Mobile Tutorial

MSACL 2018 US: Final Conference Program

Palm Springs, CALIFORNIA • January 21 - 25, 2018

With Thanks to Our Corporate Conference Sponsors:
Thermo Shimadzu 
Agilent  SCIEX Indigo 
PerkinElmer

Sunday

8:00
18:00
BADGE PICKUP
@ Renaissance Ballroom Foyer
8:00
12:00

AGILENT BREAKFAST WORKSHOP
@ Rm 3

Agilent Technologies
Room 3 (Madera)

Pre-Register

Join Agilent for breakfast on Sunday, January 21 and meet a few of our Mass Spectrometry Experts. We will be covering the following material:

MassHunter Software Overview: Review by Exception and PDF Reporting.

New Innovations and New Synthetic Opioids. Introducing the Agilent Ultivo Miniature Tandem LC/Mass Spectrometer with clinical research application to Toxicological analytes of interest.

Jet Steam Proteomics with Automated Sample Prep for High-Throughput Peptide Quantitation in Clinical Research.

We hope to see you there!

11:00
14:00
LUNCH ON OWN
@ Your Decision

Check out a downtown restaurant.
14:00
18:00

SHORT COURSES

COURSE START
Clinical MS 301
A Comprehensive Review of Clinical Mass Spectrometry Technology & Techniques, including Miniaturization
Jack Henion, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Mesquite D
COURSE START
Data Science 101
Breaking up with Excel: A Newbie's Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Stephen Master, MD, PhD
Level: 1-2 (Beginner - Intermediate)
Location: Room 2 (Catalina)
COURSE START
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Randall Julian, PhD
Level: 2 (Intermediate)
Location: Room 1 (Mojave Learning Center)
COURSE START
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD, Lorin Bachmann, PhD & Grace van der Gugten
Level: 1-2 (Beginner - Intermediate)
Location: Room 3 (Madera)
COURSE START
LC-MSMS 201
Understanding and Optimization of LC-MS/MS to Develop Successful Methods for Identification and Quantitation in Complex Matrices
Robert D. Voyksner, PhD
Level: 2 (Intermediate)
Location: Andreas
COURSE START
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD, Erik J. Soderblom, PhD & Chris Shuford, PhD
Level: 2 (Intermediate)
Location: Mesquite H
COURSE START
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Matthew Crawford
Level: 3 (Advanced)
Location: Room 4 (Pasadena)
COURSE START
MALDI 102
Practical Considerations for MALDI Imaging Mass Spectrometry
Michelle Reyzer, PhD
Level: 1-2 (Beginner - Intermediate)
Location: Snowcreek
COURSE START
MALDI 103
MALDI-MS Fundamentals and its Emerging Role in Pathology and Laboratory Medicine
Mark W. Duncan, PhD & Mari L. DeMarco, PhD
with Guest lecturers:
Zhen Zhao, Weill Cornell Medical School,
Fang Wu, University of Saskatchewan,
Dobrin Nedelkov, Isoformix Inc,
Jeff Spraggins, Vanderbilt, and
Clifton Fagerquist, USDA
Level: 1-2 (Beginner - Intermediate)
Location: Mesquite G
COURSE START
Metabolomics 201
Application of High Resolution Mass Spectrometry and Metabolomics in Clinical Analysis
Timothy Garrett, PhD & Erin Baker, PhD
Level: 2 (Intermediate)
Location: Mesquite F
COURSE START
Presentations 101
How to Maximize Your Influence Through Creating Compelling Presentations
Karen Mahooti, MBA
Level: 1-2 (Beginner - Intermediate)
Location: Chino A
COURSE START
Proteomics 201
Clinical Proteomics
Andy Hoofnagle, MD, PhD, Cory Bystrom, PhD & Chris Shuford, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Room 5 (Sierra/Ventura)
COURSE START
Proteomics 202
Practical Proteomics Using the Skyline Software Ecosystem
Mike MacCoss, PhD, Brendan MacLean, Lindsay Pino, and Sandi Spencer, PhD
Level: 1-3 (Beginner -Advanced)
Location: Chino B
COURSE START
Sample Prep 201
Sample Preparation and Alternative Matrices for LC-MS Assays
William Clarke, PhD & Mark Marzinke, PhD
Level: Beginner / Intermediate
Location: Mesquite E
Every 0:50
for 10 min
COFFEE BREAK
@ Renaissance Ballroom Foyer

Take a break and get a coffee, juice, water and/or small snack to refresh for the next session.
18:00
20:00
DINNER ON OWN
@ Your Decision.

Haven't decided on a dinner location yet? Head to the Hospitality Lounge at Rocks Patio to meet up with old friends or make new ones over drinks and light appetizers before heading to dinner in Palm Springs.
18:00
22:00
HOSPITALITY LOUNGE
@ Santa Rosa and/or Rocks Terrace (if weather is agreeable)

If we're lucky we'll get to enjoy the warm, dry Palm Springs atmosphere on the patio overlooking the pool, with fire pits.
18:30
20:00

PRIVATE DISCUSSION GROUP
Private Dinner for Scientific Committee members to discuss development of the scientific program.
Chair: David Herold
@ Pueblo

Monday

6:00
7:00
YOGA
@ San Jacinto

Energize yourself for the day! Yoga is a complimentary offering for all MSACL registrants.
A limited number of yoga mats will be provided.
6:00
9:00
BREAKFAST
@ Date Restaurant

MSACL Breakfast Voucher provides comped breakfast.
Others can purchase breakfast at restaurant.
Short Course registrants receive meal vouchers during badge pick-up.
7:00
20:00
BADGE PICKUP
@ Renaissance Ballroom Foyer
8:00
12:00

SHORT COURSES: Group A
10 minute Coffee Breaks at every :50, except before lunch and last hour of class.
Lunch 12:00 - 1:00 PM at Date Restaurant.

Continued from Sunday
Clinical MS 301
A Comprehensive Review of Clinical Mass Spectrometry Technology & Techniques, including Miniaturization
Jack Henion, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Mesquite D
Continued from Sunday
Data Science 101
Breaking up with Excel: A Newbie's Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Stephen Master, MD, PhD
Level: 1-2 (Beginner - Intermediate)
Location: Room 2 (Catalina)
Continued from Sunday
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD, Lorin Bachmann, PhD & Grace van der Gugten
Level: 1-2 (Beginner - Intermediate)
Location: Room 3 (Madera)
Continued from Sunday
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Matthew Crawford
Level: 3 (Advanced)
Location: Room 4 (Pasadena)
Continued from Sunday
Proteomics 202
Practical Proteomics Using the Skyline Software Ecosystem
Mike MacCoss, PhD, Brendan MacLean, Lindsay Pino, and Sandi Spencer, PhD
Level: 1-3 (Beginner -Advanced)
Location: Chino B
8:30
12:30

SHORT COURSES: Group B
10 minute Coffee Breaks at every :20, except before lunch and last hour of class.
Lunch 12:30 - 1:30 PM at Date Restaurant.

Continued from Sunday
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Randall Julian, PhD
Level: 2 (Intermediate)
Location: Room 1 (Mojave Learning Center)
Continued from Sunday
MALDI 103
MALDI-MS Fundamentals and its Emerging Role in Pathology and Laboratory Medicine
Mark W. Duncan, PhD & Mari L. DeMarco, PhD
with Guest lecturers:
Zhen Zhao, Weill Cornell Medical School,
Fang Wu, University of Saskatchewan,
Dobrin Nedelkov, Isoformix Inc,
Jeff Spraggins, Vanderbilt, and
Clifton Fagerquist, USDA
Level: 1-2 (Beginner - Intermediate)
Location: Mesquite G
Continued from Sunday
Metabolomics 201
Application of High Resolution Mass Spectrometry and Metabolomics in Clinical Analysis
Timothy Garrett, PhD & Erin Baker, PhD
Level: 2 (Intermediate)
Location: Mesquite F
Continued from Sunday
Presentations 101
How to Maximize Your Influence Through Creating Compelling Presentations
Karen Mahooti, MBA
Level: 1-2 (Beginner - Intermediate)
Location: Chino A
Continued from Sunday
Proteomics 201
Clinical Proteomics
Andy Hoofnagle, MD, PhD, Cory Bystrom, PhD & Chris Shuford, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Room 5 (Sierra/Ventura)
9:00
13:00

SHORT COURSES: Group C
10 minute Coffee Breaks at every :50, except before lunch and last hour of class.
Lunch 1:00 - 2:00 PM at Date Restaurant.

Continued from Sunday
LC-MSMS 201
Understanding and Optimization of LC-MS/MS to Develop Successful Methods for Identification and Quantitation in Complex Matrices
Robert D. Voyksner, PhD
Level: 2 (Intermediate)
Location: Andreas
Continued from Sunday
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD, Erik J. Soderblom, PhD & Chris Shuford, PhD
Level: 2 (Intermediate)
Location: Mesquite H
Continued from Sunday
MALDI 102
Practical Considerations for MALDI Imaging Mass Spectrometry
Michelle Reyzer, PhD
Level: 1-2 (Beginner - Intermediate)
Location: Snowcreek
Continued from Sunday
Sample Prep 201
Sample Preparation and Alternative Matrices for LC-MS Assays
William Clarke, PhD & Mark Marzinke, PhD
Level: Beginner / Intermediate
Location: Mesquite E
0:20 or 0:50
for 10 min
COFFEE BREAK
@ Renaissance Ballroom Foyer

Take a break and get a coffee, juice, water and/or small snack to refresh for the next session.
12:00
14:00
LUNCH
@ Date Restaurant & Patio

Short Course Registrants: You have 1 hr for lunch.
MSACL Lunch Voucher will provide you comped meal. Others can purchase lunch at the restaurant.
Short Course registrants receive lunch voucher during badge pick-up.
13:00
17:00

SHORT COURSES: Group A
10 minute Coffee Breaks at every :50, except last hour of class.

Continued from Monday AM
Clinical MS 301
A Comprehensive Review of Clinical Mass Spectrometry Technology & Techniques, including Miniaturization
Jack Henion, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Mesquite D
Continued from Monday AM
Data Science 101
Breaking up with Excel: A Newbie's Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Stephen Master, MD, PhD
Level: 1-2 (Beginner - Intermediate)
Location: Room 2 (Catalina)
Continued from Monday AM
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD, Lorin Bachmann, PhD & Grace van der Gugten
Level: 1-2 (Beginner - Intermediate)
Location: Room 3 (Madera)
Continued from Monday AM
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Matthew Crawford
Level: 3 (Advanced)
Location: Room 4 (Pasadena)
Continued from Monday AM
Proteomics 202
Practical Proteomics Using the Skyline Software Ecosystem
Mike MacCoss, PhD, Brendan MacLean, Lindsay Pino, and Sandi Spencer, PhD
Level: 1-3 (Beginner -Advanced)
Location: Chino B
13:30
17:30

SHORT COURSES: Group B
10 minute Coffee Breaks at every :20, except last hour of class.

