= Emerging. More than 5 years before clinical availability. (10.58%)
= Expected to be clinically available in 1 to 4 years. (13.94%)
= Clinically available now. (24.52%)
Percent of submitters indicating Clinical Use Status: 49.04%

Mobile Tutorial



MSACL 2018 EU: Congress Program

Salzburg, Austria • September 9 - 13, 2018

With Thanks to Our Corporate Congress Sponsors:
Thermo   Shimadzu
Agilent   Chromsystems
And Special Thanks to Our Travel Grant Sponsors:
Thermo

Sunday

1100
1900
Badge Pickup
@ Entrance Foyer
1100
1400
Lunch on Own
@ Your Choice

Some nearby (within one block) recommendations include:
1. The Heart of Joy (Vegetarian and Vegan)
2. my Indigo Kongresshaus (Asian Fusion)
3. Cafe Fingerlos (Cafe with the best breakfast in town)
4. IMLAUER Sky (Rooftop patio with a view)
5. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily with Sunday Brunch buffet until 2pm)

A little further afield:
1. Cafe Sacher (for a patio on the river)
2. Barenwirt (Cozy and Traditional Austrian, fills up so arrive early)
3. Antichi Sapori (Tasty Italian food and pizza in casual family run style, Open 11:30-2:00pm and 5:30-9:00pm, Closed Wed and Thurs)

1400
1800

Short Course

COURSE START
Data Science 101
Breaking up with Excel: An Introduction to the R Statistical Programming Language
Daniel Holmes, MD & William Slade, PhD
Level: Beginner - Intermediate
@ Mozart 5
COURSE START
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Randall Julian, PhD
Level: Intermediate
@ Mozart 4
COURSE START
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD & Grace van der Gugten
Level: Beginner
@ Mozart 2
COURSE START
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD & Erik J. Soderblom, PhD
Level: Intermediate
@ Paracelsus Hall
COURSE START
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Brian Rappold
Level: Advanced
@ Papageno Hall
COURSE START
Metabolomics 202
Metabolomics: Approaches, Applications and Challenges
Julijana Ivanisevic, PhD & Elizabeth Want, PhD
Level: Beginner to Intermediate
@ Doppler Hall
COURSE START
Proteomics 201
Clinical Proteomics
Cory Bystrom, PhD & Chris Shuford, PhD
Level: Intermediate - Advanced
@ Trakl Hall
Every 0:50
for 10 min
Coffee Break
@ Entrance Foyer

1800
1830
Petite Reception
@ Entrance Foyer

A quick touch of wine and cheese before exploring the city for dinner.
1800
Dinner on Own
@ Your Choice

Dinner Suggestions:
1. Gablerbrau (Historic ambiance with traditional food)
2. Augustiner Braustubl (Historic Abby turned beer garden with food stalls)
3. Antichi Sapori (Tasty Italian food and pizza in casual family run style, open 11:30-2:00pm and 5:30-9:00pm, closed Wed and Thurs)
4. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily)

After dinner:
1. Murphys Law Irish Pub

1830
2100
SciCom Discussion Group
@ 1st Floor Cafe

Private Meeting for Scientific Committee members; includes dinner

Monday

800
900
Welcome Coffee
@ Entrance Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
900
1300

Short Course

Continued from Sunday
Data Science 101
Breaking up with Excel: An Introduction to the R Statistical Programming Language
Daniel Holmes, MD & William Slade, PhD
Level: Beginner - Intermediate
@ Mozart 5
Continued from Sunday
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Randall Julian, PhD
Level: Intermediate
@ Mozart 4
Continued from Sunday
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD & Grace van der Gugten
Level: Beginner
@ Mozart 2
Continued from Sunday
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD & Erik J. Soderblom, PhD
Level: Intermediate
@ Paracelsus Hall
Continued from Sunday
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Brian Rappold
Level: Advanced
@ Papageno Hall
Continued from Sunday
Metabolomics 202
Metabolomics: Approaches, Applications and Challenges
Julijana Ivanisevic, PhD & Elizabeth Want, PhD
Level: Beginner to Intermediate
@ Doppler Hall
Continued from Sunday
Proteomics 201
Clinical Proteomics
Cory Bystrom, PhD & Chris Shuford, PhD
Level: Intermediate - Advanced
@ Trakl Hall
1300
1400
Lunch
@ Entrance Foyer

Lunch provided for short course attendees.
1400
1800

Short Course

COURSE START
Lab Medicine 101
Basics of Laboratory Medicine
Prof. Dr. med. Michael Vogeser
Level: Beginner
@ Mozart 3
COURSE START
Proteomic Microbiology 201
Bottom-Up and Top-Down Proteomic Approaches for Bacterial Identification and Characterization, a Focus on MALDI-TOF and Advanced Technologies
Jean Armengaud, PhD, Stefan Zimmermann, MD
Level: Beginner - Intermediate
@ Trapp Zimmer
Continued from Monday AM
Data Science 101
Breaking up with Excel: An Introduction to the R Statistical Programming Language
Daniel Holmes, MD & William Slade, PhD
Level: Beginner - Intermediate
@ Mozart 5
Continued from Monday AM
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Randall Julian, PhD
Level: Intermediate
@ Mozart 4
Continued from Monday AM
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD & Grace van der Gugten
Level: Beginner
@ Mozart 2
Continued from Monday AM
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD & Erik J. Soderblom, PhD
Level: Intermediate
@ Paracelsus Hall
Continued from Monday AM
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Brian Rappold
Level: Advanced
@ Papageno Hall
Continued from Monday AM
Metabolomics 202
Metabolomics: Approaches, Applications and Challenges
Julijana Ivanisevic, PhD & Elizabeth Want, PhD
Level: Beginner to Intermediate
@ Doppler Hall
Continued from Monday AM
Proteomics 201
Clinical Proteomics
Cory Bystrom, PhD & Chris Shuford, PhD
Level: Intermediate - Advanced
@ Trakl Hall
1800
1830
Petite Reception
@ Entrance Foyer

