MSACL 2018 EU: Preliminary Congress Program

Salzburg, Austria • September 9 - 13, 2018

With Thanks to Our Corporate Congress Sponsors:
Thermo   Shimadzu
Agilent   Chromsystems
And Special Thanks to Our Travel Grant Sponsors:
Thermo

Sunday

1100
1900
Badge Pickup
@ Entrance Foyer
1100
1400
Lunch on Own
@ Your Choice

Try lunch in the city or visit a pre-con workshop.
1400
1800

Short Course

COURSE START
Data Science 101
Breaking up with Excel: A Newbie's Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Stephen Master, MD, PhD
Level: 1-2 (Beginner - Intermediate)
Location: TBD
COURSE START
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Randall Julian, PhD
Level: 2 (Intermediate)
Location: TBD
COURSE START
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD & Grace van der Gugten
Level: 1-2 (Beginner - Intermediate)
Location: TBD
COURSE START
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD & Erik J. Soderblom, PhD
Level: 2 (Intermediate)
Location: TBD
COURSE START
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Brian Rappold
Level: 3 (Advanced)
Location: TBD
COURSE START
Metabolomics 202
Metabolomics: Approaches, Applications and Challenges
Julijana Ivanisevic, PhD & Elizabeth Want, PhD
Level: 1-2 (Beginner to Intermediate)
Location: TBD
COURSE START
Proteomics 201
Clinical Proteomics
Cory Bystrom, PhD & Chris Shuford, PhD
Level: 2-3 (Intermediate - Advanced)
Location: TBD
Every 0:50
for 10 min
Coffee Break
@ Entrance Foyer

1800
1830
Petite Reception
@ Entrance Foyer

A quick touch of wine and cheese before exploring the city for dinner.
1800
2100
Dinner on Own
@ Your Choice
1830
2100
SciCom Discussion Group
@ TBA

Private Meeting for Scientific Committee members; includes dinner

Monday

800
900
Welcome Coffee
@ Entrance Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
900
1300

Short Courses

Continued from Sunday
Data Science 101
Breaking up with Excel: A Newbie's Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Stephen Master, MD, PhD
Level: 1-2 (Beginner - Intermediate)
Location: TBD
Continued from Sunday
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Randall Julian, PhD
Level: 2 (Intermediate)
Location: TBD
Continued from Sunday
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD & Grace van der Gugten
Level: 1-2 (Beginner - Intermediate)
Location: TBD
Continued from Sunday
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD & Erik J. Soderblom, PhD
Level: 2 (Intermediate)
Location: TBD
Continued from Sunday
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Brian Rappold
Level: 3 (Advanced)
Location: TBD
Continued from Sunday
Metabolomics 202
Metabolomics: Approaches, Applications and Challenges
Julijana Ivanisevic, PhD & Elizabeth Want, PhD
Level: 1-2 (Beginner to Intermediate)
Location: TBD
Continued from Sunday
Proteomics 201
Clinical Proteomics
Cory Bystrom, PhD & Chris Shuford, PhD
Level: 2-3 (Intermediate - Advanced)
Location: TBD
1300
1400
Lunch
@ Entrance Foyer

Lunch provided for short course attendees.
1400
1800

Short Courses

COURSE START
Lab Medicine 101
Basics of Laboratory Medicine
Prof. Dr. med. Michael Vogeser
Level: 1 (Beginner)
Location: TBD
COURSE START
Proteomic Microbiology 201
Bottom-Up and Top-Down Proteomic Approaches for Bacterial Identification and Characterization, a Focus on MALDI-TOF and Advanced Technologies
Jean Armengaud, PhD, Stefan Zimmermann, MD
Level: 1-2 (Beginner - Intermediate)
Location: TBD
Continued from Monday AM
Data Science 101
Breaking up with Excel: A Newbie's Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Stephen Master, MD, PhD
Level: 1-2 (Beginner - Intermediate)
Location: TBD
Continued from Monday AM
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Randall Julian, PhD
Level: 2 (Intermediate)
Location: TBD
Continued from Monday AM
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD & Grace van der Gugten
Level: 1-2 (Beginner - Intermediate)
Location: TBD
Continued from Monday AM
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD & Erik J. Soderblom, PhD
Level: 2 (Intermediate)
Location: TBD
Continued from Monday AM
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Brian Rappold
Level: 3 (Advanced)
Location: TBD
Continued from Monday AM
Metabolomics 202
Metabolomics: Approaches, Applications and Challenges
Julijana Ivanisevic, PhD & Elizabeth Want, PhD
Level: 1-2 (Beginner to Intermediate)
Location: TBD
Continued from Monday AM
Proteomics 201
Clinical Proteomics
Cory Bystrom, PhD & Chris Shuford, PhD
Level: 2-3 (Intermediate - Advanced)
Location: TBD
1800
1830
Petite Reception
@ Entrance Foyer

