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Presented at 2015_EU

Diagnostic and Prognostic Biomarker Discovery of Soft Tissue Sarcomas by Mass Spectrometry Imaging
Sha Lou
Leiden University Medical Center

Ability of Matrix-assisted laser desorption/ionization Mass Spectrometry Imaging to distinguish between the most encountered but clinically challenging high grade Soft Tissue Sarcomas (four subtypes) were investigated (leading to diagnostic biomarkers discovery) and if there are individual proteins (signatures) that are statistically associated with patient survival and development of metastases were also investigated (thus would be prognostic biomarkers). Twenty protein peaks were found as diagnostic biomarkers. Fourteen protein peaks were found as prognostic biomarkers. Based on comparisons with databases, Acyl-CoA-binding protein, Macrophage migration inhibitory factor, Thioredoxin and Galectin-1 were tentatively assigned among diagnostic biomarkers; Thymosin beta-10, Proteasome activator complex subunit 1, two modified Histone H4 were tentatively assigned among prognostic biomarkers.

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