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An Accurate Mass Imaging MS Approach to Support Preclinical PK/PD Assessments
Sheerin Shahidi-Latham
Genentech, Inc.
[email protected]

This seminar will provide an overview of label-free high resolution mass spectrometric applications in support of drug discovery and development. Examples will include imaging MALDI MS of dosed tissues in support of effective drug delivery evaluations, highlighting the accurate mass approach for the simultaneous detection of drug and metabolites, and additionally the detection of endogenous components that provide a means for simultaneous PK/PD assessments while retaining spatial resolution. A synopsis of the advantages of high-resolution mass spectrometry, as well as, the technical challenges and opportunities in the context of the pharmaceutical industry will be discussed.

Presented at MSACL 2016 US