COURSE START
Forensic Toxicology 101
Basic Forensic Toxicology
Jarrad Wagner, Ph.D., F-ABFT, Allison Veitenheimer, Ph.D., Russell Lewis, Ph.D., F-ABFT
Level: 1 (Beginner)
Location: Pueblo A
COURSE START
Lab Medicine 101
Basics of Laboratory Medicine
Prof. Dr. med. Michael Vogeser
Level: 1 (Beginner)
Location: Agua Caliente
COURSE START
Microbiology 201
Mass Spectrometric Methods of Microbial identification
John Lapek, PhD & Chris Cox, PhD
Level: 2 (Intermediate)
Location: Pueblo B
Continued from Monday AM
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Randall Julian, PhD
Level: 2 (Intermediate)
Location: Room 1 (Mojave Learning Center)
Continued from Monday AM
MALDI 103
MALDI-MS Fundamentals and its Emerging Role in Pathology and Laboratory Medicine
Mark W. Duncan, PhD & Mari L. DeMarco, PhD
with Guest lecturers:
Zhen Zhao, Weill Cornell Medical School,
Fang Wu, University of Saskatchewan,
Dobrin Nedelkov, Isoformix Inc,
Jeff Spraggins, Vanderbilt, and
Clifton Fagerquist, USDA
Level: 1-2 (Beginner - Intermediate)
Location: Mesquite G
Continued from Monday AM
Metabolomics 201
Application of High Resolution Mass Spectrometry and Metabolomics in Clinical Analysis
Timothy Garrett, PhD & Erin Baker, PhD
Level: 2 (Intermediate)
Location: Mesquite F
Continued from Monday AM
Presentations 101
How to Maximize Your Influence Through Creating Compelling Presentations
Karen Mahooti, MBA
Level: 1-2 (Beginner - Intermediate)
Location: Chino A
Continued from Monday AM
Proteomics 201
Clinical Proteomics
Andy Hoofnagle, MD, PhD, Cory Bystrom, PhD & Chris Shuford, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Room 5 (Sierra/Ventura)
14:00
18:00

SHORT COURSES: Group C
10 minute Coffee Breaks at every :50, except last hour of class.

Continued from Monday AM
LC-MSMS 201
Understanding and Optimization of LC-MS/MS to Develop Successful Methods for Identification and Quantitation in Complex Matrices
Robert D. Voyksner, PhD
Level: 2 (Intermediate)
Location: Andreas
Continued from Monday AM
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD, Erik J. Soderblom, PhD & Chris Shuford, PhD
Level: 2 (Intermediate)
Location: Mesquite H
Continued from Monday AM
MALDI 102
Practical Considerations for MALDI Imaging Mass Spectrometry
Michelle Reyzer, PhD
Level: 1-2 (Beginner - Intermediate)
Location: Snowcreek
Continued from Monday AM
Sample Prep 201
Sample Preparation and Alternative Matrices for LC-MS Assays
William Clarke, PhD & Mark Marzinke, PhD
Level: Beginner / Intermediate
Location: Mesquite E
0:20 or 0:50
for 10 min
COFFEE BREAK
@ Renaissance Ballroom Foyer

Take a break and get a coffee.
17:00
20:00
DINNER ON OWN
@ Your Decision
17:00
22:00
HOSPITALITY
@ Santa Rosa and/or Rocks Terrace (if weather is agreeable)

Meet here for a quick drink before going out for dinner. Cheese and fruit come out at 20:00.

Tuesday

6:00
7:00
YOGA
@ San Jacinto

Energize yourself for the day! Yoga is a complimentary offering for all MSACL registrants.
A limited number of yoga mats will be provided.
6:00
9:00
BREAKFAST
@ Date Restaurant

MSACL Breakfast Voucher provides comped breakfast.
Others can purchase breakfast at restaurant.
Short Course registrants receive meal vouchers during badge pick-up.
7:00
20:00
BADGE PICKUP
@ Renaissance Ballroom Foyer
8:00
12:00

SHORT COURSES: Group A
10 minute Coffee Breaks at every :50, except last hour.

Continued from Monday PM
Clinical MS 301
A Comprehensive Review of Clinical Mass Spectrometry Technology & Techniques, including Miniaturization
Jack Henion, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Mesquite D
Continued from Monday PM
Data Science 101
Breaking up with Excel: A Newbie's Introduction to the R Statistical Programming Language
Daniel Holmes, MD & Stephen Master, MD, PhD
Level: 1-2 (Beginner - Intermediate)
Location: Room 2 (Catalina)
Continued from Monday PM
LC-MSMS 101
Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory
Judy Stone, PhD, Lorin Bachmann, PhD & Grace van der Gugten
Level: 1-2 (Beginner - Intermediate)
Location: Room 3 (Madera)
Continued from Monday PM
LC-MSMS 301
Development and Validation of Quantitative LC-MS/MS Assays for Use in Clinical Diagnostics
Russell Grant, PhD & Matthew Crawford
Level: 3 (Advanced)
Location: Room 4 (Pasadena)
Continued from Monday PM
Proteomics 202
Practical Proteomics Using the Skyline Software Ecosystem
Mike MacCoss, PhD, Brendan MacLean, Lindsay Pino, and Sandi Spencer, PhD
Level: 1-3 (Beginner -Advanced)
Location: Chino B
8:30
12:30

SHORT COURSES: Group B
10 minute Coffee Breaks at every :50, except last hour.

Continued from Monday PM
Forensic Toxicology 101
Basic Forensic Toxicology
Jarrad Wagner, Ph.D., F-ABFT, Allison Veitenheimer, Ph.D., Russell Lewis, Ph.D., F-ABFT
Level: 1 (Beginner)
Location: Pueblo A
Continued from Monday PM
Lab Medicine 101
Basics of Laboratory Medicine
Prof. Dr. med. Michael Vogeser
Level: 1 (Beginner)
Location: Agua Caliente
Continued from Monday PM
Microbiology 201
Mass Spectrometric Methods of Microbial identification
John Lapek, PhD & Chris Cox, PhD
Level: 2 (Intermediate)
Location: Pueblo B
Continued from Monday PM
Data Science 201
Going Further With R: Tackling Clinical Laboratory Data Manipulation and Modeling
Patrick Mathias, MD, PhD & Randall Julian, PhD
Level: 2 (Intermediate)
Location: Room 1 (Mojave Learning Center)
Continued from Monday PM
MALDI 103
MALDI-MS Fundamentals and its Emerging Role in Pathology and Laboratory Medicine
Mark W. Duncan, PhD & Mari L. DeMarco, PhD
with Guest lecturers:
Zhen Zhao, Weill Cornell Medical School,
Fang Wu, University of Saskatchewan,
Dobrin Nedelkov, Isoformix Inc,
Jeff Spraggins, Vanderbilt, and
Clifton Fagerquist, USDA
Level: 1-2 (Beginner - Intermediate)
Location: Mesquite G
Continued from Monday PM
Metabolomics 201
Application of High Resolution Mass Spectrometry and Metabolomics in Clinical Analysis
Timothy Garrett, PhD & Erin Baker, PhD
Level: 2 (Intermediate)
Location: Mesquite F
Continued from Monday PM
Presentations 101
How to Maximize Your Influence Through Creating Compelling Presentations
Karen Mahooti, MBA
Level: 1-2 (Beginner - Intermediate)
Location: Chino A
Continued from Monday PM
Proteomics 201
Clinical Proteomics
Andy Hoofnagle, MD, PhD, Cory Bystrom, PhD & Chris Shuford, PhD
Level: 2-3 (Intermediate - Advanced)
Location: Room 5 (Sierra/Ventura)
9:00
13:00

SHORT COURSES: Group C
10 minute Coffee Breaks at every :50, except last hour.

Continued from Monday PM
LC-MSMS 201
Understanding and Optimization of LC-MS/MS to Develop Successful Methods for Identification and Quantitation in Complex Matrices
Robert D. Voyksner, PhD
Level: 2 (Intermediate)
Location: Andreas
Continued from Monday PM
LC-MSMS 202
Practical LC-MS Maintenance and Troubleshooting
J. Will Thompson, PhD, Erik J. Soderblom, PhD & Chris Shuford, PhD
Level: 2 (Intermediate)
Location: Mesquite H
Continued from Monday PM
MALDI 102
Practical Considerations for MALDI Imaging Mass Spectrometry
Michelle Reyzer, PhD
Level: 1-2 (Beginner - Intermediate)
Location: Snowcreek
Continued from Monday PM
Sample Prep 201
Sample Preparation and Alternative Matrices for LC-MS Assays
William Clarke, PhD & Mark Marzinke, PhD
Level: Beginner / Intermediate
Location: Mesquite E
0:20 or 0:50
for 10 min
COFFEE BREAK
@ Renaissance Ballroom Foyer

Take a break and get a coffee, juice, water and/or small snack to refresh for the next session.
11:00
16:00
PLACE POSTERS
@ Exhibit Hall

All posters for entire conference to be placed during this period.
12:00
14:00
LUNCH
@ Date Restaurant and Terrace

Comped for Short Course attendees with Voucher. Others can purchase at restaurant.
14:00
END OF SHORT COURSE PROGRAM
@ Various
14:00
14:15
WELCOME & ORIENTATION
@ Rms 2-4
PLENARY 1
@ Rooms 2-4
Chair: Stephen Master
14:15
15:00
Community-Scale Translation of Mass Spectrometry Big Data into Crowdsourced Proteomics and Metabolomics Resources
Nuno Bandeira
University of California, San Diego
Translating the growing volumes of proteomics mass spectrometry data into reusable evidence of the occurrence and provenance of proteomics and metabolomics events requires the development of novel community-scale computational workflows. We show how advanced distributed computing algorithms can be used to process tens of terabytes of public data to reveal hundreds of millions of new identifications, including the discovery of novel proteins and hypermodified peptides with over 100 modification variants. We further show how large scale reanalyses can be reliably aggregated into community-scale crowdsourced spectral libraries enabling high-throughput detection and discovery in newly acquired data.
16:00
16:45
Community-Scale Translation of Mass Spectrometry Big Data into Crowdsourced Proteomics and Metabolomics Resources
Nuno Bandeira
University of California, San Diego
Translating the growing volumes of proteomics mass spectrometry data into reusable evidence of the occurrence and provenance of proteomics and metabolomics events requires the development of novel community-scale computational workflows. We show how advanced distributed computing algorithms can be used to process tens of terabytes of public data to reveal hundreds of millions of new identifications, including the discovery of novel proteins and hypermodified peptides with over 100 modification variants. We further show how large scale reanalyses can be reliably aggregated into community-scale crowdsourced spectral libraries enabling high-throughput detection and discovery in newly acquired data.
15:00
15:30
COFFEE BREAK
@ Renaissance Ballroom Foyer

