= Emerging. More than 5 years before clinical availability. (36.32%)
= Expected to be clinically available in 1 to 4 years. (32.29%)
= Clinically available now. (31.39%)
Percent of confirmed presenters indicating Clinical Use Status: 100.00%



MSACL 2019 EU: Congress Program

Salzburg, Austria • September 22 - 26, 2019

With Thanks to Our Corporate Congress Sponsors:
Waters Thermo   Shimadzu
Agilent
Chromsystems
And Special Thanks to Our Educational Grant Sponsors:
Thermo

Sunday

1100
1830
Badge Pickup
@ Entrance Foyer
1100
1300
Lunch on Own
@ Your Choice

Some nearby (within one block) recommendations include:
1. The Heart of Joy (Vegetarian and Vegan)
2. my Indigo Kongresshaus (Asian Fusion)
3. Cafe Fingerlos (Cafe with the best breakfast in town)
4. IMLAUER Sky (Rooftop patio with a view)
5. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily with Sunday Brunch buffet until 2pm)
6. Braurestaurant IMLAUER (Austrian, traditional interior plus a beer garden, good for groups)

A little further afield:
1. Cafe Sacher (for a patio on the river)
2. Barenwirt (Cozy and Traditional Austrian, fills up so arrive early)
3. Antichi Sapori (Tasty Italian food and pizza in casual family run style, Open 11:30-2:00pm and 5:30-9:00pm, Closed Wed and Thurs)

Or see the complete list of recommendations.

1130
1230

Pre-Con Workshop(s)

No workshops currently booked for this time period.

1300
1800

Short Course

COURSE START
Data Science 101
Breaking up with Excel: An Introduction to the R Statistical Programming Language
Daniel Holmes, MD & William Slade, PhD
Level: Beginner - Intermediate
@ TBD
COURSE START
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Shannon Haymond, PhD
Level: Intermediate
@ TBD
COURSE START
Glyco-Proteomics 101
Unravelling The Sweetness Of Life: Clinical Glyco(Proteo)Mics By Mass Spectrometry
Noortje de Haan, PhD & Guinevere Lageveen-Kammeijer, PhD
Level: Beginner to Intermediate
@ TBD
COURSE START
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Laura Owen, PhD & Michael Wright
Level: Beginner
@ TBD
COURSE START
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Brian Rappold & Chris Shuford
Level: Advanced
@ TBD
COURSE START
Metabolomics 202
Metabolomics: Approaches, Applications and Challenges
Julijana Ivanisevic, PhD & Elizabeth Want, PhD
Level: Beginner to Intermediate
@ TBD
Every 0:50
for 10 min
Coffee Break
@ Entrance Foyer

1800
1830
Petite Reception
@ Entrance Foyer

A quick touch of wine and cheese before exploring the city for dinner.
1800
Dinner on Own
@ Your Choice

Dinner Suggestions:
1. Gablerbrau (Historic ambiance with traditional food)
2. Augustiner Braustubl (Historic Abby turned beer garden with food stalls)
3. Antichi Sapori (Tasty Italian food and pizza in casual family run style, open 11:30-2:00pm and 5:30-9:00pm, closed Wed and Thurs)
4. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily)
5. Braurestaurant IMLAUER (Austrian, traditional interior plus a beer garden, good for groups)

After dinner:
1. Murphys Law Irish Pub

1900
Private Instructor Dinner
@ TBA

Expected to be held at M32.

Monday

800
830
Welcome Coffee
@ Entrance Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
830
1230

Short Course

Continued from Sunday
Data Science 101
Breaking up with Excel: An Introduction to the R Statistical Programming Language
Daniel Holmes, MD & William Slade, PhD
Level: Beginner - Intermediate
@ TBD
Continued from Sunday
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Shannon Haymond, PhD
Level: Intermediate
@ TBD
Continued from Sunday
Glyco-Proteomics 101
Unravelling The Sweetness Of Life: Clinical Glyco(Proteo)Mics By Mass Spectrometry
Noortje de Haan, PhD & Guinevere Lageveen-Kammeijer, PhD
Level: Beginner to Intermediate
@ TBD
Continued from Sunday
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Laura Owen, PhD & Michael Wright
Level: Beginner
@ TBD
Continued from Sunday
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Brian Rappold & Chris Shuford
Level: Advanced
@ TBD
COURSE START
Lipidomics 101
Mass Spectrometry-based Lipidomics and Clinical Applications
Anne K Bendt, PhD, Amaury Cazenave-Gassiot, PhD, Michael Chen, MD
Level: Beginner - Intermediate
@ TBD
Continued from Sunday
Metabolomics 202
Metabolomics: Approaches, Applications and Challenges
Julijana Ivanisevic, PhD & Elizabeth Want, PhD
Level: Beginner to Intermediate
@ TBD
1230
1330
Lunch
@ Entrance Foyer

