Imaging Mass Spectrometry and Metabolomics in Parkinson’s Disease
University of Florida
Imaging mass spectrometry (IMS) enables the direct analysis of compounds from tissue and the technique produces images that correlate to the distribution in tissue. When connected to metabolomics, this technique can provide a unique perspective of metabolism. Parkinson’s Disease (PD) is a movement disorder involving the loss of dopaminergic neurons as well as degeneration of multiple brain circuits. Deep brain stimulation (DBS) is a surgical treatment utilizing electrical stimulation to target a specific brain nucleus. Despite the effectiveness of DBS, little is known about the mechanism. We have utilized IMS and LC-HRMS metabolomics to evaluate the changes in small molecules in relation to PD and the potential changes to small molecules following DBS.
Presented at MSACL 2016 US