Coffee break with cookies and fruit.
15:30
16:15

PLENARY PANEL : The Future of Clinical Mass Spectrometry
@ Rms 2-4

The Future of Clinical Mass Spectrometry
California Ballroom
Lead(s): Daniel Holmes

Panel Discussion on where we go from here with academic and industry leaders in the field including Jennifer van Eyk, Ceders-Sinai, Erin Baker, Pacific Northwest National Laboratories, Randall Julian, Indigo BioAutomation, Rob DeWitte, Thermo Scientific, Nigel Clarke, Quest Diagnostics,and Dennis Dietzen, Washington University, AACC Current President

16:15
16:30
INTERMISSION
@ Renaissance Foyer
16:30
17:00
POSTER LIGHTNING TALKS
@ Rms 2-4

90 seconds a couple of slides. View up to 15 poster presentation presented.
17:00
17:30
EXHIBITOR LIGHTNING TALKS
@ Rms 2-4

90 seconds and a couple of slides. Get to know some vendors ... fast. Up to 15 vendor summaries to be presented.
17:30
20:00
EXHIBITS DINNER RECEPTION
@ Exhibit Hall

Drinks, beer & wine with BBQ buffet. Enjoy mingling with colleagues and Exhibitors. Take time to explore the Posters.
18:00
19:00
MEET-THE-EXPERTS: BOOTH TOURS
@ Exhibit Hall : Meet-the-Experts Rally Point
19:00
20:00
TROUBLESHOOTING FORUM : POSTER ROUNDS
@ Exhibit Hall - Poster Board 40

Co-Chairs: Judy Stone & Grace van der Gugten
Join a troubleshooting poster discussion to learn something new or add your two cents.
19:00
Charge Wars of Ion Suppression - Awakening the Force for the Analysis of Estrogens in Clinical Research
Robert Wardle
Waters Corporation
19:20
Metformin Interference in LC-MS/MS Analysis of Plasma Methoxycatecholamines
Marianne Bergmann
Lillebaelt Hospital
19:40
Fat Loving Vitamins – the Struggle is Real
Matthew Crawford
LabCorp
20:00
Is your internal standard pulling its weight? Top tips for clinical research method development
Stephen Balloch
Waters Corporation
20:00
22:00

DISCUSSION GROUPS
@ various

CDC Standardization Programs Forum
Rm 2: Catalina
Lead(s): Julianne Botelho & Hubert Vesper

Participants will discuss how CDC Standardization Programs support laboratories with improving measurements for key hormones such as 25-hydroxyvitamin D, estradiol, and testosterone. Included will be additional discussions about new projects and tools available in CDC Standardization Programs.

FDA Overview of the Process for Clearance and Approval of Mass Spectrometry-based In vitro Diagnostic Devices
Rm 3: Madera
Lead(s): Doug Jeffery & Matthew Humbard
20:00
22:00
HOSPITALITY
@ Santa Rosa and Rocks Terrace (if weather is agreeable)

Light Appetizers and Drinks served.

Wednesday

6:00
7:00
YOGA
@ San Jacinto

Energize yourself for the day! Yoga is a complimentary offering for all MSACL registrants.
A limited number of yoga mats will be provided.
6:30
8:15
WORKSHOP BREAKFAST
@ Renaissance Ballroom Foyer

Enjoy a light continental breakfast before exploring a corporate workshop.
7:00
7:45

CORPORATE WORKSHOPS AM β
@ Rm 1-5

MilliporeSigma
Room 2 (Catalina)

Biompatible Solid Phase Microextraction Coupled to MS for Improved Analysis of Biological Fluids

Microextraction using newly developed biocompatible solid phase microextraction (BioSPME) devices can be used to directly sample from complex biological matrices without significant co-extraction of interferences. BioSPME extractions may be coupled with a mass spectrometer directly or analyzed via a standard LC/MS workflow. This sample preparation methodology has evolved into a useful tool for clinical applications. Performing direct MS analysis eliminates time-consuming and costly steps specific to LC and GC separations. This rapid detection technique facilitates fast screening methods and, due to analyte concentration as well as extraction from matrix interferences, often provides highly quantitative results. This workshop will provide an overview of the technique including method development and optimization schemes. Applications including analysis of drugs of abuse, steroids and hormones from a variety of biological matrices including plasma, urine and saliva, will be explored and contrasted to conventional approaches.

Waters
Room 4 (Pasadena)

It's all about the Base: How much Simpler, Cleaner and Faster can Mixed Mode Ion Exchange SPE Methods get?

Kim Haynes, Principal Product Marketing Manager, Chemistry Technology Center

Mixed-mode ion exchange solid phase extraction (SPE) is an extremely powerful sample cleanup tool when higher degrees of analyte specificity and sample cleanliness are required. However, these methods are often associated with extra method development time and complicated processes.
In this seminar we will explore the compromise scientists have had to make between analyte specificity, sample cleanliness and simple workflows. We will then introduce an easy-to-implement solution to this problem using a new solid phase extraction product recently developed by scientists at Waters Corporation. Finally, we will demonstrate how this new product simplifies workflows, reduces method development and processing time, while improving sample cleanliness in applications.

Veritomyx
Room 5 (Sierra)

Pre-Register

Discover a new era of mass spectrometry effectiveness - revealing the power hidden in your existing MS data!

Transform your existing mass spectral data sets and subsequent analyses to unexpected new levels of quality and effectiveness. Discover how to employ fully-automated PeakInvestigator® advanced post-processing software to open a new era of effective life sciences problem solving with the introduction of statistically-valid MS peak determinations, including error bars on every mass and abundance call.

Learn how PeakInvestigator can transform your existing MS results into more powerful and complete data sets by deconvolving overlapped peaks, extracting remarkably improved sensitivity with noise rejection, and providing higher precision in peak determinations. These remarkable improvements extracted from your existing MS data outputs enable you to open a new era of effectiveness in subsequent data analysis, discoveries and confirmations.

Join the Veritomyx team and renowned guest speakers for presentations and Q&A including:
“Fully-Automated, Advanced Mass Spectral Data Analysis”
“Increased Quantity & Quality Of Proteomics Identifications"
“Transformation in Metabolic Biomarkers Blind Discovery Effectiveness”

7:45
8:00
INTERMISSION
@ Renaissance Ballroom Foyer
8:00
8:45

CORPORATE WORKSHOPS AM γ
@ Rm 1-5

Restek
Room 1 (Mojave)

Ethyl Glucuronide (EtG) and Ethyl Sulfate (EtS) are unique biomarkers of alcohol use. EtG and EtS analysis offers many advantages for abstinence monitoring including the detection window, stability in stored specimens, and specificity. EtG and EtS are both polar, making them difficult to retain via reversed-phase chromatography. Both compounds are also very sensitive to matrix interferences which can result in being unable to achieve low limits of detection and can also make quantitation impossible. In this study, a simple dilute and shoot method was developed and validated for the analysis of EtG and EtS in human urine by LC-MS/MS.

Neoteryx
Room 2 (Catalina)

Pre-Register

The Patient & Lab Perspective: Capillary vs. Venous Monitoring of Immunosuppressants

Dr. Paul Jannetto, Mayo Clinic, Director, Clinical Mass Spectrometry Lab, Clinical and Forensic Toxicology Lab, and Metals Lab

This session will provide a brief summary of a clinical pilot study where 100 patients were enrolled to compare the analytical results and patient satisfaction from a traditional venous whole blood draw versus a capillary collected whole blood sample using the Mitra microsampling collection device. In addition, the operational and analytical validation of the new automated Mitra workflow will be discussed.

SCIEX
Room 3 (Madera)

Pre-Register

Endocrine Applications requiring high sensitivity: performance of the new SCIEX Citrine™ Mass Spectrometry System for measuring Thyroglobulin and 1,25 dihydroxyvitamin D
Dr. Daniel T. Holmes, MD; FRCPC Division Head, Clinical Chemistry,
St. Paul's Hospital Department of Pathology and Laboratory Medicine Vancouver, BC, Canada


SCIEX is very pleased to invite you to attend the unveiling of the Citrine™ MS/MS system, our fastest, most sensitive IVD mass spectrometer. The Citrine MS/MS system provides the clinical lab with the performance and robustness to address the most challenging applications. In this session, data will be presented to highlight the performance of the Citrine MS/MS system for (i) the measurement of 1,25-dihydroxyvitamin D, and (ii) the measurement of thyroglobulin, using the SISCAPA workflow.

Waters
Room 4 (Pasadena)

Measurement of Eicosanoids and their Urinary Metabolites using Mass Spectrometry

Ginger L. Milne, PhD, Research Associate Professor, Director, Eicosanoid & Neurochemistry Core Laboratories, School of Medicine, Vanderbilt University, TN

Eicosanoids are important signaling molecules central to many critical physiological processes such as inflammation, pregnancy and childbirth, and cardiovascular function. Dysregulation of eicosanoid production has been implicated in a number of diseases such as oncology, metabolic syndrome, and cardiovascular disease. Derived by the enzymatic or non-enzymatic oxidation of arachidonic acid or other 20 carbon length polyunsaturated fatty acids (PUFAs), eicosanoids are challenging to quantitatively measure due to their inherent structural and chemical similarities. This workshop will demonstrate how targeted mass spectrometry workflows are key to accurate and precise measurement of eicosanoids for clinical research and why they are required to further biomedical research of these important class of biochemicals.

For Research Use Only. Not for use in Diagnostic Procedures.

Indigo BioAutomation
Room 5 (Sierra)

The Batch and Beyond - LCMS Result Automation Strategies and Analytics

Jim Edwards

The utilization of self-aware peak processing algorithms, a comprehensive quality architecture, and a streamlined, exception-based data/result review process have proven to be a successful strategy for improving both quality and throughput of LCMS analysis. The positive impacts of these batch-oriented optimizations can be significantly magnified by an additional layer of analytics and visualization which provide comprehensive information across instruments, assays, and batches over time. Please join us for a discussion on how these analytics are used to diagnose and prevent issues, target quality improvement efforts where they will be most effective, improve the quality and speed of automated result release, and align both the business and science aspects of the laboratory for an elevation in the efficiency and effectiveness of both.

