Translating Pre-Clinical Research to Clinical Patient Care™

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SCIEX

Brian Kelly


Agenda (Preliminary) - View Program

Thursday, September 25

Time

Sessions

Registration + Help Desk

Location: Foyer, Conference Level

Breakfast

Location: St Laurent (Exhibits)

Breakfast buffet will open at 7am in the Exhibit Hall. Grab a plate and find a seat at a Roundtable Discussion (in exhibit hall) or Petite Suite (in a breakout room) of your choice (listed below), which begin at 7:30am. Seating is limited for all discussions, so first come first seated.

Phenomenex Petite Suite : Toward Efficient, Reproducible, and Greener Sample Preparation in Clinical Research

Location: Outremont 4

Rajashree Chakravarti, Ph.D
Phenomenex

Anthony Maus, B.S., Ph. D.
Mayo Clinic

Shahana Huq
Phenomenex

Stephanie Marin, PhD
Phenomenex

7:00Check-in and Phenomenex-catered breakfast
7:30Welcome and Introductions
7:45Strata SE SLE - Reproducible, Sustainable Sample Preparation
Rajashree Chakrvarti, PhD Product Manager, Phenomenex
8:00Optimizing Aldosterone Purification Using Strata SE
Anthony Maus, PhD, Co-Director Clinical Mass Spectrometry Laboratory, Mayo Clinic
8:30Methylmalonic Acid in Human Serum for Clinical Research
Shahana W. Huq, Senior Applications Scientist, Phenomenex
8:45Quantitation of Underivatized Estrogens for Clinical Research
Stephanie J. Marin, Ph.D. Senior Market Development Manager, Phenomenex
Waters Petite Suite : Xevo TQ-Absolute IVD & Absolute XR

Location: Westmount 2

Lisa Calton, BSc(Hons), Ph.D
Waters Corporation

Daniel Kenny, PhD, MRes(Phil), BSc (Hons)
Waters Corporation

PRE-REGISTER

7:30am-8:15am Free hormone analysis using the Xevo TQ Absolute for Clinical Research
Lisa Calton, Senior Director Assay Research & Development
8:15am-9:00am Absolute Confidence in Quantitation – Introduction to the new Xevo TQ Absolute XR System
Daniel Kenny, Senior Director Clinical System & Software Development
Thermo Petite Suite : Promising Applications of Clinical LC-MS – A Review of Existing and New QQQ Technologies to Advance Free Testosterone Measurement

Location: Outremont 1

Leslie Farris, B.S.
Cleveland Clinic Foundation

Jessica Colón-Franco, PhD
Cleveland Clinic Foundation

Kerry Hassell
ThermoFisher Scientific

PRE-REGISTER

Accurate assessment of free testosterone (FT) is essential in evaluating androgen status, particularly in cases where total testosterone may be misleading due to altered binding protein levels. This workshop will describe a practical and state-of-the-art LC-MS/MS method for directly measuring FT from dialysate using equilibrium dialysis (ED), offering a streamlined and efficient solution for clinical laboratories.

Presenters will also introduce a new high-end triple quadrupole from Thermo Fisher and discuss how the newest hardware and software features enabled on the system deliver enhanced performance, increased system robustness, and improved productivity to meet demands of the high-volume clinical research and applied markets.

Learning Objectives

By the end of this session, participants will be able to:

1. Recognize the clinical relevance and limitations of total testosterone and free testosterone (calculated and measured) tests in assessing androgen status.
2. Describe the principles and challenges of measuring free testosterone using equilibrium dialysis and LC-MS/MS.
3. Assess the analytical and clinical performance of a direct equilibrium dialysis free testosterone measurement method.

Petite Suite Discussion : MSACL-Compliance and Accreditation Committee, what is that (MSACL-CAC)?

Location: Westmount 1

Judy Stone, MT (ASCP), PhD, DABCC
Clinical Chemist (retired)

Melissa Budelier, PhD
TriCore Reference Laboratories

Alejandro Molinelli, PhD
St. Jude Children's Research Hospital

What (if anything) would you like the MSACL-CAC to do for CLIA, CAP, ISO 15189 or (other) LCMS labs to support their regulatory compliance and ease accreditation?

Some options below-come and tell us what you think, thumbs up or down, what else is needed?