Lunch provided for short course attendees.
1330
1730

Short Course

COURSE START
Proteomic Microbiology 201
Bottom-Up and Top-Down Proteomic Approaches for Bacterial Identification and Characterization, a Focus on MALDI-TOF and Advanced Technologies
Jean Armengaud, PhD, Stefan Zimmermann, MD
Level: Beginner - Intermediate
@ TBD
Continued from Monday AM
Data Science 101
Breaking up with Excel: An Introduction to the R Statistical Programming Language
Daniel Holmes, MD & William Slade, PhD
Level: Beginner - Intermediate
@ TBD
Continued from Monday AM
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Shannon Haymond, PhD
Level: Intermediate
@ TBD
Continued from Monday AM
Glyco-Proteomics 101
Unravelling The Sweetness Of Life: Clinical Glyco(Proteo)Mics By Mass Spectrometry
Noortje de Haan, PhD & Guinevere Lageveen-Kammeijer, PhD
Level: Beginner to Intermediate
@ TBD
Continued from Monday AM
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Laura Owen, PhD & Michael Wright
Level: Beginner
@ TBD
Continued from Monday AM
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Brian Rappold & Chris Shuford
Level: Advanced
@ TBD
Continued from Monday AM
Lipidomics 101
Mass Spectrometry-based Lipidomics and Clinical Applications
Anne K Bendt, PhD, Amaury Cazenave-Gassiot, PhD, Michael Chen, MD
Level: Beginner - Intermediate
@ TBD
Continued from Monday AM
Metabolomics 202
Metabolomics: Approaches, Applications and Challenges
Julijana Ivanisevic, PhD & Elizabeth Want, PhD
Level: Beginner to Intermediate
@ TBD
1730
1800
Petite Reception
@ Entrance Foyer

A quick touch of wine and cheese before exploring the city for dinner.
1800
Dinner on Own
@ Your Choice

Dinner suggestions:
1. Zum fidelen Affen (best patio dinner on a nice evening, closed Sunday)
2. Die Wiesse (Brewery Pub with beer garden open till 2am Mon-Sat)
3. Gablerbrau (Historic ambiance with traditional food)
4. Augustiner Braustubl (Historic Abby turned beer garden with food stalls)
5. Antichi Sapori (Tasty Italian food and pizza in casual family run style, open 5:30-9:00pm, closed Wed and Thurs)
6. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily)
7. Braurestaurant IMLAUER (Austrian, traditional interior plus a beer garden, good for groups)

After dinner:
1. Murphys Law Irish Pub

1830
2030
Private Faculty Dinner
@ TBA

Tuesday

800
1600
Place Posters
@ 1st Floor Exhibit Hall

ALL posters should be placed by 16:00.
800
830
Welcome Coffee
@ Entrance Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
830
1130

Short Course

Continued from Monday PM
Proteomic Microbiology 201
Bottom-Up and Top-Down Proteomic Approaches for Bacterial Identification and Characterization, a Focus on MALDI-TOF and Advanced Technologies
Jean Armengaud, PhD, Stefan Zimmermann, MD
Level: Beginner - Intermediate
@ TBD
Continued from Monday PM
Data Science 101
Breaking up with Excel: An Introduction to the R Statistical Programming Language
Daniel Holmes, MD & William Slade, PhD
Level: Beginner - Intermediate
@ TBD
Continued from Monday PM
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Shannon Haymond, PhD
Level: Intermediate
@ TBD
Continued from Monday PM
Glyco-Proteomics 101
Unravelling The Sweetness Of Life: Clinical Glyco(Proteo)Mics By Mass Spectrometry
Noortje de Haan, PhD & Guinevere Lageveen-Kammeijer, PhD
Level: Beginner to Intermediate
@ TBD
Continued from Monday PM
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Laura Owen, PhD & Michael Wright
Level: Beginner
@ TBD
Continued from Monday PM
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Brian Rappold & Chris Shuford
Level: Advanced
@ TBD
Continued from Monday PM
Metabolomics 202
Metabolomics: Approaches, Applications and Challenges
Julijana Ivanisevic, PhD & Elizabeth Want, PhD
Level: Beginner to Intermediate
@ TBD
900
1300
Get the Basics
@ Paracelsus Hall

This series of Primers on emerging fields within Clinical Mass Spec is free to attend for ALL registrants of the MSACL Congress or Short Courses, including Partial Pass holders.

Take aways for each session include:
1. Be able to define what the field is, why it matters, and why you personally should care. What is the clinical relevance?
2. Understand what role mass spectrometry plays in this field. Where does mass spec fit in to the big picture of the field?
3. Define any terminology that is specific to this field.
4. Describe how it works, what are the methods and workflows used when studying this field and/or how is it implemented in clinical labs.
5. Identify any challenges to implementation/adoption, where do the opportunities lie?

09:00 - 09:40 Glycomics with Manfred Wuhrer
09:50 - 10:30 Mass Spec Imaging with Tiffany Porta
10:40 - 11:20 Lipidomics with Anne Bendt
11:30 - 12:10 Data Science with Randy Julian
12:20 - 13:00 Breath Analysis with Ilaria Belluomo
1130
1400
Lunch on Own
@ Your Choice

Some nearby (within one block) recommendations include:
1. The Heart of Joy (Vegetarian and Vegan)
2. my Indigo Kongresshaus (Asian Fusion, great choice if short on time, pre-packaged take-away options available, pleasant interior)
3. Cafe Fingerlos (Cafe with the best breakfast in town)
4. IMLAUER Sky (Rooftop patio with a view)
5. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily with Sunday Brunch buffet until 2pm)
6. Braurestaurant IMLAUER (Austrian, traditional interior plus a beer garden, good for groups)

A little further afield:
1. Balkan Grill Walter (Take-away street food at its best in the Old Town. Grab a FroYo at Fabi's after.)
2. Stieglkeller (Lovely historical building in Old Town, it's Beer Garden has a fantastic view over the town. Large beer selection.)

Or see the complete list of recommendations.