A quick touch of wine and cheese before exploring the city for dinner.
1800
Dinner on Own
@ Your Choice

Dinner suggestions:
1. Zum fidelen Affen (best patio dinner on a nice evening, closed Sunday)
2. Die Wiesse (Brewery Pub with beer garden open till 2am Mon-Sat)
3. Gablerbrau (Historic ambiance with traditional food)
4. Augustiner Braustubl (Historic Abby turned beer garden with food stalls)
5. Antichi Sapori (Tasty Italian food and pizza in casual family run style, open 5:30-9:00pm, closed Wed and Thurs)
6. Cafe Wernbacher (Austrian, great interior for a rainy day with much of the original 1950s decor, open 9am-midnight daily)

After dinner:
1. Murphys Law Irish Pub

Tuesday

800
1600
Place Posters
@ 1st Floor Exhibit Hall

ALL posters should be placed by 16:00.
800
900
Welcome Coffee
@ Entrance Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
900
1230

Short Course

Continued from Monday PM
Lab Medicine 101
Basics of Laboratory Medicine
Prof. Dr. med. Michael Vogeser
Level: Beginner
@ Mozart 3
Continued from Monday PM
Proteomic Microbiology 201
Bottom-Up and Top-Down Proteomic Approaches for Bacterial Identification and Characterization, a Focus on MALDI-TOF and Advanced Technologies
Jean Armengaud, PhD, Stefan Zimmermann, MD
Level: Beginner - Intermediate
@ Trapp Zimmer
Continued from Monday PM
Data Science 101
Breaking up with Excel: An Introduction to the R Statistical Programming Language
Daniel Holmes, MD & William Slade, PhD
Level: Beginner - Intermediate
@ Mozart 5
Continued from Monday PM
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Randall Julian, PhD
Level: Intermediate
@ Mozart 4
Continued from Monday PM
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD & Grace van der Gugten
Level: Beginner
@ Mozart 2
Continued from Monday PM
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD & Erik J. Soderblom, PhD
Level: Intermediate
@ Paracelsus Hall
Continued from Monday PM
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Brian Rappold
Level: Advanced
@ Papageno Hall
Continued from Monday PM
Metabolomics 202
Metabolomics: Approaches, Applications and Challenges
Julijana Ivanisevic, PhD & Elizabeth Want, PhD
Level: Beginner to Intermediate
@ Doppler Hall
Continued from Monday PM
Proteomics 201
Clinical Proteomics
Cory Bystrom, PhD & Chris Shuford, PhD
Level: Intermediate - Advanced
@ Trakl Hall
1230
CONGRESS OPEN
@ Europa Hall
1230
1400
Opening Lunch
@ Europa Hall
1330
1345
Welcome, Introduction & Orientation
@ Europa Hall
1345
1400
CMS Journal Overview
@ Europa Hall

An overview on the current state of the journal, how to subscribe, the path to an Impact Factor, citations, scope, desired article format, webinars.
1400

Opening Plenary Lecture


@ Europa Hall
Chair: Oleg Mayboroda

1400
1445
Metabolomics Messages on Human Health and Disease
Jurek Adamski
Helmholtz Zentrum München

The human metabolome represents functional read out of processes in health and disease. The metabolome is both stable and highly dynamic. Stable components are determined by genetics, genomic imprinting or physiological homeostasis. The dynamics originates from circadian rhythm, hormonal status, nutrition, environmental exposure, ageing, medication or disease. Despite its interlaced origin metabolome specifically reflects distinct processes. Metabolomics studies request therefore a special study design. Unique metabolomics signatures have been identified pre-disease (like type 2 diabetes), in disease progression (chronic kidney disease) or in companion diagnostics (drug action monitoring). Metabolomics informed diagnostics has great potential for selectivity, specificity and multiplexing of indications to be screened for.

1445
1500
Coffee Break
@ Europa Foyer
1500
1600

State of the Science Address
@ Europa Hall

Presented by MSACL EU Scientific Committee Topic Leads, this address will provide an overview of the applications and technologies currently being used in Clinical Labs, and a clear view of the development pipeline. It will highlight applications expected to be available in the near-future, as well as emerging applications, and key contributors. Relevant talks, posters, and people present at the congress will be identified, enabling you to optimize your learning path and more effectively target potential network connections. Whether you are new to Clinical Mass Spectrometry, or a seasoned veteran, the State of the Science address should be on your agenda.

Brian Keevil (Endocrinology)
Manfred Wuhrer (Glycomics)
Oleg Mayboroda (Metabolomics)
Jean Armengaud (Microbiology)
Christa Cobbaert (Proteomics)
Michael Vogeser (Small Molecules)
Tiffany Porta (Tissue Imaging)

1600
1630
Coffee Break
@ Europa Foyer
1630
1700
Poster Lightning Talks
@ Europa Hall

15-20 poster presenters will be selected to present their pitch from the plenary podium within 90 seconds and with 1 slide (PDF format).
1700
1730
Exhibitor Lightning Talks
@ Europa Hall

15-20 exhibitors will be selected to present their pitch from the plenary podium within 90 seconds and with 1 slide (PDF format).
1730
EXHIBITS OPEN
@ 1st Floor Exhibit Hall
1730
2000
Exhibitor Reception
@ 1st Floor Exhibit Hall

Buffet dinner served.
1800
1900
MEET-THE-EXPERTS : Booth Tours
@ 1st Floor Exhibit Hall

Join an expert as they tour the booths and learn more about technologies available, what experts are looking for during the exchange, and how they interact with the booth vendors. Increase your network and your knowledge of products and services available.
1900
2000
Troubleshooting Poster Rounds : Part I
@ 1st Floor Exhibit Hall

19:00 at poster #25a
What Happened to My Topiramate?
Magdalena Rajska
SPADIA Lab, a.s.
19:15 at poster #25b
Optimizing Chromatographic Conditions for HILIC Analysis of Catecholamines
Gareth Hammond
Waters Corporation
19:30 at poster #25c
An Alternative Solution to High Blank Problems
Anne Schmedes
Department of Clinical Biochemistry
2000
2200

