidates who are eager to contribute to your organization's success. MSACL is offering the opportunity for you to be recognized by the event chair at no charge (RSVP required) to facilitate your discussion of career opportunities with interested parties in attendance. If you are interested in representing your organization/company/lab at this event, please register your interest here. This event is formatted as a social mixer to facilitate active networking throughout the event. For representatives and hiring managers: -> There will be no booths. -> Please bring business cards or QR codes describing positions to share with attendees or place on the job board. -> You may also advertise employment opportunities on a job board. Each open position is limited to an 8.5 x 11 inch poster. Don’t miss this unique opportunity to blend career exploration, networking, and relaxation.
2643
|
|||||
|
Wednesday 1830 |
Moderated by:
2789
|
||||||||||||||
|
Wednesday 1830 |
2641
|
|
Wednesday 1830 |
Africa bears a substantial proportion of the global burden of both infectious and non-communicable diseases, yet remains markedly underrepresented in clinically driven molecular discovery and translation. While mass spectrometry–based approaches are increasingly integrated into diagnostic development, biomarker discovery, and translational research pipelines across the Global North, the infrastructure, expertise, and sustained investment required to deploy these technologies within clinical and healthcare settings remain limited across much of the African continent. This gap has important consequences. Many of the most pressing African health challenges including cardiometabolic disorders, infectious diseases, cancers, and inflammatory conditions would benefit from molecularly informed approaches that improve disease understanding, patient stratification, and therapeutic development. However, limited local capacity for advanced mass spectrometry–based research and clinical translation means that African patient populations, disease phenotypes, and biological samples are rarely investigated using these technologies. As a result, the molecular knowledge that underpins diagnostics and therapeutic development is often generated elsewhere, creating a persistent disconnect between disease burden and discovery. This discussion session provides an opportunity to examine the unique challenges and opportunities for translating mass spectrometry–based technologies into clinical and healthcare contexts in Africa. By convening researchers from established international centres alongside emerging African initiatives, the session aims to explore how clinical mass spectrometry can be developed in resource-constrained environments, what infrastructure and training models are needed to build sustainable local capacity, and how equitable partnerships can support meaningful clinical impact. Addressing these questions is essential if advances in mass spectrometry are to contribute meaningfully to global health rather than reinforce existing inequities in biomedical discovery and translation.
2777
|
|||||
|
Wednesday 1830 |
SummaryClinical mass spectrometry has historically focused on absolute quantification of single analytes, with well-established conventions around calibration, QC, and regulatory expectations. However, clinical innovation is moving toward multi-marker panels and composite score outputs that incorporate algorithmic interpretation. This is already occurring in the research and translational literature for LC-MS-based proteomic panels, where multiple proteins are combined into predictive models or classifier outputs for disease detection, triage, or risk stratification. While these approaches show promise, they challenge the field because the final clinical result is not a concentration but a probability score or classification. This shift raises important questions on the validation metrics for clinical mass spectrometry-based multivariate index assays:
By comparing traditional targeted assays with emerging score-based LC-MS panels, this roundtable aims to identify best practices and highlight gaps in current clinical, regulatory, and quality frameworks for translating these novel assays. The session is intended as a neutral, field-level discussion of translational challenges as the community navigates this next frontier of clinical mass spectrometry, not promotion of any specific product.
2768
|
|||||
|
Wednesday 1830 |
2709
|
|
Wednesday 2100 |
Your choice! Dinner is off-site on your own. This non-MSACL sponsored meal break is your chance to explore the culinary delights within the city of Montreal. MSACL recommendations.
2644
|
|
Wednesday 2330 |
All attendees are welcome to close out the evening in Salon Bonaventure. MSACL will host snacks and drinks (requires token - pick up tokens at the door or from MSACL Staff). Must be wearing your badge to attend. Drinks will be available through 11:30pm. The Lounge includes a pleasant outdoor patio along a stream and among trees and shrubbery, which may be enjoyable should we have nice weather. Open to all conference registrants.
2645
|
Thursday |
|
Thursday 1730 |
2648
|
|
Thursday 800 |
Breakfast buffet is available for attendees participating in Discussion Sessions, including Industry Petite Suite Discussions and Academic Discussions. Prepare your breakfast plate in Montreal 1-3 and and proceed to your selected discussion breakout room, which begins promptly at 7:45 AM. Seating in all discussion rooms is first come, first served. If you are not attending a Discussion Session, breakfast is available for purchase on the hotel level at Le Bisco.