13:10
13:50

Discussion Group: Study Design and Logistics for Metabolomics Studies
Study design is a very critical step in metabolomic experiment. It has to ensure that phenotype resolution, metabolite coverage, quality-driving resources and logistic processes are considered. During the session we will interactively discuss steps like type of the study, consideration of confounders, power calculation, pre-analytical requirements, sample storage, randomization, metabolite analytics to be chosen and replication considerations. Chair - Jerzy Adamski

1400
1415
Welcome, Introduction & Orientation
@ Mozart 1-5
1400
CONGRESS OPEN
@ Mozart 1-5
1415

Opening Plenary Lecture


@ Mozart 1-5

1415
1500
Inflammatory Stories in Time and Space: Using Mass Spectrometry Imaging, Ion Mobility and High Throughput Lipidomics to Understand Human Disease
Jules Griffin
Computational and Systems Medicine, Surgery and Cancer, Imperial College London, London and Department of Biochemistry, University of Cambridge, Cambridge, UK

A central aspect of the development of many of the pathologies associated with the metabolic syndrome is a chronic progression of inflammation in the affected tissues. This is in part driven by lipid remodelling in the cell membrane and the production of pro-inflammatory lipid mediators produced from polyunsaturated fatty acids such as arachidonic, docosahexaenoic and eicosapentaenoic acids. To explore lipid remodelling during the development of non-alcoholic fatty liver disease we have applied MALDI-based mass spectrometry imaging (MSI) to examine both human tissue and animal models of the disease progression. Using a combination of high fat feeding and genetic modification (the ob/ob mouse which lacks leptin) to cause hepatic steatosis with and without inflammation, MSI shows that one of the events associated with disease progression is a lipid remodelling of phosphatidylcholines (PCs), and in particular, a reduction in arachidonic acid containing PCs. We have also developed a ultra-high performance liquid chromatography ion mobility mass spectrometry-based method to profile known and novel lipid mediators, using a KNIME workflow to process the data and annotate the detected lipids, in part relying on collision cross-section values for these species to aid assignments. This will be illustrated in following the time course of lipid changes in thrombin activated human platelets.

1500
1515
Intermission
@ Entrance Foyer
1515
1600

State of the Science Address
@ Mozart 1-5

Presented by MSACL EU Scientific Committee Topic Leads, this address will provide an overview of the applications and technologies currently being used in Clinical Labs, and a clear view of the development pipeline. It will highlight applications expected to be available in the near-future, as well as emerging applications, and key contributors. Relevant talks, posters, and people present at the congress will be identified, enabling you to optimize your learning path and more effectively target potential network connections. Whether you are new to Clinical Mass Spectrometry, or a seasoned veteran, the State of the Science address should be on your agenda.
1600
1615
Intermission
@ Entrance Foyer
1615
1645
Poster Lightning Talks
@ Mozart 1-5

Poster Contest Semi-Finalists will be selected to present their pitch from the plenary podium within 90 seconds and with 1 slide (PDF format).
1645
1715
Exhibitor Lightning Talks
@ Mozart 1-5

15-20 exhibitors will be selected to present their pitch from the plenary podium within 90 seconds and with 1 slide (PDF format).
1715
EXHIBITS OPEN
@ 1st Floor Exhibit Hall
1715
1930
Exhibitor Reception
@ 1st Floor Exhibit Hall

Heavy appetizers served.
1800
1845
Meet-a-Mentor : Booth Tours
@ 1st Floor Exhibit Hall

Join an expert as they tour the booths and learn more about technologies available, what experts are looking for during the exchange, and how they interact with the booth vendors. Increase your network and your knowledge of products and services available.
1845
1930
Troubleshooting Poster Rounds : Part I
@ 1st Floor Exhibit Hall
18:45 at poster #23a
The Hurdles of Developing an LC-MS/MS Assay for Desmosine, a Biomarker for Elastin Degradation
Jody van den Ouweland
Canisius-Wilhelmina Hospital
19:00 at poster #23b
Fast and Efficient Method for Detection and Quantification of Catecholamines in Human Plasma by LC-MS/MS - Troubleshooting
Chiara Calaprice
University hospital of Liege
1930
2030

Discussion Group
FeMS : Females in MS : Inaugural Meeting

2030
Enjoy the City
@ Your Choice

or get a good night's sleep

Wednesday

745
900
Welcome Coffee
@ Entrance Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
800
845

Corporate Workshop(s)

Merck
@ Mozart 4-5 (Track 2)

Workshop summary coming soon ...

Thermo Fisher Scientific
@ Papageno (Track 3)

Workshop summary coming soon ...

SCIEX
@ Paracelsus (Track 4)

Advanced mass spectrometry techniques provide deeper access into the vitamin D metabolome.

Pascal Schorr, Humboldt-University, Berlin

845
900
Intermission
@ Entrance Foyer

Scientific Session 1

Mozart 1-3

Metabolomics Keynote: Oscar Yanes
Chair: Oleg Mayboroda

Mozart 4-5

Proteomics: Reinventing Old Biomarkers
Chair: TBA

Papageno Hall

Quality Control
Chair: Rita Horvath

Paracelsus Hall

Small Molecules: Metabolomics in Toxicology
Chair: Jody van den Ouweland
2nd Chair: Juliane Fagotti

Trakl Hall

Lipidomics: Applications for Doping, Nutrition and Lab Med
Chair: Erika Dorado
2nd Chair: Panagiotis Vorkas