A quick touch of wine and cheese before exploring the city for dinner.
1800
2100
Dinner on Own
@ Your Choice

Tuesday

800
1600
Place Posters
@ 1st Floor Exhibit Hall

ALL posters should be placed by 16:00.
800
900
Welcome Coffee
@ Entrance Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
900
1230

Short Course

Continued from Monday PM
Lab Medicine 101
Basics of Laboratory Medicine
Prof. Dr. med. Michael Vogeser
Level: 1 (Beginner)
Location: TBD
Continued from Monday PM
Proteomic Microbiology 201
Bottom-Up and Top-Down Proteomic Approaches for Bacterial Identification and Characterization, a Focus on MALDI-TOF and Advanced Technologies
Jean Armengaud, PhD, Stefan Zimmermann, MD
Level: 1-2 (Beginner - Intermediate)
Location: TBD
Continued from Monday PM
Data Science 101
Breaking up with Excel: A Newbie's Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Stephen Master, MD, PhD
Level: 1-2 (Beginner - Intermediate)
Location: TBD
Continued from Monday PM
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Randall Julian, PhD
Level: 2 (Intermediate)
Location: TBD
Continued from Monday PM
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD & Grace van der Gugten
Level: 1-2 (Beginner - Intermediate)
Location: TBD
Continued from Monday PM
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD & Erik J. Soderblom, PhD
Level: 2 (Intermediate)
Location: TBD
Continued from Monday PM
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Brian Rappold
Level: 3 (Advanced)
Location: TBD
Continued from Monday PM
Metabolomics 202
Metabolomics: Approaches, Applications and Challenges
Julijana Ivanisevic, PhD & Elizabeth Want, PhD
Level: 1-2 (Beginner to Intermediate)
Location: TBD
Continued from Monday PM
Proteomics 201
Clinical Proteomics
Cory Bystrom, PhD & Chris Shuford, PhD
Level: 2-3 (Intermediate - Advanced)
Location: TBD
1230
1300
CONGRESS OPEN
@ Europa Hall
1230
1400
Opening Lunch
@ Europa Hall
1330
1345
Welcome, Introduction & Orientation
@ Europa Hall
1345
1400
CMS Journal Overview
@ Europa Hall

An overview on the current state of the journal, how to subscribe, the path to an Impact Factor, citations, scope, desired article format, webinars.

Opening Plenary Lecture


@ Europa Hall
Opening Plenary Lecture
Chair: TBA
1445
1500
Coffee Break
@ Europa Foyer
1500
1600
Plenary Panel: The Future of Clinical Mass Spectrometry
@ Europa Hall
1600
1630
Coffee Break
@ Europa Foyer
1630
1700
Poster Lightning Talks
@ Europa Hall

15-20 poster presenters will be selected to present their pitch from the plenary podium within 90 seconds and with 1 slide (PDF format).
1700
1730
Exhibitor Lightning Talks
@ Europa Hall

15-20 exhibitors will be selected to present their pitch from the plenary podium within 90 seconds and with 1 slide (PDF format).
1730
1800
EXHIBITS OPEN
@ 1st Floor Exhibit Hall
1730
2000
Exhibitor Reception
@ 1st Floor Exhibit Hall

Buffet dinner served.
1800
1900
MEET-THE-EXPERTS: Booth Tours
@ 1st Floor Exhibit Hall

Join an expert as they tour the booths and learn more about technologies available, what experts are looking for during the exchange, and how they interact with the booth vendors. Increase your network and your knowledge of products and services available.
1900
2000
Troubleshooting Poster Rounds : Part I
@ 1st Floor Exhibit Hall
19:00
What Happened to My Topiramate?
Magdalena Rajska
SPADIA Lab, a.s.
19:15
Inconsistent Performance of Two Similar Instruments during Method Transfer: Towards Implementation of Apolipoprotein Quantification in Clinical Routine
Mervin Pieterse
LUMC Leiden
2000
2100
Enjoy the City
@ Your Choice

Wednesday

745
900
Welcome Coffee
@ Entrance Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
800
845