Discussion Group

Strengths, Weaknesses, Opportunities and Threats (SWOT) : The Road to Comprehensive MS Implementation in the Clinic
@ Mozart 4-5 (Track 2)

Chair(s): Daniel Holmes

Panelists:
Michael Vogeser, University Hospital, LMU Munich,
Elizabeth Want, Imperial College London,
Robert DeWitte, Thermo Scientific,
Christa Cobbaert, Leiden University Medical Center

The process of bringing mass spectrometry from esoteric research niche to high throughput clinical analyzer is more complex and nuanced than it initially appeared. Superior analytical technology is not all that is necessary to successfully cross the chasm from early adopters to early majority. A recent editorial by Zhang and Vogeser, in Clinical Mass Spectrometry, provides an overview of the current landscape by highlighting the strengths, weaknesses, opportunities and threats that support and temper the path towards wide-spread implementation.

This discussion group is intended to bring this reality under a brighter light to increase awareness and, thereby, stimulate discussion, collaboration and strategizing.

2200
Enjoy the City
@ Your Choice

or get a good night's sleep

Wednesday

745
900
Welcome Coffee
@ Entrance Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
800
845

Corporate Workshop(s)

Thermo Scientific
@ Papageno (Track 3)

Pre-Register

Targeted Screening and Semi-Quantitation of Drugs in Plasma using High-Resolution Accurate-Mass Detection and Online Sample Preparation

Sensitive and selective analytical methods are required in clinical research and forensic toxicology to properly identify a broad range of analytes in complex matrices. The existing methods need to be constantly updated as new compounds, such as designer drugs, become readily available to the illicit drug market. Liquid chromatography coupled to mass spectrometry (LC-MS) has been widely used in this area for years. So far, the preferred detection technology has been triple quadrupole MS for its selectivity in selected reaction monitoring (SRM) mode. However, this approach suffers from the limitation of being able to perform only targeted analysis, while not being useful for unknown screening of new drugs.

Come to our educational seminar to learn more.

For Research Use Only. Not for use in diagnostic procedures.

SCIEX
@ Paracelsus (Track 4)

Pre-Register

A Clinical Method for Determination of Anti-Infectious Drugs in Serum
Anders Blomgren
Associate professor at Division of Clinical Chemistry and Pharmacology, Lund University

The initiative for this work was taken by physicians from four different disciplines; intensive care, clinics for infection, thorax and transplantation. There has been an unmet need for these types of analysis and especially with short response times. A TDM wish list was produced that containing about 25 different anti-infection drugs and we agreed on starting to develop methods for 7 of them as a first step.
During this talk the following will be presented.
• Introduction
• Analytes – chemistry/properties/stability
• LC, MS and Sample prep development and problem solving
• Validation with results
• Conclusion and future

845
900
Intermission
@ Entrance Foyer

Scientific Session 1

Track 1
Mozart 1-3
Lipidomics
Chair: Julijana Ivanisevic
Track 2
Mozart 4-5
Disease Implications and Diagnosis
Chair: Grace van der Gugten
Track 3
Papageno
Proteomics Keynote
Chair: Christa Cobbaert
Track 4
Paracelsus
New Technologies
Chair: Vladimir Frankevich
Track 5
Trakl
Endocrinology
Chair: Flaminia Fanelli
Track 6
Doppler
Practical Training : Proteomic Assay Development
Chair: Tim Collier
900
920
Defining Boundaries of Lipidomic Variations in Human Cohorts
Federico Torta
National University of Singapore
Simultaneous and Automated LC-MS Analysis of Plasma Methylmalonic Acid and Short Chain Fatty Acids Using a Carbodiimide-based Derivatization
Mark Pratt
University Medical Center Groningen
Clinical Proteomics: The Path Towards Implementation
Harald Mischak
mosaiques therapeutics GmbH & University of Glasgow
Probing Amyloid Aggregation Dynamics in vivo, Using SILK Imaging (iSILK)
Jörg Hanrieder
University of Gothenburg
Evaluation of Age and Metabolic Status Impact on Serum Steroid Hormones and Product/Precursor Ratios for the Generation of LC-MS/MS Reference Interval in Men
Marco Mezzullo
University of Bologna
Proteomic Assay Development: Digest Optimization and Quality Control
Timothy Collier
Quest Diagnostics - Cleveland HeartLab
920
940
Shotgun Lipidomics of Cerebrospinal Fluid in Neurological Disorders
Gábor Balogh
Biological Research Centre, Hungarian Academy of Sciences
Mitochondrial Proteins as Parkinson’s Disease Circulatory Biomarkers – a Translational Study
Sandra Anjo
University of Coimbra (CNC-UC)

Replacing A. Gaudl. Different Abstract.

...
Keynote
...
Identifying Biomarkers in FFPE Breast TMAs Using DESI-MSI
Ólöf Gerdur Ísberg
University of Iceland
Quantification of Testosterone, Androstenedione and 17-Hydroxyprogesterone Collected Using Mitra Micro Sampling Devices
David Marshall
Manchester University NHS Foundation Trust
...
Extended Session
...
940
1000
Understanding the Interplay Between Inflammatory Lipid Signaling and Demyelination Process: A Lipidomics Approach Applied to 3D Human Brain Model
Maria Laura Santoru
University of Cagliari / University of Lausanne
The Singapore Lipidomics Incubator: A Model for Engagement and Translation
Anne Bendt
National University of Singapore
...
Keynote
...
MALDI Imaging Through Laser-Induced Post-Ionization Pushes the Boundaries of Pharmaceutical Development Studies
Florian Barré
M4I, Maastricht University
Direct Analysis - No Sample Preparation - of Bioavailable Cortisol in Human Plasma by Weak Affinity Chromatography (WAC; Affinity LC/MS)
Sten Ohlson
Nanyang Technological University
...
Extended Session
...
1000
1100
Poster Session 1
@ 1st Floor Exhibit Hall