Doppler Hall

Breath Analysis and VOC in Cancer
Chair: Kseniya Dryahina

900
920
From Spectrometric Data to Metabolic Networks: An Integrated Quantitative View of Cell Metabolism
Oscar Yanes
CIBER & URV & IISPV
HILIC-LC-MRM-MS Enables the Quantitation of PSA and its Major Glycoforms to Improve Prostate Cancer Diagnostics
L.Renee Ruhaak
Leiden University Medical Center
A Proposal to Standardize the Description of LC-MS -based Measurement Methods in Laboratory Medicine
Michael Vogeser
Hospital of the University of Munich (LMU)
UPLC-MS/MS-based Assays for Diagnosis and Therapeutic Monitoring in Patients with APRT Deficiency
Unnur Arna Thorsteinsdottir
University of Iceland
Development and Validation of a Gas-Chromatography Mass Spectrometry Method for the Analysis of Testosterone Esters in Biological Matrices
Michele Iannone
Laboratorio Antidoping FMSI, Rome, Italy
Investigating the Relationship between TRIM44 and P53 Metabolic Pathways in Human Colon Cancer Cells in a 3D Model, Using PTR-ToF-MS
Katerina-Vanessa Savva
PhD, Imperial College London
920
940
...
Keynote
...
Proteomic Analysis of Prostate Cancer Biopsies
Gábor Tóth
MS Proteomics Research Group, RCNS-HAS
Metrological Traceability of Lp(a) Requires Defining the Measurand and Introducing Molar Units
Christa Cobbaert
Leiden University Medical Center
Investigation of Bacterial β-Glucuronidase Inhibition on the Metabolic Profile of Mice Using a Combined Platform of NMR and LCMS-based Untargeted Metabolomics
Marine Letertre
Imperial College London
Determination of Serum Triglyceride by Isotope Dilution LC-MS/MS
Weiyan Zhou
NCCL,Beijing Hospital
VOC-based Real-Time Breast Cancer Diagnostic Using LTP-MS
Flore Herve
PhD student, PRISM U1192
940
1000
...
Keynote
...
The Analysis of Alpha-1-Antitrypsin Glycosylation in HCC Patient Serum
Haidi Yin
The Hong Kong Polytechnic University
Rigorous Quality Management Enables Long-Term Robustness of MS-based Protein Quantitation
Nico Smit
Leiden University Medical Center
Development of a Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (LC-QTof MS) Method for the Screening of Antihypertensive Drugs in Urine
Alexander Lawson
University Hospitals Birmingham NHS FT
Whole Blood Omega-3 Index by Gas Chromatography Dependence on Age and Gender in Caucasian Population
Vasiliy Yurasov
Scientific laboratory "Chromolab"
Volatile Organic Compound (VOC) Profiling in Liver Disease via Selected-Ion Flow-Tube Mass Spectrometry (SIFT-MS)
Michael Hewitt
Imperial College London
1000
1100
Poster Session 1
@ 1st Floor Exhibit Hall

Selected posters to be attended for 1 hour. Refer to program for posters attended during this period.

Scientific Session 2

Mozart 1-3

Metabolomics: Clinical Apps I
Chair: Oleg Mayboroda
2nd Chair: Chung-Ho Lau

Mozart 4-5

Proteomics: Metrological Traceability and Absolute Quantification
Chair: Christa Cobbaert

Papageno Hall

Practical Training: Traceable Clinical Measurement
Chair: Roland Geyer

Paracelsus Hall

Endocrinology: Serum Steroids
Chair: TBA

Trakl Hall

Clinical Glycomics I
Chair: Guinevere Lageveen-Kammeijer
2nd Chair: Gábor Tóth

Doppler Hall

Microbiology Keynote: Johan Malmström
Chair: TBA

1100
1120
Metabolomics Analysis of Blood Plasma for Early Diagnosis of Uterus Leiomyoma Recurrences
Vladimir Frankevich
Research Center for Obstetrics and Gynecology
Development of an Immunoprecipitation Method for the Analysis of Intact Parathyroid Hormone (PTH) and Related Forms by LC-MS/MS
Jordi Farré-Segura
University of Liège
Traceable Clinical Measurement
Chris Hopley
NML
The Harmoster Initiative: Preliminary Results on the Comparability of Circulating Steroid Measurement Among Ten European Laboratories Using LC-MS/MS
Flaminia Fanelli
University of Bologna
Comprehensive Glycopeptide Profiling in Blood Plasma for Clinical Applications
Melissa Baerenfaenger
Radboudumc
Large-Scale Inference of Protein Tissue Origin in Sepsis Plasma Using Quantitative Targeted Proteomics
Johan Malmström
Department of Clinical Sciences
1120
1140
Metabolomics Applied to Coronary Clinical Burden: Use of Mass Spectrometry to Re-Stratify Asymptomatic Subjects of Intermediate Cardiovascular Risk
Aline Martins
Universidad CEU San Pablo Madrid
Multiplexing Kidney Injury and Kidney Specific Biomarkers in Urine Using MS-based Bottom-Up Proteomics: A Robust and Feasible Approach
Tirsa van Duijl
Leiden University Medical Center (LUMC)
...
Extended Session
...
Multidimensional Diagnostics with Machine Learning for Primary Aldosteronism
Graeme Eisenhofer
Technische Universität Dresden
Ultrahigh Resolution MS Profiling of Plasma N-Glycans in Large Type 2 Diabetes Cohorts
Elham Memarian
Leiden University Medical Center
...
Keynote
...
1140
1200
Metabotyping Burn Injury Using UPLC-MS Coupled with Microdialysis
Elizabeth Want
Imperial College London
The Combined Use of Lys-C and Trypsin Provides Better Digestion Efficiency for MS-based Protein Quantitation
Fred Romijn
Leiden University Medical Center
...
Extended Session
...
An Ultrasensitive High-Throughput LCMS/MS-Method for Estradiol and Estrone in the Sub-Picomolar Range
Bjørn-Erik Bertelsen
Hormone Laboratory, Haukeland University Hospital
IgG and IgA Glycopeptide Characterization by LC-MS Reveals Associations with Inflammatory Bowel Disease Subtypes and Behavior
Noortje de Haan
Leiden University Medical Center
...
Keynote
...
1200
1330
Lunch
@ 1st Floor Exhibit Hall

Lunch to be provided in the Exhibit Hall. Get ready to join a Corporate Workshop after lunch.
1230
1315
Troubleshooting Poster Rounds : Part II
@ 1st Floor Exhibit Hall
No Troubleshooting Posters have yet been booked for this event.

