Accelerating the Implementation of Mass Spectrometry in the Clinical Lab

CMS Logo MSACL

UNITED STATES 2019

Help Us Reach Our Educational Support Goal of $40,000
Educational Grants supported in part by:
Brian Kelly
Danyel Tacker
Amadeo Pesce

Meet-a-Mentor

MSACL strives to offer a congress experience that values training and mentorship (see travel grants, short courses and Practical Training tracks), and provides avenues by which early-career attendees can gain experience presenting (see Poster Lightning Talks, the Poster Contest, Podium opportunities).

The Meet-a-Mentor program has been developed to create a channel by which early-career attendees can approach, interact and connect with mid- to late-career attendees to share intellect and experience.

Booth and Poster Tours: Mentors browse booths or view posters as they normally do, but with one or more mentees along to observe, participate and learn from experience.

Office Hours: Mentors will be available at tables in the Meet-a-Mentor area of the Exhibit Hall where attendees can sign up to have a 10-15 minute chat about ... anything.

You can sign up at the congress to participate in one or more Meet-a-Mentor activities (i.e., Booth Tour, Poster Tour, Office Hours).

Tuesday 18:15 - 19:00 Meet-a-Mentor: Booth Tours
Exhibit Hall in Oasis 3-4
Wednesday 14:15 - 15:00 Meet-a-Mentor: Poster Tours 1
Exhibit Hall in Oasis 3-4
Wednesday 16:15 - 17:15 Meet-a-Mentor: Office Hours
Exhibit Hall in Oasis 3-4
Thursday 10:15 - 11:00 Meet-a-Mentor: Poster Tours 2
Exhibit Hall in Oasis 3-4

Erin Baker, PhD
North Carolina State University

Poster Judging on See Details @ See Details
Office Hours 1 on Wednesday @ 16:15
Dr. Erin Baker is a bioanalytical chemist with more than 18 years experience utilizing ion mobility spectrometry in conjunction with mass spectrometry (IMS-MS) to study environmental and biological systems. In the last 13 years she has worked primarily on IMS-MS applications in the field of proteomics and more recently she has optimized IMS-MS metabolomic, glycomic and lipidomic separations. Her research involves the development and evaluation of high throughput IMS-MS, SPE-IMS-MS and LC-IMS-MS analyses to quickly study numerous samples in a short time period without losing valuable biological information, as well as assessing the number and quality of features detected with IMS-MS for comparison with existing MS platforms. Dr. Baker is also presently working with various informatics teams to design and implement software tools that automatically analyze the complex multidimensional SPE-IMS-MS and LC-IMS-MS data.

Anne Bendt, PhD (Biochem)
Singapore Lipidomics Incubator (SLING)

Office Hours 1 on Wednesday @ 16:15
With a MSc in Marine Biotechnology (Greifswald University, Germany) and a PhD in Biochemistry (Cologne University, Germany) in close collaboration with industry, Anne Bendt has always been working on topics which are translatable into applications outside of the laboratory. Driven by her fascination for infectious diseases, she joined the National University of Singapore (NUS) in 2004 to develop lipidomics tools for tuberculosis studies. She is now a Principal Investigator at the Life Sciences Institute, NUS, focussing on translation of mass spec technologies into clinical applications, primarily for lipids and small molecules. Additionally, she is serving as the Associate Director of the Singapore Lipidomics Incubator (SLING) being in charge of operations and commercialization. Anne is passionate about training and education and has made substantial contributions to SLING’s various workshops and the highly successful ‘ic lipid’ training course.

Cory Bystrom, PhD
Cleveland HeartLab/Quest Diagnostics

Poster Judging on See Details @ See Details
Office Hours 1 on Wednesday @ 16:15
Dr. Cory Bystrom serves as Director of Research and Development at Cleveland HeartLab where he is responsible for novel biomarker identification, validation and commercialization with an emphasis on quantitative biological mass spectrometry. Dr. Bystrom has over a decade of experience as a laboratory leader and chemist. Prior to joining CHL, he was at Quest Diagnostics Nichols Institute as associate director of research and development with responsibilities for development of tests and identification of analytical strategies for commercialization of new biomarkers. He also has held research and development roles at Oregon Health Science University, Fonterra, and Pharmacia and Upjohn.

William Clarke, PhD
Johns Hopkins University

Booth Tours on Tuesday @ 18:00
Office Hours 1 on Wednesday @ 16:15
Dr. William Clarke is a professor of pathology at the Johns Hopkins University School of Medicine. His research focuses on the development of analytical methods for drug analysis, clinical mass spectrometry, and devices for point-of-care testing. Dr. Clarke serves as the director of Clinical Toxicology as well as Critical and Point-of-Care Testing Program at The Johns Hopkins Hospital.