Corporate Workshop

Thermo Scientific
@ Papageno (Track 3)

Pre-Register

Targeted screening and semi-quantitation of drugs in plasma using high-resolution accurate-mass detection and online sample preparation

Sensitive and selective analytical methods are required in clinical research and forensic toxicology to properly identify a broad range of analytes in complex matrices. The existing methods need to be constantly updated as new compounds, such as designer drugs, become readily available to the illicit drug market. Liquid chromatography coupled to mass spectrometry (LC-MS) has been widely used in this area for years. So far, the preferred detection technology has been triple quadrupole MS for its selectivity in selected reaction monitoring (SRM) mode. However, this approach suffers from the limitation of being able to perform only targeted analysis, while not useful for unknown screening of new drugs.

Come to our educational seminar to know more.

For Research Use Only. Not for use in diagnostic procedures.

SCIEX
@ Paracelsus (Track 4)

Workshop summary coming soon ...

845
900
Intermission
@ Entrance Foyer

Scientific Session 1

Track 1
Mozart 1-3
Lipidomics
Chair: TBA
Track 2
Mozart 4-5
Disease Implications and Diagnosis
Chair: TBA
Track 3
Papageno Hall
Proteomics Keynote
Chair: TBA
Track 4
Paracelsus
New Technologies
Chair: TBA
Track 5
Trakl Hall
Endocrinology
Chair: TBA
Track 6
Doppler Hall
Practical Training : Proteomic Assay Development
Chair: TBA
900
920
Defining Boundaries of Lipidomic Variations in Human Cohorts
Federico Torta
National University of Singapore
Simultaneous and Automated LC-MS Analysis of Plasma Methylmalonic Acid and Short Chain Fatty Acids Using a Carbodiimide-based Derivatization
Mark Pratt
University Medical Center Groningen
Clinical Proteomics: The Path Towards Implementation
Harald Mischak
mosaiques therapeutics GmbH & University of Glasgow
Probing Amyloid Aggregation Dynamics in vivo, Using SILK Imaging (iSILK)
Jörg Hanrieder
University of Gothenburg
Evaluation of Age and Metabolic Status Impact on Serum Steroid Hormones and Product/Precursor Ratios for the Generation of LC-MS/MS Reference Interval in Men
Marco Mezzullo
University of Bologna
Proteomic Assay Development: Digest Optimization and Quality Control
Timothy Collier
Quest Diagnostics - Cleveland HeartLab
920
940
Shotgun Lipidomics of Cerebrospinal Fluid in Neurological Disorders
Gábor Balogh
Biological Research Centre, Hungarian Academy of Sciences
Quantitation of Trimethylamine N-Oxide and its Precursors by HILIC-MS/MS and Their Potential Role in Cognitive Behavior
Alexander Gaudl
Leipzig University
...
Keynote
...
Identifying Biomarkers in FFPE Breast TMAs Using DESI-MSI
Ólöf Gerdur Ísberg
University of Iceland
Quantification of Testosterone, Androstenedione and 17-Hydroxyprogesterone Collected Using Mitra Micro Sampling Devices
David Marshall
Manchester University NHS Foundation Trust
...
Extended Session
...
940
1000
Understanding the Interplay Between Inflammatory Lipid Signaling and Demyelination Process: A Lipidomics Approach Applied to 3D Human Brain Model
Maria Laura Santoru
University of Cagliari / University of Lausanne
The Singapore Lipidomics Incubator: A Model for Engagement and Translation
Anne Bendt
NATIONAL UNIVERSITY OF SINGAPORE
...
Keynote
...
MALDI Imaging Through Laser-Induced Post-Ionization Pushes the Boundaries of Pharmaceutical Development Studies
Florian Barré
M4I, Maastricht University
Direct Analysis - No Sample Preparation - of Bioavailable Cortisol in Human Plasma by Weak Affinity Chromatography (WAC; Affinity LC/MS)
Sten Ohlson
Nanyang Technological University
...
Extended Session
...
1000
1100
Poster Session 1
@ 1st Floor Exhibit Hall

Selected posters to be attended for 1 hour. Refer to program for posters attended during this period.
1000
1100
MEET-THE-EXPERTS : Poster Tours
@ 1st Floor Exhibit Hall

