Translating Pre-Clinical Research to Clinical Patient Care™

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Brian Kelly


Discussion Groups

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1. Career Exploration in Clinical Mass Spectrometry
Wednesday, 16:45–18:15, Sep 24
@ Salon Bonaventure, Hotel Level

2. Mass Spectrometry Imaging in the Clinic : When Can This Be a Reality?
Wednesday, 16:45–18:15, Sep 24
@ Montreal 1-2

3. Troubleshooting Cases
Wednesday, 16:45–18:15, Sep 24
@ Montreal 3

4. LDTs in Flux: Will Evolving Regulations Enhance or Complicate Laboratory Practices?
Wednesday, 16:45–18:15, Sep 24
@ Outremont 1

Discussion Group Summaries

Wednesday
1645
1815
Discussion Group : Career Exploration in Clinical Mass Spectrometry
@ Salon Bonaventure, Hotel Level

Ashley Beasley-Green, PhD
NIST

Claire Knezevic, PhD
Lurie Childrens Hospital

Elie Fux
Roche

Joseph Medeiros
Waters

Peggi Angel, PhD
MUSC Proteomics Center

Matthew Crawford
Labcorp


Discover clinical mass spectrometry career paths. This networking event is geared to early career attendees, but open to all.

Get insights through informative, brief presentations on various job profiles within clinical mass spectrometry. Experts and seasoned professionals will guide you through diverse roles, making it easier to envision your own journey in this exciting industry.

In addition to short panelist presentations, the event promises a delightful networking experience. Unwind and engage with fellow attendees, experts, and potential employers to expand your professional connections. Enjoy selections of refreshments; creating a relaxed environment for further discussion and relationship-building. This networking event is the perfect opportunity to continue conversations, ask questions, and make lasting connections.

Employers

This is your chance to connect with talent. We invite you to advertise your job postings at the event and interact with potential candidates who are passionate about clinical mass spectrometry. Share your opportunities and meet prospective candidates who are eager to contribute to your organization's success.

MSACL is offering the opportunity for you to be recognized by the event chair at no charge (RSVP required) to facilitate your discussion of career opportunities with interested parties in attendance.

If you are interested in representing your organization/company/lab at this event, please register your interest here.

This event is formatted as a social mixer to facilitate active networking throughout the event.

For representatives and hiring managers:

-> There will be no booths.

-> Please bring business cards or QR codes describing positions to share with attendees or place on the job board.

-> You may also advertise employment opportunities on a job board. Each open position is limited to an 8.5 x 11 inch poster.

Don’t miss this unique opportunity to blend career exploration, networking, and relaxation.

Signup as an employer here.

Moderated by:

Matthew Crawford
Labcorp

Peggi Angel, PhD
MUSC Proteomics Center

2420
Wednesday
1645
1815
Discussion Group : Mass Spectrometry Imaging in the Clinic : When Can This Be a Reality?
@ Montreal 1-2

Pierre Chaurand, PhD
Université de Montréal

Emina Torlakovic, MD, PhD
College of Medicine, University of Saskatchewan

Katerina Djambazova, PhD
Vanderbilt University

Angela Kruse, PhD
Ohio State University


Mass spectrometry imaging (MSI) is a powerful tool with implications in the clinic including diagnostics and patient stratification. This discussion focuses on how immunohistochemistry (IHC) diagnostics have been developed for use in the clinic and how these workflows could be translated to developing MSI diagnostics. A key goal is to have a discussion within the broad range of attendees on moving MSI workflows to a standardization level that can be implemented for diagnostics.

Agenda:

1. Historical overview of MALDI MSI and potential use for diagnostics (10 minutes maximum)
Pierre Chaurand, PhD

2. IHC validation for a predictive biomarker and a diagnostic biomarker: Procedure and Pitfalls (12 minutes maximum)
Dr. Emina Emilia Torlakovic MD, PhD, FCAP

3. Multimodal Mass Spectrometry Imaging: Implementation and Benchmarking (12 minutes maximum)
Katerina Djambazova, PhD & Angela Kruse, PhD

4. Audience and Speaker Discussion Objectives (30 minutes) :
- Identify parallels between early development of quality assurances for IHC and current practices in MSI
- Summarize regulations and guidelines in IHC diagnostics and implementation in MSI
- Define analytical and clinical validation parameters (or procedures) needed for MSI practice

Moderated by:

Pierre Chaurand, PhD
Université de Montréal

2418
Wednesday
1645
1815
Discussion Group : Troubleshooting Cases
@ Montreal 3

Moderated by:

Deborah French, PhD, DABCC (CC, TC), FADLM
UCSF

Grace van der Gugten, B.Sc. Chemistry
Provincial Health Services Authority, BCCDC Toxicology Lab

Joshua Hayden, PhD, DABCC, FACB
Cleveland Clinic

2419
Wednesday
1645
1815
Discussion Group : LDTs in Flux: Will Evolving Regulations Enhance or Complicate Laboratory Practices?
@ Outremont 1

Alejandro Molinelli, PhD
St. Jude Children's Research Hospital

Melissa Budelier, PhD
TriCore Reference Laboratories


Lab Developed Test (LDT) regulation is a complex and evolving area of clinical laboratory practice. This interactive workshop, led by members of the MSACL Compliance and Accreditation Committee, will offer an in-depth exploration of the current regulatory landscape and provide insights into potential future developments. Participants will gain a historical perspective on LDT oversight and how regulatory frameworks have evolved over time. The session will feature interactive breakout discussions, allowing attendees to share experiences and challenges in navigating LDT regulations. A key focus will be on quality management systems (QMS), including a review of current U.S. requirements under CLIA and CAP, alongside a comparison with international guidelines such as CLSI EPLDT Ed1-QG, C62, and the new ISO5649. The session will explore how laboratories might align their practices with these standards and highlight the role of a robust QMS in supporting quality and compliance, including considerations of ISO15189. Attendees will also examine the concept of clinical validity and how it applies to different areas of laboratory practice. The workshop will conclude with a forward-looking discussion on the adequacy of the current regulatory framework and potential future changes, encouraging participants to reflect on their existing practices and how they may need to evolve.

Syllabus

  1. Historical overview of LDT Regulations.
  2. Overview of existing requirements and guidelines for LDT Regulations
  3. Explore the role of a Quality Management System in complying with LDT regulations.
  4. Discuss the adequacy of the current regulatory framework and the potential future outlook for LDTs in clinical laboratories
  5. Provide attendees with resources to assist with regulatory compliance and proactive quality improvement for LDTs

Objectives

  1. Review the historical and current state of LDT regulations.
  2. Assess the sufficiency of the current regulatory framework for LDTs
  3. Develop Practical Compliance Strategies and Quality Management Practices for LDTs
2417
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