2652
|
|
Thursday 845 |
2710
|
|
Thursday 845 |
Host Guidance: Attendees will pick up breakfast in Montreal 1-3.
2764
|
|
Thursday 845 |
Summary: Ion mobility-mass spectrometry (IM-MS) is now a ubiquitous technique in biomedical research, with nearly all major MS vendors offering one or more commercially-available IM options. Nevertheless, its transition into the “prime-time” of clinical analysis has been slowed by numerous challenges, not the least of which being difficult/cumbersome data analysis. In this workshop, we will briefly introduce the various IM techniques and their deliverables, ranging from drift/arrival time to mobility (K) and collision cross section (CCS). We will then focus on real datasets (applicable to the clinical lab) and discuss how/where ion mobility can be beneficial. Finally, we will present several “open-source” IM data processing software options and also how these and other tools could be integrated into a clinical lab data processing workflow. Syllabus
2642
|
||||||||
|
Thursday 845 |
Numerous technologies are now commercially available that facilitate the collection of human blood samples in locations away from the clinical setting. This approach is termed patient centric sampling, or microsampling and can involve the collection of samples from a finger stick, or from elsewhere on the body. The samples can be dried or liquid and are often a smaller volume than those obtained by traditional phlebotomy. The use of these approaches potentially enables samples to be collected from currently underserved communities (pediatric, elderly, remote areas, etc). Furthermore, the approach may enable more regular sampling of individuals to be performed and facilitates choice for the patient about how and where samples will be collected. These technologies also have the potential to overcome the discomfort, pain and fear that is encountered by many when collecting samples by traditional phlebotomy. However, there are challenges around the regulatory status of the sampling devices and assays developed for clinical diagnostic purposes using these technologies. Following last year’s initial discussions on this topic, progress has been made. This workshop will take part in a facilitated discussion on what the regulatory challenges have been overcome and new challenges that have emerged. Different regulatory frameworks and quality systems will be discussed relative to EU (Medical Device Regulation + In Vitro Diagnostic Regulation), USA (FDA class 1 & 2 test “systems”) and Canada (Medical Device Directorate, ICH M10). Exemplars will be discussed relative to current products and workflows that have achieved regulatory approval in these jurisdictions. Participant discussion will then focus on how these barriers may be overcome and what future activities might be required to enable this.
2598
|
|||||
|
Thursday 845 |
Summary
In 2026 the MSACL Compliance and Accreditation Committee is forming several new Working Groups (WG) to help clinical mass spectrometry laboratories tackle compliance, quality and training challenges. These groups focus on creating practical resources to support accreditation, regulatory compliance, quality management, and workforce development. We’re gathering input from the MSACL community to identify gaps and prioritize projects. Future outcomes from these workgroups may include but are not limited to continuing education sessions; white papers; position statements; publications; templates for quality and compliance procedures, policies, and job aids; quality management software discussions; implementation and accreditation case histories. The session will include a brief presentation, followed by Q&A and discussion. Topics to be covered include:
2771
|
|||||
|
Thursday 845 |
Discussion Topics:
2767
|
|||||
|
Thursday 845 |
SummaryUnlike small drug molecules, the monoclonal antibody therapies often lack a well-defined maximum tolerated dose, have delayed pharmacodynamic responses, and cause the formation of anti-drug antibodies. Despite these challenges, TDM has shown clinical benefits for tyrosine kinases inhibitors suggesting the potential in Oncology. This session will discuss the challenges and considerations of using mass spectrometry to measure concentrations of programmed cell death protein 1 (PD1) inhibitors (e.g. Pembrolizumab, Nivolumab, etc.), a class of immunotherapy drugs that have revolutionized the treatment of various malignancies, to minimize toxicity and maximize efficacy.
2770
|
|||||
|
Thursday 900 |
Coffee available in Montreal 1-3.
2711
|
Scientific Session 3 |
| Montreal 4 Keynote : Proteomics - Emerging Technology
|
Montreal 5 Spatialomics Metabolism
|
Montreal 6 Clinical Microbiology Applications
|
Montreal 7-8 DBS Analysis
|
Salon Bonaventure, Hotel Level Practical Training
|
|||||||||
920 | TBA |
|
|
|
| ||||||||
940 | TBA | ... Keynote, continued ... |
Maxim Seferovic Baylor College of Medicine |
| ... Extended Talk ... | ||||||||
1000 |
Amandine Boeuf Laboratoire National de Métrologie et d'Essais Keynote Speaker |
|
| ... Extended Talk ... |
|
Thursday 1700 |
2712
|
|
Thursday 1115 |
2670
|
|
Thursday 1105 |
Early Career and first time attendees are encouraged to meet at the MSACL registration desk at 5 minutes prior to join a POSTER TOUR with a guiding mentor. Poster Tour Overview
2678
|
|
Thursday 1215 |
2662
|
|
Thursday 1315 |
Lunch hosted by MSACL. If joining an Industry Petite Suite Workshop pick up your lunch in the Exhibit Hall. Alternatively, skip the Exhibit Hall lunch lines and join the Industry Workshop in Montreal 1-3 where a box lunch will be available.