Scientific Session 2

Track 1
Mozart 1-3
Metabolomics Methodology
Chair: TBA
Track 2
Mozart 4-5
All about Breath Analysis
Chair: TBA
Track 3
Papageno Hall
Endocrine Keynote
Chair: TBA
Track 4
Paracelsus
Glycomics 1
Chair: TBA
Track 5
Trakl Hall
MS/MS for Proteotyping Pathogens
Chair: TBA
Track 6
Doppler Hall
Practical Training : Calibrators and Internal Standards for Protein MS
Chair: TBA
1100
1120
New Insights in CE-MS-based Metabolomics
Nicolas Drouin
University of Geneva
Mass Spectrometry Applied to Large-Scale Multi-Centre Clinical Project in Breath Research
Ilaria Belluomo
Imperial College London
Mass Spectrometry Harmonisation: Paediatric Steroid Tales
Ronda Greaves
Murdoch Children's Research Institute
Global Glycoproteomic Analysis of O-glycosylation in Human Herpesviruses
Ieva Bagdonaite
University of Copenhagen
Phylopeptidomics: A Step Closer to Adopting the Microbiome Data into Clinical Practice
Lucia Grenga
CEA
Calibrators and Internal Standards in Protein Mass Spectrometry Assays: Differences, Commonalities, and Best-Practice
Christopher Shuford
Laboratory Corporation of America
1120
1140
Combined Targeted and Untargeted Strategy for Quantification of Amino Acids and Acylcarnitines in Clinically Relevant Biofluids and Tissue Lysates
Vera van der Velpen
Metabolomics Unit, University of Lausanne
Cross Platform Validation of Mass Spectrometry for the Diagnosis of Colorectal Cancer Using a Breath Test
Georgia Woodfield
Imperial College London
...
Keynote
...
In Depth O-Glycosylation Structural Analysis of Colorectal Cancer Cell Lines
Katarina Madunic
Leiden University Medical Center
Characterization of the Virulome of Staphylococcus Aureus by a Highly Multiplex Approach with Scout-MRM
Mouton Nicolas
University de Lyon Claude Bernard
...
Extended Session
...
1140
1200
Development of a Pipeline for Automated Reconstruction and Annotation of Data Independent Acquisition LC-MS Datasets
Gonçalo Graça
Imperial College London
A Pilot Study Profiling Volatile Organic Compounds (VOCs) in the Breath of Patients with CRC Using Proton Transfer Mass Spectrometry
Harrypal Panesar
Imperial College London
...
Keynote
...
HT UPLC Profiling of Total Plasma N-Glycans in Type II Diabetes Mellitus from Patients and Healthy Individuals in a Ghanaian Population
Elham Memarian
Leiden University medical centre
Deciphering MALDI-TOF Identification of Bacteria Using a Proteogenomic Approach
Frédéric Jauffrit
Université de Lyon
...
Extended Session
...
1200
1330
Lunch
@ 1st Floor Exhibit Hall

Lunch to be provided in the Exhibit Hall. Get ready to join a Corporate Workshop after lunch.
1230
1330
Troubleshooting Poster Rounds : Part II
@ 1st Floor Exhibit Hall
12:30
Metformin Interference in LC-MS/MS Analysis of Plasma Methoxycatecholamines
Marianne Bergmann
Lillebaelt Hospital, Vejle
12:45
Charge Wars of Ion Suppression - Awakening the Force for the Analysis of Estrogens in Clinical Research
Robert Wardle
Waters Corporation
1330
1415

Corporate Workshop

Shimadzu
@ Mozart 1-3 (Track 1)

Pre-Register

"Better ways of working in routine clinical pathology laboratories"
Healthcare is dynamic and knows no bounds and so routine clinical pathology laboratories face increasing pressures on cost, time and delivering actionable data.
At Shimadzu, we believe there's always a way to make life better. This seminar explores a few options to make a difference.

1) Neil LOFTUS - SHIMADZU Corporation, UK
"Expanding the capability of mass spectrometry in routine clinical pathology – creating better ways of delivering actionable data."

2) Andrea Radeljak, Matea Ivić – KB Merkur, Croatia
"Automating standardized workflows in the clinical laboratory – using the Shimadzu CLAM-2000 integrated with LC-MS/MS to help increase sample throughput and make it easier for users."

3) Sigrid BAUMGARTEN - Alsachim SAS, France
"From core expertise of Stable Isotope Labelled Compounds to reagent kits for high quality LCMS data"

Disclaimer: For Research Use Only. Not for use in diagnostic procedures. Not available in the USA, Canada and China.