Selected posters to be attended for 1 hour. Refer to program for posters attended during this period.
1000
1100
MEET-THE-EXPERTS : Poster Tours
@ 1st Floor Exhibit Hall

Scientific Session 2

Track 1
Mozart 1-3
Metabolomics Methodology
Chair: Elizabeth Want
Track 2
Mozart 4-5
All About Breath Analysis
Chair: Neus Fabregat-Cabello
Track 3
Papageno
Endocrine Keynote
Chair: Brian Keevil
Track 4
Paracelsus
Glycomics 1
Chair: Guinevere Lageveen-Kammeijer
Track 5
Trakl
MS/MS for Proteotyping Pathogens
Chair: Simon Cameron
Track 6
Doppler
Practical Training : Calibrators and Internal Standards for Protein MS
Chair: Chris Shuford
1100
1120
New Insights in CE-MS-based Metabolomics
Nicolas Drouin
University of Geneva
Mass Spectrometry Applied to Large-Scale Multi-Centre Clinical Project in Breath Research
Ilaria Belluomo
Imperial College London
Mass Spectrometry Harmonisation: Paediatric Steroid Tales
Ronda Greaves
Murdoch Children's Research Institute
Global Glycoproteomic Analysis of O-glycosylation in Human Herpesviruses
Ieva Bagdonaite
University of Copenhagen
Phylopeptidomics: A Step Closer to Adopting the Microbiome Data into Clinical Practice
Lucia Grenga
CEA
Calibrators and Internal Standards in Protein Mass Spectrometry Assays: Differences, Commonalities, and Best-Practice
Christopher Shuford
Laboratory Corporation of America
View Slides (PDF)

1120
1140
Combined Targeted and Untargeted Strategy for Quantification of Amino Acids and Acylcarnitines in Clinically Relevant Biofluids and Tissue Lysates
Vera van der Velpen
Metabolomics Unit, University of Lausanne
Cross Platform Validation of Mass Spectrometry for the Diagnosis of Colorectal Cancer Using a Breath Test
Georgia Woodfield
Imperial College London
...
Keynote
...
In Depth O-Glycosylation Structural Analysis of Colorectal Cancer Cell Lines
Katarina Madunic
Leiden University Medical Center
Characterization of the Virulome of Staphylococcus Aureus by a Highly Multiplex Approach with Scout-MRM
Mouton Nicolas
University de Lyon Claude Bernard
...
Extended Session
...
1140
1200
Development of a Pipeline for Automated Reconstruction and Annotation of Data Independent Acquisition LC-MS Datasets
Gonçalo Graça
Imperial College London
A Pilot Study Profiling Volatile Organic Compounds (VOCs) in the Breath of Patients with CRC Using Proton Transfer Mass Spectrometry
Harrypal Panesar
Imperial College London
...
Keynote
...
HT UPLC Profiling of Total Plasma N-Glycans in Type II Diabetes Mellitus from Patients and Healthy Individuals in a Ghanaian Population
Elham Memarian
Leiden University medical centre
Deciphering MALDI-TOF Identification of Bacteria Using a Proteogenomic Approach
Frédéric Jauffrit
Université de Lyon
...
Extended Session
...
1200
1330
Lunch
@ 1st Floor Exhibit Hall

Lunch to be provided in the Exhibit Hall. Get ready to join a Corporate Workshop after lunch.
1230
1330
Troubleshooting Poster Rounds : Part II
@ 1st Floor Exhibit Hall

12:30 at poster #26a
Metformin Interference in LC-MS/MS Analysis of Plasma Methoxycatecholamines
Marianne Bergmann
Lillebaelt Hospital, Vejle
12:45 at poster #26b
Charge Wars of Ion Suppression - Awakening the Force for the Analysis of Estrogens in Clinical Research
Robert Wardle
Waters Corporation
13:00 at poster #26c
Cortisol Everywhere!
Neus Fabregat-Cabello
University of Ličge, CHU de Ličge
13:15 at poster #26d
Deuterium or 13C-labeled internal standards for quantification of methylmalonic acid in serum?
Morten Trelle
Department of Clinical Biochemistry, OUH Svendborg
1330
1415

Corporate Workshop(s)

Shimadzu
@ Mozart 1-3 (Track 1)

Pre-Register

Better Ways of Working in Routine Clinical Pathology Laboratories

Healthcare is dynamic and knows no bounds and so routine clinical pathology laboratories face increasing pressures on cost, time and delivering actionable data.

At Shimadzu, we believe there’s always a way to make life better. This seminar explores a few options to make a difference.

1) Neil LOFTUS - SHIMADZU Corporation, UK
Expanding the capability of mass spectrometry in routine clinical pathology – creating better ways of delivering actionable data.

2) Andrea Radeljak, Matea Ivić – KB Merkur, Croatia
Automating standardized workflows in the clinical laboratory – using the Shimadzu CLAM-2000 integrated with LC-MS/MS to help increase sample throughput and make it easier for users.

3) Sigrid BAUMGARTEN - Alsachim SAS, France
From core expertise of Stable Isotope Labelled Compounds to reagent kits for high quality LCMS data

Disclaimer: For Research Use Only. Not for use in diagnostic procedures. Not available in the USA, Canada and China.

Thermo Scientific
@ Mozart 4-5 (Track 2)

Pre-Register

Fully Automated LC-MS – Theory becomes Reality

The use of LC-MS in diagnostic pathology has been limited by the complexity of equipment, materials and skills required to establish a fully validated service. A review showed only 19% of respondents were running VitaminD using LC-MS. On the basis that this is the gold standard, a fully validated and simple-to-use mass spectrometer has been a long awaited development. This presentation shares the first practical experience of using the Thermo Scientific™ Cascadion™ SM Clinical Analyser, in a laboratory, where staff have no prior experience of using LC-MS technology.