2669
|
|
Thursday 1315 |
Box lunch will be available in the workshop room.
2714
|
|
Thursday 1315 |
Host Guidance: Attendees will pick up lunch in Exhibit Hall. Plan for a 30-minute speaker/discussion from 12:30-13:00. Allow attendees time to get to their next session at 13:15.
2713
|
Scientific Session 4 |
| Montreal 4 Data Science: Fresh Approaches with Modern Tools
|
Montreal 5 Metabolomics and NBS
|
Montreal 6 New Tools to Interrogate Microbial Metabolism
|
Montreal 7-8 Spatialomics Methods
|
Salon Bonaventure, Hotel Level Practical Training
|
|||||||
1335 |
| TBA |
Min Soo Kim Pennsylvania State University |
|
| ||||||
1355 | ... Keynote, continued ... |
Christiane Auray-Blais Université de Sherbrooke |
Vincent Charron-Lamoureux University of California San Diego |
| ... Extended Talk ... | ||||||
1415 |
|
|
| ... Extended Talk ... |
|
Thursday 1530 |
2677
|
|
Thursday 1630 |
Exhibitors are invited to join MSACL Admin to provide feedback on MSACL 2026 and begin planning for MSACL 2027 in Montreal (September 26 - October 1, 2027).
2676
|
Scientific Session 5 |
| Montreal 4 Metabolomics - Breath analysis
|
Montreal 5 Toxicology
|
Montreal 6 Spatialomics Data Integration
|
Montreal 7-8 Proteomics - Other
|
Salon Bonaventure, Hotel Level Practical Training
|
|||||||||
1550 |
|
|
|
| |||||||||
1610 |
|
|
|
| ... Extended Talk ... | ||||||||
1630 |
|
|
|
| ... Extended Talk ... |
|
Thursday 1700 |
ALL POSTERS TO BE REMOVED DURING THIS BREAK.
2663
|
|
Thursday |
Booth STAFF : Please follow this timetable to avoid disruptions to scientific sessions.
2684
|
Scientific Session 6 |
|
Montreal 4 CLOSED Session CLOSED | Montreal 5 Lipidomics
|
Montreal 6 Data Science: From Instrument to EMR
|
Montreal 7-8 Proteomics - Spatial
|
Salon Bonaventure, Hotel Level Practical Training
|
|||||
1720 | CLOSED | TBA |
| ||||||
1740 | CLOSED |
|
| ... Extended Talk ... | |||||
1800 | CLOSED |
| ... Extended Talk ... |
|
Thursday 2030 |
All MSACL attendees are invited to this interactive, celebratory dinner. There is no additional sign‑up or fee required; however, seating is first-come, first-served. Form a team with your tablemates and test your esoteric knowledge in a classic pub-style trivia game! If you prefer to dine off‑site, you are welcome to enjoy a drink in the foyer before meeting up with your dinner group and heading out.
2691
|
|
Thursday 2330 |
All attendees are welcome to close out the evening in Salon Bonaventure. MSACL will host snacks and drinks (drinks require tokens - pick up tokens at the door or from MSACL Staff). Drinks will be available through 11:30pm. The Lounge includes a pleasant outdoor patio along a stream and among trees and shrubbery, which may be enjoyable should we have nice weather. Must be wearing your badge to attend. Prepare for karaoke!
2692
|
Friday |
|
Friday 900 |
3 mile round trip run/walk. 554 ft elevation gain. Check-in at 7:00 am for water, coffee, bananas. Group photo at 7:10 then we will proceed down the elevator. Run/walk commences at 7:15-7:20.
2693
|
|
Friday 930 |
All attendees are welcome to partake of a hearty breakfast and closing seminar before departure.
2695
|
|
Friday 1115 |
Yes, it is ok to arrive in your running attire. 12pm checkout time at Hotel Bonaventure.
2696
|
||||||||























