1. Recommendations on LCMS LDTs to CMS for CLIA modernization
2. Practical resources on operations and quality assurance for LCMS best practice and to meet specific accreditation checklists (justifications, policies, procedures, worksheets, recommendations, webinars, job aids, data examples)
3. Quality Management Systems (QMS) for Clinical LCMS - what, why, how?
4. Staff training materials online

Petite Suite Discussion : Multi-omics by the MS Imaging Platform : What's new and what's needed?

Location: Outremont 5

Angela Kruse, PhD
Ohio State University

Peggi Angel, PhD
MUSC Proteomics Center

MS Pathology studies are becoming increasingly complex as work is done to present a comprehensive portrait of the tissue microenvironment. At the same time, the mass spectrometry imaging platform is increasingly being used for not just multiomic tissues but is being extended to multiomics of cells and biofluids. We will discuss progress in the most recent applications of multiomics and explore to what end the extensive workflows are expected to have or have had an impact on understanding health status compared to other spatialomics. We will examine the utility of these workflows in moving to the clinic from the standpoint of creating standardized workflows to data analysis. We anticipate a robust discussion that will point towards necessary work in leveraging these workflows for human health.

Petite Suite Discussion : CANCELLED : Patient centric remote sampling for clinical diagnostics – How do we integrate these samples with existing (non-MS) laboratory workflows?

Location: Outremont 6

Shelley Hossenlopp, MS
Poca International LLC

Enaksha Wickremsinhe, PhD
Gates Medical Research Institute

Dajana Vuckovic, PhD
Concordia University

THIS SESSION HAS BEEN CANCELLED (as of Sept 8, 2025)

Numerous technologies are now commercially available that facilitate the collection of human blood samples in locations away from the clinical setting. This approach is termed patient centric sampling, or microsampling and can involve the collection of samples from a finger stick, or from elsewhere on the body. The samples can be dried, or liquid and are often a smaller volume than those obtained by traditional phlebotomy.

The use of these approaches potentially enables samples to be collected from currently underserved communities (pediatric, elderly, remote areas, etc). Furthermore, the approach may enable more regular sampling of individuals to be performed and facilitates choice for the patient about how and where samples will be collected. These technologies also have the potential to overcome the discomfort, pain and fear that is encountered by many when collecting samples by traditional phlebotomy. However, the format of samples collected this way is often different to those routinely analyzed in the clinical laboratory, i.e. small volume, whole blood, dried blood, particularly for non LC/MS based assays. Participants of this workshop will take part in a facilitated discussion on what the challenges are in the clinical laboratory to the adoption of these technologies and will then focus on how they might be overcome and what future activities might be required to enable this.

Petite Suite Discussion : Ensuring Statistical Power in Biomarker Discovery in Assay Development

Location: Outremont 7

Timothy Collier, PhD
Quest Diagnostics

The increasingly multiplexable capability LC-MS makes it a powerful tool for the discovery of not just single biomarkers but also make possible the use of statistical algorithms to translate the simultaneous measurement of multiple analytes into indicators of patients’ health status and prognoses. The successful development of novel biomarkers and panels requires experimental frameworks that ensure clinical results have sufficient statistical power. Regulatory agencies, including the NY State Department of Health, require descriptions of assay development processes, including the description of any statistical processes and software tools to derive analytical algorithms, from simple statistical approaches up to advanced artificial intelligence, machine learning, and/or natural language processing approaches. Regulatory agencies are also requiring detailed descriptions of discovery, test, and validation cohorts, power calculations to justify cohort sizes, and justification of said calculations.

These requirements have implications not only for commercial laboratories seeking to introduce a test to the market, but also for the academy, where most new biomarker discovery occurs. After this roundtable discussion, attendees should emerge with an understanding of some of the regulatory requirements on algorithms used in clinical measurements and what practices laboratories can adopt to meet these new requirements and enhance the translation of academic research into clinical application.

