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Presented at 2015_EU

Urinary Metabolic Profiling as Method to Assess Kidney Functionality
Tiziana Pacchiarotta
LUMC (Leiden University Mdical Centre)

Ischemia/reperfusion injury (IRI) is an inevitable event after kidney transplantation, leading to extensive injury and poor graft survival. Current markers for the evaluation of IRI are considered insensitive and reliable markers are highly needed. Here we use a well-established rat model to document the protective role of MBL in renal IRI as target for therapeutic intervention in kidney transplantation and we show that the urinary metabolic pattern can be used to evaluate an in-tissue IRI event. Using a combination of statistical models, we link the metabolic trajectory to the recovery process under different antibody treatment. We demonstrate that “protective” urinary metabolic signature correlates with expression of GRP 78.

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