His team’s current projects include qualitative screening for antiretroviral drugs and substances of abuse in various HIV- prevention clinical trials, development and validation of mass spectrometry methods for clinical analysis, and development of clinical assays for use on microfluidic platforms.

Dr. Clarke received his B.S. in Chemistry from the University of Nebraska at Kearney and his Ph.D. in Analytical Chemistry from the University of Nebraska-Lincoln, as well as an M.B.A. from the Carey School of Business at Johns Hopkins University. He completed a post-doctoral fellowship in Clinical Chemistry at the Johns Hopkins School of Medicine.

Jennifer Colby, PhD
Vanderbilt

Poster Judging on See Details @ See Details

Mari DeMarco, PhD
University of British Columbia

Poster Judging on See Details @ See Details
Office Hours 1 on Wednesday @ 16:15
Mari DeMarco is a clinical chemist at St Paul's Hospital, and a clinical associate professor in the Department of Pathology and Laboratory Medicine at the University of British Columbia in Vancouver Canada. Her research lab develops strategies for streamlined sample preparation workflows for both qualitative and quantitative mass spectrometric analysis of peptide and protein biomarkers. In addition, a major focus of her laboratory is the development biofluid tests for Alzheimer’s disease and related neurodegenerative disorders, and their application to clinical research and patient care.

Rob DeWitte, PhD
Thermo Fisher Scientific

Office Hours 1 on Wednesday @ 16:15
Rob is a scientist who has evolved into a business leader over the course of his career. He has a PhD in theoretical Chemical Physics (Harvard University), but has managed to follow his interests into Pharma R&D (startup & Big Pharma), technologies for drug discovery, and most recently platforms for clinical diagnostics. Along the way he has been involved in, or responsible for, R&D, Marketing, Strategy, Business Development, QARA, Manufacturing and General Management. Join Rob in his office hour if you’d like to talk about alternative careers. There are a lot of different paths that lead to interesting opportunities!

Timothy Garrett, PhD
University of Florida

Poster Judging on See Details @ See Details

Russ Grant, PhD
Lab Corp

Poster Judging on See Details @ See Details
Poster Tours 1 on Wednesday @ 14:15
Russell Grant, PhD received his PhD in chromatographic and mass spectrometric technologies from Swansea University in 1995. He continued his scientific training in various industrial settings which have included: Senior scientist at GSK, Principal scientist at Cohesive Technologies, Technical Director at Eli Lilly and Director of Mass Spectrometry at Esoterix Endocrinology.

Dr. Grant has pioneered the use of direct injection technologies, chromatographic systems multiplexing, utility of automation and new analytical platforms for utility in bioanalytical applications. Dr Grant has extensive experience in developing, validating and launching clinical tests using Mass Spectrometry. Dr Grant is regarded as an expert in many facets of the clinical mass spectrometry discipline. His contributions including a significant degree of teaching (MSACL, ASMS, AACC, FDA), chairing usergroups and workshops (ASMS, MSACL) and contributing heavily or chairing guidance documents (FDA, CLSI). His research goals are focused upon improvements in automation, systems integration, throughput, sensitivity and quality of LC-MS/MS analytical systems for all clinically relevant biomarkers and therapeutics.

Shannon Haymond, PhD
Ann and Robert H. Lurie Children’s Hospital of Chicago, Northwestern University, Feinberg School of Medicine

Poster Judging on See Details @ See Details
Office Hours 1 on Wednesday @ 16:15
Hi! I am Dr. Shannon Haymond, the Director of Mass Spectrometry and the Vice Chair for Computational Pathology at Ann & Robert H. Lurie Children?s Hospital of Chicago. I am an Associate Professor of Pathology at Northwestern University Feinberg School of Medicine.

My current interests include automating data workflows in mass spectrometry labs and improving the capacity and application of data analytics within laboratory medicine. That said, I especially enjoy meeting early career colleagues and am happy to share my experiences on a broad array of topics.

Daniel Holmes, MD
St. Paul’s Hospital

Poster Tours 2 on Thursday @ 10:15
Daniel Holmes earned his undergraduate degree in Chemical Physics from the University of Toronto. He went to medical school at the University of British Columbia (UBC) where he also did his residency in Medical Biochemistry. He is a Clinical Professor of Pathology and Laboratory Medicine at UBC and Division Head of Clinical Chemistry at St. Paul's Hospital in Vancouver. Interests include laboratory medicine informatics – particularly using the R language, clinical endocrinology with a focus on secondary hypertension, clinical lipidology and clinical mass spectrometry. Assay development efforts in the last five years have focused on novel use of mass spectrometry for quantitative protein mass spectrometry and for specialized endocrine testing.