1330
1415

Corporate Workshop(s)

Shimadzu
@ Mozart 4-5 (Track 2)

Workshop summary coming soon ...

Thermo Fisher Scientific
@ Papageno (Track 3)

Workshop summary coming soon ...

Waters
@ Paracelsus (Track 4)

Pre-Register

Mass Spectrometry advantages for Therapeutic Drug Monitoring: a closer look at teicoplanin

Guest Speaker: Brian Keevil, Professor at University Hospital Southern Manchester, UK

Agilent Technologies
@ Trakl (Track 5)

Workshop summary coming soon ...

1415
1430
Intermission
@ Entrance Foyer

Scientific Session 3

Mozart 1-3

Metabolomics: Clinical Apps II
Chair: Nicola Gray

Mozart 4-5

Proteomics Keynote: Kevin Mills
Chair: TBA

Papageno Hall

Breath Analysis Keynote: Patrik Španěl
Chair: Ilaria Belluomo

Paracelsus Hall

Small Molecules: From Vitamins, Drugs to Chemical Warfare
Chair: Michael Vogeser

Trakl Hall

Lipidomics in Cancer
Chair: Vladimir Frankevich
2nd Chair: Kenji Nakayama

Doppler Hall

MALDI for the Clinical Laboratory
Chair: David Herold

1430
1450
Assessing the Metabolome of Preterm Newborns: Findings from a Danish Population-based Study
Madeleine Ernst
Statens Serum Institut
The Development of Targeted Proteomic Assays, Attempting to Take Biomarkers from the Research Lab to the Clinic
Kevin Mills
University College London
Selected Ion Flow Drift Tube Mass Spectrometry SIFDT-MS for Real-Time Measurement of Trace Concentrations of Volatile Compounds in Breath and Culture Headspace
Patrik Španěl
J. Heyrovský Institute of Physical Chemistry
Development of an LC-MS/MS Assay for Biotin Quantitation to Support Research on Biotin Interference of Immunoassays
Antoinette IJpelaar
CWZ Hospital
MALDI-TOF/MS Analyses of Urinary Phospholipids and Lysophospholipids as Potential Diagnostic Biomarkers for Prostate Cancer
Xin Li
Kyoto University
Optimization of MALDI-based Techniques for the Rapid Diagnostics of Sepsis
Miriam Cordovana
A.O.U. Policlinico Sant'Orsola-Malpighi
1450
1510
Podocyturia Evaluation in Women with Preeclampsia and Fabry Disease Patients Using a Tandem Mass Spectrometry Approach
Christiane Auray-Blais
Université de Sherbrooke
...
Keynote
...
...
Keynote
...
LC-MS/MS for Peptide-Adduct Analysis to Verify Poisoning with Chemical Warfare Agents and Pesticides
Harald John
Bundeswehr Institute of Pharmacology & Toxicology
Can Rapid Evaporative Ionization Mass Spectrometry (REIMS), the Intelligent Surgical Knife (iKnife) Provide a Point-of-Care Diagnosis for Endometrial Cancer
Diana Marcus
Imperial College London
MALDI Chip Technology for in situ Detection of Human Procalcitonin
Petr Pompach
Institute of Microbiology
1510
1530
Exploratory Metabolomics of Urine and Plasma to Identify Novel Pharmacodynamic Biomarkers in a Phase I Clinical Trial of AZD3965
Alexandros Siskos
Imperial College London
...
Keynote
...
...
Keynote
...
Analysis of Fentanyl and Metabolite in Clinical and Post-Mortem Samples
Karen Scott
Arcadia University
Lipidomic Study of Cell Lines Reveals Differences between Breast Cancer Subtypes
Finnur Freyr Eiriksson
University of Iceland
Potential of TiO2 Nanoparticles for Mass Spectrometric Detection and Quantification of Biologically-Relevant Small Molecules
Marijana Petkovic
University of Madeira, CQM-Centre for Chemistry
1530
1630
Poster Session 2
@ 1st Floor Exhibit Hall
1530
1630
Meet-a-Mentor : Poster Tours
@ 1st Floor Exhibit Hall
1630

Distinguished Contribution Award Lecture


@ Mozart 1-5
Chair: Elizabeth Want

1630
1730

On the Award

15 years of Ambient Mass Spectrometry: From Amino Acid Clusters to Surgical Robotics
Zoltan Takats
Imperial College London

1730
1900
Exhibitor Reception
@ 1st Floor Exhibit Hall

Wine and Light Appetizers served in Exhibit Hall.
1800
1900
Meet-a-Mentor : Office Hours Forum
@ 1st Floor Cafe

Have a question from the congress that you have been itching to ask? Or a problem from work that you want to get feedback on? Or feedback on the congress? Sign up at the registration desk for 15-min blocks to share time and ideas with domain experts in a relaxed setting.
1900
Enjoy the City
@ Your Choice

Plan to join a few colleagues for dinner in Salzburg tonight.

Thursday

800
830
Welcome Coffee
@ Entrance Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.