Thermo Scientific
@ Mozart 4-5 (Track 2)

Pre-Register

“Fully Automated LC-MS – Theory becomes Reality”
The use of LC-MS in diagnostic pathology has been limited by the complexity of equipment, materials and skills required to establish a fully validated service. A review showed only 19% of respondents were running VitaminD using LC-MS. On the basis that this is the gold standard, a fully validated and simple-to-use mass spectrometer has been a long awaited development. This presentation shares the first practical experience of using the Thermo Scientific™ Cascadion™ SM Clinical Analyser, in a laboratory, where staff have no prior experience of using LC-MS technology.

Automated LC-MS/MS: A disruptive technology will improve the quality of care for our patients
The LC-MS/MS platform provides solutions to complex analytical problems for clinical routine laboratories. This development started decades ago and the technology has proven to deliver reliable results with unreached specificity in TDM, DoA testing, endocrine diagnostics and newborn screening. In this presentation the concept of a fully integrated and automated LC-MS/MS is described. Special focus is on features of the Thermo Scientific™ Cascadion™ SM Clinical Analyzer that can overcome the limitations of open systems.

Product IVD/CE-marked. Product not 510(k) cleared and not yet available for sale in the US.

Agilent Technologies
@ Paracelsus (Track 4)

Workshop summary coming soon ...

Waters
@ Trakl (Track 5)

Workshop summary coming soon ...

1415
1430
Intermission
@ Entrance Foyer

Scientific Session 3

Track 1
Mozart 1-3
Metabolic Markers
Chair: TBA
Track 2
Mozart 4-5
Keynote Small Molecules
Chair: TBA
Track 3
Papageno Hall
Cardiovascular and Thrombotic Disease
Chair: TBA
Track 4
Paracelsus
Tissue Imaging Keynote
Chair: TBA
Track 5
Trakl Hall
Glycomics 2
Chair: TBA
Track 6
Doppler Hall
Practical Training : EU Regulations
Chair: TBA
1430
1450
Discovery of Novel Galabiosylceramide-Related Biomarkers of Fabry Disease by Semi-Targeted Metabolomics: the Complex Issue of Structural Isomer Interferences
Michel Boutin
Université de Sherbrooke
Tackling Analytical Challenges in Sports Drug Testing by Mass Spectrometric Approaches
Mario Thevis
German Sport University, Cologne, Germany
European Monitoring Center for Emerging Doping Agents (EuMoCEDA), Cologne/Bonn, Germany
Building Standards for Proteomics: A Targeted Mass Spectrometry Approach for Quantification of Cardiovascular Disease Biomarker in Human Blood
Albert Sickmann
ISAS
Combining Mass Spectrometry Imaging & Microproteomics to Investigate Intratumor Heterogeneity
Liam McDonnell
Fondazione Pisana per la Scienza ONLUS, Pisa, Italy
In-Depth Characterisation of Heavily Glycosylated Proteins and Their Potential as Colorectal Cancer Biomarkers
Valeriia Kuzyk
Vrije Universiteit Amsterdam
EU LC-MS Verification
Brian Keevil
Manchester University
1450
1510
Identifying the Metabolic “Achilles Heel” of Adult and Childhood Brain Cancers Using LC-MS-based Metabolite Profiling
Dong-Hyun Kim
University of Nottingham
...
Keynote
...
Validation of ApolipoProtein A-I Associated Lipoprotein Panel for the Prediction of Cholesterol Efflux Capacity
Cory Bystrom
Cleveland HeartLab
...
Keynote
...
Characterisation of Prostate-Specific Antigen Isolated from Patients’ Urine
Alan Moran
Leiden University Medical Centre
...
Extended Session
...
1510
1530
Urinary Biomarkers of Dietary Intake - Quantification of Sugars for Epidemiology Studies Using LC-MS/MS
Nicola Gray
University of Reading
...
Keynote
...
Defining the Measurands for Antithrombin and its Proteoforms Using Mass Spectrometry Based Techniques
Renee Ruhaak
Leiden University Medical Center
...
Keynote
...
Development of MS-based Prostate-Specific Antigen Test with In-Depth Glycosylation Analysis
Guinevere S.M. Kammeijer
Center for Proteomics and Metabolomics, LUMC
...
Extended Session
...
1530
1630
Poster Session 2
@ 1st Floor Exhibit Hall
1530
1630
MEET-THE-EXPERTS : Poster Tours
@ 1st Floor Exhibit Hall
1630
1730
Plenary Lecture : Distinguished Contribution Award
@ Mozart 1-5
1730
1930
Exhibitor Reception
@ 1st Floor Exhibit Hall