Andy Hoofnagle, MD, PhD
University of Washington

Poster Judging on See Details @ See Details
Dr. Hoofnagle’s laboratory focuses on the precise quantification of recognized protein biomarkers in human plasma using LC-MRM/MS. In addition, they have worked to develop novel assays for the quantification of small molecules in clinical and research settings. His laboratory also studies the role that the systemic inflammation plays in the pathophysiology of obesity, diabetes, and cardiovascular disease. He also likes to hike and jump up onto large tree stumps in a single bound.

Marilyn Huestis, PhD
Center for the Study of Medicinal Cannabis and Hemp, Thomas Jefferson University

Poster Judging on See Details @ See Details
Office Hours 1 on Wednesday @ 16:15
Professor Dr. Dr. (h.c.) Marilyn A. Huestis recently retired as a tenured senior investigator and Chief, Chemistry and Drug Metabolism Section, IRP, National Institute on Drug Abuse, National Institutes of Health, after 23 years of conducting controlled drug administration studies. She currently is a Senior Fellow and a member of the Steering Committee of The Lambert Center for the Study of Medicinal Cannabis and Hemp, Thomas Jefferson Medical School, Philadelphia, PA, Science and Policy Advisor, Pinney Associates, Bethesda, MD, on the Smart Approaches to Marijuana (SAM) Science Advisory Board, Senior Scientific Advisor of NMS Labs, Consultant to the US Department of Transportation, a Fellow at the Center for Forensic Science Research & Education, Willow Grove, PA and President of Huestis & Smith Toxicology, LLC. Her research program focused on discovering mechanisms of action of cannabinoid agonists and antagonists, effects of in utero drug exposure, oral fluid testing, driving under the influence of drugs, and the neurobiology and pharmacokinetics of novel psychoactive substances. Professor Huestis’ research also explored new medication targets for cannabis dependence, including oral tetrahydrocannabinol (THC), Sativex, a 1:1 ratio of tetrahydrocannabinol and cannabidiol. She has published 475 peer-reviewed manuscripts and book chapters and more than 500 abstracts were presented at national and international meetings. Her mass spectrometry experience focused on the use of GC-MS, LC-MS/MS, and high resolution mass spectrometry to determine the unknown major urinary metabolites of novel psychoactive substances, and the disposition of licit and illicit drugs in humans after controlled drug administration and after drug use by pregnant and breastfeeding women.

Randy Julian, PhD
Indigo BioAutomation

Poster Judging on See Details @ See Details
Randy Julian is CEO, President, and Founder of Indigo BioAutomation located in Indianapolis, Indiana. Randy earned a Ph.D. in Chemistry from Purdue University in 1993 and then worked in Discovery Chemistry at Eli Lilly for 14 years. Randy founded Indigo based on informatics technology developed in his research group. Dr. Julian led Indigo from its founding to profitability, building a world class management, engineering and research team to commercialize laboratory data analysis software.

Dr. Julian is a frequent speaker in the mass spectrometry community and teaches short courses in statistics and data analysis. Randy is the past Chairman of the Human Proteome Organization’s Proteomics Standards Initiative Steering Group where he coauthored two international standards for analytical data. He was also the chairman of the ASTM committee on analytical data standards. Dr. Julian also maintains an active research relationship with the faculty at Purdue University where he is an Adjunct Professor of Chemistry.

Mark Marzinke, PhD
Johns Hopkins University

Office Hours 1 on Wednesday @ 16:15
Dr. Marzinke is Associate Professor of Pathology and Medicine in the Johns Hopkins University School of Medicine. He is the Director of Preanalytics and the General Chemistry Laboratory in the Johns Hopkins Hospital Core Laboratories and the Director of the Clinical Pharmacology Analytical Laboratory in the Division of Clinical Pharmacology. He is Co-Director of the HIV Prevention Trials Network (HPTN) Laboratory Center (LC) and Core leader in the Johns Hopkins Center for AIDS Research. Dr. Marzinke currently sits on the Board of Editors for Clinical Laboratory News, and is on the editorial board for the Journal of Applied Laboratory Medicine. Dr. Marzinke received his Ph.D. in Biochemistry from the University of Wisconsin-Madison, followed by a post-doctoral fellowship in Clinical Chemistry at the Johns Hopkins University School of Medicine. Dr. Marzinke is board certified in Clinical Chemistry by the American Board of Clinical Chemistry. His primary research interests are in the areas of antiretroviral pharmacology, precision medicine, mass spectrometry, and laboratory automation. He is a principal investigator or co-investigator on several NIH-funded grants.