Breakfast Roundtables

Location: St Laurent (Exhibits)

Tiffany Payne
Veris Marketing

Emma Guiberson, PhD
Middlebury College

Stacy Beal, MD
LetsGetChecked and University of Florida

Tim Garrett, PhD
University of Florida College of Medicine

Christa Cobbaert, PhD
Leiden University Medical Centre (LUMC)

Renee Ruhaak, PhD
LUMC

Table 01: PFAS Blood Serum Testing: Market Drivers, Resistors, and Research

Tiffany Payne

The state of Maine made headlines in May 2025 for unanimously passing legislation to require insurance coverage for blood serum testing for PFAS—similar to legislation New Hampshire passed in 2020. Testing capacity in the U.S. for PFAS in blood serum is limited, and some patients report waiting as long as three months for results. Meanwhile, conflicting medical recommendations and reduced funding for PFAS research present challenges to steady growth of the PFAS testing market.

Table 02: Undergraduate Research in Mass Spectrometry: How to make our labs more undergraduate friendly.

Emma Guiberson

More and more industries are looking for graduates trained in mass spectrometry, even at the bachelors level. Training our undergraduate population in these technologies is important now more than ever, yet requires a very different approach than graduate students. How do we best prepare our undergraduates for both industry and academic experiences using MS? What systems do we need in place within our labs to both support these students, and ensure consistency in data collection, analysis, and reporting? How do we keep these systems in place with the high rates of turnover in undergraduate researchers compared to graduate students? This brainstorming and networking roundtable will address these questions and share positive and negative experiences that can help inform groups including undergraduates moving forward.

Table 03: Women in Laboratory Leadership Roles

Stacy Beal

This discussion will focus on the importance and impact of women in leadership roles within the laboratory. Despite the increasing representation of women in healthcare, leadership positions remain disproportionately occupied by men. This discussion aims to highlight the barriers women face in advancing to leadership roles, such as gender bias, lack of mentorship, and work-life balance challenges. Additionally, we will discuss the critical value women bring to laboratory leadership, including diverse perspectives, empathy, and innovative approaches to patient care and organizational management. We will examine strategies for fostering gender equity in leadership, including mentorship programs, organizational support for work-life integration, and policies aimed at addressing unconscious bias. Furthermore, we will explore the role of male allies in advancing these efforts and the importance of creating inclusive environments that allow women to thrive in senior roles. Through this discussion, we will propose actionable insights and recommendations.

Table 04: OPEN (start your own conversation)

Table 05: OPEN (start your own conversation)

Table 06: Effective Reviewing and Appropriate Author Responses for Submitted Manuscripts

Tim Garrett

Responding to reviewer comments is an essential part of resubmitting a manuscript. This roundtable will discuss effective ways of communicating your reviewer responses, answer questions you may have about the review process and enable you to improve your communication skills. It will also help you become a better reviewer.

Table 07: Standardization of Clinical Chemistry Tests: Why, What and How

Christa Cobbaert and Renee Ruhaak

Standardization of medical tests is of high importance to obtain accurate results. Accuracy and global exchangeability of results is imperative for global reference values, decision points and therapeutic targets as well as to make accurate deductions from large datasets through AI. In this roundtable we will discuss the current status of standardization of clinical chemistry tests, the initiation and coordination of standardization efforts, the role of mass spectrometry in standardization and the potential impact of standardization. So, if you want to know why and how to get involved in standardization initiatives, join this roundtable discussion!

Table 08: OPEN (start your own conversation)

Coffee & Exhibits

Location: St Laurent (Exhibits)

Plenary Lecture : Deciphering Proteopathies : Molecular Fingerprinting of Neurodegenerative Diseases

Location: Montreal 4-5

Judith Steen, PhD
Harvard Medical School & Boston Children's Hospital

Neurodegenerative disorders such as Alzheimer's Disease, Frontotemporal Degeneration, Parkinson's Disease, and Amyotrophic Lateral Sclerosis share a common pathological signature: the aggregation of specific proteins, including tau, TDP43, and alpha-synuclein. These proteopathies represent a critical juncture where normal proteins transform into pathological entities, driving neuronal dysfunction and death. Despite decades of research, the precise molecular mechanisms governing this transformation remain elusive.

To address this fundamental gap, we developed innovative mass spectrometry-based proteomic platforms with unprecedented sensitivity and specificity for characterizing disease-associated protein modifications. Our approaches comprehensively map and quantify post-translational modifications on pathological protein aggregates extracted from human patients and animal models across disease progression timelines. By analyzing these "molecular fingerprints" in large patient cohorts, we have revealed distinct modification patterns that define disease stages, patient subtypes, and predict clinical trajectories.