Buffet dinner, appetizers and drinks to be provided. Enjoy mingling with colleagues and Exhibitors. Take time to browse the posters.
1830
1930
MEET-THE-EXPERTS: Office Hours Forum
@ 1st Floor Exhibit Hall

Have a question from the congress that you have been itching to ask? Or a problem from work that you want to get feedback on? Or feedback on the congress? Sign up at the registration desk for 15-min blocks to share time and ideas with domain experts in a relaxed setting.
1930
2030

Discussion Group

Development of LC-MS Certification Programs
@ Mozart 4-5 (Track 2)

Chair(s): Judy Stone

Panelists:
Fumio Nomura, Chima University Hospital

Design of Experiments – get it right from the beginning
@ Papageno (Track 3)

Chair(s): Margrét  and Unnur Thorsteinsdóttir

We will demonstrate how method development can become much more efficient by utilizing design of experiments (DoE). DoE offers a practical approach for performing experiments in accordance to predefined plan, modelling by empirical functions, and graphical visualization. Example from optimization of a UPLC-MS/MS method for clinical application will be used to show the cost-effective benefit of DoE, where it allows the effect of variables to be assessed with only a fraction of the experiments that would be required by changing one-separate-factor-at-time (COST) approach and spots critical setting early on.

2030
2200
Enjoy the City
@ Your Choice

Thursday

745
900
Welcome Coffee
@ Entrance Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
800
845

Corporate Workshop

Zivak Technologies
@ Paracelsus (Track 4)

Pre-Register

From Primary Sample Tubes to Results: World’s First Fully Automated Sample Preparation and Injection UHPLC System

Zivak Technologies is delivering solution to manual sample preparation related problems of chromatography analysis and enabling clinical laboratories to make the most of their MS/MS instruments by full automatization.

Fully automated Zivak analyzers allow you to get results from primary sample tubes without any user intervention. After the tubes are placed in the sample tray and the analysis is started on the computer, the robotic arms carry out all sample preparation steps, inject the prepared sample to MS/MS and chromatographic run starts. With Zivak analyzers, opening the sample tubes’ caps is never required.

Attend the workshop and listen a detailed review of World’s First Walk Away Sample Preparation and Injection UHPLC System Multitasker and Zivak’s Revolutionary VD-200, Fully Automated Vitamin D2-D3 UHPLC Analyzer from Prof. Dr. Şahabettin Selek and Prof. Dr. Ahmet Ceyhan Gören.

800
900
SciCom Discussion Group
@ 1st Floor Cafe
845
900
Intermission
@ Entrance Foyer
900
1000
Exhibitor Feedback
@ 1st Floor Cafe

An opportunity for exhibiting vendors to provide feedback on what worked and what could use improvement.

Scientific Session 4

Track 1
Mozart 1-3
Metabolomics – Clinical Studies I
Chair: TBA
Track 2
Mozart 4-5
Quality Issues
Chair: TBA
Track 3
Papageno Hall
Clinical Chemistry I
Chair: TBA
Track 4
Paracelsus
MSI for Clinical Applications
Chair: TBA
Track 5
Trakl Hall
Keynote for Microbiology
Chair: TBA
Track 6
Doppler Hall
Practical Training : Finding Your Analyte
Chair: TBA
900
920
Metabolomic Analysis of Changes in the Serum of Diabetic Patients Caused by Ulcers
Arsenty Melnikov
Internatrional Tomography Center SB RAS
Quality Assurance and Quality Control in LC-MS-based Targeted Lipidomics of Human Blood Plasma
Bo Burla
National University of Singapore
A Newly Developed LC-MS/MS Method for the Quantitation of Glucagon in Plasma Shows the Lack of Specificity of Former RIA Methods
Jordi Farre-Segura
University of Liège, CHU de Liège
Next Generation Sequencing After MALDI MSI – A Feasibility Study
Kristina Schwamborn
Institute of Pathology, TU Munich
Tandem MS-Proteotyping: Proteomics- and Genomics-based Characterization and Typing of Infectious Bacteria
Edward Moore
University of Gothenburg
1/3 “Where Did My Analyte Go?” – coping with poor solubility and non-specific binding
Catarina Horro Pita
LGC, Drug Development Solutions
920
940
A Metabolite Level View of the Gut-Brain Axis in Dementia and Aging: Quantification of the Kynurenine/Tryptophan Pathway Using Mass Spectrometry
Luke Whiley
Imperial College London
Stable Isotope-Dilution-LC-MS/MS-based Reference Methods – Suggestion for Description of Methods and Structure of Analytical Series
Michael Vogeser
University Hospital, LMU Munich
Progress in Clinical Applications for the MALDI-Imaging Analysis of Thyroid Biopsies: Evaluation of Proteomic Stability in Preservative Solutions
Isabella Piga
University of Milano-Bicocca
MALDI-MSI in the Search for Proteomic Indicators of Response to Therapy in Membranous Nephropathy
Andrew Smith
University of Milano-Bicocca
...
Keynote
...
2/3 “Where Did My Analyte Go?” – coping with poor solubility and non-specific binding
Catarina Horro Pita
LGC, Drug Development Solutions
940
1000
Estimation of the Post Mortem Interval via Metabolomic Approach
Lyudmila Yanshole
International Tomography Center SB RAS
Development of an Assay for Citrate and Oxalate in Urine by Hydrophilic Interaction LC-MS/MS After Weak Anion Exchange SPE
Albert Dijkhuizen
Leiden University Medical Center
Selective Determination of Human and Synthetic Insulins in Plasma Using LC-MS – How Does it Help the Clinician?
Jean-Christophe Prost
Bern University Hospital (Inselspital)
Bringing Mass Spectrometry to Pathologists for Diagnostics of Frozen Surgically Resected Tissue Specimen
Tiffany Porta Siegel
M4I, Maastricht University
...
Keynote
...
3/3 “Where Did My Analyte Go?” – coping with poor solubility and non-specific binding
Catarina Horro Pita
LGC, Drug Development Solutions
1000
1100
Poster Session 3
@ 1st Floor Exhibit Hall

