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EUROPE 2015

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Presented at 2015_EU

Novel Insights into Apolipoprotein Metabolism in Mice and Man by Application of a Targeted Peptide-based LC-MS/MS Assay
Uta Ceglarek
University Hospital Leipzig

Apoproteins are key components of lipoproteins and mediate diverse functions in lipid transport and metabolism. A LC-MS/MS methods to analyze apoproteins using species-unique peptide sequences for Apo A-I, Apo A-II, Apo A-IV, Apo B48, Apo B100, Apo C-I, Apo E and Apo J in 3 µl human or murine plasma. In human plasma Apo A-I and Apo A-II showed the highest concentrations. The simultaneous analysis of apoproteins in only 3 µl murine and human plasma allows us a comprehensive characterization of apolipoprotein levels using normo- and hyperlipidemic patients and different mice strains under different nutritional conditions.

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