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Presented at 2015_EU

MS-based Serum Proteomics in Clinical Chemistry: Requirements for Candidate Translation and Implementation as a Routine Assay
Christa Cobbaert
Leiden University Medical Center

Numerous serum protein profiling efforts have aimed for biomarker discovery since the early days of mass spectrometry(MS)-based proteomics. These pipelines have yielded many promising protein candidates, but disappointingly none of these has been translated into a truly validated medical test. Alternatively, strategies have been followed to convert existing routine uniplex protein assays into an MS-based in-vitro diagnostic test, however also in this case the success rate has been low so far. In this presentation both approaches will be discussed with regard to requirements needed for translation or implementation these into a clinical chemistry laboratory.

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