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Presented at 2015_EU

Endogenous Ouabain – LC-MS/MS Identifies a Fiction
Silvia Baecher
Hospital of the University of Munich

For decades immunoassays were applied in an attempt to quantify the cardiac glycoside ouabain in plasma of patients with cardiovascular conditions. This compound (CAS 630-60-4) was supposed to be of endogenous origin as a counterpart of exogenous cardiac glycosides such as digoxin. Using a fully validated, highly specific and extremely sensitive LC-MS/MS method we were able to show that ouabain cannot be present in relevant concentrations in human plasma - as claimed by immunoassay studies.

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