Selected posters to be attended for 1 hour. Refer to program for posters attended during this period.
1000
1100
MEET-THE-EXPERTS : Poster Tours
@ 1st Floor Exhibit Hall
1000
1100
Poster Contest Finalist Interviews
@ 1st Floor Exhibit Hall

Poster Contest Finalists to attend posters and meet with poster Judges. Judges may arrive in groups or individually.

Scientific Session 5

Track 1
Mozart 1-3
Metabolomics Clinical Studies II
Chair: TBA
Track 2
Mozart 4-5
Quantitation Issues
Chair: TBA
Track 3
Papageno Hall
Clinical Proteomics II
Chair: TBA
Track 4
Paracelsus
Glycomics Keynote
Chair: TBA
Track 5
Trakl Hall
Technological Innovations for the Microbiology Laboratory
Chair: TBA
Track 6
Doppler Hall
Practical Training: Internal Standards
Chair: TBA
1100
1120
Analytical Strategies to Study the Interaction Between Microbiota and Drug Metabolism Using Targeted and Untargeted LC-MS-based Metabolomics
Marine Letertre
Imperial College London
Semi-Quantitative LC/ESI/MS Analysis Using Predictive Models of ESI Ionization Efficiencies
Jaanus Liigand
University of Tartu
Paving the Way for MS-based Protein Tests that Target Unmet Clinical Needs
Christa Cobbaert
Leiden University Medical Center
TBALaser Assisted Rapid Evaporative Ionisation Mass Spectrometry: An Automated Platform for Direct-From-Culture Speciation and Clinical Sample Analysis
Simon Cameron
Imperial College London
Everything You Wanted to Know about Internal Standards But Were Too Afraid to Ask
Russ Grant
Labcorp
1120
1140
Clinical Validation of an Automated Dried Blood Spot Sampling Device – Fluispotter®
Khem Adhikari
Rigshospitalet
Quantification and Library Identification of 248 Compounds Commonly Detected in Systematic Toxicology Analysis Using an Automated Extraction Coupled to LC-MS/MS
Robin Tiphaine
CHU of Limoges
Combination of Stable Labelled Antibodies and LC-MS to Accurately Quantify Therapeutic Monoclonal Antibodies in the Clinical Laboratory
Ravindra Chaudhari
PROMISE Advanced Proteomics
TBAIn-situ Detection of the Botulinum Neurotoxin A by Functionalized MALDI Chips
Petra Darebna
BioCeV
...
Extended Session
...
1140
1200
Use of Quantitative Metabolomics for Investigation of Age-Related Nuclear Cataracts
Vadim Yanshole
International Tomography Center SB RAS
Clinical Mass Spectrometry: the Assessment of Acidosis Profiles and Acute Kidney Injury in Severe Malaria
Natthida Sriboonvorakul
Mahidol University
Clinical Analytical Assay for AFP-L3 Using Multiple Reaction Monitoring-Mass Spectrometry for Diagnosing Hepatocellular Carcinoma
Youngsoo Kim
Seoul National University College of Medicine
TBAMALDI-TOF Mass Spectrometry: A Method for the Detection of Bacterial Contamination in Platelet Concentrates
Yasmine Chetouane
IHU méditerranée infection
...
Extended Session
...
1200
1330
Lunch
@ 1st Floor Exhibit Hall
1230
1330
Poster Session 4
@ 1st Floor Exhibit Hall