8:45
9:00
INTERMISSION
@ Renaissance Foyer
GENERAL SCIENTIFIC Session 1
Track 1
Room 1 (Mojave Learning Center)
Keynote - Cannabinoids
Chair: David Schwope
Track 2
Room 2 (Catalina)
Keynote - Informatics
Chair: Patrick Mathias
Track 3
Room 3 (Madera)
Mobilize, Derivatize and Free: Novel Approaches to Vitamin D
Chair: Joe El-Khoury
Track 4
Room 4 (Pasadena)
Therapeutic Proteins
Chair: Andy Hoofnagle
Track 5
Room 5 (Sierra)
Targeted Metabolomics Analysis
Chair: Erin Baker
Track 6
Room 6 (SmokeTree)
Keynote - Tissue Imaging
Chair: Jeff Spraggins
Track 7
Pueblo
Practical Training : Intermediate
Chair: TBA
Track 8
Chino
Practical Training : Beginner
Chair: TBA
Track 9
Andreas
Microbiology Identification
Chair: Kent Voorhees
9:00
9:20
Mass Spectrometry Meets Medical and Legal Cannabis
Marilyn Huestis
University of Maryland School of Medicine
On the Building of the Skyline Targeted Mass Spec Software
Brendan MacLean
University of Washington
Using Ion Mobility to Reduce Chromatography Time for Liquid Chromatography-Ion Mobility-Mass Spectrometry Quantitation of 25-Hydroxyvitamin D in Human Serum
Nicholas Oranzi
University of Florida
Tumor Tissue Proteomics in the CAP/CLIA Laboratory: A 5-year Update
Maryann Vogelsang
NantOmics
Measurement of Underivatized Amino Acids in Dried Blood Spots by Isocratic LC-MS/MS to Diagnose and Monitor Multiple Metabolic Disorders
Cheryl Garganta
University of Florida
Application of N-Glycan MALDI MS Imaging to Identify Biomarker Signatures of Advanced Cancers in FFPE Tissues
Richard Drake
Medical University of South Carolina

CANCELLED DUE TO FLU. To be replaced by Jeffrey Spraggins.
...
Starts
Next
Session
...
...
Starts
Next
Session
...
Metal Oxide Laser Ionization MS Bacterial Fatty Acid Composition for Rapid ID and Antibiotic Resistance Determination
Chris Cox
Colorado School of Mines
9:20
9:40
...
Keynote
...
...
Keynote
...
LC-MS/MS Method for Measurement of Free 25-Hydroxy Vitamin D
Mark Kushnir
ARUP Institute for Clinical and Experimental Patho
Stop the Inflixi-Madness: Comparison of Immunometric and Mass Spectrometric Therapeutic Drug Monitoring Assay
Grace van der Gugten
St Paul's Hospital
Persistently Increased Alloisoleucine in a Patient without Maple Syrup Urine Disease
Joesph Wiencek
University of Virginia School of Medicine
...
Keynote
...
...
Starts
Next
Session
...
...
Starts
Next
Session
...
Laser Assisted Rapid Evaporative Ionisation Mass Spectrometry (LA-REIMS): An Automated High-Throughput Platform for Clinical Microbiology and Beyond
Simon Cameron
Imperial College London
9:40
10:00
...
Keynote
...
...
Keynote
...
Optimized Derivatization Techniques for Quantitation of Vitamin D in Serum by LC-MS/MS
Carl Jenkinson
University of Birmingham
Comparison of Protein Extraction, Detection, and Quantitation Methods for Therapeutic Monoclonal Antibodies; LC-MS/MS Tryptic Peptide vs Intact LC-MS
Paula Ladwig
Mayo Clinic
Multiple Reaction Monitoring (MRM) Profiling: Metabolomics Discovery Methodology Demonstrated with a Human Plasma Coronary Artery Disease Study
Karen Yannell
Purdue University
...
Keynote
...
...
Starts
Next
Session
...
...
Starts
Next
Session
...
Metabolic Phenotyping of Pseudomonas aeruginosa Using Rapid Evaporative Ionization Mass Spectrometry: Strain Characterization and Clinical Applications
Emmanuelle Bardin
Imperial College London
10:00
11:00
EXHIBITS & POSTER SESSION
@ Exhibit Hall

Positions A & D on Odd Poster #'s to be attended.
Soft drinks & fruit served. Coffee and Tea available at participating vendor booths.
10:00
11:00
MEET-THE-EXPERTS: POSTER TOURS 1
@ Exhibit Hall : Meet-the-Experts Rally Point
GENERAL SCIENTIFIC Session 2
Track 1
Room 1 (Mojave Learning Center)
Cannabinoids - Alternative Matrices
Chair: Jackie Hubbard
Track 2
Room 2 (Catalina)
Keynote - Joint Informatics and Microbiology
Chair: Brendan MacLean
Track 3
Room 3 (Madera)
Keynote - Endocrine
Chair: Dan Holmes
Track 4
Room 4 (Pasadena)
Proteomics and Precision Medicine
Chair: Tim Collier
Track 5
Room 5 (Sierra)
Direct Analysis in Metabolomics
Chair: Gary Patti
Track 6
Room 6 (SmokeTree)
New Applications
Chair: Stephanie Cologna
Track 7
Pueblo
Practical Training Intermediate: How to Achieve Lower Quantitation Limits
Chair: Russ Grant
Track 8
Chino
Practical Training Basic: Introduction to Quantitative LC-MSMS
Chair: Alec Saitman
Track 9
Andreas
Keynote - Joint Informatics and Microbiology
Chair: TBA
11:00
11:20
Simple and Rapid LC-MS/MS Methods for Quantitation of Five Cannabinoids in Breath and Blood Samples – Correlation in the Two Sample Forms
Y. Ruben Luo
University of California, San Francisco
Can We Advance Health Monitoring the Way Google Has Advanced Text Mining for the General Population?
Pieter Dorrestein
UCSD
24,25(OH)2 Vitamin D and Vitamin D Metabolite Ratio: New Players in the Exploration of Non-Parathyroid Hypercalcemia
Etienne Cavalier
University of Liege
Proteomics Identifies DNAJB9 as a Pathogenic Protein in Fibrillary Glomerulonephritis
Surendra Dasari
Mayo Clinic
Metabolic Phenotyping of ex vivo Human Lung Perfusion
Vincen Wu
Imperial College London
Assessing the Effect of Immunization on the Global Lipidome of Mouse Spleen Using MALDI FTICR IMS
Marissa Jones
Vanderbilt University
How to Achieve Lower Quantification Limits : Part 1 : Foundations
Russ Grant
LabCorp
View Slides (PDF)
Clinical Mass Spectrometry Case Studies: How We Can “Read Between the Lines”
Alec Saitman
Providence Regional Laboratories
View Slides (PDF)
...
See
Track 2
...
11:20
11:40
Detection of in utero Exposure to Cannabis, What Are We Missing?
Triniti Scroggin
ARUP Laboratories
...
Keynote
...
...
Keynote
...
Differential Processing of High-Molecular-Weight Kininogen Throughout Normal Pregnancy
Stephenie Droll
National Institutes of Health
Innovations for Direct Tissue Analysis and Imaging with Mass Spectrometry
Richard Yost
University of Florida
Spatially Resolved Profiling of Polymyxin B Induced Acute Kidney Injury
Andreas Dannhorn
Imperial College London
How to Achieve Lower Quantification Limits : Part 2 : Formulation
Russ Grant
LabCorp
Clinical Mass Spectrometry: Benefits and Considerations
Jeff Young
Providence Health And Services
...
See
Track 2
...
11:40
12:00
Cannabinoids in Oral Fluid: Roadside Screening & Markers of Recent Use
Madeleine Swortwood
Sam Houston State University
...
Keynote
...
...
Keynote
...
MALDI-TOF MS Profiling of Biological Fluids in Precision Medicine
Mark Duncan
Biodesix Inc.
Targeted Full-Scan Data Analysis Using the ChromXtractor Tool Suite
Adam Rosebrock
Stony Brook University
Ambient Ionization Mass Spectrometry for Molecular Characterization and Surgical Diagnosis of Endometriosis
Clara Feider
University of Texas at Austin
How to Achieve Lower Quantification Limits : Part 3 : Finesse
Russ Grant
LabCorp
A Brief Introduction to the Basics of LC-MS in the Clinical Laboratory
Nandu Chindarkar
Kaiser Permanente Regional Lab
...
See
Track 2
...
12:00
13:30
LUNCH
@ Renaissance Ballroom Foyer

Boxed lunch. • Get ready to jump into a Corporate Workshop at 12:15 after picking up lunch.
12:30
13:15

CORPORATE WORKSHOPS PM
@ Rm 1-5

DPX Technologies
Room 1 (Mojave)

Innovative Filtration Method to Rapidly Remove Protein from Biological Matrices Prior to LC/MS/MS Analyses

Daniel B. Kassel, Ph.D., Founder & CEO, SciAnalytical Strategies, Inc., La Jolla, CA; Kaylee R. Mastrianni, Ph.D., Applications Chemist, DPX Technologies, LLC,
Columbia, SC

Conventional protein precipitation methods require centrifugation and oftentimes offline sample handling prior to LC/MS/MS analyses. We introduce a rapid and readily automated patent pending method for protein precipitation with automated filtration. The method utilizes Tip-On-Tip (ToT) technology for the streamlined analysis of urine, whole blood, and serum/plasma. We will discuss numerous applications such as filtration of hydrolyzed urine samples, comprehensive drug testing in whole blood, and steroid analysis in serum. We will also present a validated method for the analysis of total testosterone in serum, and show detailed patient results obtained from a collaborative clinical laboratory. Using this ToT technology, up to 96 serum samples were processed simultaneously in less than 10 minutes using a Hamilton Nimbus96, providing clean extracts immediately ready for injection into LC/MS instrumentation.