Scientific Session 4

Mozart 1-3

Metabolomics: Clinical Applications III
Chair: Christiane Auray-Blais (pending)
2nd Chair: Vitaliy Chagovets

Mozart 4-5

Proteomics: High Throughput Methodology
Chair: Éva Hunyadi-Gulyás (pending)

Papageno Hall

Practical Training
Chair: Michael Wright

Paracelsus Hall

Endocrinology Keynote: Karl Storbeck
Chair: Brian Keevil

Trakl Hall

Clinical Glycomics II
Chair: Valeriia Kuzyk

Doppler Hall

Data Science
Chair: TBA

830
850
The Use of Rapid Evaporative Ionisation Mass Spectrometry (REIMS) as a Real-Time Bedside Test in Cervical Cancer Screening
Maria Paraskevaidi
Imperial College London
Maximize the Output of Routine Proteome Analyses by Using Micro Pillar Array Column Technology
Christof Mitterer
PharmaFluidics NV
Multi-Analyte Methods: A Free Lunch or a Frightening Bill?
Coral Munday
LGC Ltd
Rethinking Sex Steroids: Understanding the Clinical Relevance of 11-Oxygenated Androgens
Karl Storbeck
Stellenbosch University
Successful Faecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection Associates with Decreased Complexity of the Serum N-Glycome
Maja Pučić Baković
Genos Glycoscience Research Laboratory
A Chromatogram Says a Thousand Numbers: Data, Decisions, and Directions
William Slade
Laboratory Corporation of America Holdings
850
910
Clinically Relevant Metabolites of the Human Gut Microbiota
Zdenek Spacil
Masaryk University
DirectMS1: A High-Throughput Analysis for Identification and Quantification of 1000 Proteins in 5 Minutes
Mark Ivanov
INEPCP FRCCP RAS
...
Extended Session
...
...
Keynote
...
Novel Glycopeptide Analysis Strategy for Prostate-Specific Antigen in Seminal Plasma of Infertile Men
Wei Wang
Leiden University Medical Center
Chemometric Strategies for Sensitive Regions of Interest Annotation in Complex Imaging Mass Spectrometry Data
Patrick Wehrli
University of Gothenburg
910
930
Exploring the Interactions between Dietary Polyphenols, the Gut Microbiome and Human Health
Nicola Gray
University of Reading, UK
Comparison of MRM- and DIA-based Protein Quantification Using a 500 Protein Blood Panel in Plasma Samples Demonstrates Linearity between Methods
Claudia Escher
Biognosys AG
...
Extended Session
...
...
Keynote
...
Colorectal Cancer Cell Lines Reveal Striking Isomeric Diversity of Human Cancer O-Glycome
Katarina Madunic
LUMC
TBA
930
1030
Poster Session 3
@ 1st Floor Exhibit Hall

Selected posters to be attended for 1 hour. Refer to program for posters attended during this period.
930
1030
Poster Contest Finalist Interviews
@ 1st Floor Exhibit Hall

Poster Contest Finalists to attend posters and meet with poster Judges. Judges may arrive in groups or individually.

Scientific Session 5

Mozart 1-3

Metabolomics: Data Analysis Workflows
Chair: Julien Boccard
2nd Chair: Víctor González Ruiz

Mozart 4-5

Proteomics: Pre-analytical Considerations for Patient and Specimen Preparation
Chair: Lars Rasmussen

Papageno Hall

Practical Training: Assessing the Quality and Robustness of LC-MS/MS assays
Chair: Laura Owen (pending)

Paracelsus Hall

Small Molecules: From Basic to Novel Approaches in TDM
Chair: Marine Letertre

Trakl Hall

Glycomics Keynote: Gordan Lauc
Chair: Manfred Wuhrer

Doppler Hall

Microbiology: Tandem MS-MS Proteomics and Clinical Diagnostics
Chair: TBA

1030
1050
Plasma Metabolomics Profiles Associated with Endothelial Health and Dysfunction and their Influence on Endothelial Metabolism
Óttar Rolfsson
University of Iceland
Precise Quantitative Serum LC-MS/MS Profiling: The Impact of Sample Preparation and Sample Source on Biomarker Discovery Studies
Oleksandr Boychenko
Thermo Fisher Scientific
Assessing the Quality and Robustness of LC-MS/MS Assays
James Hawley
Manchester University NHS Foundation Trust
Application of a Molecular Networking Approach for Therapeutic Drug Monitoring (TDM) and Toxicology
Emmanuel Bourgogne
Université de Paris, Faculté de Pharmacie, UMR8038
The Human Glycome Project - Exploring the New Frontier in Personalised Medicine
Gordan Lauc
University of Zagreb
Discovery of Species-Unique Peptides as Candidate Peptide Biomarkers for Respiratory Tract Pathogens Using Tandem Mass Spectrometry-based Proteotyping
Roger Karlsson
Sahlgrenska University Hospital
1050
1110
KIMBLE: A Versatile Visual NMR Metabolomics Workbench in KNIME
Aswin Verhoeven
Leiden University Medical Center
Proteomic Discovery and Validation of the Confounding Effect of Heparin Administration on the Analysis of Candidate Cardiovascular Biomarkers
Hans Christian Beck
Odense universitetshospital
...
Extended Session
...
Potential of MALDI MS for Detection of [Ru(η5-C5H5)(PPh3)2Cl] Metabolites in Patient Body Fluids – a Preliminary Study
Nádia Nunes
CQM, University of Madeira
...
Keynote
...
Quick Pathogen Identification and Antibiogram for the Clinics by MS/MS Proteotyping
Jean Armengaud
CEA
1110
1130
Computational Analysis of Mass Spectrometry Data for Standardised Diagnosis of Inborn Disorders of Steroidogenesis
Elizabeth Baranowski
IMSR, University of Birmingham
The Predictive Potential of Salivary Proteomics for Characterization of the Phases of Allogeneic Hematopoietic Stem Cell Transplants
Milena Souza
International Research Center, A.C.Camargo Cancer
...
Extended Session
...
Therapeutic Drug Monitoring of Clofazimine in Indian MDR-TB Patients
Prerna Chawla
P.D. HINDUJA HOSPITAL & MRC
...
Keynote
...
Robust Accurate Identification and Biomass Estimates of Microorganisms via Tandem Mass Spectrometry
Yu Yi-Kuo
National Center for Biotechnology Information
1030
1130
Exhibitor Feedback
@ 1st Floor Cafe