Automated LC-MS/MS: A disruptive technology will improve the quality of care for our patients
The LC-MS/MS platform provides solutions to complex analytical problems for clinical routine laboratories. This development started decades ago and the technology has proven to deliver reliable results with unreached specificity in TDM, DoA testing, endocrine diagnostics and newborn screening. In this presentation the concept of a fully integrated and automated LC-MS/MS is described. Special focus is on features of the Thermo Scientific™ Cascadion™ SM Clinical Analyzer that can overcome the limitations of open systems.

Product IVD/CE-marked. Product not 510(k) cleared and not yet available for sale in the US.

Agilent Technologies
@ Paracelsus (Track 4)

Pre-Register

Developing and Delivering Advanced Protein Biomarker Tests for an Era of Precision Medicine
Speaker: Prof. Stephen R Pennington, Senior Fellow UCD Conway Institute, University College Dublin, Ireland

This presentation will address the key issues around the development of protein signatures in areas of significant unmet clinical need and potential strategies for the delivery and implementation of multiplexed protein biomarkers in a diagnostic setting.

View abstract

For Research Use Only. Not for use in diagnostic procedures.

Waters
@ Trakl (Track 5)

Pre-Register

Determination of Steroid Hormones in biological matrices by Tandem Mass Spectrometry

The determination of steroid hormones in biological matrices requires high analytical sensitivity and is particularly challenging due to analytical interferences from structurally related steroid hormones and synthetic derivatives. LC-MS/MS can provide the analytical sensitivity, selectivity and precision required to enable accurate quantification of organic compounds in human biological liquid matrices.

As a leading clinical LC-MS/MS solutions partner, Waters is a trusted provider of in vitro diagnostic medical devices, consumables, informatics, and support services for high performance LC-MS/MS systems.

Join us at this workshop to gain insights into how our customers have addressed the challenging analysis of steroid hormones by implementing Waters solutions.

LC-MS/MS Analysis of Steroids in the Clinical Laboratory
Dr. Brian Keevil, University Hospital of South Manchester , Biochemistry Department

Download Dr. Keevil’s abstract

For Research Use Only. Not for use in diagnostic procedures.

Learn more on Waters Solutions for LC/MS Analysis

1415
1430
Intermission
@ Entrance Foyer

Scientific Session 3

Track 1
Mozart 1-3
Metabolic Markers
Chair: Luke Whiley
Track 2
Mozart 4-5
Small Molecule Keynote
Chair: Michael Vogeser
Track 3
Papageno
Cardiovascular and Thrombotic Disease
Chair: Tim Collier
Track 4
Paracelsus
Tissue Imaging Keynote
Chair: Tiffany Porta Siegel
Track 5
Trakl
Glycomics 2
Chair: TBA
Track 6
Doppler
Practical Training : EU Regulations
Chair: Brian Keevil
1430
1450
Discovery of Novel Galabiosylceramide-Related Biomarkers of Fabry Disease by Semi-Targeted Metabolomics: the Complex Issue of Structural Isomer Interferences
Michel Boutin
Université de Sherbrooke
Tackling Analytical Challenges in Sports Drug Testing by Mass Spectrometric Approaches
Mario Thevis
German Sport University, Cologne, Germany
European Monitoring Center for Emerging Doping Agents (EuMoCEDA), Cologne/Bonn, Germany
Building Standards for Proteomics: A Targeted Mass Spectrometry Approach for Quantification of Cardiovascular Disease Biomarker in Human Blood
Albert Sickmann
ISAS
Combining Mass Spectrometry Imaging & Microproteomics to Investigate Intratumor Heterogeneity
Liam McDonnell
Fondazione Pisana per la Scienza ONLUS, Pisa, Italy
In-Depth Characterisation of Heavily Glycosylated Proteins and Their Potential as Colorectal Cancer Biomarkers
Valeriia Kuzyk
Vrije Universiteit Amsterdam
EU LC-MS Verification
Brian Keevil
Manchester University
1450
1510
Identifying the Metabolic “Achilles Heel” of Adult and Childhood Brain Cancers Using LC-MS-based Metabolite Profiling
Dong-Hyun Kim
University of Nottingham
...
Keynote
...
Validation of ApolipoProtein A-I Associated Lipoprotein Panel for the Prediction of Cholesterol Efflux Capacity
Cory Bystrom
Cleveland HeartLab
...
Keynote
...
Development of MS-based Prostate-Specific Antigen Test with In-Depth Glycosylation Analysis
Guinevere S.M. Lageveen-Kammeijer
Center for Proteomics and Metabolomics, LUMC

Switched with A Moran

...
Extended Session
...
1510
1530
Urinary Biomarkers of Dietary Intake - Quantification of Sugars for Epidemiology Studies Using LC-MS/MS
Nicola Gray
University of Reading
...
Keynote
...
Defining the Measurands for Antithrombin and its Proteoforms Using Mass Spectrometry Based Techniques
Renee Ruhaak
Leiden University Medical Center
...
Keynote
...
Characterisation of Prostate-Specific Antigen Isolated from Patients’ Urine
Alan Moran
Leiden University Medical Centre

Switched with G Lageveen-Kammeijer

...
Extended Session
...
1530
1630
Poster Session 2
@ 1st Floor Exhibit Hall
1530
1630
MEET-THE-EXPERTS : Poster Tours
@ 1st Floor Exhibit Hall
1630

Distinguished Contribution Award Lecture


@ Mozart 1-5
Chair: Elizabeth Want & Brian Keevil

1630
1730

On the Award

Mass Spectrometry and the Elucidation of Steroid Metabolome
Cedric Shackleton
UCSF Benioff Children’s Hospital Oakland Research Institute, Oakland, California, and Institute of Metabolism and Systems Research (IMSR), College of Medical and Dental Sciences, University of Birmingham, UK