Thermo Scientific
Room 2 (Catalina)

Mass Spectrometry Approaches to the Opioid Epidemic

Marilyn Huestis, Retired Chief, Chemistry and Drug Metabolism, NIDA, Huestis & Smith Toxicology, LLC, USA

The opioid epidemic began when pain became the 6th vital sign. More than 100 million US citizens report chronic pain that requires treatment. Physicians rapidly moved to potent opioid analgesics rather than other non-steroidal anti-inflammatory drugs, leading to opioid dependence. Prescription opioid abuse is estimated to cost $72.5 B annually in health-care costs. The Drug Enforcement Agency's increased controls on health care providers and clandestine laboratories offerings of designer opioids and synthetic fentanyls resulted in opioid-dependent users moving to these new potent opioid drugs. These developments challenge laboratories to identify and quantify a wide variety of prescription opioids, heroin, and novel psychoactive opioids. Laboratories need analytical solutions to address the opioid epidemic. Liquid chromatography tandem mass spectrometry (LC-MS/MS) offers the power of multi-opioid analysis and rapid quantification of numerous analgesics. To determine the utility of high resolution accurate mass spectrometry (HRAM) to enable broad spectrum screening for prescription, illicit and clandestine laboratory opioids in clinical research will be discussed.

Shimadzu
Room 3 (Madera)

Pre-Register

Implementation of a fully integrated automated sample preparation system for routine clinical LC-MS/MS analysis

Lorin Bachmann, PhD, DABCC, Associate Professor of Pathology, Co-Director of Clinical Chemistry, Virginia Commonwealth University

Lack of availability of a fully automated LC-MS/MS system has been one of the largest barriers to meaningful adoption of mass spectrometry in the routine clinical laboratory. Our laboratory evaluated the workflow attributes and analytical performance characteristics of the Clinical Laboratory Automation Module 2000 (CLAM-2000) integrated with the Prominence LCMS-8050 platform for routine analysis of total 25-OH Vitamin D (25-OHD). This configuration enabled complete integration of automated sample preparation with LCMS analysis during the validation study. The method validation included patient samples obtained from our academic medical center and was performed according to Clinical and Laboratory Standards Institute (CLSI) guidelines. The CLAM-2000 Prominence LCMS-8050 method was linear from 2ng/mL- 150 ng/mL for 25-OH D3, 3-epi 25-OH D3 and 25-OH D2. Precision was excellent with coefficients of variation < 6%. The method agreed with our validated manual LCMS method, however the CLAM-2000 Prominence LCMS-8050 system had the additional advantage of resolving the 3-epimer of 25-OH Vitamin D3. Trueness was confirmed using NIST 972a Vitamin D reference materials.

Agilent Technologies
Room 4 (Pasadena)

Pre-Register

Despite a few decades of proteomics research and the apparent discovery of multiple protein biomarkers to support the diagnosis and treatment of patients, the number of protein biomarkers that have been developed to the stage of being used routinely is disappointingly low. So, it's clear that whilst there’s huge interest in the field of research for development of new protein biomarkers and major drivers for this to happen: including the pharmaceutical industry’s need to better stratify patients for effective treatment, as yet biomarker development and delivery is proving very challenging. Why is this?

By enabling rapid assay development and evaluation, SRM/MRM on triple quadrupole mass spectrometers holds huge potential as a platform for the development of specific and sensitive 'biomarker signatures' comprising multiple proteins. However, once such prototype signatures are developed can they be clinically validated and then delivered to a clinical test environment? Addressing this current bottleneck may be dependent on the implementation of robust and reliable workflows with methods that are easy, quick and inexpensive and may be automated.

For Research Use Only. Not for use in diagnostic procedures.

Biognosys
Room 5 (Sierra)

Pre-Register

Next-Generation Proteomics Technology to Increase Depth of Coverage and Data Reproducibility In Clinical Proteomics

Recent major advancements in label free mass spectrometry based proteomics have enabled deeper and more reproducible quantification of thousands of proteins in a single measurement. This next generation proteomics technology is based on data independent acquisition (DIA) which overcomes the technical limitation of sampling speed of mass spectrometers by isolating broad ranges of peptide ions in parallel and utilizing powerful data deconvolution algorithms. DIA technology is only limited by the sensitivity of the detector, and not the sequential speed of the instrument. Researchers can now carry out deeper analysis of proteins in clinical samples and with new chromatographic set-ups the studies can be extended to hundreds of samples without any loss in depth, coverage and reproducibility.
During the lunch symposium proteomics experts from Biognosys will present the latest improvements in data acquisition, analysis and interpretation. Attendees will learn how to identify more than 8`000 protein groups in single shot DIA with almost no missing values across technical replicates.
Further we will present an optimized capillary flow system coupled to the Thermo Fisher Orbitrap Fusion Lumos. This system was used to analyse over 1500 human plasma samples.

13:30
14:30
EXHIBITS & POSTER SESSION
@ Exhibit Hall

Positions B & C on Even Poster #'s to be attended.
Soft drinks & fruit served. Coffee and Tea available at participating vendor booths.
13:30
14:30
MEET-THE-EXPERTS: POSTER TOURS 2
@ Exhibit Hall : Meet-the-Experts Rally Point
GENERAL SCIENTIFIC Session 3
Track 1
Room 1 (Mojave Learning Center)
Synthetic Cannabinoids Detection
Chair: Madeline Swortwood
Track 2
Room 2 (Catalina)
Clinical Operations
Chair: Shannon Haymond
Track 3
Room 3 (Madera)
Clinical Nuances In Ion Ratios, Intensive Care TDM And Assessment Of Malabsorption
Chair: Michael Chen
Track 4
Room 4 (Pasadena)
Applications of High Resolution Mass Spectrometry
Chair: Jenny Van Eyk
Track 5
Room 5 (Sierra)
Ion Mobility and High Resolution in Metabolomics
Chair: Adam Rosebrock
Track 6
Room 6 (SmokeTree)
Intraoperative Diagnosis
Chair: David Muddiman
Track 7
Pueblo
Practical Training Intermediate: Pharmacogenetics & MALDI-TOF
Chair: Fang Wu
Track 8
Chino
Practical Training Basic: Purchasing Your First LC-MSMS
Chair: Deborah French
Track 9
Andreas
Keynote - Microbiology
Chair: Chris Cox
14:30
14:50
The Utility of LC-QTOF/MS in Proactive Synthetic Cannabinoid Testing in the Psychoactives Surveillance Consortium and Analysis Network (P SCAN)
Roy Gerona
University of California, San Francisco
Current Perspectives on Clinical Mass Spectrometry Auto-Data Review: An Innovative Solution
Alec Saitman
Providence Regional Laboratories
View Slides (PDF)
Simvastatin as a Biomarker for Intestinal Villous Health for Celiac Disease Patients
Robert Voyksner
ImmunogenX
Everything You Wanted to Know (sort of) about High Resolution Q-TOF Quantitation of Peptides But Were Afraid to Ask
Michael Lassman
Merck & Co
Lipidomic and Metabolomic Profiles Investigating the Role of Alzheimer’s Disease and Genotype
Xueyun Zheng
Pacific Northwest National Laboratory
An International “iKnife” Network to Validate Tissue-Specific Database Across Multi-Centers
Zsolt Bodai
Imperial College London
Getting Started with Pharmacogenetics Testing and Mass Spectrometry - I
Fang Wu
St. Paul
Addl Info (PDF)
Selecting and Planning for the Right Mass Spectrometer_i
Deborah French
University of California San Francisco
View Slides (PDF)
Addl Info (PDF)
Microbial Applications of Mass Spectrometry
Kent Voorhees
Colorado School of Mines
14:50
15:10
Screening for Synthetic Cannabinoids in Blood Using LC-QTRAP
Matthew McMullin
NMS Labs
Interfacing MS Instrumentation in a Clinical Chemistry Routine Laboratory: Squeezing Standards vs Real Life Constraints
Pierre-Alain Binz
CHUV Lausanne University Hospital
A Sensitive Method for the Simultaneous UHPLC-MS/MS Analysis of Milrinone and Dobutamine in Blood Plasma Using NH4F as the Eluent Additive
Ruta Veigure
University of Tartu
Top-Down Quantitative Determination of Intact Proteins in Serum by Multi-Dimensional LC/QTOF Mass Spectrometry
Jack Henion
Q2 Solutions
Interest of High Resolution Mass Spectrometry in Metabolomics Studies for a Better Characterization of Primary Immunodeficiency in Humans
Anne Claire Boschat
Institut Imagine
Advanced Development of the MasSpec Pen Technology for Laparoscopic and Robotic Surgical Applications
Noah Giese
University of Texas at Austin
Getting Started with Pharmacogenetics Testing and Mass Spectrometry - II
Fang Wu
St. Paul

Addl Info (PDF)
Making the Most of Vendor Visits and Discussions with Colleagues during Instrument Vendor Selection_II
Deborah French
University of California San Francisco
View Slides (PDF)
...
Keynote
...
15:10
15:30
A Sustainable LC-MS/MS Testing Platform for K2 Synthetic Cannabinoids
Jeffery Moran
University of Arkansas for Medical Sciences
A Survey of Clinical Laboratories to Determine Needs for Clinical Mass Spectrometry Data Exchange
Patrick Mathias
University of Washington
Matrix and Instrument Effects on Analyte Fragmentation and Ion Ratios
Geoffrey Rule
ARUP Laboratories
Quantitation of the Therapeutic Monoclonal Antibody Eculizumab Using High Resolution Accurate Mass Spectrometry
Ann Rivard
Mayo Clinic Clincal Mass Spec Dev Lab- DLMP
Isotopic Ratio Outlier Analysis (IROA) in Combination with Ion Mobility/Mass Spectrometry for Higher Quality Metabolomic Profiling
Robin Kemperman
University of Florida
Towards in situ Tissue Classification to Improve Prostate Cancer Diagnosis Using Mass Spectrometry Imaging
Elizabeth Randall
Brigham and Women's Hospital, Harvard Medical Scho
Getting Started with Pharmacogenetics Testing and Mass Spectrometry - III
Fang Wu
St. Paul Hospital, Saskatoon Health Region

Addl Info (PDF)
Financial Considerations for Purchasing a Mass Spectrometer_III
Joe El-Khoury
Yale University
View Slides (PDF)
...
Keynote
...
15:30
17:00
EXHIBITS & APPETIZERS
@ Exhibit Hall
15:45
16:45
MEET-THE-EXPERTS: OFFICE HOURS
@ Exhibit Hall : Meet-the-Experts Rally Point

Meet with various experts and benefit from up to 15 minutes of private mentorship with each. Sign up at the Meet-the-Experts Rally Point in the Exhibit Hall.
PLENARY 2
@ Rooms 2-4
Chair: Andy Hoofnagle & Russell Grant
17:00
18:00
The Triple Quadrupole: Innovation, Serendipity and Persistence
Richard Yost
University of Florida