An opportunity for exhibiting vendors to provide feedback on what worked and what could use improvement.
1130
1315
Lunch
@ 1st Floor Exhibit Hall
1200
1300
Poster Session 4
@ 1st Floor Exhibit Hall

Selected posters to be attended for 1 hour. Refer to program for posters attended during this period.
1200
1300
Meet-a-Mentor : Poster Tours
@ 1st Floor Exhibit Hall
1300
1315
Remove Posters
@ 1st Floor Exhibit Hall
1315
EXHIBITS CLOSED
@ 1st Floor Exhibit Hall

Scientific Session 6

Mozart 1-3

Metabolomics of Model Systems
Chair: Petra Paizs

Mozart 4-5

Proteomics Keynote: Theo Luider
Chair: Christa Cobbaert

Papageno Hall

Practical Training: Calibration and Metrology for Protein MS tests
Chair: Michael Wright

Paracelsus Hall

Endocrinology: Miscellaneous
Chair: TBA

Trakl Hall

MS Imaging: Method Development
Chair: Isabelle Fournier

Doppler Hall

Breath Analysis and VOC: New Technology
Chair: Patrik Spanel

1315
1335
LC- and CE-MS-based Workflow for Metabolic Read-Across of New Toxicants in Neuroinflammation
Víctor González-Ruiz
University of Geneva
Antibody Sequencing and Quantitation
Theo Marten Luider
Erasmus MC
Calibration and Metrology for Protein MS Tests
L.Renee Ruhaak
Leiden University Medical Center
Validation of a Rapid LC-MS/MS Method with Simple Solid Phase Extraction for Analysis of Catecholamines and their Metabolites in Plasma
Songlin Yu
Peking Union Medical College Hospital
Imaging Spatial Abeta Plaque Aggregation Dynamics in Evolving AD Pathology Using iSILK
Wojciech Michno
Sahlgrenka Academy at the University of Gothenburg
Real-Time Therapeutic Monitoring of Valproic Acid in Exhaled Breath
Kapil Dev Singh
University of Basel
1335
1355
Metabolomics analysis of human atherosclerotic plaques reveals a pathway of foam cell apoptosis in advanced atherosclerosis.
Panagiotis Vorkas
Imperial College London
...
Keynote
...
...
Extended Session
...
A Novel LC-MS/MS Method for the Quantification of Five Androgens in Saliva
Malcolm McTaggart
Manchester University NHS Foundation Trust
High-Throughput Automated Tissue Imaging by DESI-MS, Three-Dimensional Tissue Imaging or Large Sample Cohort Mapping
Emrys Jones
Waters Corporation
Determination of Aldehydes, Ketones, Short Chain Fatty Acids and Alkanes in Breath and Biofluids with GcxGC-TOF-MS-FID
Antonis Myridakis
Imperial College London
1355
1415
Nontargeted Metabolite Profiling of Human Lung Epithelial Cells (A549) with HILIC Mode UPLC HRMS: Silica Nanoparticle Mediated Cytotoxicity Effects
Kalyan Paila
Pemiscot Memorial Hospital
...
Keynote
...
...
Extended Session
...
C-20 Hydrogenation is Involved in Intrauterine Cortisol Homeostasis Offering an Additional Sex-Driven Protection to Prenatal Stress. Implications in Birthweight
Alex Gomez
Fundació Institut Mar d'Investigacions Mèdiques
Strategy for the Prediction of Neoadjuvant Therapy Response in Breast Cancer by MALDI-MSI
Tiffany Porta
M4I institute, Maastricht University
Deep Urinary Volatile Organic Compound Profiling with Headspace Sorptive Extraction and GCxGC-MS for Oesophago-Gastric Cancer Detection
Qing Wen
Imperial College London
1415
1430
Intermission
@ Entrance Foyer

Scientific Session 7

Mozart 1-3

Exploratory Metabolomics
Chair: Zdenek Spacil

Mozart 4-5

Proteomics: Emerging Clinical Applications
Chair: Renee Ruhaak
2nd Chair: Tirsa van Duijl

Papageno Hall

Practical Training: Biomarker Discovery and Translational Research
Chair: Laura Owen

Paracelsus Hall

Small Molecule Keynote: Folker Spitzenberger
Chair: TBA

Trakl Hall

MS Imaging: Clinical Diagnostics
Chair: Kristina Schwamborn (pending)

