Accelerating the Implementation of Mass Spectrometry in the Clinical Lab

CMS Logo MSACL

UNITED STATES 2018

Help Us Reach Our Educational Support Goal of $40,000
Educational Travel Grants supported in part by:

Plenary Lecture Series

>> Tuesday 14:15 @ California Ballroom
Community-Scale Translation of Mass Spectrometry Big Data into Crowdsourced Proteomics and Metabolomics Resources
Nuno Bandeira
University of California, San Diego

View Long Abstract

Translating the growing volumes of proteomics mass spectrometry data into reusable evidence of the occurrence and provenance of proteomics and metabolomics events requires the development of novel community-scale computational workflows. We show how advanced distributed computing algorithms can be used to process tens of terabytes of public data to reveal hundreds of millions of new identifications, including the discovery of novel proteins and hypermodified peptides with over 100 modification variants. We further show how large scale reanalyses can be reliably aggregated into community-scale crowdsourced spectral libraries enabling high-throughput detection and discovery in newly acquired data.

>> Wednesday 17:00 @ California Ballroom
Distinguished Contribution Award Plenary Lecture
The Triple Quadrupole: Innovation, Serendipity and Persistence
Richard Yost

>> Thursday 18:15 @ California Ballroom
A New Approach to Genome Editing
Alexis Komor
University of California, San Diego

The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes within living cells. Here I describe the development of base editing, a new approach to genome editing that enables the direct, irreversible conversion of one target DNA base into another in a programmable manner, without requiring double-stranded DNA backbone cleavage or a donor template. Base editing is one of many recent developments in the genome editing field that advances both the scope and effectiveness of genome editing.