Steve Master, MD, PhD
Children’s Hospital of Philadelphia

Poster Judging on See Details @ See Details
Stephen Master received his undergraduate degree in Molecular Biology from Princeton University, and subsequently obtained his MD and PhD from the University of Pennsylvania School of Medicine. After residency in Clinical Pathology at Penn, he stayed on as a faculty member with a research focus in mass spectrometry-based proteomics as well as extensive course development experience in bioinformatics. He is currently Associate Professor of Pathology and Laboratory Medicine at Children’s Hospital of Philadelphia. One of his current interests is in the applications of bioinformatics and machine learning for the development of clinical laboratory assays. He would play with R for fun even if he weren’t getting paid, but he would appreciate it if you didn’t tell that to his department chair.

Brian Rappold
Lab Corp

Poster Judging on See Details @ See Details
Poster Tours 1 on Wednesday @ 14:15
Office Hours 1 on Wednesday @ 16:15
Brian Rappold is the Director of Mass Spectrometry for LabCorp and has been involved in MSACL for nearly a decade as a presenter and short course instructor.  He is a renowned expert in the field of method development and validation of mass spectrometry assays for clinical diagnostic use, teaching courses on this subject at numerous scientific conferences. His extensive knowledge and clinical perspective has granted him several opportunities to present his research internationally on the topics of hydrophilic interaction liquid chromatography for bio-analysis, multiplexed mass spectrometric detection of amino acidopathies and the origins and solutions of ion suppression in electrospray ionization. He has served as the chair of Clinical Chemistry for the American Society for Mass Spectrometry (ASMS) and has served on the Metabolomics and Small Molecule Analysis/Toxicology Scientific Committee for The Association for Mass Spectrometry: Applications to the Clinical Laboratory (MSACL). His research interests include the realization of open-access mass spectrometric systems and antibody-capture/mass spectrometry applications to diagnostic medicine. He enjoys Spanish wine, Belgian beer and American Whiskey.

Adam Rosebrock, PhD
Stony Brook School of Medicine

Poster Judging on See Details @ See Details

Chris Shuford, PhD
LabCorp

Office Hours 1 on Wednesday @ 16:15
Chris Shuford, Ph.D., is Associate Vice President and Technical Director for research and development at Laboratory Corporation of America in Burlington, North Carolina. Chris received his B.S. in Chemistry & Physics at Longwood University and obtained his Ph.D. in Bioanalytical Chemistry from North Carolina State University under the tutelage of Professor David Muddiman, where his research focused on applications of nano-flow chromatography for multiplexed peptide quantification using protein cleavage coupled with isotope dilution mass spectrometry (PC-IDMS). In 2012, Chris joined LabCorp’s research and development team where his efforts have focused on development of high-flow chromatographic methods (>1 mL/min) for multiplexed and single protein assays for clinical diagnostics.

Will Slade, PhD
Laboratory Corporation of America

Poster Judging on See Details @ See Details
Booth Tours on Tuesday @ 18:00
Poster Tours 1 on Wednesday @ 14:15
Office Hours 1 on Wednesday @ 16:15
Poster Tours 2 on Thursday @ 10:15
William Slade, PhD did his undergraduate degree in Biology from Concord University with a focus on Recombinant Gene Technology. He completed a PhD in Biological Sciences at Virginia Tech with a focus on Biological Mass Spectrometry before postdoctoral work at the University of North Carolina at Chapel Hill in the Analytical Chemistry department. He is currently a Researcher in the Mass Spectrometry Research and Development group at Laboratory Corporation of America Holdings in Burlington, North Carolina. His interests include clinical mass spectrometry and informatics.

Judy Stone, PhD
Univ. of Calif. San Francisco Health

Poster Judging on See Details @ See Details
Booth Tours on Tuesday @ 18:00
Judy will lead a Booth Tour for LC-MS 101 short course attendees & all other interested parties. This tour will highlight and build on discussions from the course.

Judy Stone served as Asst. Professor and Assoc. Director of Clinical Chemistry at the University of Connecticut Health Center, as Asst. Professor and Director of the Core, Immunology and Toxicology Laboratories at the University of Massachusetts Medical Center; and has worked with mass spectrometry at Specialty Laboratories, San Francisco General Hospital, Kaiser Regional Laboratories in Northern California and the Clinical Mass Spectrometry Laboratory, Center for Advanced Laboratory Medicine, Univ. of Calif. San Diego Health System. She currently works in the automated chemistry STAT laboratory, Parnassus Campus, at Univ. of California, San Francisco Health.