Distinguished Contribution Award Plenary Lecture

In this presentation I will provide a personal perspective on the conceptualization, development and demonstration of the analytical capabilities of the triple quadrupole mass spectrometer. And in that perspective, I will try to illustrate the roles of innovation, serendipity and persistence that are fundamental to scientific research. The triple quadrupole mass spectrometer has become the most common mass spectrometer in the world today, with sales of over $1 billion per year. It is today the gold standard for quantitative analysis in metabolomics, clinical analysis, drug discovery and development, environmental analysis, and a wide variety of other application areas. That invention and related research have helped propel mass spectrometry into the most commonly used analytical method in the world.
16:30
17:30
The Triple Quadrupole: Innovation, Serendipity and Persistence
Richard Yost
University of Florida

Distinguished Contribution Award Plenary Lecture

In this presentation I will provide a personal perspective on the conceptualization, development and demonstration of the analytical capabilities of the triple quadrupole mass spectrometer. And in that perspective, I will try to illustrate the roles of innovation, serendipity and persistence that are fundamental to scientific research. The triple quadrupole mass spectrometer has become the most common mass spectrometer in the world today, with sales of over $1 billion per year. It is today the gold standard for quantitative analysis in metabolomics, clinical analysis, drug discovery and development, environmental analysis, and a wide variety of other application areas. That invention and related research have helped propel mass spectrometry into the most commonly used analytical method in the world.
18:00
22:00
FREE EVENING / OFF-SITE MEETINGS / DINNER ON OWN
@ Your Decision

Haven't decided on a dinner location yet? Head to the Hospitality Lounge at Rocks Patio to meet up with old friends or make new ones over drinks and light appetizers before heading to dinner in Palm Springs.
18:00
22:00
HOSPITALITY
@ Santa Rosa and/or Rocks Terrace (if weather is agreeable)

Thursday

6:00
7:00
YOGA
@ San Jacinto

Energize yourself for the day! Yoga is a complimentary offering for all MSACL registrants.
A limited number of yoga mats will be provided.
6:30
8:15
WORKSHOP BREAKFAST
@ Renaissance Ballroom Foyer

Enjoy a light continental breakfast before exploring a corporate workshop.
7:00
7:45

CORPORATE WORKSHOPS AM β
@ Rm1 - Rm5

MilliporeSigma
Room 2 (Catalina)

Sample Preparation for Meaningful LC-MS

Mass spectrometry-based analysis is playing an increasingly vital role in basic research and more significantly, clinical applications. Sample preparation is an integral, but often overlooked, component of a successful LC-MS experiment. However, given the highly manual nature of the process, dearth of efficient standardized methods, and the wide variability in sample content, sample processing is the predominant source of errors and reporting bias. Due to the nature of the workflow, sample prep errors remain undetected until the final data analysis step; such issues are particularly costly in clinical settings where samples are precious or access is limited.
This workshop will offer simple tips and tricks to expedite sample preparation while ensuring sample integrity is maintained. Aspects of sample preparation to be covered in the workshop include:

- Quick guidance to filtration membrane selection allowing efficient and contamination (extractables) free sample cleanup
- Importance of plate selection for high throughput removal of matrix components while retaining desired analyte(s)
- Filter Aided Sample Preparation (FASP) and attempts on quantitative analysis
- Quick ZipTip based sample pre-treatment to enhance LC-MS quality

7:45
8:00
INTERMISSION
@ Renaissance Foyer
8:00
9:00
PRIVATE: Scientific Committee Discussion Group
@ Mesquite H
8:00
8:45

CORPORATE WORKSHOPS AM γ
@ Rm1 - Rm5

Biotage
Room 1 (Mojave)

Pre-Register

Achieving Low Level Detection of Clinical Samples Prior to LC-MS/MS Analysis through efficient Sample Prep

Dr. Lee Williams, Biotage GB Limited, UK

The use of LC/MS analysis in the clinical lab has increased exponentially over the last 10 years. Modern mass spectrometers are extremely sensitive allowing low level detection of many target analytes. However, this sensitivity can come at a price, in that levels of contamination not previous detected with less sensitive instruments can now have larger impact on analysis. The complexity of common matrices such as plasma/serum and urine while presenting different challenges can have a marked influence on method performance. As a result sample preparation is an extremely important part of the process in order to provide robust methods. This seminar will focus on some of the method development challenges our lab faced when looking at two clinical assays; Endogenous steroid hormone extraction from serum, and catecholamine extraction from plasma and urine. Particular emphasis will be placed on the various sample preparation options we looked at for the extraction of these analytes. Optimization of the extraction process we investigated included recovery, co-extractable matrix components, HPLC column degradation, calibration curve performance and limits of quantitation.

Thermo Scientific
Room 2 (Catalina)

Comparison of Sample Purification Methods for Therapeutic Monoclonal Antibody Quantitation in Human Serum

Mohsin el Amrani, University Medical Center, University of Utrecht, The Netherlands

In recent years, there has been growing interest in quantifying biopharmaceuticals such as monoclonal antibodies (mAbs) with liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) in biological matrices for clinical research and drug monitoring research. LC-MS/MS possesses notable advantages over several other technologies with capabilities that ensure faster method development, wider linear dynamic range, and most importantly, higher selectivity. However, it can be challenging to select an appropriate and feasible sample purification method for absolute quantification of the target mAb with LC-MS/MS. In this study, a comparison between various sample purification methods for the quantification of total mAbs, including fast, economical and easy pre-analytical sample work-up will be shown. Furthermore, optimized workflow enabling the use of a stable isotopically labelled (SIL) peptide instead of SIL proteins which are commercially unavailable for most mAbs and a successful validation of quantitation assays of mAbs following EMA guidelines using the therapeutic mAbs infliximab and dinutuximab will be discussed.

SCIEX
Room 3 (Madera)

Pre-Register

The Vitamin D 200M Assay for the Topaz™ System as a Model for LC-MS-based Diagnostics

Jason Cournoyer, Ph.D. Senior Development Scientist, SCIEX R&D

The SCIEX Vitamin D 200M Assay for the Topaz™ System is the first FDA-cleared LC-MS/MS assay for Vitamin D. It represents an evolution towards simple, turnkey solutions that enable rapid adoption of this powerful technology in a standard clinical diagnostic lab setting. This workshop will review the development and performance characteristics and advantages of this novel assay, and it's streamlined utilization on the intuitive ClearCore™ MD software platform.

Waters
Room 4 (Pasadena)

Automation and Integration of LC/MS/MS Assays into the Workflow of a Clinical Laboratory

Dr. Emma Walker, Charing Cross Hospital, London, UK

LC-MS/MS has been utilized in the clinical laboratory for approximately two decades and offers increased specificity over more traditional immunoassay based techniques. Widespread adoption of this technique has been hindered as a result of the high capital cost of the equipment, need for highly trained laboratory personnel and the often labor intensive sample preparation required. Automation of sample preparation and interfacing of the LC-MS/MS system to the laboratory information system has the potential to reduce staff time and increase sample throughput. The options available to improve automation and to integrate LC-MS/MS into the workflow of the clinical laboratory will be discussed, including the steps that we have taken within the laboratory at Charing Cross hospital.

8:45
9:00
INTERMISSION
@ Renaissance Foyer
9:00
10:00
EXHIBITOR FEEDBACK MEETING
@ Mesquite H
GENERAL SCIENTIFIC Session 4
Track 1
Room 1 (Mojave Learning Center)
Driving and MJ: Analytical Approaches and the Washington State Experience
Chair: Jack Henion
Track 2
Room 2 (Catalina)
Proteomic Analysis
Chair: Pierre-Alain Binz
Track 3
Room 3 (Madera)
LC Free: Is it for me?
Chair: Jenn Colby
Track 4
Room 4 (Pasadena)
Keynote - Proteomics
Chair: Michael Lassman
Track 5
Room 5 (Sierra)
Biomarkers in Metabolomics
Chair: Xueyun Zheng
Track 6
Room 6 (SmokeTree)
Biomarker Discovery and Validation
Chair: Clara L. Feider
Track 7
Pueblo
Practical Training Intermediate: LC-MSMS Interference Testing
Chair: Zlatuse Clark
Track 8
Chino
Practical Training Basic: LC Theory for Troubleshooting
Chair: Autumn Breaud
Track 9
Andreas
Analysis of Microbial Antibiotic Resistance
Chair: John Lapek
9:00
9:20
Method Development and Validation of LC-MS/MS Assay for Quantification of Cannabinoids in Whole Blood
Breland Smith
InSource Diagnostics
Statistical Identification and Quantitative Deconvolution of Hemoglobin Beta Chain Isotypes Unresolved by LC-MS by Isotopic Vector Angle Analysis
Luke Schneider
Target Discovery, Inc./ Veritomyx, Inc.
View Slides (PDF)
Can LC-MS be Replaced by Direct Coupling of SPME to MS in Clinical Applications?
German Gomez-Rios
University of Waterloo
Protein Biomarker Immunoaffinity Mass Spectrometry: Enabling Translational Pharmacology of Biologics in Pharma
Hendrik Neubert
Pfizer Inc
In vitro Volatile Compound Bacterial Profiling Using GC-MS and their Potential Role for the Diagnosis of Oesophago-Gastric Cancer
Mina Adam
Imperial College London UK
Lipid Mapping in Niemann-Pick Disease, Type C1
Stephanie Cologna
University of Illinois at Chicago
Taking Aim at Interference (Without Shooting Yourself in the Foot) : Part 1
Zlatuse Clark
ARUP Laboratories

