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Presented at 2015_EU

Skin Imprinting in Silica Plates: A Potential Diagnostic Methodology for Leprosy Using High-Resolution Mass Spectrometry
Estela de Oliveira Lima
Universidade Estadual de Campinas

Leprosy is an infectious disease caused by Mycobacterium leprae, primarily present at skin macrophages and Schwann cells. Presently, the available laboratorial diagnostic methods for Leprosy are invasive, expensive, and present low sensibility for the asymptomatic cases. Therefore, this work intended to develop a noninvasive, fast and sensible method for leprosy diagnosis, associated to high-resolution mass spectrometry. Our data analysis has elected two mycobacterial biomarkers at leprosy skin patients, absent at control samples. These results indicate that our new methodology can be candidate as a fast and sensible leprosy diagnostic method, even for patients without clinical skin manifestations.

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