Her research interests are in mass spectrometry applications and automation for clinical toxicology and endocrinology. She teaches, with a team of colleagues, a two day short course on “Getting Started with Quantitative LC-tandem MS in the Diagnostic Laboratory” at the MSACL meetings in the U.S. and Europe. She is a member of AACC and ASMS and serves as Chair, Board of Editors for the Mass Spectrometry Feature Series, Clinical Laboratory News. She is interested in developing a certification program for basic clinical mass spectrometry.

Irene Van den Broek, PhD
Cedars-Sinai Medical Center

Poster Judging on See Details @ See Details
Booth Tours on Tuesday @ 18:00
Poster Tours 1 on Wednesday @ 14:15
Irene van den Broek is the lead clinical R&D of the Cedars-Sinai Precision Biomarker Laboratories at Cedars-Sinai Medical Center in Los Angeles. Dr. van den Broek received her PhD in LC-MS/MS method development for peptide therapeutics from the Utrecht University, followed by a post-doctoral fellowship in LC-MS/MS for clinical protein assays at the Leiden University Medical Center, both in the Netherlands. Her primary research interests are clinical protein mass spectrometry, (automation of) protein sample preparation, and applications of clinical protein mass spectrometry in remote monitoring and precision medicine. At the Precision Biomarker Laboratories, a newly-founded clinical-contract research laboratory consortium, she leads the research, development and validation of small and large molecule LC-MS/MS assays for use in the routine clinical laboratory.

Jarrad Wagner, PhD
Oklahoma State University Center for Health Sciences (OSU CHS)

Booth Tours on Tuesday @ 18:00
Dr. Jarrad Wagner is a Professor of Forensic Sciences at Oklahoma State University Center for Health Sciences (OSU CHS), where he is the Director of the Forensic Toxicology and Trace Laboratory. He works primarily with triple quadrupole LC/MS/MS instruments and supporting forensic and clinical laboratories in method development, validation and training. Dr. Wagner is a Fellow of the American Board of Forensic Toxicology and also a Fellow in the Criminalistics section of the American Academy of Forensic Sciences. He serves as a member of the AAFS/SOFT Drugs and Driving Committee, the Drug Facilitated Crimes committee, and the Oral Fluid committee. He is also a member of the Alcohol, Drugs and Impairment Division of the National Safety Council and Vice Chair of the Oklahoma State Board of Tests for Alcohol and Drug Influence. In addition to his current role as faculty and Clinical Lab Director, he has also formerly been a chemist, a forensic scientist and reserve police officer.

Richard Yost, PhD
University of Florida

Poster Judging on See Details @ See Details
Office Hours 1 on Wednesday @ 16:15
Dr. Yost is the University Professor and Head of Analytical Chemistry at the University of Florida. He is recognized internationally as a leader in the field of analytical chemistry, particularly tandem mass spectrometry (MS/MS). Dr. Yost received his BS degree in Chemistry in 1974 from the University of Arizona, having performed undergraduate research in chromatography with Professor Mike Burke and his PhD degree in Analytical Chemistry in 1979 from Michigan State University, having performed graduate research with Professor Chris Enke. He then joined the faculty of the University of Florida.

Dr. Yost's professional activities have focused on research and teaching in analytical mass spectrometry, particularly tandem mass spectrometry (MS/MS). His group’s research has reflected a unique balance between instrumentation development, fundamental studies, and applications in analytical chemistry. His group has led in the application of novel mass spectrometric methods and techniques to areas such as metabolomics, clinical, biomedical, pharmaceutical, environmental, petrochemical, and forensic chemistry. Dr. Yost has supervised the research of well over 100 graduate students during the past 39 years, graduating over 90 PhDs from his group. He has served as PI or Co-PI on grants and contracts totaling over $60M of funding. Research in the group has led to over 210 publications and 25 patents. He still loves teaching undergraduates and graduates in the classroom each semester. Dr. Yost recently completed terms on the Florida Board of Governors (Regents) and the University of Florida Board of Trustees. He is director of the Southeast Center for Integrated Metabolomics (SECIM) and of NIH’s Metabolomics Consortium Coordinating Center (M3C). He is also a Professor of Pathology at both the University of Florida and the University of Utah/ARUP. His research has been recognized with the 1993 ASMS Award for Distinguished Contribution in Mass Spectrometry and the 2018 MSACL Award for Distinguished Contribution to Clinical Mass Spectrometry. In 2019 he received the Distinguished Eagle Scout Award and was named the Florida Academy of Sciences Medalist. He currently serves as the President of the American Society for Mass Spectrometry (ASMS).