Addl Info (PDF)
LC Basics Part I: Demystifying Liquid Chromatography Separations and Hardware
Autumn Breaud
Johns Hopkins University
View Slides (PDF)
A Rapid, Functional, Mass Spectrometry-based Assay for Detecting Carbapenemase Activity and Differentiating Carbapenemase Class
Joshua Hayden
Weill Cornell Medical College
9:20
9:40
Detection and Levels of Cannabinoids in Whole Blood and Oral Fluid After Recent Marijuana Inhalation
Jacqueline Hubbard
University of California, San Diego
Using Data Independent Acquisition to Develop a Targeted Assay for the Generation of Molecular Signatures of Neurodegenerative Disease in Biological Fluids
Sandra Spencer
University of Washington
Evolution of Sponge Spray for Direct Sampling and Analysis by MS
Max Hecht
University of Tartu
...
Keynote
...
Metabolomic Profiling of a Large Cohort of Glioblastoma Stem Cell Lines Identifies Metabolites Associated with Clinical Outcome
Amy Caudy
University of Toronto
Combining MALDI MS Imaging with 2D Gel-based Proteomics to Reveal Potential Penile Carcinoma Biomarkers
Elisangela Silva
A.C.Camargo Cancer center
Taking Aim at Interference (Without Shooting Yourself in the Foot) : Part 2
Zlatuse Clark
ARUP Laboratories
LC Basics Part II: Troubleshooting and Staying Productive, or Up a Creek? Pick a Paddle
Autumn Breaud
Johns Hopkins University
Resistome Profiling in Gram Negative Bacteria to Identify Selection-Averse Antimicrobial Drug Targets
Anaamika Campeau
University of California, San Diego
9:40
10:00
The Prevalence of Marijuana in Suspected Impaired Driving Cases in Washington State
Brianna Peterson
Washington State Patrol
A Systematic Approach to Data-Independent Acquisition-MS for Plasma-based Proteomics Analyses
Shenyan Zhang
Cedars Sinai Medical Center
Multiple Point-of-Care Applications of Ambient Mass Spectrometry for the Emergency Department
Jentaie Shiea
National Sun Yat-Sen University
...
Keynote
...
Metabolomic Biomarkers for Human Plasma Quality
Casey Chamberlain
University of Florida
Mitochondrial Changes of Articular Cartilage by Oxygen
Brenda Bakker
University of Twente
Taking Aim at Interference (Without Shooting Yourself in the Foot) : Part 3
Zlatuse Clark
ARUP Laboratories
LC Basics Part III: Case Studies in Separations Sleuthing
Autumn Breaud
Johns Hopkins University
Lipid Signatures as Diagnostic Predictors of β-Lactam “Seesaw Effect” in Glycopeptide, Lipopeptide, and Lipoglycopeptide Resistance
Kelly Hines
University of Washington
10:00
11:00
EXHIBITS & POSTER SESSION
@ Exhibit Hall

Positions B & C on Odd Poster Board #'s to be attended.
Soft drinks & fruit served. Coffee and Tea available at participating vendor booths.
10:00
11:00
MEET-THE-EXPERTS: POSTER TOURS 3
@ Exhibit Hall : Meet-the-Experts Rally Point
GENERAL SCIENTIFIC Session 5
Track 1
Room 1 (Mojave Learning Center)
Certifying Marijuana for Consumption
Chair: Brianna Peterson
Track 2
Room 2 (Catalina)
Machine learning and Data mining
Chair: Steve Master
Track 3
Room 3 (Madera)
Neonatal Toxicology: from bench to bedside
Chair: Mark Marzinke
Track 4
Room 4 (Pasadena)
Proteome methods and insights
Chair: Mari DeMarco
Track 5
Room 5 (Sierra)
Keynote - Joint Metabolomics and Microbiology
Chair: Tim Garrett
Track 6
Room 6 (SmokeTree)
New Developments and Technologies
Chair: Raf Van de Plas
Track 7
Pueblo
Practical Training Intermediate: Quality Assurance - The Path to Peace of Mind
Chair: Kara Lynch
Track 8
Chino
Practical Training Basic: MSMS Survival Training
Chair: Phil Sobolesky
Track 9
Andreas
Keynote - Joint Metabolomics and Microbiology
Chair: NA
11:00
11:20
Analysis of Cannabis-Related Samples for Composition via LC-MS Employing a Compact Mass Spectrometer
Jack Henion
Advion, Inc
Data Mining Routine Results for Reference Intervals: Common Errors and Modern Techniques
Daniel Holmes
St. Paul's Hospital, Univ. of British Columbia
Analysis of 44 Drugs and their Metabolites in Umbilical Cord by LC-MS/MS
Vandana Megaraj
Cincinnati Childrens Hospital
Potential Clinical Implications for Measuring Thyroglobulin in Human Serum on a Micro-Flow LC-MS/MS System
Christopher Shuford
Laboratory Corporation of America
Early Detection of Cystic Fibrosis Acute Pulmonary Exacerbations by Exhaled Breath Condensate Metabolomics
Facundo Fernández
Georgia Institute of Technology
Metabolic Phenotyping of Fresh Frozen and Formalin-Fixed, Paraffin-Embedded Colorectal Tissue Samples Using DESI-MSI
Anna Mroz
Imperial College London
A Regulatory Review of QA Monitoring for LC-MS/MS: the Real Work Begins After Validation : Part 1
Kara Lynch
University of California San Francisco
View Slides (PDF)
Understanding the Importance of System Suitability Testing for Monitoring Instrument Health
Philip Sobolesky
University of California San Diego

Addl Info (PDF)
...
See
Track 5
...
11:20
11:40
Mass Spectrometric Analysis of Medicinal Cannabis and Synthetic Cannabinoids at a State Public Health Laboratory
Kenneth Aldous
Wadsworth Center , NY State Department of Health
Data Mining at Scale – Turning the Data Gaze into the Data Result
Adam Zabell
Indigo BioAutomation
Performance of Umbilical Cord Tissue and Meconium Toxicology Testing in a Population of Subjects Diagnosed with Neonatal Abstinence Syndrome
Jennifer Colby
Vanderbilt University
Multiplexed Quantification of Proteins in Dried Blood Spots
Clark Henderson
University of Washington
...
Keynote
...
Hyperspectral Chemical Imaging to Probe Amyloid Pathology in Alzheimer’s Disease
Jörg Hanrieder
University of Gothenburg
Design a Customized and Effective Quality Assurance Program for Your Laboratory : Part 2
Kara Lynch
University of California San Francisco
Zen and the Art of LC-MS/MS Maintenance: Assuring Optimal Instrument Performance
Joshua Akin
UC San Diego Health
...
See
Track 5
...
11:40
12:00
A New Approach for Phytocannabinoids Comprehensive Metabolic Profiling: A Step Towards Understanding the Clinical Effects of Cannabis
Paula Berman
Technion - Israel Institute of Technology
High-Throughput Mass Spectrometry Coupled to Machine Learning Algorithms to Enable Accelerated Biomarker Discovery
Jacques Corbeil
Laval University
Method Performance and Clinical Workflow Outcomes Associated with Meconium and Umbilical Cord Toxicology Testing
Steven Cotten
Ohio State University Wexner Medical Center
Albumin Oxidizability: A Rigorous Yardstick of Plasma/Serum Exposure to Thawed Conditions
Chad Borges
Arizona State University
...
Keynote
...
Optimised Desorption Electrospray Ionisationmass Spectrometry Imaging (DESI-MSI) Method for the Analysis of Proteins/Peptides Directly from Tissue Sections
Emmanuelle Claude
Waters Corporation
Potential New Approaches for Quality Assurance Monitoring : Part 3
Lorin Bachmann
Virginia Commonwealth University
Choosing the Right Internal Standard for Good LC-MS/MS Method Development
Imir Metushi
Endocrine Sciences (LabCorp)
...
See
Track 5
...
12:00
13:30
LUNCH & EXHIBITS
@ Exhibit Hall

Box Lunch to be provided in the Exhibit Hall.
12:30
13:30
EXHIBITS & POSTER SESSION
@ Exhibit Hall

Positions A & D on Even Poster Board #'s to be attended.
Soft drinks & fruit served. Coffee and Tea available at participating vendor booths.
12:30
13:30
MEET-THE-EXPERTS: POSTER TOURS 4
@ Exhibit Hall : Meet-the-Experts Rally Point
13:30
14:00

CORPORATE WORKSHOPS PM
@ Rm1 - Rm5

Thermo Scientific
Room 2 (Catalina)

Introducing the Thermo Scientific Cascadion SM Clinical Analyzer

Peter Cooke, Market Development Specialist, Thermo Fisher Scientific

The Thermo Scientific Cascadion SM Clinical Analyzer will be the first all-in-one LC-MS/MS solution designed to meet the needs of clinical laboratories. Our fresh vision for fully automated liquid chromatography-tandem mass spectrometry (LC-MS/MS) testing is cultivated by listening to our customers. You asked for a complete solution that was accurate, easy-to-use, and designed for the clinical laboratory. The Cascadion Clinical Analyzer is designed as a turnkey solution to enable clinical labs to easily adopt the power and capabilities of LC-MS/MS as the gold standard in diagnostic testing. The Cascadion system will combine assays, software, accessories, consumables and support/service in a standalone system designed to meet the regulatory requirements for routine and specialized clinical testing. This presentation will showcase the Cascadion solution.
Product under development, not CE/IVD marked nor FDA cleared yet.

Shimadzu
Room 3 (Madera)

Pre-Register

Simultaneous analysis of multiple steroid hormones by LC-MS/MS

David Erikson, PhD, Director of the Endocrine Technologies Support Core at OHSU

Measurement of steroid hormones has been traditionally performed by radioimmunoassay (RIA) or automatic immunoassay (AI). Recently, liquid chromatography-tandem mass spectrometry (LC-MS/MS) has emerged as the "gold standard" for steroid analysis in the clinical laboratory, as this method offers dramatic improvements in sensitivity, specificity, and automation of serum steroid measurements over immunoassay.

Our laboratory has focused on simultaneous, sensitive measurement of multiple steroid hormones in nonhuman primate and human samples for basic and clinical research using a Shimadzu Nexera-LCMS-8050 platform. Using this technology we are often able to quantify as low as 10 pg/ml using as little as 200 ul of serum from a single sample. The purpose of this presentation is to describe methodology for quantitation of endogenous steroid hormones in serum samples, as well as methods for quantitation of synthetic hormones used for contraception and therapeutic reasons.

We will discuss application of an analytical method for quantitating synthetic hormone levels in women for the purpose of monitoring systemic exposure to determine drug interactions, nonadherence, misreporting, and proper dosing.