Sterols and steroids were among the first biomolecule groups to be studied by mass-spectrometry. The early success of GC separation in 1960 by Sweeley and Horning and the combination of GC and MS by Ragner Ryhage in Stockholm with invention of a technique for separating the bulk of carrier gas from analytes prior to ionization were fundamental. This led in the mid-60s to the first commercial dedicated GC/MS instrument, the LKB 9000. Professor Jan Sjövall (a colleague of Dr Ryhage) in particular spearheaded studies of sterols and steroids leading to multiple publications of mass spectra, and steroid quantification of serum, urinary and biliary steroids. Developments in derivatization, capillary columns and computerization were all important constituents of these developments. This presenter (a student of Sjövall) was early involved in the clinical diagnostic use of GC/MS in the 1970s and has been involved in studying urinary steroids and defining new disorders through metabolic profiles ever since. Particle beam MS (eg. FAB) was introduced in the 80s and allowed for the first time analysis of underivatised steroids and steroid conjugates. Steroid LC/MS (Thermospray) arrived in 1987 but it was a decade later before ESI and LC/MS/MS made the use of MS in the routine steroid analytical lab a practicality. Now the technique has essentially replaced RIA in routine endocrinological applications. GC/MS is labour-intensive and was never really suited to individual serum hormone analysis but has always been powerful for profiling urinary steroid metabolites, which now forms a branch of the recently-termed metabolome discipline. Recently there has been a re-birth in urinary steroid analysis in diagnosis and several groups are working on transferring GC/MS methodologies to LC/MS/MS to avoid need of derivatization and shorten chromatography times. This is a challenge because many of the “metabolite-type” steroids have weak ESI ionization and poor CID sensitivity. Two steroid groups are particularly suited to LC/MS/MS and those are the steroid sulfates and glucuronides since they have an existing ionic center. Analysis of intact conjugates avoids the labour-intensive enzyme hydrolysis, and we a pursuing their analysis. A drawback here is the paucity of authentic reference materials. A huge challenge in steroid metabolomics is the presentation of diagnostic data in a form friendly to researchers and clinicians. Many recent publications have addressed this issue, including use of heat-maps and machine learning for metabolome diagnostic interpretation.

1730
1930
Exhibitor Reception
@ 1st Floor Exhibit Hall

Buffet dinner, appetizers and drinks to be provided. Enjoy mingling with colleagues and Exhibitors. Take time to browse the posters.
1830
1930
MEET-THE-EXPERTS : Office Hours Forum
@ 1st Floor Cafe

Have a question from the congress that you have been itching to ask? Or a problem from work that you want to get feedback on? Or feedback on the congress? Sign up at the registration desk for 15-min blocks to share time and ideas with domain experts in a relaxed setting.
1930
2030

Discussion Group

Development of LC-MS Certification Programs
@ Mozart 4-5 (Track 2)

Chair(s): Judy Stone

Panelists:
Fumio Nomura, Chima University Hospital
Ronda Greaves, Murdoch Children's Research Institute
Michael Vogeser, University Hospital, LMU Munich
Daniel Holmes, St Paul's, Vancouver, Canada
Joshua Hayden, Weill Cornell Medicine

One major barrier to implementation of mass spectrometry (MS) in diagnostic laboratories is the lack of staff trained for use of the technique in a production setting. A variety of training options exist, but for most laboratories the assumption is that staff will have to be trained onsite. We queried the MSACL community about clinical MS training options and present a summary of the responses here. This discussion session will explore the question of certification (why, who, how) as an aid (or perhaps a barrier) to increasing the availability and recognition of competency for users of clinical mass spectrometry.

Design of Experiments – get it right from the beginning
@ Papageno Hall (Track 3)

Chair(s): Margrét  and Unnur Thorsteinsdóttir

We will demonstrate how method development can become much more efficient by utilizing design of experiments (DoE). DoE offers a practical approach for performing experiments in accordance to predefined plan, modelling by empirical functions, and graphical visualization. Example from optimization of a UPLC-MS/MS method for clinical application will be used to show the cost-effective benefit of DoE, where it allows the effect of variables to be assessed with only a fraction of the experiments that would be required by changing one-separate-factor-at-time (COST) approach and spots critical setting early on.

2030
Enjoy the City
@ Your Choice

Thursday

745
900
Welcome Coffee
@ Entrance Foyer

Enjoy coffee, a pastry and a chat with colleagues before the day starts.
800
845

Corporate Workshop(s)

Zivak Technologies
@ Paracelsus (Track 4)

Pre-Register

From Primary Sample Tubes to Results: World’s First Fully Automated Sample Preparation and Injection UHPLC System

Zivak Technologies is delivering solution to manual sample preparation related problems of chromatography analysis and enabling clinical laboratories to make the most of their MS/MS instruments by full automatization.

Fully automated Zivak analyzers allow you to get results from primary sample tubes without any user intervention. After the tubes are placed in the sample tray and the analysis is started on the computer, the robotic arms carry out all sample preparation steps, inject the prepared sample to MS/MS and chromatographic run starts. With Zivak analyzers, opening the sample tubes’ caps is never required.

Attend the workshop and listen a detailed review of World’s First Walk Away Sample Preparation and Injection UHPLC System Multitasker and Zivak’s Revolutionary VD-200, Fully Automated Vitamin D2-D3 UHPLC Analyzer from Prof. Dr. Ahmet Ceyhan Gören.

800
900
SciCom Discussion Group
@ 1st Floor Cafe
845
900
Intermission
@ Entrance Foyer
900
1000
Exhibitor Feedback
@ 1st Floor Cafe

An opportunity for exhibiting vendors to provide feedback on what worked and what could use improvement.