Selected posters to be attended for 1 hour. Refer to program for posters attended during this period.
1230
1330
MEET-THE-EXPERTS : Poster Tours
@ 1st Floor Exhibit Hall
1330
1415

Corporate Workshop

Tecan
@ Papageno (Track 3)

Workshop summary coming soon ...

1330
1400
EXHIBITS CLOSED
@ 1st Floor Exhibit Hall
1415
1430
Intermission
@ Entrance Foyer

Scientific Session 6

Track 1
Mozart 1-3
Keynote for Metabolomics
Chair: TBA
Track 2
Mozart 4-5
Monitoring Metabolites in Inborn Errors of Metabolism
Chair: TBA
Track 3
Papageno Hall
Oncology
Chair: TBA
Track 4
Paracelsus
Tissue Imaging Keynote
Chair: TBA
Track 5
Trakl Hall
Biomarkers in Infectious Disease
Chair: TBA
Track 6
Doppler Hall
Practical Training : Getting to Lower Limits of Quanitation
Chair: TBA
1430
1450
How Tandem Mass Spectrometry Revolutionized Newborn Screening
David Millington
Duke University School of Medicine
Development of a 2D-UPLC-MS/MS Assay for Therapeutic Monitoring for Patients with APRT Deficiency
Unnur Arna Thorsteinsdottir
University of Iceland
Proteomic Analysis of MGL Binding Protein in Human Cancer Cells
Martina Pirro
Leiden University Medical Center LUMC
Advances in Computational Methods for Tissue Imaging by Mass Spectrometry
Raf Van de Plas
Delft University of Technology
Sepsis by Enterobacteria: A MALDI Affair
Markus Kostrzewa
Bruker Daltonik GmbH
1/3 Getting Lower Limits of Quantification in LC-MS/MS assays : Prologue
Brian Rappold
LabCorp
1450
1510
...
Keynote
...
The Role of Chromatography in the Separation of Glucosylceramide Isoforms from Their Isobaric Galactosylceramide Counterparts in the Era of Precision Medicine
Christiane Auray-Blais
Universite de Sherbrooke
Exosome-like Vesicles of Uterine Aspirates Permit the Identification of Diagnostic and Stratification Biomarkers of Endometrial Cancer
Eva Colas
Vall Hebron Research Institute
...
Keynote
...
Omics Approaches Towards Discovery of Biomarkers for Early Diagnosis of Tuberculosis
Ana Varela Coelho
ITQB NOVA
2/3 Getting Lower Limits of Quantification in LC-MS/MS assays : Phases and Stages
Brian Rappold
LabCorp
1510
1530
...
Keynote
...
First Experience with a Second-Tier LC-MS/MS Assay for Newborn Screening of Propionic Acidemia, Methylmalonic Acidemias and Combined Remethylation Disorders
Glynis Klinke
University of Heidelberg
In Depth Proteomic Analysis of Prostate Cancer Biopsies
Gabor Toth
Hungarian Academy of Sciences
...
Keynote
...
Identification and Validation of Two Peptide Markers for the Recognition of Clostridium difficile MLST-1 and MLST-11 by MALDI-MS
Simone Nicolardi
Leiden University Medical Center
3/3 Getting Lower Limits of Quantification in LC-MS/MS assays : The Words Don’t Fit the Picture
Brian Rappold
LabCorp
1530
1545
Reception
@ Entrance Foyer
1545
1600
Poster Award Presentation
@ Entrance Foyer
1600
1645
Closing Plenary Lecture
@ Mozart 4-5
1645
1800
Closing Reception & Discussion
@ Entrance Foyer

Wine & Cheese, Beer & Nuts ... and maybe Kaiserschmarrn. Winning posters to be on display.
1800
2200
After Congress Meet-Up
@ Your Choice

Meet up at the Augustiner Brauhaus for an unofficial and unsponsored post-con gathering.