14:00
14:15
INTERMISSION
@ Renaissance Foyer
GENERAL SCIENTIFIC Session 6
Track 1
Room 1 (Mojave Learning Center)
Endnote - Cannabinoids
Chair: Marilyn Huestis
Track 2
Room 2 (Catalina)
Joint Informatics and Tissue Imaging
Chair: TBA
Track 3
Room 3 (Madera)
Global Reach: MS Public Health Applications
Chair: Xander van Wijk
Track 4
Room 4 (Pasadena)
Cardiovascular Proteomics
Chair: Surendra Dasari
Track 5
Room 5 (Sierra)
Discovery Metabolomics
Chair: Karen Yannell
Track 6
Room 6 (SmokeTree)
Joint Informatics and Tissue Imaging
Chair: Jörg Hanrieder
Track 7
Pueblo
Practical Training Intermediate: A Method Development Case History
Chair: Stephanie Marin
Track 8
Chino
Practical Training Basic: Staff Training for Mass Spectrometry
Chair: Shannon Haymond
Track 9
Andreas
Microbiology Metabolomics
Chair: Kelly Hines
14:15
14:35
Cannabis sativa L.: Cultivation, Chemistry, Analysis and Prospect Therapeutic Cannabis-based Pharmaceutical Products
Mahmoud ElSohly
University of Mississippi
...
See
Track
6
...
Detection of Synthetic Opioids Using High Resolution Mass Spectrometry
Kara Lynch
University of California San Francisco
Rapid, Accurate, and Cost-Effective Quantification of C-Reactive Protein in Plasma by High-Performance LC-MS/MS
Junyan Shi
University of British Columbia
Target Metabolomics Analysis Reveals Alteration in Pathways in 5p minus Patients by UPLC-MS/MS
Nilson Assuncao
UNIFESP
Linking Exploratory Tissue Analysis to Established Clinical Targets: Automated Discovery of Bio-Molecular Relationships Between Stained Microscopy and IMS
Raf Van de Plas
Delft University of Technology
Method Development Case History Part 1: Development and Validation
Stephanie Marin
Biotage
View Slides (PDF)
Developing a Training Curriculum for LC-MS/MS Labs
Faye Vicente1 & Judy Stone2
1Ann & Robert H Lurie Children, 2CALM, UCSD
View Slides (PDF)
Addl Info (PDF)
Untargeted Metabolomics of 2400 Fecal Samples from American Gut Participants and ICU Subjects Reveals Information about Our Health, Behavior, and Microbiota
Alan Jarmusch
University of California, San Diego
14:35
14:55
...
Keynote
...
...
See
Track
6
...
Use of a MS-based Targeted Approach for Detection of Minimal Residual Disease (MRD) in Multiple Myeloma
Carlo Martins
Memorial Sloan Kettering Cancer Center


Replacing Dr. Sujeewa Piyankarage, out bc of govt shutdown
Development and Characterization of a High-Throughput Method for the Enrichment of ApoA-I Associated High-Density Lipoproteins
Timothy Collier
Cleveland Heartlab, Inc.
Evaluation of the Lipid Profile in the Saliva of Children Affected by Zika Virus Infection
Diogo de Oliveira
University of Campinas
Identifying Predictive Markers of Breast Cancer Receptor Status and Molecular Subtypes Using DESI-MS Imaging
Kyana Garza
University of Texas at Austin
Method Development Case History Part 2: Can’t You Do this Faster and Better? Understanding and Addressing Needs of Clinicians, Technical Staff and Operations
Gwen McMillin
ARUP Laboratories
Developing a Curriculum for Training_II
Shannon Haymond
Northwestern University

Addl Info (PDF)
Daily Dynamics of the Microbiome and Metabolome in Chronically Infected Lungs
Robert Quinn
University of California at San Diego
14:55
15:15
...
Keynote
...
...
See
Track
6
...
The First Precision Diagnosis of Multiple Myeloma by Use of 21 Tesla FT-ICR Top/Middle-Down de novo Sequencing
Lidong He
Florida State University


Replacing Victor De Jesus, out bc of govt shutdown
Development of a Multiplexed Mass Spectrometry-based Method for Absolute Quantitation of Serum Apolipoprotein (A), Independent of its Size Polymorphism
Lucia Renee Ruhaak
Leiden University Medical Center
High-Throughput Screening of Enzymatic Reactions Using IR-MALDESI
Mans Ekelof
North Carolina State University
IR MALDESI: from Technological Innovations to Cancer, HIV Treatment and Exposomics
David Muddiman
North Carolina State University
Method Development Case History Part 3: Re-Development and Re-Validation
Simuli Wabuyele
ARUP Institute for Clinical and Experimental Pathology
Developing a Curriculum for Training_III
Shannon Haymond
Northwestern University
Integration of Non-Targeted Metabolic and Metagenomic Profiling of Feces After Chemical- and Salmonella-Induced Inflammation of Murine Intestines
Jikang Wu
The Ohio State University
15:15
15:30
INTERMISSION
@ Renaissance Foyer
GENERAL SCIENTIFIC Session 7
Track 1
Room 1 (Mojave Learning Center)
Beyond Cannabis: Detection of Natural Products & Alternative Medicines
Chair: Kenneth Aldous
Track 2
Room 2 (Catalina)
Endnote - Statistics in Science
Chair: Randy Julian
Track 3
Room 3 (Madera)
Benzodiazepines: basic applications and beyond
Chair: Kara Lynch
Track 4
Room 4 (Pasadena)
Biomarkers
Chair: Cory Bystrom
Track 5
Room 5 (Sierra)
TBA
Chair: TBA
Track 6
Room 6 (SmokeTree)
Endnote - Tissue Imaging
Chair: Kristina Schwamborn
Track 7
Pueblo
TBA
Chair: TBA
Track 8
Chino

Chair: TBA
Track 9
Andreas
Proteomic Approaches to Bacterial Analysis
Chair: Anaamika Campeau
15:30
15:50
Pharmacokinetic Interactions Between Drugs and Hop Botanical Dietary Supplements Used by Menopausal Women
Richard van Breemen
Linus Pauling Institute
The Importance of Reproducible Research in High-Throughput Biology: Case Studies in Forensic Bioinformatics
Keith Baggerly
UT MD Anderson Cancer Center
A High-Resolution Mass Spectrometry Method for Designer Benzodiazepines
Xander van Wijk
The University of Chicago
Mass Spectrometry Analysis of Immune Checkpoint Proteins in Lung Cancer
Theresa Boyle
Moffitt Cancer Center


Flu; David Koomen replacing. Same talk.
Track ClosedAdvanced Development of the MasSpec Pen for Cancer Diagnosis and Surgical Margin Evaluation
Livia S. Eberlin
University of Texas at Austin
Track ClosedTrack ClosedExploring the Hidden World of MRSA Pathogenesis
Jacob Wozniak
UCSD
15:50
16:10
The Grapefruit Effect: Identifying Potential Drug-Food Interactions in Patients Through Mass-Spectrometric Urinary Furanocoumarin Detection
David Schwope
Aegis Sciences Corporation
...
Keynote
...
Confirming 23-Benzodiazepines in Urine for Pain Management Using LC-MS/MS – a Challenging Assay Development
Richard Lahr
Development Technologist, Mayo Clinic
Diagnosis of Male Infertility with Proteomic and Proteogenomic Biomarkers Measured in Seminal Plasma
Andrei Drabovich
University of Toronto
Track Closed...
Keynote
...
Track ClosedTrack ClosedDefining Systemic Bacterial Infection Through a Murine Organ Atlas of Response to Group A and B Strep Infections
John Lapek
UCSD
16:10
16:30
3D Volume Cartography of Diseased Human Lungs
Alexey Melnik
UCSD


Replacing Cory Holder, out bc of govt shutdown
...
Keynote
...
Quantitation of Seven Benzodiazepines and Metabolites in Urine by LC-MSMS
Yuzi (Emma) Zheng
Cleveland Clinic
Anemia, Altitude, and Autologous Blood Transfusions – Applications of a Novel Method to Measure Membrane Proteins in Dried Blood Spots
Holly Cox
Sports Medicine Research and Testing Laboratory
Track Closed...
Keynote
...
Track ClosedTrack ClosedTop-Down Proteomic Identification of Clinical Subtypes of Shiga Toxin from Shiga Toxin-Producing Escherichia coli Using MALDI-TOF-TOF Tandem Mass Spectrometry
Clifton Fagerquist
Agricultural Research Service, USDA


Back on due to Govt Restart
16:30
18:00
CLOSING EXHIBITS RECEPTION
@ Exhibit Hall

Wine, beer & cheese.
16:30
17:30
POSTER FINALISTS to ATTEND POSTERS
@ Exhibit Hall

Poster Finalists to attend posters for final evaluation by Poster judges.
16:45
17:45
TROUBLESHOOTING FORUM : POSTER ROUNDS
@ Exhibit Hall - Poster Board 41

Co-Chairs: Judy Stone & Grace van der Gugten
Join a troubleshooting poster discussion to learn something new or add your two cents.
16:45
Evaluation of Surrogate Matrices for Serum 25-Hydroxyvitamin D Calibrators by LC-MS/MS Method
Bei-bei ZHAO
KingMed Diagnostics
17:05
Low Extraction Rate of 6-Methylmercaptopurine in RBC
Soo Young Moon
Seoul National University Hospital
17:15
Autosampler Tray Troubleshooting Tales
Kristine Van Natta
Thermo Fisher Scientific
17:30
Troubles with Water (Troubleshooting High Glycine Background Signal)
Zlatuse Clark
ARUP Laboratories
17:45
18:00
REMOVE POSTERS FROM EXHIBIT HALL
@ Exhibit Hall

You can store your poster between Smoketree F and Rm6 until 20:00.
18:00
EXHIBITS CLOSED
@ Exhibit Hall
17:45
18:15
PLENARY RECEPTION
@ California Ballroom Foyer

Wine, beer and other beverages.
18:15
18:30
POSTER AWARDS
@ Rms 2-4
Chair: TBA
Join us in congratulating the winners of the poster contest.
PLENARY 3
@ Rooms 2-4
Chair: TBA
18:30
19:15
A New Approach to Genome Editing
Alexis Komor
University of California, San Diego
The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes within living cells. Here I describe the development of base editing, a new approach to genome editing that enables the direct, irreversible conversion of one target DNA base into another in a programmable manner, without requiring double-stranded DNA backbone cleavage or a donor template. Base editing is one of many recent developments in the genome editing field that advances both the scope and effectiveness of genome editing.
14:00
14:45
A New Approach to Genome Editing
Alexis Komor
University of California, San Diego
The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes within living cells. Here I describe the development of base editing, a new approach to genome editing that enables the direct, irreversible conversion of one target DNA base into another in a programmable manner, without requiring double-stranded DNA backbone cleavage or a donor template. Base editing is one of many recent developments in the genome editing field that advances both the scope and effectiveness of genome editing.
19:15
21:00
CLOSING DINNER: MEXICAN FIESTA
@ California Ballroom, Renaissance Foyer & Patio

Enjoy a taste of southern California / Northern Mexico!
21:00
22:00
HOSPITALITY
@ Rocks Terrace (COLD/RAIN: Santa Rosa)

Relax, network and digest during the final moments of the conference.
22:00
CONFERENCE CLOSED
@ Renaissance