Scientific Session 4

Track 1
Mozart 1-3
Metabolomics – Clinical Studies I
Chair: Oleg Mayboroda
Track 2
Mozart 4-5
Quality Issues
Chair: Anne Bendt
Track 3
Papageno
Clinical Chemistry I
Chair: Éva Hunyadi-Gulyás
Track 4
Paracelsus
MSI for Clinical Applications
Chair: Raf Van de Plas
Track 5
Trakl
Microbiology Keynote
Chair: Jean Armengaud
Track 6
Doppler
Practical Training : Finding Your Analyte
Chair: Catarina Horro-Pita
900
920
Metabolomic Analysis of Changes in the Serum of Diabetic Patients Caused by Ulcers
Arsenty Melnikov
Internatrional Tomography Center SB RAS
Quality Assurance and Quality Control in LC-MS-based Targeted Lipidomics of Human Blood Plasma
Bo Burla
National University of Singapore
A Newly Developed LC-MS/MS Method for the Quantitation of Glucagon in Plasma Shows the Lack of Specificity of Former RIA Methods
Jordi Farre-Segura
University of Ličge, CHU de Ličge
Next Generation Sequencing After MALDI MSI – A Feasibility Study
Kristina Schwamborn
Institute of Pathology, TU Munich
Tandem MS-Proteotyping: Proteomics- and Genomics-based Characterization and Typing of Infectious Bacteria
Edward Moore
University of Gothenburg
Where Did My Analyte Go? – coping with poor solubility and non-specific binding
Catarina Horro Pita
LGC, Drug Development Solutions
View Slides (PDF)

920
940
A Metabolite Level View of the Gut-Brain Axis in Dementia and Aging: Quantification of the Kynurenine/Tryptophan Pathway Using Mass Spectrometry
Luke Whiley
Imperial College London
Stable Isotope-Dilution-LC-MS/MS-based Reference Methods – Suggestion for Description of Methods and Structure of Analytical Series
Michael Vogeser
University Hospital, LMU Munich
Progress in Clinical Applications for the MALDI-Imaging Analysis of Thyroid Biopsies: Evaluation of Proteomic Stability in Preservative Solutions
Isabella Piga
University of Milano-Bicocca
MALDI-MSI in the Search for Proteomic Indicators of Response to Therapy in Membranous Nephropathy
Andrew Smith
University of Milano-Bicocca
...
Keynote
...
...
Extended Session
...
940
1000
Estimation of the Post Mortem Interval via Metabolomic Approach
Lyudmila Yanshole
International Tomography Center SB RAS
The Use of Ion Mobility Coupled with High Resolution Mass Spectrometry to Improve Separation and Identification of Lipid Biomarkers in Metabolic Diseases
Julian Griffin
Department of Biochemistry, University of Cambridge, Cambridge, UK & University of Cagliari, Italy

New Addition

Profiling Pathways of Estrogen Metabolism in Patients with Pulmonary Arterial Hypertension: Development of a Novel Assay for Estrogen Metabolites by LC-MS/MS
Nina Denver
University of Glasgow

New Addition

Bringing Mass Spectrometry to Pathologists for Diagnostics of Frozen Surgically Resected Tissue Specimen
Tiffany Porta Siegel
M4I, Maastricht University
...
Keynote
...
...
Extended Session
...
1000
1100
Poster Session 3
@ 1st Floor Exhibit Hall

Selected posters to be attended for 1 hour. Refer to program for posters attended during this period.
1000
1100
MEET-THE-EXPERTS : Poster Tours
@ 1st Floor Exhibit Hall
1000
1100
Poster Contest Finalist Interviews
@ 1st Floor Exhibit Hall

Poster Contest Finalists to attend posters and meet with poster Judges. Judges may arrive in groups or individually.

Scientific Session 5

Track 1
Mozart 1-3
Metabolomics – Clinical Studies II
Chair: Nicola Gray
Track 2
Mozart 4-5
Quantitation Issues
Chair: Christiane Auray-Blais
Track 3
Papageno
Clinical Proteomics II
Chair: Renee Ruhaak
Track 4
Paracelsus
Glycomics Keynote
Chair: Manfred Wuhrer
Track 5
Trakl
Technological Innovations for the Microbiology Laboratory
Chair: Ed Moore
Track 6
Doppler
Practical Training: Internal Standards
Chair: Russ Grant
1100
1120
Analytical Strategies to Study the Interaction Between Microbiota and Drug Metabolism Using Targeted and Untargeted LC-MS-based Metabolomics
Marine Letertre
Imperial College London
Semi-Quantitative LC/ESI/MS Analysis Using Predictive Models of ESI Ionization Efficiencies
Jaanus Liigand
University of Tartu
Paving the Way for MS-based Protein Tests that Target Unmet Clinical Needs
Christa Cobbaert
Leiden University Medical Center
High-throughput Glycomics in Patient Stratification - What Did We Learn from the First 60,000 Analyses
Gordon Lauc
University of Zagreb & Genos Glycoscience Research Laboratory, Zagreb, Croatia
Laser Assisted Rapid Evaporative Ionisation Mass Spectrometry: An Automated Platform for Direct-From-Culture Speciation and Clinical Sample Analysis
Simon Cameron
Imperial College London
Everything You Wanted to Know about Internal Standards But Were Too Afraid to Ask
Russ Grant
Labcorp
View Slides (PDF)

1120
1140
Clinical Validation of an Automated Dried Blood Spot Sampling Device – Fluispotter®
Khem Adhikari
Rigshospitalet
Quantification and Library Identification of 248 Compounds Commonly Detected in Systematic Toxicology Analysis Using an Automated Extraction Coupled to LC-MS/MS
Robin Tiphaine
CHU of Limoges
Combination of Stable Labelled Antibodies and LC-MS to Accurately Quantify Therapeutic Monoclonal Antibodies in the Clinical Laboratory
Ravindra Chaudhari
PROMISE Advanced Proteomics
...
Keynote
...
In-situ Detection of the Botulinum Neurotoxin A by Functionalized MALDI Chips
Petra Darebna
BioCeV
...
Extended Session
...
1140
1200
Use of Quantitative Metabolomics for Investigation of Age-Related Nuclear Cataracts
Vadim Yanshole
International Tomography Center SB RAS
Clinical Mass Spectrometry: the Assessment of Acidosis Profiles and Acute Kidney Injury in Severe Malaria
Natthida Sriboonvorakul
Mahidol University
Clinical Analytical Assay for AFP-L3 Using Multiple Reaction Monitoring-Mass Spectrometry for Diagnosing Hepatocellular Carcinoma
Youngsoo Kim
Seoul National University College of Medicine
...
Keynote
...
MALDI-TOF Mass Spectrometry: A Method for the Detection of Bacterial Contamination in Platelet Concentrates
Yasmine Chetouane
IHU méditerranée infection
...
Extended Session
...
1200
1330
Lunch
@ 1st Floor Exhibit Hall
1230
1330
Poster Session 4
@ 1st Floor Exhibit Hall

Selected posters to be attended for 1 hour. Refer to program for posters attended during this period.
1230
1330
MEET-THE-EXPERTS : Poster Tours
@ 1st Floor Exhibit Hall
1330
EXHIBITS CLOSED
@ 1st Floor Exhibit Hall
1330
1415

Corporate Workshop(s)

Tecan
@ Papageno (Track 3)

Meet our experts in MS sample prep who will present innovative workflows using positive pressure workstations and liquid handling platforms to prep samples for clinical proteomics and steroid analysis.