Our studies have uncovered the sequential accumulation of tau modifications during Alzheimer's pathogenesis and identified specific chemical alterations that enhance tau's propensity to aggregate and propagate between neurons. Importantly, these precise molecular characterizations distinguish pathological protein species from their normal counterparts, enabling the development of highly selective therapeutic strategies that target disease-driving protein forms while preserving essential physiological functions.

This presentation will highlight how quantitative proteomics has transformed our understanding of proteopathies and demonstrate how these insights create new paradigms for early diagnosis and precision therapeutics in neurodegenerative diseases.

Coffee & Exhibits

Location: St Laurent (Exhibits)

Scientific Session 3
Spatialomics - Pathology 1

Location: Montreal 1-2

Scientific Session 3
Practical Training

Location: Montreal 3

Scientific Session 3
Toxicology

Location: Montreal 4

Scientific Session 3
Microbiology Innovations and Applications

Location: Montreal 5

Scientific Session 3
Metabolomics - Rare Diseases

Location: Montreal 6-8

Lunch & Exhibits

Location: St Laurent (Exhibits)

Buffet Lunch hosted by MSACL.

Poster Session C

Location: St Laurent (Exhibits)

All posters in position 'c' will be attended during this poster session.

Exhibitor Feedback Meeting

Location: Westmount 6

Exhibitors are invited to join MSACL Admin to provide feedback on MSACL 2025 and begin planning for MSACL 2026 in Montreal (October 4-9, 2026).

Scientific Session 4
Spatialomics : Pathology 2

Location: Montreal 1-2

Scientific Session 4
Practical Training

Location: Montreal 3

Scientific Session 4
Curious Clinical Cases

Location: Montreal 4

Scientific Session 4
Proteomics: Neurology

Location: Montreal 5

Scientific Session 4
Metabolomics - Human Health

Location: Montreal 6-8

Poster Session D

Location: St Laurent (Exhibits)

All posters in position 'd' will be attended during this poster session.

Poster Tour #2

Location: St Laurent (Exhibits)

Early Career and first time attendees are encouraged to meet at the MSACL registration desk at 2:40pm to join a POSTER TOUR with a guiding mentor. Poster Tour Overview

Scientific Session 5
Spatialomics - AI and Medical Imaging

Location: Montreal 1-2

Scientific Session 5
Practical Training

Location: Montreal 3

Scientific Session 5
Toxicological Trends

Location: Montreal 4

Scientific Session 5
Proteomics: Antibodies

Location: Montreal 5

Scientific Session 5
Alternate Sampling Mechanisms

Location: Montreal 6-8

Exhibits Close

Location: St Laurent (Exhibits)

Intermission

Location: Foyer, Conference Level

Scientific Session 6
Spatialomics - Single Cells

Location: Montreal 1-2

Scientific Session 6
Practical Training

Location: Montreal 3

Scientific Session 6
Endocrinology

Location: Montreal 4

Scientific Session 6
Proteomics: Emerging Technologies

Location: Montreal 5

Scientific Session 6
Metabolomics - Microbiome

Location: Montreal 6-8

Celebration Dinner: Trivia or Lounge — Choose Your Experience!

Location: Salon Bonaventure, Hotel Level

Margret Thorsteinsdottir, PhD
University of Iceland

Timothy Collier, PhD
Quest Diagnostics

Daniel Holmes, MD, FRCPC
St. Paul’s Hospital

All MSACL 2025 attendees are invited to our closing dinner — no extra sign-up or fee required. Pick your preferred atmosphere:

  • Team Trivia Dinner (Salon Bonaventure) – Grab a table, form a team, and test your wits in a classic pub-style trivia game.
  • Dinner Club Lounge (Salon Ville Marie) – Kick back in a more casual lounge setting designed for mingling, conversation, and connection.
Both rooms will feature Closing Remarks and the Poster Award Winner Announcements — so no matter where you go, you won’t miss a thing.
MSACL Hospitality Lounge

Location: Salon Ville-Marie, Hotel Level

All attendees are welcome to close out the evening in Salon Ville Marie. MSACL will host drinks and snacks. The evening will open with a live jazz duo and close out with karaoke.

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