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Presented at 2015_EU

Ovarian Tissue Identification with Rapid Evaporative Ionisation Mass Spectrometry (REIMS); the Surgical Intelligent Knife
David Phelps
Imperial College, London

Ovarian cancer is common and 5-year survival is 43.5%. Surgeons use intra-operative frozen section for tissue identification but this is time-consuming and expensive. Microscopic non-descript lesions during surgery, which may be cancer can be difficult to correctly identify. The near-real-time tissue identification abilities of the iKnife were tested in this study. We have shown for the first time that ovarian, peritoneal and fallopian tube tissues have unique REIMS spectral signatures, which can be used to accurately classify tissue histopathology. Leave-one out patient cross-validation resulted in 100% sensitivity and 100% specificity in the separation of normal and cancerous ovary (n=189).

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