Have you faced an LC-MS/MS problem—whether resolved or still in progress? This session is your chance to share that experience with other clinical laboratory users. No issue is too simple or too complex: from method development and validation to day-to-day production troubleshooting. If you learned something from the process, chances are others can too.

The purpose is to spark discussion and spread practical expertise on the aspects of mass spectrometry that usually stay hidden—when things go wrong. This is not about being perfect. It’s about learning together.

During the Troubleshooting Cases Session, presenters will give a 3–5 minute summary of their case:

The problem encountered
The troubleshooting steps taken
Any insights or lessons learned

A panel of experienced users — and interested attendees — will then join in the discussion, offering suggestions and perspectives.

This session is informal and collegial, designed to encourage interaction between poster presenters, reviewers, and any conference-goers who join. The goal is mutual learning: presenters benefit from group insights, and attendees gain exposure to real-world troubleshooting approaches.

Troubleshooting Cases, along with other Practical Training events at MSACL, aim to foster networking, collaboration, and education within the clinical mass spectrometry community.

The Troubleshooting Cases will be presented in Montreal 3.

Time and Date : September 24

	16:45 Investigating Intermittent Retention Time Shifts Darcy Dochterman U.S. Department of Veterans Affairs
	17:00 Quantitative Sulfatide Measurement in Body Fluids: LC Optimization and Investigation of Non-Specific Adsorption Kaitlyn King The Children's Hospital of Philadelphia
	17:15 Investigation of Noroxycodone Interference in LC-MS/MS Urine Drug Testing Jacob Rininger John Carroll University
	17:30 Distorted Oxymorphone Peak in Urine Drug Testing Panel Jaime Noguez University Hospitals Cleveland Medical Center/Case Western Reserve University
	17:45 Contamination in 3MTO Internal Standard Peaks in a Quantitative LC-MS/MS Plasma Metanephrine Assay Sherrine Alleyne North West London Pathology
	18:00 Start as You Mean to Go On; Controlling Batch Effects in Quantitative LC-SRM Measures Russell Grant Labcorp