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Presented at 2015_EU
Mass Spectrometry Based Molecular Imaging for Probing Aβ-Plaque Pathology
in Transgenic Alzheimer’s Disease Mice
The major pathological hallmarks of Alzheimer’s disease (AD) is the progressive accumulation and aggregation of beta-amyloid (Aβ) and phospho-tau, into neurotoxic deposits. However, the exact molecular processes underlying protein aggregation and plaque pathology remains unknown. The primary goal of this project was to employ advanced molecular imaging mass spectrometry (IMS) to probe the chemical and structural aspects of Aβ plaque pathology in experimental AD. MALDI IMS followed by multivariate image analysis reveal region specific accumulation of differently truncated amyloid peptides in various regions of the brain. Moreover, different protein species were selectively regulated in plaque proximity. In conclusion, MS imaging is a promising approach to probe plaque chemistry in Alzheimer's disease.
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