Semi-automated sample processing for clinical proteomics
Stefan Loroch, Leibniz Institute for Analytical Sciences (ISAS), Proteomics Facility

Powerful automated multi-steroid extraction via positive pressure and liquid handling platform for LC-MS analysis
Dr. Christian Scherling, Tecan Germany, MS Sample Prep Application Specialist

1415
1430
Intermission
@ Entrance Foyer

Scientific Session 6

Track 1
Mozart 1-3
Metabolomics Keynote
Chair: Russ Grant
Track 2
Mozart 4-5
Monitoring Metabolites in Inborn Errors of Metabolism
Chair: Zdenek Spacil
Track 3
Papageno
Oncology
Chair: Yuri van der Burgt
Track 4
Paracelsus
Tissue Imaging Keynote
Chair: Kristina Schwamborn
Track 5
Trakl
Biomarkers in Infectious Disease
Chair: Stefan Zimmerman
Track 6
Doppler
Practical Training : Getting to Lower Limits of Quantitation
Chair: Brian Rappold
1430
1450
How Tandem Mass Spectrometry Revolutionized Newborn Screening
David Millington
Duke University School of Medicine
Development of a 2D-UPLC-MS/MS Assay for Therapeutic Monitoring for Patients with APRT Deficiency
Unnur Arna Thorsteinsdottir
University of Iceland
Proteomic Analysis of MGL Binding Protein in Human Cancer Cells
Martina Pirro
Leiden University Medical Center LUMC
Advances in Computational Methods for Tissue Imaging by Mass Spectrometry
Raf Van de Plas
Delft University of Technology
Omics Approaches Towards Discovery of Biomarkers for Early Diagnosis of Tuberculosis
Ana Varela Coelho
ITQB NOVA

Switched with M Kostrzewa

1/3 Getting Lower Limits of Quantification in LC-MS/MS assays : Prologue
Brian Rappold
LabCorp
View Slides (PDF)

1450
1510
...
Keynote
...
The Role of Chromatography in the Separation of Glucosylceramide Isoforms from Their Isobaric Galactosylceramide Counterparts in the Era of Precision Medicine
Christiane Auray-Blais
Universite de Sherbrooke
Exosome-like Vesicles of Uterine Aspirates Permit the Identification of Diagnostic and Stratification Biomarkers of Endometrial Cancer
Eva Coll de la Rubia
Vall Hebron Research Institute

Replacing Eva Colas. Same Lab & Abstract.

...
Keynote
...
Sepsis by Enterobacteria: A MALDI Affair
Markus Kostrzewa
Bruker Daltonik GmbH

Switched with Ana Varela Coelho

2/3 Getting Lower Limits of Quantification in LC-MS/MS assays : Phases and Stages
Brian Rappold
LabCorp
1510
1530
...
Keynote
...
First Experience with a Second-Tier LC-MS/MS Assay for Newborn Screening of Propionic Acidemia, Methylmalonic Acidemias and Combined Remethylation Disorders
Glynis Klinke
University of Heidelberg
In Depth Proteomic Analysis of Prostate Cancer Biopsies
Gabor Toth
Hungarian Academy of Sciences
...
Keynote
...
Identification and Validation of Two Peptide Markers for the Recognition of Clostridium difficile MLST-1 and MLST-11 by MALDI-MS
Simone Nicolardi
Leiden University Medical Center
3/3 Getting Lower Limits of Quantification in LC-MS/MS assays : The Words Don’t Fit the Picture
Brian Rappold
LabCorp
1530
1545
Petite Reception
@ Mozart 4-5

Passed beer, wine and other beverages while we prepare for the poster awards.
1545
1600
Poster Award Presentation
@ Mozart 4-5
1600

Closing Plenary Lecture


@ Mozart 4-5
Chair: Guinevere Lageveen-Kammeijer

1600
1645
Mass Spectrometric Analysis of Glycomic Signatures of Cancer and Autoimmune Diseases: Towards Clinical Application
Manfred Wuhrer
LUMC

Many major human diseases including various types of cancer and autoimmune diseases are associated with protein glycosylation changes. These changes are often instrumental in disease development and progression. In cancer, glycosylation changes of both tumor tissues and tumor-derived circulating antigens have been described. However, diagnostic test often merely rely on the measurement of antigen concentrations and fail to register glycosylation changes, largely due to the lack of suitable technology and workflows. In this presentation, examples will be given of recently developed mass spectrometric workflows to determine disease-associated glycosylation changes from tumor tissues and in the circulation, but also from other body fluids including urine and saliva. Promising markers will be presented including immunoglobulin G glycosylation, cancer glycoprotein antigens, as well as tissue glycosylation signatures revealed by mass spectrometry imaging. Steps towards the clinical translation of these markers will be discussed.

1645
1800
Closing Reception & Discussion
@ Entrance Foyer

Wine & Cheese, Beer & Nuts ... and maybe Kaiserschmarrn. Winning posters to be on display.
1800
2200
After Congress Meet-Up
@ Your Choice

Meet up at the Augustiner Braustubl (Historic Abby turned beer garden with food stalls) for an unofficial and unsponsored post-con gathering.