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Presented at 2015_EU

What Is Wrong in Your LC-MS Analysis? Post Column Infusion as a Diagnosis Tool
Oskar Gonzalez
University of the Basque Country

Continuous post-column infusion of standards is a very useful tool to obtain additional and very valuable information about a LC-MS method. Here we show multiple applications of this technique in method development and routine analysis based on our experience in the laboratory: detection of compounds causing ion suppression, aid in sample treatment choice, understanding of abnormal results, compensation of matrix effect and some others. Considering all these benefits, we encourage to use this technique in clinical analysis to improve the reliability of LC-MS methods and to obtain more accurate results.

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