Doppler Hall

Microbiology: Novel MS Clinical Applications
Chair: TBA

1430
1450
Untargeted Steroidomics for the Identification of Novel Steroid Profiles in Dysregulated Steroidogenesis
Paal William Wallace
Technische Universität Dresden
The End of Kozak Dogma: The Ghost Proteome
Michel Salzet
Université Lille
Biomarker Discovery and Translational Research Leading to Clinical Utility: Experimental Approaches and Pitfalls
Christiane/Michel Auray-Blais/Boutin
Université de Sherbrooke
Impact of the New European IVD Regulation on Medical Laboratories - Opportunities and Challenges
Folker Spitzenberger
University of Applied Sciences Luebeck
High-Throughput Analysis on FFPE Breast Cancer TMAs with DESI-MSI
Olof Gerdur Isberg
University of Iceland
MBT FAST – Rapid Antimicrobial Susceptibility Testing by MALDI-TOF MS
Markus Kostrzewa
Bruker Daltonik GmbH
1450
1510
Untargeted Metabolomic Profiles of Newborns that Will or Will Not Develop Autism: A Pilot Study on Dried Blood Spots
Julie Courraud
Statens Serum Institut
Shortgun Proteomics for Differential Diagnosis of HPV-associated Cervix Transformation
Natalia Starodubtseva
National Medical Research Center of Obstetrics
...
Extended Session
...
...
Keynote
...
Laser Desorption Imaging – Rapid Evaporative Ionisation Mass Spectrometry Platform for Tissue Imaging
Daniel Simon
Imperial College London
Detection of Vancomycin-Resistant Enterococcus faecium Using MALDI-TOF Mass Spectrometry
Belén Rodríguez-Sanchez
Hospital General Universitario Gregorio Marañón
1510
1530
Exploring the Volatomic Fingerprinting of Breast Cancer Tissue as an Untargeted Approach to Identify Potential Biomarkers
Rosa Perestrelo
Centro de Química da Madeira, UMa
Multiplex Assay for Absolute Quantification of Inflammatory Proteins in 134 Meconium and First Stool Swabs from CELSPAC-TNG Birth Cohort Study
Eliška Stuchlíková
Masaryk University
...
Extended Session
...
...
Keynote
...
Towards In vivo Molecular Diagnostics of Esogastric Cancer with Spidermass Real-Time, Mini Invasive Analysis
Nina Ogrinc
University of Lille, PRISM laboratory
Development of Laser Assisted Rapid Evaporative Ionization Mass Spectrometry (LA-REIMS) as a Platform for Clinical Microbiology: The Past and the Future
Simon Cameron
Queen's University Belfast
1530
1545
Intermission
@ Entrance Foyer

Scientific Session 8

Mozart 1-3

Metabolomics: Tackling Challenging Samples
Chair: Elizabeth Want

Mozart 4-5

MS Imaging Keynote: Frits Koning
Chair: TBA

Papageno Hall

Practical Training
Chair: Laura Owen

Paracelsus Hall

Lipidomics Keynote: Anna Nicolaou
Chair: Anne Bendt

Trakl Hall

TBA
Chair: TBA

Doppler Hall

TBA
Chair: TBA

1545
1605
Determination of D- and L-Lactic Acid in Urine by UPLC-MS with Electrospray Ionization Quantification
Juliane Fagotti
Imperial College London
Imaging the Unimaginable with Imaging Mass Cytometry
Frits Koning
LUMC
Design of Experiments (DoE) – Get it Right from the Beginning
Margrét Thorsteinsdottir
University of Iceland
Skin Lipidomics in the Diagnosis and Treatment of Cutaneous Inflammation
Anna Nicolaou
The University of Manchester
TBATBA
1605
1625
Optimising Laser Assisted - Rapid Evaporative Ionization - Mass Spectrometry Imaging (LA-REI-MSI) for the Spatially Resolved Analysis of Faecal Metabolites
Petra Paizs
Imperial College London
...
Keynote
...
...
Extended Session
...
...
Keynote
...
TBATBA
1625
1645
Steroidomics Profile Analysis by LCHR-MS in Human Seminal Fluid
Eulalia Olesti
University of Geneve
...
Keynote
...
...
Extended Session
...
...
Keynote
...
TBATBA
1645
1700
Plenary Reception
@ Entrance Foyer

Ground Floor Bar to serve, wine and other beverages for intermission while preparing for the poster awards.
1700
1715
Poster Award Presentation
@ Mozart 4-5
1715

Closing Plenary Lecture


@ Mozart 4-5

1715
1800
Donor-derived cell-free DNA as a biomarker in organ transplantation
Michael Oellerich
Institute for Clinical Pharmacology, University Medicine Göttingen, Germany

Molecular biomarkers have attracted special attention in solid organ transplantation because of unresolved problems that limit long-term outcome. There is a lack of reliable noninvasive markers. Immunosuppressive drug monitoring mainly indicates potential toxicity, but is a poor biomarker of graft damage. In kidney transplant patients, for example, an increase of plasma creatinine may be also be due to exsiccation, the use of ACE inhibitors, or immunosuppressive drug toxicity. By the time a rejection-related increase in plasma creatinine is evident, a significant degree of tissue damage has already occurred within the kidney. A further limitation of the current standard of care is that rejection episodes can only be confirmed by biopsies. Biomarkers are needed to achieve personalized immunosuppression to reduce premature graft loss. Against this background, a particularly promising new approach for the early detection of acute or chronic rejection or asymptomatic graft injury leading to irreversible damage is based on the determination of donor-derived circulating cell-free DNA (dd-cfDNA). Data on clinical validity have been documented in more than 48 independent studies which have shown that dd-cfDNA detects rejection episodes early, at an actionable stage, and is a more reliable marker of graft injury, compared to conventional tests. dd-cfDNA may also be useful to guide changes in immunosuppression, to monitor immunosuppression minimization (e.g. during tapering), and to prevent immune activation. The high negative predictive value of dd-cfDNA is the reason why this test can be helpful to avoid unnecessary biopsies. It could be shown that dd-cfDNA can be useful to detect subclinical (e.g. clinically unsuspected) graft damage as a result of immune activation triggered by under-immunosuppression. Early diagnosis of subclinical antibody-mediated rejection may improve outcomes after kidney transplantation. In summary, dd-cfDNA monitoring will allow more personalized treatment that shifts emphasis from reaction to prevention.

1800
1815
Final Remarks
@ Mozart 4-5
1815
1900
Closing Petite Reception
@ Entrance Foyer

Wine & Cheese, Beer & Nuts ... and maybe Kaiserschmarrn. Winning posters to be on display.
1900
2200
After Congress Meet-Up
@ Your Choice

Meet up at the Augustiner Braustubl (Historic Abby turned beer garden with food stalls) for an unofficial and unsponsored post-con gathering.
1900
CONGRESS CLOSED
@ Entrance Foyer

Friday

800
1000
SciCom Group Meeting
@ TBA

Private Meeting for Scientific Committee Topic Leads and Incoming Leads; Planning for next event.